Antimicrobial resistance is a widely recognized public health threat, and stewardship interventions to combat this problem are well described. Less is known about antifungal stewardship (AFS) initiatives and t...
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Antibiotics, Vol. 8, Pages 126: The Perfect Bacteriophage for Therapeutic Applications—A Quick Guide
Antibiotics, Vol. 8, Pages 126: The Perfect Bacteriophage for Therapeutic Applications—A Quick Guide Antibiotics doi: 10.3390/antibiotics8030126 Authors: Lucía Fernández Diana Gutiérrez Pilar García Ana Rodríguez The alarming spread of multiresistant infections has kick-started the quest for alternative antimicrobials. In a way, given the steady increase in untreatable infectious diseases, success in this endeavor has become a matter of life and death. Perhaps we should stop...
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Antibiotics, Vol. 8, Pages 125: Pharmacokinetic/Pharmacodynamic (PK/PD) Simulation for Dosage Optimization of Colistin Against Carbapenem-Resistant Klebsiella pneumoniae and Carbapenem-Resistant Escherichia coli Antibiotics doi: 10.3390/antibiotics8030125 Authors: Kamonchanok Jitaree Korbtham Sathirakul Jantana Houngsaitong Orarik Asuphon Weerayuth Saelim Visanu Thamlikitkul Preecha Montakantikul The purpose was to explore the optimal dosage regimen of colistin using...
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Inhibiting tumour metastasis by DQA modified paclitaxel plus ligustrazine micelles in treatment of non-small-cell lung cancer. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3465-3477 Authors: Xie HJ, Zhao J, Zhuo-Ma D, Zhan-Dui N, Er-Bu A, Tsering T Abstract Lung cancer is a kind of malignant tumour characterized as uncontrolled cell growth in lung. These malignant cell growth can spread beyond the lung by process of metastasis into other tissues or...
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Silencing circular ANRIL protects HK-2 cells from lipopolysaccharide-induced inflammatory injury through up-regulating microRNA-9. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3478-3484 Authors: Deng W, Chen K, Liu S, Wang Y Abstract Circular antisense non-coding RNA in the INK4 locus (cANRIL) participated in inflammation of endothelial cells. However, whether cANRIL is associated with inflammatory injury of HK-2 cells, thereby affecting chronic kidney...
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Long non-coding RNA UCA1 relieves cardiomyocytes H9c2 injury aroused by oxygen-glucose deprivation via declining miR-122. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3492-3499 Authors: Zhang Z, Li H, Cui Z, Zhou Z, Chen S, Ma J, Hou L, Pan X, Li Q Abstract Background: Many lncRNAs have been recognized as critical regulatory factors in acute myocardial infarction (AMI). Herein, we further tested the influence of long non-coding RNA urothelial carcinoma...
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Anti-gastric cancer effect of Salidroside through elevating miR-99a expression. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3500-3510 Authors: Yang L, Yu Y, Zhang Q, Li X, Zhang C, Mao T, Liu S, Tian Z Abstract Salidroside is an active ingredient extracted from Rhodiola rosea that has anti-tumor activities. The current paper attempted to assess the impact of Salidroside on gastric cancer (GC) and explore the potential mechanism. GC cell lines (SNU-216...
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LncRNA TUG1 protects against cardiomyocyte ischaemia reperfusion injury by inhibiting HMGB1. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3511-3516 Authors: Shi H, Dong Z, Gao H Abstract The aim of this study was to investigate whether lncRNA TUG1 could mediate the progression of ischemia-reperfusion injury following acute myocardial infraction. Mouse cardiomyocytes HL-1 cells were subjected to oxygen glucose deprivation followed by reperfusion (OGD/R)...
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All animals use sensorimotor integration to generate context‐specific actions, and independent of the organism, inhibitory neurons powerfully shape the motor control during sensorimotor computation. Essential sensorimotor circuit properties observed in complex animals (e.g., the fly and mammals) are conserved in organisms with more compact circuitry, such as the nematode. From single‐cell organisms to complex neural networks, all evolved to provide control solutions to generate context‐ and goal‐specific...
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Abstract There are substantial inequalities associated with antibiotics and the determinants of their effectiveness, including the risk of exposure to antibiotic‐resistant microbes, access to relevant treatment advice, diagnostic facilities, risk of life‐threatening infectious disease, and access to antibiotics. Current arrangements (social, political, economic) allow inequalities in the distribution of antibiotic benefits and burdens. This article focuses on the justification of relevant inequalities...
