Publication date: Available online 21 August 2019Source: Annals of Diagnostic PathologyAuthor(s): Sara A.J. Sinno, Nawaf M.H. JurdiAbstractGoblet cell tumors are rare tumors of the appendix that exhibit both neuroendocrine and mucinous differentiation. This dual differentiation has led to a controversy regarding the proper classification of these neoplasms as to whether they should be considered neuroendocrine tumors or adenocarcinomas. Multiple grading systems have been proposed that were able to...
16h
Radiotherapy (RT) is considered an important therapeutic strategy in the fight against colorectal cancer (CRC). However, the existence of some radioresistance factors becomes the main challenge for the RT. Rec...
8h
Sexuality is an important aspect of quality of life for adolescent and young adults that remains understudied in cancer patients. Most current knowledge about how cancer and cancer treatments can affect patien...
8h
Carbon ion (12C) radiotherapy is becoming very promising to kill highly metastatic cancer cells keeping adjacent normal cells least affected. Our previous study shows that combined PARP-1 inhibition with 12C ion ...
8h
SMARCB1-deficient sinonasal carcinoma (SDSC) is an aggressive subtype of head and neck cancers that has a poor prognosis despite multimodal therapy. We present a unique case with next generation sequencing dat...
8h
To develop a new 18 high-risk human papillomavirus (HR HPV) detection and genotyping assay, which is important to evaluate the risk degree of HR HPV for causing cancers.
8h
An investigation by The BMJ has found that a scientific body advising the US Food and Drug Administration on opioid policies did not publicly disclose that one of its presidents had recent links to...
6h
As lawsuits proliferate against members of the Sackler family, owners of Purdue Pharma, for allegedly downplaying the risks of Purdue’s opioid painkiller Oxycontin (oxycodone), the family faces not...
6h
The scale of the NHS pension crisis is becoming clear. Surveys by the BMA,1 the Hospital Consultants and Specialists Association,2 and NHS Employers3 indicate that around half of senior doctors in...
6h
An investigation by The BMJ has found that a scientific body advising the US Food and Drug Administration on opioid policies did not publicly disclose that one of its presidents had recent links to...
9h
As lawsuits proliferate against members of the Sackler family, owners of Purdue Pharma, for allegedly downplaying the risks of Purdue’s opioid painkiller Oxycontin (oxycodone), the family faces not...
9h
The rising popularity of complementary and alternative medicine (CAM) is an undeniable contributing factor in the UK’s loss of its measles-free status,1 says Edzard Ernst, professor and researcher of...
16h
A 32 year old man presented to the emergency department with trismus and a painful swollen right side of his face. He was intoxicated and unable to provide a clear history, but he mentioned an...
16h
A 9 year old boy presented with a sudden onset atraumatic painful purplish red indurated swelling around the eyes (fig 1). Physical examination showed a few areas of tender erythema of up to 4 cm in...
16h
What you need to knowIn patients with newly diagnosed colorectal cancer, order a test for serum carcinoembryonic antigen (CEA) level and computed tomography (CT) scan of the chest, abdomen, and...
16h
Gun lawsAfter motor vehicle crashes, firearms related injury is the leading cause of death among children in the United States. Twice as many children die from firearms than do from childhood...
16h
It would be a tragic irony if something as fundamentally benign and beneficial as doctors’ pensions proved to be the final downfall of the NHS. But when senior doctors find themselves with little...
16h
The rising popularity of complementary and alternative medicine (CAM) is an undeniable contributing factor in the UK’s loss of its measles-free status,1 says Edzard Ernst, professor and researcher of...
19h
A 32 year old man presented to the emergency department with trismus and a painful swollen right side of his face. He was intoxicated and unable to provide a clear history, but he mentioned an...
19h
A 9 year old boy presented with a sudden onset atraumatic painful purplish red indurated swelling around the eyes (fig 1). Physical examination showed a few areas of tender erythema of up to 4 cm in...
20h
What you need to knowIn patients with newly diagnosed colorectal cancer, order a test for serum carcinoembryonic antigen (CEA) level and computed tomography (CT) scan of the chest, abdomen, and...
20h
Gun lawsAfter motor vehicle crashes, firearms related injury is the leading cause of death among children in the United States. Twice as many children die from firearms than do from childhood...
20h
It would be a tragic irony if something as fundamentally benign and beneficial as doctors’ pensions proved to be the final downfall of the NHS. But when senior doctors find themselves with little...
20h
I am one of thousands of senior doctors facing a situation where my pension, once perceived as a benefit for long and committed service to the NHS, is now a financial liability. The combination of an...
20h
Drug deathsEngland and Wales report all time highSome 4359 deaths were related to drug poisoning in England and Wales in 2018, the highest number and biggest annual increase (16%) since the time...
21h
The scale of the NHS pension crisis is becoming clear. Surveys by the BMA,1 the Hospital Consultants and Specialists Association,2 and NHS Employers3 indicate that around half of senior doctors in...
21h
Background Partnered status is an independent predictor of clinical outcomes, including overall survival, among patients with cancer. However, the mechanisms by which partnered status impacts survival are not fully understood and to the authors' knowledge the associations between partnered status and the specific attributes of chemotherapy have not been studied to date. Methods The current study was an observational study of patients with resected American Joint Committee on Cancer (AJCC) stage...
22h
Despite recent advances in the management of colorectal cancer, metastatic disease remains challenging, and patients are rarely cured. However, a better understanding of the pathways implicated in the evolution and proliferation of cancer cells has led to the development of targeted therapies, that is, agents with action directed at these pathways/features. This approach is more specific to cells within which these pathways, such as epidermal growth factor receptor (EGFR), are overactive; this is...
22h
Background Blinatumomab, a bispecific T‐cell‐engaging (BiTE®) immuno‐oncology therapy, demonstrated superior overall survival versus standard‐of‐care chemotherapy (SOC) in adults with relapsed/refractory B‐cell precursor acute lymphoblastic leukemia (R/R ALL) in the phase 3 TOWER study. Herein, the authors reported clinical features and outcomes for those patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) after treatment with blinatumomab. Methods In the TOWER...
22h
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
3h
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
3h
Melanoma is an extremely aggressive malignant skin tumor with high mortality. Many types of long noncoding RNAs and microRNAs have been reported to be associated with the oncogenesis of melanoma. However, a no...
8h
The MDM2 protein encoded by the mouse double minute 2 (MDM2) gene is the primary negative regulatory factor of the p53 protein. MDM2 can ligate the p53 protein via its E3 ubiquitin ligase, and the ubiquitinated p...
8h
Here, we report that Sam68, an early signaling molecule in DDR, is elevated in skin tumor tissues derived from NMSC patients and skin lesions from Gli2‐transgenic mice. Downregulation of Sam68 impacts the growth and survival of human tumor keratinocytes and genetic ablation of Sam68 delays the onset of basal cell carcinomas (BCC) in Gli2‐transgenic mice. Moreover, Sam68 plays a critical role in DNA damage‐induced DNA repair and nuclear factor kappa B (NF‐κB) signaling pathways in keratinocytes, hence...
21h
This study examined the real‐world benefits of osimertinib in patients with tissue or plasma T790M mutations. The progression‐free survival, overall survival, and tumor response rates of 46 non‐small‐cell lung cancer patients were calculated and compared with those of previous clinical trials. It was determined that both tissue and plasma T790M mutations can be used to guide treatment with osimertinib. Abstract Background Osimertinib yields significant tumor responses and durations of progression‐free...
21h
In this manuscript, we performed the up‐to‐date comprehensive network meta‐analysis as well as bioinformatic analysis for the angiogenesis inhibitors on the survival of patients with small cell lung cancer in terms of both PFS and PS. Moreover, we found that the overall expression level of angiogenesis inhibitor targets is low expressed in SCLC tissue compared with matched normal tissue which could be the reason for the unideal response. Abstract Background Small cell lung cancer (SCLC) is a...
21h
We demonstrated that aberrantly down‐regulated miR‐449b‐3p targeted ADAM17 to promote NPC metastasis, and ADAM17‐activated NF‐κB could transcriptionally suppress miR‐449b‐3p gene expression in turn. Abstract An emerging body of evidence has promoted the understanding of the role of microRNAs (miRNAs) in tumorigenesis and progression, but the mediating function of miRNAs in nasopharyngeal carcinoma (NPC) development remains poorly elucidated. In this study, miR‐449b‐3p was downregulated in NPC specimens...