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Evaluating the risks of public health programs: Rational antibiotic use and antimicrobial resistance
Abstract Existing ethical frameworks for public health provide insufficient guidance on how to evaluate the risks of public health programs that compromise the best clinical interests of present patients for the benefit of others. Given the relevant similarity of such programs to clinical research, we suggest that insights from the long‐standing debate about acceptable risk in clinical research can helpfully inform and guide the evaluation of risks posed by public health programs that compromise...
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Abstract Drug‐resistant bacterial infections constitute a major threat to global public health. Several key bacteria that are becoming increasingly resistant are among those that are ubiquitously carried by human beings and usually cause no symptoms (i.e. individuals are asymptomatic carriers) until and/or unless a precipitating event leads to symptomatic infection (and thus disease). Carriers of drug‐resistant bacteria can also transmit resistant pathogens to others, thus putting the latter at...
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Biomolecules, Vol. 9, Pages 403: Overexposure to Bisphenol A and Its Chlorinated Derivatives of Patients with End-Stage Renal Disease during Online Hemodiafiltration Biomolecules doi: 10.3390/biom9090403 Authors: Bacle Dupuis Belmouaz Bauwens Cambien Venisse Pierre-Eugene Potin Migeot Ayraud-Thevenot The health safety conditions governing the practice of online hemodiafiltration (OL-HDF) do not yet incorporate the risks related to the presence of...
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Biomolecules, Vol. 9, Pages 402: For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors Biomolecules doi: 10.3390/biom9090402 Authors: Buchanan Lee Shepherd The hyper-activation of the phosphoinositide (PI) 3-kinase signaling pathway is a hallmark of many cancers and overgrowth syndromes, and as a result, there has been intense interest in the development of drugs that target the various isoforms of PI 3-kinase. Given the key role...
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Biomolecules, Vol. 9, Pages 404: Mechanisms of Fasting-Mediated Protection against Renal Injury and Fibrosis Development after Ischemic Acute Kidney Injury Biomolecules doi: 10.3390/biom9090404 Authors: Pedro Rojas-Morales Edilia Tapia Juan Carlos León-Contreras Susana González-Reyes Angélica Saraí Jiménez-Osorio Joyce Trujillo Natalia Pavón Jessica Granados-Pineda Rogelio Hernández-Pando Laura Gabriela Sánchez-Lozada Horacio Osorio-Alonso José Pedraza-Chaverri...
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Biomolecules, Vol. 9, Pages 399: Colletotrichum Gloesporioides Inhibition In Situ by Chitosan-Ruta graveolens Essential Oil Coatings: Effect on Microbiological, Physicochemical, and Organoleptic Properties of Guava (Psidium guajava L.) during Room Temperature Storage Biomolecules doi: 10.3390/biom9090399 Authors: Carlos David Grande Tovar Johannes Delgado-Ospina Diana Paola Navia Porras Yeimmy Peralta-Ruiz Alexander Pérez Cordero Jorge Iván Castro Manuel Noé Chaur Valencia...
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Biomolecules, Vol. 9, Pages 400: Phenolic Profiling and Biological Potential of Ficus curtipes Corner Leaves and Stem Bark: 5-Lipoxygenase Inhibition and Interference with NO Levels in LPS-Stimulated RAW 264.7 Macrophages Biomolecules doi: 10.3390/biom9090400 Authors: Catarina Andrade Federico Ferreres Nelson G. M. Gomes Sutsawat Duangsrisai Nattawut Srisombat Srunya Vajrodaya David M. Pereira Angel Gil-Izquierdo Paula B. Andrade Patrícia Valentão The economic...
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Biomolecules, Vol. 9, Pages 401: Endogenous Neuropeptide Nocistatin Is a Direct Agonist of Acid-Sensing Ion Channels (ASIC1, ASIC2 and ASIC3) Biomolecules doi: 10.3390/biom9090401 Authors: Dmitry I. Osmakov Sergey G. Koshelev Igor A. Ivanov Yaroslav A. Andreev Sergey A. Kozlov Acid-sensing ion channel (ASIC) channels belong to the family of ligand-gated ion channels known as acid-sensing (proton-gated) ion channels. Only a few activators of ASICs are known. These are exogenous...
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Biomolecules, Vol. 9, Pages 398: Organometallic Compounds and Metal Complexes in Current and Future Treatments of Inflammatory Bowel Disease and Colorectal Cancer—a Critical Review Biomolecules doi: 10.3390/biom9090398 Authors: Adrian Szczepaniak Jakub Fichna In recent years, there has been a significant increase in the clinical use of organometallic compounds and metal complexes for therapeutic purposes including treatment of inflammatory bowel diseases (IBD). Their action is based...
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Biomolecules, Vol. 9, Pages 397: Molecular Responses during Plant Grafting and Its Regulation by Auxins, Cytokinins, and Gibberellins Biomolecules doi: 10.3390/biom9090397 Authors: Anket Sharma Bingsong Zheng Plant grafting is an important horticulture technique used to produce a new plant after joining rootstock and scion. This is one of the most used techniques by horticulturists to enhance the quality and production of various crops. Grafting helps in improving the health of plants,...
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Biomolecules, Vol. 9, Pages 396: Jumping on the Edge—First Evidence for a 2 × 6-meric Hemocyanin in Springtails Biomolecules doi: 10.3390/biom9090396 Authors: Juliane Schmidt Heinz Decker Michael T. Marx Hemocyanins are respiratory dioxygen carrier proteins found in many arthropods including ancient terrestrial species such as spiders and scorpions as well as marine horseshoe crabs. As hemocyanins are highly conserved in this lineage, it is possible to observe an evolutionary descent...
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Biomolecules, Vol. 9, Pages 395: How the 26S Proteasome Degrades Ubiquitinated Proteins in the Cell Biomolecules doi: 10.3390/biom9090395 Authors: Bernat Coll-Martínez Bernat Crosas The 26S proteasome is the central element of proteostasis regulation in eukaryotic cells, it is required for the degradation of protein factors in multiple cellular pathways and it plays a fundamental role in cell stability. The main aspects of proteasome mediated protein degradation have been highly (but...
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Thymidylate synthase (TS) catalyzes the production of the nucleotide dTMP from dUMP, making the enzyme necessary for DNA replication and consequently a target for cancer therapeutics. TSs are homodimers with active sites separated by ∼30 Å. Reports of half-the-sites activity in TSs from multiple species demonstrate the presence of allosteric communication between the active sites of this enzyme. A simple explanation for the negative allosteric regulation occurring in half-the-sites activity would...
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Eukaryotic genomes are hierarchically organized into protein-DNA assemblies for compaction into the nucleus. Nucleosomes, with the (H3-H4)2 tetrasome as a likely intermediate, are highly dynamic in nature by way of several different mechanisms. We have recently shown that tetrasomes spontaneously change the direction of their DNA wrapping between left- and right-handed conformations, which may prevent torque build-up in chromatin during active transcription or replication. DNA sequence has been shown...
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Extraction from simulations of the area compressibility moduli of the monolayers in a bilayer is considered theoretically. A statistical mechanical derivation shows that the bilayer modulus is the sum of the two monolayer moduli, as is often supposed, but contrary to a recent study. Seemingly plausible assumptions regarding fluctuations are tested rigorously. Prospects for future research are discussed.
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From observations of colloidal tracer particles in fibrin undergoing gelation, we introduce an analytical framework that allows determination of the probability density function (PDF) for a stochastic process beyond fractional Brownian motion. Using passive microrheology via videomicroscopy, mean square displacements (MSD) of tracer particles suspended in fibrin at different ageing times are obtained. The anomalous diffusion is then described by a damped white noise process with memory, with analytical...
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We describe a new method to prepare asymmetric giant unilamellar vesicles (aGUVs) via hemifusion. Hemifusion of GUVs and a supported lipid bilayer (SLB), triggered by calcium, promotes the lipid exchange of the fused outer leaflets mediated by lipid diffusion. We used different fluorescent dyes to monitor the inner and the outer leaflets of the unsupported aGUVs. We confirmed that almost all new exchanged lipids in the aGUVs are found in the outer leaflet of these asymmetric vesicles. In addition,...
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Voltage-gated potassium (Kv) channels play a fundamental role in neuronal and cardiac excitability and are potential therapeutic targets. They assemble as tetramers with a centrally located pore-domain surrounded by a voltage-sensing domain (VSD), which is critical for sensing transmembrane potential and subsequent gating. Although the sensor is supposed to be in ‘Up’ conformation in both n-octylglucoside (OG) micelles and phospholipid membranes in the absence of membrane potential, toxins that bind...