21h
Cellular adaptation brought upon by insults such as old age and therapeutic exposure is a complex phenomenon in which cells undergo adaptive phenotypic changes. Our lab has focused on understanding the mechanisms underlying adaptation during the evolution of cancer, from the early stages of development to the ability of cancer cells to escape therapeutic challenges. Our studies span hematopoietic and lung systems. Herein, we discuss the advantages and disadvantages involved in studying two vastly...
5h
Metabolic reprogramming in tumor-associated macrophages (TAMs) is associated with cancer development, however, the role of macrophage triglyceride metabolism in cancer metastasis is unclear. Here, we showed that TAMs exhibit heterogeneous expression of abhydrolase domain containing 5 (ABHD5), an activator of triglyceride hydrolysis, with migratory TAMs expressing lower levels of ABHD5 compared to the non-migratory TAMs. ABHD5 expression in macrophages inhibited cancer cell migration in vitro, in...
5h
Cancer-associated fibroblasts (CAFs) constitute a major component of the tumor microenvironment. Recent observations in genetically engineered mouse models and clinical studies have suggested that there may exist at least two functionally different populations of CAFs, i.e., cancer-promoting CAFs (pCAFs) and cancer-restraining CAFs (rCAFs). Although various pCAF markers have been identified, the identity of rCAFs remains unknown because of the lack of rCAF-specific marker(s). In the present study,...
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Pre-Surgical Nutrition Support Reduces the Incidence of Surgical Wound Complications in Oncological Patients. Nutr Cancer. 2019 Aug 21;:1-7 Authors: Mudarra García N, Naranjo Peña I, Olivares Pizarro SP, Riquelme Oliveira A, Granizo Martínez JJ, Rodríguez Prieto I, Pérez Muñoz R Abstract Patients who suffer from cancer are at a higher risk of complications when they experience malnutrition. Evidence shows that oral nutritional supplements favor the healing...
16h
Related ArticlesDietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial. Gut. 2019 08;68(8):1430-1438 Authors: Chambers ES, Byrne CS, Morrison DJ, Murphy KG, Preston T, Tedford C, Garcia-Perez I, Fountana S, Serrano-Contreras JI, Holmes E, Reynolds CJ, Roberts JF, Boyton...
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Cancers, Vol. 11, Pages 1230: Predictive Factors of Recurrence in Patients with Differentiated Thyroid Carcinoma: A Retrospective Analysis on 579 Patients Cancers doi: 10.3390/cancers11091230 Authors: Medas Canu Boi Lai Erdas Calò Differentiated thyroid carcinoma (DTC) is usually associated with a favorable prognosis. Nevertheless, up to 30% of patients present a local or distant recurrence. The aim of this study was to assess the incidence of recurrence after surgery...
15h
Cancers, Vol. 11, Pages 1229: Targeted Gene Next-Generation Sequencing Panel in Patients with Advanced Lung Adenocarcinoma: Paving the Way for Clinical Implementation Cancers doi: 10.3390/cancers11091229 Authors: Maria Gabriela O. Fernandes Maria Jacob Natália Martins Conceição Souto Moura Susana Guimarães Joana Pereira Reis Ana Justino Maria João Pina Luís Cirnes Catarina Sousa Josué Pinto José Agostinho Marques José Carlos Machado Venceslau Hespanhol...
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Cancers, Vol. 11, Pages 1227: The Changing Therapeutic Landscape of Metastatic Renal Cancer Cancers doi: 10.3390/cancers11091227 Authors: Javier C. Angulo Oleg Shapiro The practising clinician treating a patient with metastatic clear cell renal cell carcinoma (CCRCC) faces a difficult task of choosing the most appropriate therapeutic regimen in a rapidly developing field with recommendations derived from clinical trials. NCCN guidelines for kidney cancer initiated a major shift in...
18h
Cancers, Vol. 11, Pages 1226: A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions Cancers doi: 10.3390/cancers11091226 Authors: Herwig P. Moll Julian Mohrherr Leander Blaas Monica Musteanu Patricia Stiedl Beatrice Grabner Katalin Zboray Margit König Dagmar Stoiber Thomas Rülicke Sabine Strehl Robert Eferl Emilio Casanova Genetically-engineered mouse models (GEMMs) lacking diseased-associated gene(s) globally...
18h
Cancers, Vol. 11, Pages 1228: Keratin-14 (KRT14) Positive Leader Cells Mediate Mesothelial Clearance and Invasion by Ovarian Cancer Cells Cancers doi: 10.3390/cancers11091228 Authors: Maree Bilandzic Adam Rainczuk Emma Green Nicole Fairweather Thomas W. Jobling Magdalena Plebanski Andrew N. Stephens Epithelial ovarian cancer metastasis is driven by spheroids, which are heterogeneous cancer cell aggregates released from the primary tumour mass that passively disseminate...
18h
Cancers, Vol. 11, Pages 1225: Key Role of Obesity in Genitourinary Tumors with Emphasis on Urothelial and Prostate Cancers Cancers doi: 10.3390/cancers11091225 Authors: Matteo Santoni Alessia Cimadamore Francesco Massari Francesco Piva Gaetano Aurilio Angelo Martignetti Marina Scarpelli Vincenzo Di Nunno Lidia Gatto Nicola Battelli Liang Cheng Antonio Lopez-Beltran Rodolfo Montironi Background: In human populations, a certain amount of data correlate...
22h
CONCLUSIONS: This study creates a foundation for molecular understanding of and drug development for canine lung cancer. These data also establish molecular contexts for comparative studies in dogs and humans of low mutation burden, never-smoker lung cancer and mutant HER2 function and inhibition. PMID: 31431454 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
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Purpose: This study was to perform preclinical evaluation of a novel class I and IIb HDAC selective inhibitor, Purinostat Mesylate (PM), for the treatment of Ph+ B-ALL. Experimental Design: Biochemical assays were used to test enzymatic activity inhibition of PM. Ph+ leukemic cell lines and patient cells were used to evaluate PM activity in vitro. BL-2 secondary transplantation Ph+ B-ALL mouse model was used to validate its efficacy, mechanism and pharmacokinetics properties in vivo. BCR-ABL(T315I)-induced...
4h
Purpose: No study have investigated the precise perioperative dynamic changes in circulating tumor DNA (ctDNA) in any early stage cancer patients. This study (DYNAMIC) investigated perioperative dynamic changes in ctDNA and determine the appropriate detection time of ctDNA-based surveillance for surgical lung cancer patients. Experimental Design: Consecutive patients who underwent curative-intent lung resections were enrolled prospectively (NCT02965391). Plasma samples were obtained at multiple pre-specified...
4h
Early drug development for cancer requires broad collaboration and skilled clinical investigators to enable enrollment of patients whose tumors have defined molecular profiles. To respond to these challenges, the National Cancer Institute (NCI) transformed its 60-year old early phase drug development program in 2014 into the Experimental Therapeutics Clinical Trials Network (ETCTN). The ETCTN is a consolidated, national network of 40+ academic institutions responsible for conducting over 100 early...
4h
Purpose: To assess the utility of the cobas® EGFR Mutation Test, with tissue and plasma, for first-line osimertinib therapy for patients with EGFR-mutated (EGFRm) (Ex19del and/or L858R) advanced or metastatic non-small cell lung cancer (NSCLC) from the FLAURA study (NCT02296125). Experimental Design: Tumor tissue EGFRm status was determined at screening using the central cobas tissue test or a local tissue test. Baseline circulating tumor (ct)DNA EGFRm status was retrospectively determined with the...
4h
Purpose: Radiolabeled somatostatin receptor 2 (SSTR2) antagonists have shown higher tumor uptake and tumor-to-organ ratios than somatostatin agonists in preclinical models of NETs. We performed a phase I study to evaluate the safety and efficacy of SSTR2 antagonist 177Lu-satoreotide tetraxetan. EXPERIMENTAL DESIGN: Twenty patients with advanced SSTR2 positive NETs were treated with 177Lu-satoreotide tetraxetan. Patients first underwent a dosimetry study with 177Lu-satoreotide tetraxetan to determine...