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Biosensors, Vol. 9, Pages 101: Advances in Nanosensors for Biological and Environmental Analysis: Book Review. Akash Deep, Sandeep Kumar (Eds.); Elsevier 2019; ISBN: 978-0-12-817456-2 Biosensors doi: 10.3390/bios9030101 Authors: Kaushik A book entitled “Advances in Nanosensors for Biological and Environmental Analysis” published by Elsevier in 2019, is reviewed carefully and critically in this report. In this book, editors explored nanotechnology assisted approaches...
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Publication date: 15 October 2019Source: Biosensors and Bioelectronics, Volume 143Author(s): Shofarul Wustoni, Shaofei Wang, Juan R. Alvarez, Tania C. Hidalgo, Suzana P. Nunes, Sahika InalAbstractAlzheimer's disease (AD) is a progressive neurodegenerative disease associated with severe memory loss and impaired cognitive skills. A common pathological change found in AD-affected brains is the accumulation of a peptide named amyloid-β (Aβ) that can form plaques. Aβ aggregates are visible to structural...
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Publication date: 15 October 2019Source: Biosensors and Bioelectronics, Volume 143Author(s): Xianbao Sun, Yongkang Ye, Shudong He, Zeyu Wu, Junyang Yue, Hanju Sun, Xiaodong CaoAbstract:As a well-known allergenic indicator in kidney beans, lectins have always been the serious threats for human health. Herein, we introduced a new label-free voltammetric immunosensor for the direct determination of kidney bean lectin (KBL) with potential allergenic activity. Gold nanoparticles-polyethyleneimine-multiwalled...
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Publication date: 15 October 2019Source: Biosensors and Bioelectronics, Volume 143Author(s): Mansour Mahmoudpour, Jafar Ezzati Nazhad Dolatabadi, Mohammadali Torbati, Abbas Pirpour Tazehkand, Aziz Homayouni-Rad, Miguel de la GuardiaAbstractMycotoxins are highly toxic secondary metabolites, which may contaminate many types of food and feeds. These toxins have serious health risks for both human and animals. One of the effective ways to prevent food contamination and protect people against mycotoxins...
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Publication date: 1 October 2019Source: Biosensors and Bioelectronics, Volume 142Author(s): Zhiyong Zheng, Yong Xiao, Ranran Wu, Hans E. Mølager Christensen, Feng Zhao, Jingdong ZhangAbstractThe extracellular electron transfer of Shewanella oneidensis MR-1 (MR-1) has been extensively studied due to the importance of the biosensors and energy applications of bioelectrochemical systems. However, the oxidation of metal compounds by MR-1, which represents the inward extracellular electron transfer from...
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Publication date: Available online 22 August 2019Source: CryobiologyAuthor(s): Yuki Nakagawa, Takehito KanekoAbstractSperm preservation is a useful technique for maintaining valuable animal strains. Rat sperm could be frozen or freeze-dried in a simple Tris-EDTA solution (TE buffer), and oocytes that were fertilized with these sperm by intracytoplasmic sperm injection (ICSI) developed into offspring. Genome editing with the clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated...
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AbstractCertain microorganisms survive long periods of time as endospores to cope with adverse conditions. Since endospores are metabolically inactive the extent of aspartic acid (Asp) racemization will increase over time and might kill the spores by preventing their germination. Therefore, understanding the relationship between endospore survivability and Asp racemization is important for constraining the long-term survivability and global dispersion of spore-forming bacteria in nature. Geobacillus...
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AbstractWhile the relationship between plant and microbial diversity has been well studied in grasslands, less is known about similar relationships in forests, especially for obligately symbiotic arbuscular mycorrhizal (AM) fungi. To assess the effect of varying tree diversity on microbial alpha- and beta-diversity, we sampled soil from plots in a high-density tree diversity experiment in Minnesota, USA three years after establishment. Three of 12 tree species are AM hosts; the other nine primarily...
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AbstractBased on modern microbiology, we propose a major revision in current space exploration philosophy and planetary protection policy, especially regarding microorganisms in space. Mainly, microbial introduction should not be considered accidental but inevitable. We hypothesize the near impossibility of exploring new planets without carrying and/or delivering any microbial travelers. In addition, although we highlight the importance of controlling and tracking such contaminations—to explore the...
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The goal of treatment for early stage rectal cancer is to optimize oncologic outcome while minimizing impact of treatment on quality of life. The standard of care treatment for most early rectal cancers is radical surgery alone. Given the morbidity associated with radical surgery, local excision for early rectal cancers has been explored as an alternative approach associated with lower rates of morbidity. The American Radium Society Appropriate Use Criteria (ARS AUC) presented in this manuscript...
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Stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC) is a standard of care for medically inoperable patients. Our aim was to compare Common Terminology Criteria for Adverse Events (CTCAE) thoracic grade 3 or higher adverse events (AEs) of 30 Gy in one fraction (arm 1) vs. 60 Gy in 3 fractions (arm 2).
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Publication date: Available online 22 August 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Suzanne Russo, Christopher J. Anker, May Abdel-Wahab, Nilofer Azad, Prajnan Das, Jadranka Dragovic, Karyn A. Goodman, Joseph M. Herman, William Jones, Timothy Kennedy, Andre Konski, Rachit Kumar, Percy Lee, Nell Maloney Patel, Navesh Sharma, William Small, W.Warren Suh, Salma K. JabbourAbstractThe goal of treatment for early stage rectal cancer is to optimize oncologic outcome...
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These findings indicated that angiotensin II type 1 receptor silencing plays an inhibitory role in sepsis‐induced myocardial injury by inhibiting the mitogen‐activated protein kinase signaling pathway. Abstract Myocardial dysfunction is an important manifestation of sepsis. In addition, inactivation of the mitogen‐activated protein kinase (MAPK) signaling pathway has been reported to be beneficial in sepsis. The current study used gene expression profiling to demonstrate the overexpression of angiotensin...
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Abstract Drug-eluting stents are now routinely used in the treatment of acute coronary syndromes caused by coronary artery disease. Whilst the sustained release of anti-proliferative drugs from these devices has greatly reduced the need for repeat revascularisation procedures, this approach is not suitable for all patients and appears to delay regrowth of the endothelium, necessitating the use of prolonged dual anti-platelet therapy. Although the development of more advanced stent...
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Abstract Biosimilar filgrastim (Sandoz) was approved in Europe in 2009 and, in 2015, was the first biosimilar approved in the USA. These authorizations were based on the “totality of evidence” concept, an approach that considers data from structural and functional characterization and comparability analysis and non-clinical and clinical studies. For biosimilar filgrastim, phase III confirmatory clinical studies were performed in the most sensitive population, patients with breast...
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Abstract Microbial enzymes are high in demand and there is focus on their efficient, cost effective and eco-friendly production. The relevant microbial enzymes for respective industries needs to be identified but the conventional technologies don’t have much edge over it. So, there is more attention towards high throughput methods for production of efficient enzymes. The enzymes produced by microbes need to be modified to bear the extreme conditions of the industries in order to...
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Abstract Inflammation is a pivotal feature of myocardial reperfusion–induced microvascular injury and dysfunction. However, the molecular mechanisms by which myocardial reperfusion triggered inflammation remain incurable. The NLRP3 inflammasome is a key intracellular sensor that detection of cellular stress to activation of caspase-1, and consequent IL-1β maturation and pyroptotic cell death. Here, we showed that NLRP3 inflammasome played a key role in myocardial reperfusion–induced...
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Nature Cell Biology, Published online: 22 August 2019; doi:10.1038/s41556-019-0387-1Our mentor, Suzanne Eaton, tragically fell victim to homicide on 2 July 2019. The circumstances of her disappearance and death have shocked scientists and the public alike, worldwide. From the moment she went missing, the members of her family, laboratory and colleagues have received admirable and touching support from the scientific community. This outpouring stands testament to the inspiration that Suzanne—a world-leader...
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Publication date: Available online 22 August 2019Source: Neurobiology of DiseaseAuthor(s): Debashis Dutta, Madhuchhanda Kundu, Susanta Mondal, Avik Roy, Samantha Ruehl, Deborah A. Hall, Kalipada PahanAbstractAlthough Parkinson's disease (PD) is a progressive neurodegenerative disease, the disease does not progress or persist in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model, the most common animal model of PD. Recently, we have described that supplementation of regulated on activation,...