4h
Purpose: To determine if inhibition of mitochondrial oxidative phosphorylation (OxPhos) is an effective strategy against MAPK pathway inhibitor (MAPKi)-resistant BRAF-mutant melanomas. Experimental Design: The anti-melanoma activity of IACS-010759 (OPi), a novel OxPhos complex I inhibitor, was evaluated in vitro and in vivo. Mechanistic studies and predictors of response were evaluated using molecularly and metabolically stratified melanoma cell lines. 13C-labeling and targeted metabolomics were...
4h
Purpose: To investigate the pathobiological origin of local relapse after chemoradiotherapy (CRT), we studied genetic relationships of primary tumors (PT) and local relapses (LRs) of patients treated with CRT. Experimental design: First, low coverage whole genome sequencing was performed on DNA from 44 biopsies of resected HNSCC specimen (median 3 biopsies per tumor) to assess suitability of copy number profiles as biomarker for genetic relationships. CNAs were compared within and between tumors...
4h
Purpose: T cells engineered to express a chimeric antigen receptor (CAR) against CD19 have recently been FDA-approved for the treatment of relapsed or refractory large B cell lymphoma. Despite the success and curative potential of CD19 CAR T cells, several reports describing disease relapse due to antigen loss are now emerging. Experimental design: We developed a novel CAR construct directed against CD79b, a critical receptor for successful B cell development that remains highly expressed in several...
4h
Purpose: In this study we addressed the underlying mechanisms for the association between enzalutamide treatment and NEPC, and the critical involvement of MYCN, and loss of RB1 function in NED of prostatic epithelial cells, and the development of NEPC. We further sought to determine whether PARP inhibition could suppress NEPC, and to identify molecular determinants of this therapeutic activity. Experimental Design: We utilized a novel prostate cancer PDX treatment model, prostatic adenocarcinoma...
4h
Purpose: Gastrointestinal stromal tumors (GIST) are resistant to cytotoxic and radiation therapy. Most GIST in children are wild-type for KITand PDGFRA (WT GIST) and deficient in expression of succinate dehydrogenase (dSDH GIST). We tested the activity of vandetanib, an oral small molecule inhibitor of VEGFR2, EGFR, and RET, in patients with dSDH GIST. Experimental Design: Phase II study of vandetanib (300 mg orally once daily to patients ≥18 years, and 100 mg/m2/dose to patients < 18 years) on...
4h
Purpose: Anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancer (NSCLC) patients inevitably develop resistance to ALK-inhibitors. New diagnostic strategies are needed to assess resistance mechanisms and provide patients with the most effective therapy. We asked whether single-circulating tumor cell (CTC) sequencing can inform on resistance mutations to ALK-inhibitors and underlying tumor heterogeneity in ALK-rearranged NSCLC. Experimental Design: Resistance mutations were investigated...
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Background: The strategy of combining endocrine therapy with PI3K-mTOR inhibition has shown promise in oestrogen-receptor (ER)-positive breast cancer, but new agents and combinations with a better therapeutic index are urgently needed. Taselisib is a potent, selective, beta-isoform sparing PI3 kinase inhibitor. Patients and Methods: 30 patients with ER-positive, metastatic breast cancer who had failed prior endocrine therapy were treated with escalating doses of taselisib (2 or 4 mg in an intermittent...
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Sam68 Promotes the Progression of Human Breast Cancer through Inducing Activation of EphA3. Curr Cancer Drug Targets. 2019 Jul 18;: Authors: Chen X, Zhang L, Kuang Z, Zou Y, Tang T, Zhang W, Hu X, Xia T, Cao T, Jia H, Yuan M Abstract BACKGROUND: Src-associated in mitosis of 68 kDa (Sam68), is often elevated expressing in human cancers. Overexpression of Sam68 has been shown to be correlated with poor survival prognosis in some cancer patients. However,...
16h
Researchers at the Paul Scherrer Institute, together with colleagues from the pharmaceutical company F. Hoffmann-La Roche AG, have taken an important step towards the development of an agent against the metastasis of certain cancers. Using the Swiss...