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Publication date: Available online 22 August 2019Source: Neurobiology of DiseaseAuthor(s): Paolo Calabresi, David G. StandaertAbstractDystonia and levodopa-induced dyskinesia (LID) are both hyperkinetic movement disorders. Dystonia arises most often spontaneously, although it may be seen after stroke, injury, or as a result of genetic causes. LID is associated with Parkinson's disease (PD), emerging as a consequence of chronic therapy with levodopa, and may be either dystonic or choreiform. LID and...
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Publication date: Available online 21 August 2019Source: Neurobiology of DiseaseAuthor(s): Helle Bogetofte, Pia Jensen, Justyna Okarmus, Sissel Ida Schmidt, Mikkel Agger, Matias Ryding, Peter Nørregaard, Christina Fenger, Xianmin Zeng, Jesper Graakjær, Brent James Ryan, Richard Wade-Martins, Martin Røssel Larsen, Morten MeyerAbstractMutations in parkin, encoded by the PARK2 gene, causes early-onset familial Parkinson's disease (PD), but dysfunctional parkin has also been implicated in sporadic PD....
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Publication date: Available online 21 August 2019Source: Neurobiology of DiseaseAuthor(s): Tingting Wang, Jingyu Wang, Jie Wang, Lin Mao, Bin Tang, Peter W. Vanderklish, Xun Liao, Zhi-Qi Xiong, Lujian LiaoAbstractAngelman syndrome (AS) is a severe neurodevelopmental disorder caused by maternal mutation and paternal imprinting of the gene encoding UBE3A, an E3 ubiquitin ligase. Although several potential target proteins of UBE3A have been reported, how these proteins regulate neuronal development...
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Publication date: Available online 21 August 2019Source: Neurobiology of DiseaseAuthor(s): Darren J. Schofield, Lorraine Irving, Laura Calo, Anna Bogstedt, Gareth Rees, Annalisa Nuccitelli, Rajesh Narwal, Marcella Petrone, Jennifer Roberts, Lee Brown, Fiona Cusdin, Bhupinder Dosanjh, Christopher Lloyd, Claire Dobson, Ian Gurrell, Graham Fraser, Mary McFarlane, Edward Rockenstein, Brian Spencer, Eliezer MasliahAbstractThere are no approved drug therapies that can prevent or slow the progression of...
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Publication date: Available online 21 August 2019Source: Neurobiology of DiseaseAuthor(s): Jens Schuster, Loora Laan, Joakim Klar, Zhe Jin, Mikael Huss, Sergiy Korol, Feria Hikmet Noraddin, Maria Sobol, Bryndis Birnir, Niklas DahlAbstractDravet syndrome (DS) is an early onset refractory epilepsy typically caused by de novo heterozygous variants in SCN1A encoding the α-subunit of the neuronal sodium channel Nav1.1. The syndrome is characterized by age-related progression of seizures, cognitive decline...
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Publication date: Available online 21 August 2019Source: Neurobiology of DiseaseAuthor(s): Gregory R. Lum, Christine A. Olson, Elaine Y. HsiaoAbstractThe gut microbiome is emerging as a key regulator of brain function and behavior and is associated with symptoms of several neurological disorders. There is emerging evidence that alterations in the gut microbiota are seen in epilepsy and in response to seizure interventions. In this review, we highlight recent studies reporting that individuals with...
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Publication date: Available online 21 August 2019Source: Neurobiology of DiseaseAuthor(s): Yan Shen, Xiufen Chen, Chunling Chi, Han Wang, Jun Xue, Danying Su, Hongwei Wang, Meng Li, Bin Liu, Qi DongAbstractIntracranial atherosclerotic stenosis (ICAS), the most common cause of stroke worldwide, is associated with high risk of recurrent ischemic stroke. F-box and WD repeat domain containing protein 7 (FBW7), an ubiquitin E3 ligase, is recently suggested to be involved in atherogenesis. However, whether...
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Publication date: Available online 21 August 2019Source: Archives of Oral BiologyAuthor(s): Hyun-Kyung Song, Eun-Mi Noh, Jeong-Mi Kim, Yong-Ouk You, Kang-Beom Kwon, Young-Rae LeeAbstractObjectivePeriodontitis is an inflammatory disease of the supporting tissue around teeth commonly caused by gram-negative bacterial infections. Interleukin (IL)-1β, a cytokine involved in host immune and inflammatory responses, is known to induce the activation of various intracellular signaling pathways. One of these...