13h
Mount Sinai researchers have found a new type of therapy to be effective for patients with a particular type of bone marrow cancer that is resistant to several standard therapies, according to results of a clinical trial published in The New England...
19h
Epithelial cancers, such as cancers of the lung and pancreas, use the ανβ3 molecule to gain drug resistance to standard cancer therapies and to become highly metastatic. In a paper published in Cancer Research, University of California San Diego...
21h
Cancer deploys a vast array of resources to grow: from instability in its genome to inflammation, as well as the creation of new blood vessels, the microenvironment surrounding the tumour, and the use of mechanisms that allow it to be immortal, among...
21h
In an extensive "data mining" analysis of British medical records, researchers at the Johns Hopkins Kimmel Cancer Center conclude that taking even a single course of antibiotics might boost - albeit slightly - the risk of developing colon cancer but not...
21h
ABSTRACT Alveolar soft part sarcoma (ASPS) is a rare malignancy that, since its initial description, remains a neoplasm of uncertain histogenesis. The disease‐defining molecular event characterizing the diagnosis of ASPS is the ASPSCR1‐TFE3 fusion gene. Following identification of an index case of ASPS with a novel TFE3 fusion partner, we performed a retrospective review to determine whether this represents an isolated event. We identified two additional cases, for a total of three cases lacking...
22h
Abstract Interpretation of missense variants remains a major challenge for genetic diagnosis, even in well‐known genes such as the DNA‐mismatch repair (MMR) genes involved in Lynch syndrome. We report the characterization of a variant in MSH2: c.1022T>C, which was identified in 20 apparently unrelated families living in the North of France. A total of 150 patients from 20 families were included in this study. Family segregation studies, tumor analyses and functional analyses at both the RNA and...
22h
Abstract In 2013, The Cancer Genome Atlas (TCGA) found that endometrial carcinomas clustered into four prognostic molecular subgroups: POLE/ultramutated (POLE), microsatellite‐instable/hypermutated (MSI), copy‐number‐low/TP53‐wild‐type (CNL), and copy‐number‐high/TP53‐mutant (CNH) [1]. These results have laid the basis for a great improvement in the patient management. This article is protected by copyright. All rights reserved.
21h
Abstract The WHO Classification of Digestive System Tumours presented in the first volume of the WHO Classification of Tumours series' fifth edition reflects important advancements in our understanding of tumours of the digestive system (table 1). For the first time, certain tumour types are defined as much by their molecular phenotype as their histological characteristics; however, histopathological classification remains the gold standard for diagnosis in most instances. The WHO Classification...
21h
Abstract Purpose Few population-based studies have examined the prevalence of cardiovascular disease (CVD) and risk factors, quality of life (QOL), and health behaviors of cancer survivors and their spouses. This case-control study aimed to fill this gap using the data from a set of large-scale surveys of individuals and families across the USA. Methods Data...
7h
Abstract Background Radiotherapy (RT) is considered an important therapeutic strategy in the fight against colorectal cancer (CRC). However, the existence of some radioresistance factors becomes the main challenge for the RT. Recently, non-coding RNAs (ncRNAs) have shown an important role in modulating cancer cell responses to ionizing radiation (IR). It is therefore of great significance to elucidate the exact mechanisms of ncRNAs...
15h
Abstract Background To develop a new 18 high-risk human papillomavirus (HR HPV) detection and genotyping assay, which is important to evaluate the risk degree of HR HPV for causing cancers. Methods All 18 HR HPV and β-globin relative DNA fragments were synthesized and cloned to a plasmid pUC57 to obtain their recombinant plasmids. Based on the...
15h
Abstract Background Sexuality is an important aspect of quality of life for adolescent and young adults that remains understudied in cancer patients. Most current knowledge about how cancer and cancer treatments can affect patients’ sexuality pertains to reproductive cancer patients (breast, gynecological, male reproductive organs), whereas only little is known about how the disease affects the sex lives of patients with other types...
15h
Abstract Background SMARCB1-deficient sinonasal carcinoma (SDSC) is an aggressive subtype of head and neck cancers that has a poor prognosis despite multimodal therapy. We present a unique case with next generation sequencing data of a patient who had SDSC with perineural invasion to the trigeminal nerve that progressed to a brain metastasis and eventually leptomeningeal spread. ...
15h
Abstract Background Carbon ion (12C) radiotherapy is becoming very promising to kill highly metastatic cancer cells keeping adjacent normal cells least affected. Our previous study shows that combined PARP-1 inhibition with 12C ion reduces MMP-2,-9 synergistically in HeLa cells but detailed mechanism are not clear. To understand this mechanism and the rationale of using PARP-1 inhibitor with 12C ion radiotherapy for better outcome...
15h
Abstract Background N6-methyladenosine (m6A) methylation, a well-known modification with new epigenetic functions, has been reported to participate in the tumorigenesis of hepatocellular carcinoma (HCC), providing novel insights into the molecular pathogenesis of this disease. However, as the key component of m6A methylation, Wilms tumor 1-associated protein (WTAP) has not been well studied in HCC. Here we investigated the biological...
23h
Abstract Background An increasing number of anticancer agents has been proposed in recent years with the attempt to overcome treatment-resistant cancer cells and particularly cancer stem cells (CSC), the major culprits for tumour resistance and recurrence. However, a huge obstacle to treatment success is the ineffective delivery of drugs within the tumour environment due to limited solubility, short circulation time or inconsistent...
16h
Abstract Background Topoisomerase inhibitors (TI) can inhibit cell proliferation by preventing DNA replication, stimulating DNA damage and inducing cell cycle arrest. Although these agents have been commonly used in the chemotherapy for the anti-proliferative effect, their impacts on the metastasis of cancer cells remain obscure. Methods We...
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Abstract Background The interaction between tumor cells and their immunosuppressive microenvironment promotes tumor progression and drug resistance. Thus, simultaneously targeting tumor cells and stromal cells is expected to have synergistic antitumor effects. Herein, we present for the first time a preclinical antitumor investigation of 3D185, a novel dual inhibitor targeting FGFRs, which are oncogenic drivers, and CSF-1R, which...
16h
Abstract Background Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide, which lacks effective biomarkers for prognosis. Therefore, it is urgent to explore new potential molecular markers to discriminate patients with poorer survival in ESCC. Methods Bioinformatics analysis, qRT-PCR, and western blot were applied...
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Abstract Survivin (also named BIRC5) is a well-known cancer therapeutic target. Since its discovery more than two decades ago, the use of survivin as a target for cancer therapeutics has remained a central goal of survivin studies in the cancer field. Many studies have provided intriguing insight into survivin’s functional role in cancers, thus providing promise for survivin as a cancer therapeutic target. Despite this, moving survivin-targeting agents into and through the clinic...
16h
Abstract Background Arachidonic acid (AA) metabolic enzymes including cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1) and cytochrome P450 (CYP) 4A11 play important roles in glioma angiogenesis. Thus, there is an urgent need to identify the underlying mechanisms and develop strategies to overcome them. Methods A homology...
16h
Calcium and magnesium affect muscle mass and function. Magnesium and calcium are also important for optimal vitamin D status. Vitamin D status modifies the associations between physical activity and risk of incident cardiovascular disease (CVD) and CVD mortality. However, no study examined whether levels of magnesium and calcium and the ratio of dietary calcium to magnesium (Ca:Mg) intake modify the relationship between physical activity and mortality. We included 20,295 National Health and Nutrition...
23h
Abstract The inclusion of diverse populations in clinical trial research is a social justice imperative. Creating the communicative tools that can support cancer patients across varied cultural backgrounds in processing complex clinical trial information, to achieve informed consent, has been a challenge. This study sought to evaluate specific clinical trial multimedia—a website, four animations, and a decision aid—to meet the decision-making and informational needs of Hispanic...
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Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide, which lacks effective biomarkers for prognosis. Therefore, it is urgent to explore new potential molecular markers to disc...
2h
Arachidonic acid (AA) metabolic enzymes including cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1) and cytochrome P450 (CYP) 4A11 play important roles in glioma angiogenesis. Thus, the...
2h
An increasing number of anticancer agents has been proposed in recent years with the attempt to overcome treatment-resistant cancer cells and particularly cancer stem cells (CSC), the major culprits for tumour...
2h
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