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Publication date: Available online 21 August 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Arpita Srivastava, Siqin Bala, Hajime Motomura, Daisuke Kohda, Florence Tama, Osamu MiyashitaAbstractBackgroundTim21, a subunit of a highly dynamic translocase of the inner mitochondrial membrane (TIM23) complex, translocates proteins by interacting with subunits in the translocase of the outer membrane (TOM) complex and Tim23 channel in the TIM23 complex. A loop segment in Tim21,...
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Publication date: Available online 21 August 2019Source: BiochimieAuthor(s): Ginés Luengo-Gil, Antonio Bernardino García-Andreo, Carmen Ortega-Sabater, Nataliya Bohdan, Salvador Espín, Julia Peñas-Martínez, Elena Martínez-Planes, Álvaro García-Hernández, Vicente Vicente, Miguel Quintanilla, Irene Martínez-MartínezAbstractAntithrombin is a serine protease inhibitor that exerts a crucial role in hemostasis as the main inhibitor of the coagulation cascade. It plays also critical roles in other processes,...
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Publication date: Available online 21 August 2019Source: BiochimieAuthor(s): Beibei Liu, James K. Bashkin, Gregory M.K. Poon, Shuo Wang, Siming Wang, W. David WilsonAbstractHairpin polyamides are synthetic small molecules that bind DNA minor groove sequence-selectively and, in many sequences, induce widening of the minor groove and compression of the major groove. The structural distortion of DNA caused by polyamides has enhanced our understanding of the regulation of DNA-binding proteins via polyamides....
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Publication date: Available online 22 August 2019Source: Free Radical Biology and MedicineAuthor(s): Gangduo Wang, Maki Wakamiya, Jianling Wang, G.A. Shakeel Ansari, M. Firoze KhanAbstractReactive trichloroethene (TCE) metabolites and oxidative stress are involved in TCE-mediated autoimmunity, as evident from our earlier studies in MRL+/+ mice. However, molecular mechanisms underlying TCE-mediated autoimmunity remain largely unknown. Cytochrome P450 2E1 (CYP2E1), the major enzyme responsible for...
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Publication date: Available online 21 August 2019Source: Free Radical Biology and MedicineAuthor(s): Lindsey Y.K. Suh, Dinesh Babu, Lusine Tonoyan, Béla Reiz, Randy Whittal, S. Amirhossein Tabatabaei-Dakhili, Andrew G. Morgan, Carlos A. Velázquez-Martínez, Arno G. SirakiAbstractEdaravone is a highly potent antioxidant drug known to scavenge free radical species and prevent free radical-induced lipid peroxidation. In this study, we investigated the effect of edaravone on the myeloperoxidase (MPO)...
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Publication date: Available online 21 August 2019Source: Free Radical Biology and MedicineAuthor(s): Lu Sun, Yan-Li Liu, Fang Ye, Jing-Wen Xie, Jia-Wei Zeng, Li Qin, Jing Xue, Yi-Ting Wang, Kai-Min Guo, Ming-Ming Ma, Yong-Bo Tang, Xiao-Yan Li, Min GaoAbstractTransient Receptor Potential Melastatin-2 (TRPM2) is a nonselective cation channel mediating Ca2+ influx in response to oxidative stress. Given that insulin resistance-related endothelial dysfunction in obesity attributes to fatty-acid-induced...
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Publication date: 1 November 2019Source: International Journal of Biological Macromolecules, Volume 140Author(s): Dong-Jin Lee, Eun Young Park, Seung-Taik LimAbstractWaxy maize starch was debranched using an isoamylase (hydrolysis for 24 h or 48 h), and then the debranched starches were recrystallized for 96 h at different temperatures (4, 25, and 50 °C). The structural and crystalline characteristics of the recrystallized samples were analyzed. The longer debranching time (48 h) produced the smaller...
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Publication date: 1 November 2019Source: International Journal of Biological Macromolecules, Volume 140Author(s): Tuoping Li, Xuedong Han, Ruiwen Bao, Yubo Hao, Suhong LiAbstractShiitake mushroom (Lentinus edodes) polysaccharide (SMP), an important immunomodulatory substance, is usually hard to be absorbed by the intestinal tract, because of its macromolecule characteristics. The objective of this study was to develop the water-in-oil (W/O) nanoemulsion to improve its absorption efficiency and the...
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Publication date: 1 November 2019Source: International Journal of Biological Macromolecules, Volume 140Author(s): Zefeng Lin, Tingting Wu, Wanshun Wang, Binglin Li, Ming Wang, Lingling Chen, Hong Xia, Tao ZhangAbstractThe increase in severe infections caused by antibiotic drug resistance and the decrease in the number of new antibacterial drugs approved for use in the last few decades are driving the need for the development of new antimicrobial strategies. Antimicrobial peptides (AMPs) are a potential...
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Publication date: 1 November 2019Source: International Journal of Biological Macromolecules, Volume 140Author(s): Smita P. Pilla, Ranjit Prasad BahadurAbstractRibosomes are the translational machineries having two unequal subunits, small subunit (SSU) and large subunit (LSU) across all the domains of life. Origin and evolution of ribosome are encoded in its structure, and the core of the ribosome is highly conserved. Here, we have used Shannon entropy to analyze the evolution of ribosomal proteins...
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Publication date: 1 November 2019Source: International Journal of Biological Macromolecules, Volume 140Author(s): Raquel Martín-Sampedro, José I. Santos, María E. Eugenio, Bernd Wicklein, Laura Jiménez-López, David IbarraAbstractLignin streams produced in biorefineries are commonly used to obtain energy. In order to increase the competitiveness of this industry, new lignin valorization routes are necessary, for which a depth characterization of this biological macromolecule is essential. In this...
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Publication date: 1 November 2019Source: International Journal of Biological Macromolecules, Volume 140Author(s): Zhihao Zhang, Zhongying Ma, Qian Leng, Yuhua WangAbstractWith the increasing awareness of environmental protection, the greening of flame retardants has become an inevitable choice for flame retardant technology. Bio-based materials have the advantages of wide source, recyclability and green environmental protection, and have received extensive attention. In this work, chitosan and phytic...
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Publication date: 1 November 2019Source: International Journal of Biological Macromolecules, Volume 140Author(s): Thaís A. Pedrete, Rachel A. Hauser-Davis, Josino C. MoreiraAbstractSeveral plants have been studied for their medicinal properties, especially concerning the management of chronic diseases, such as diabetes, aiming at a more accessible form of treatment. In this context, the aim of this study was to characterize plant proteins used in folk medicine as hypoglycemic agents for the treatment...
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Publication date: 1 November 2019Source: International Journal of Biological Macromolecules, Volume 140Author(s): Hongyun Zhang, Ying Xia, Mingpeng Zhou, Jianyong Zheng, Zhao Wang, Yinjun ZhangAbstractAn intracellular esterase (BCE) from Bacillus cereus WZZ006 was purified to homogeneity with an 89.5-fold purification, specific activity of 1.79 U/mg, and 26.7% recovery. The estimated molecular weight of BCE was 96 kDa which was analyzed by SDS-PAGE and MALDI-TOF-MS. Activity staining denotes that...
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Publication date: 1 November 2019Source: International Journal of Biological Macromolecules, Volume 140Author(s): Jing ChenAbstractIn this work, a water-soluble okra polysaccharide (OP-2) was prepared by hot water extraction, and the effects of OP-2 on the spermatogenesis of KKAy mice were investigated. Forty eight KKAy mice with similar initial body weights and lipid and blood glucose levels were randomly divided into four groups, i.e., one control group and three OP-2-treatment groups (treated...
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Publication date: 1 November 2019Source: International Journal of Biological Macromolecules, Volume 140Author(s): Aysel Aslanli, Ilya Lyagin, Elena EfremenkoAbstractQuorum Quenching (QQ) enzymes can be used to prevent bacterial antibiotic resistance by degradation of Quorum Sensing (QS) signaling molecules, for example N-acyl homoserine lactones (AHLs). This paper is aimed at the in silico investigation of the possible combinations of hexahistidine-tagged organophosphorus hydrolase (His6-OPH) with...
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Publication date: Available online 21 August 2019Source: Neurobiology of AgingAuthor(s): Brianne M. Bettcher, Alden L. Gross, Brandon E. Gavett, Keith F. Widaman, Evan Fletcher, N. Maritza Dowling, Rachel F. Buckley, Eider M. Arenaza-Urquijo, Laura B. Zahodne, Timothy J. Hohman, Jet M.J. Vonk, Dorene M. Rentz, Dan MungasAbstractCognitive reserve is inherently a dynamic construct; however, traditional methods of estimating reserve have focused on static proxy variables. A recently proposed psychometric...
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