Abstract The molecular pathogenesis of esophageal carcinosarcoma (ECS) has not been fully investigated. This study includes 16 consequent cases of surgically resected ECS. Genetic alterations were independently examined for carcinoma in situ, carcinomatous, and sarcomatous areas. Six cases were analyzed by next-generation sequencing, and the remaining cases were analyzed by Sanger sequencing for TP53, PTEN, and INI1. Sarcomatous components in 3 cases showed histologically heterogenous...
now
Contributors : Petr V Nazarov ; Anke K Wienecke-Baldacchino ; Andrei Zinovyev ; Urszula Czerwińska ; Arnaud Muller ; Dorothée Nashan ; Gunnar Dittmar ; Francisco Azuaje ; Stephanie KreisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe repositories for various “omics” data collected from different cancer types are constantly growing. However, robust diagnostic and/or prognostic conclusions can often not be extracted from mixed transcriptomes or other...
2m
Contributors : Shuo Yang ; Yuqing Wu ; Sheng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe identified that GSDMD was required for the pathogenesis of EAE, and GSDMD deficiency in peripheral myeloid cells impaired the infiltration of immune cells into the CNS , leading to the suppression of neuroinflammation and demyelination.The purpose of this experiment was to identify how GSDMD induces EAE.
7h
GSE133670 Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
7h
Contributor : Yang LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBy performing m6A-seq analysis on the peritoneal macrophages that derived from ALKBH5-/- mice and littermate mice infected with or without vesicular stomatitis virus (VSV), we want to investigate whether ALKBH5 deficiency-mediated m6A RNA methylation contributes to the regulation of its target genes expression. m6A-seq analysis revealed enriched and specific m6A peaks on the transcript of...
9h
Contributor : Yang LiuSeries Type : OtherOrganism : Mus musculusTo investigate whether the ALKBH5-mediated metabolic changes via demethylation of its target mRNA(s) is important in regulating viral response, we mapped the targeting transcripts and binding sites of ALKBH5 in the virus infected cells and uninfected cells by using iCLIP-seq. Biological replicates of iCLIP-seq confirmed that OGDH is the direct targeting transcript of ALKBH5 and the binding capacity of ALKBH5 to OGDH mRNA was decreased...
9h
Contributor : Yang LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBy performing RNA sequencing (RNA-seq) analysis on the peritoneal macrophages that derived from ALKBH5-/- mice and littermate mice infected with or without vesicular stomatitis virus (VSV), we want to investigate whether deficiency of ALKBH5 controls viral replication through a more general mechanism such as enhancing innate response, and if not, what's the critical downstream target(s) of...
9h
Contributors : Kevin C Stein ; Allison Kriel ; Judith FrydmanSeries Type : OtherOrganism : Saccharomyces cerevisiaeFolding newly synthesized proteins relies on the ribosome intricately coordinating mRNA translation with a network of ribosome-associated machinery. The principles that drive the coordination of this diverse machinery remain poorly understood. Here, we use selective ribosome profiling to determine how the essential chaperonin TRiC/CCT and the Hsp70 Ssb are recruited to ribosome-nascent...
11h
Contributors : Irene Hernando-Herraez ; Brendan Evano ; Thomas Stubbs ; Pierre H CommereSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusAge-related tissue alterations have been associated with a decline in stem cell number and function. Increased cell-to-cell variability in transcription or epigenetic marks has been proposed to be a major hallmark of ageing. Here, using parallel single-cell transcriptome and DNA methylome profiling, we find a global increase...
12h
Contributors : Sheng-Zhong Duan ; Chao LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNCoR1 played an important role in regulating the expression of many genes. We were wondering what kinds of genes the NCoR1 would regulate in cardiomyocytes. Therefore we generated the cardiomyocyte-specific NCoR1 knockout mice (CMNKO). Then we tried to analyze gene expression of left ventricular from littermate control (LC) and CMNKO mice with an unbiased way. Therefore...
12h
Contributors : Aisha Burton ; Aaron DeLoughery ; Gene-Wei Li ; Daniel KearnsSeries Type : Expression profiling by high throughput sequencingOrganism : Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051Laboratory strains of Bacillus subtilis encodes as many as 16 alternative sigma factors, each dedicated to expressing a unique regulon such as those involved in stress resistance, sporulation, and motility. The ancestral strain of B. subtilis also encodes an additional sigma factor homolog,...
12h
Series Type : Expression profiling by high throughput sequencing ; Methylation profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
12h
Contributor : Qin AnSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used single-cell RNA-sequencing (scRNA-seq) on human embryonic stem cell (hESC)-derived retinal organoid to deconstruct RPC developmental trajectory in the early retinogenesis, which revealed the fate branchpoint in RPC progression.
13h
Series Type : Expression profiling by arrayOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
14h
Contributors : Kristin G Anderson ; Valentin Voillet ; Raphael Gottardo ; Philip D GreenbergSeries Type : Expression profiling by arrayOrganism : Homo sapiensPurpose: Adoptive T cell therapy using high affinity T cell receptors (TCRs) to target tumor antigens has potential for improving outcomes in high-grade serous ovarian cancer (HGSOC) patients. Ovarian tumors develop a hostile, multicomponent tumor microenvironment containing suppressive cells, inhibitory ligands, and soluble factors that facilitate...
14h
Contributors : Monika A Roy ; Karilyn E Sant ; Olivia L Venezia ; Alix B Shipman ; Stephen D McCormick ; Alicia R Timme-Laragy ; Panithi Saktrakulkla ; Keri C HornbuckleSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerio3,3’-Dichlorobiphenyl (PCB-11) is a non-legacy PCB congener widely detected in environmental samples and has been detected in human serum, but its toxicity potential is poorly understood. Zebrafish statically exposed to 4,500 µg/L PCB-11 at 24 hours...
14h
Contributors : Kristin G Anderson ; Valentin Voillet ; Raphael Gottardo ; Philip D GreenbergSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: Adoptive T cell therapy using high affinity T cell receptors (TCRs) to target tumor antigens has potential for improving outcomes in high-grade serous ovarian cancer (HGSOC) patients. Ovarian tumors develop a hostile, multicomponent tumor microenvironment containing suppressive cells, inhibitory ligands, and soluble...
14h
Contributors : Paolo Kunderfranco ; Marinos Kallikourdis ; Gianluigi CondorelliSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSingle-cell RNA sequencing is revolutionizing the mapping of tissues in physiology and pathology. Whilst immune responses are emerging as key mediators of heart failure, no thorough immune mapping of the ailing heart has been performed so far. Here we examined, at single-cell level, the cardiac immune composition after transverse...
14h
Contributors : Lei Wang ; Shaoguang SunSeries Type : Non-coding RNA profiling by arrayOrganism : Mus musculusNon-coding circular RNAs (circRNAs) have displayed dysregulated expression in the hippocampus of Nrf2-knockout mice.
15h
Contributors : Ningning Li ; Kastytis Sidlauskas ; Ying Zhang ; Sebastian BrandnerSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusHuman astrocytomas and oligodendrogliomas are defined by mutations in the metabolic enzyme isocitrate dehydrogenase (IDH) 1 or 2. Mutant IDH1 causes the production and accumulation of the metabolite 2 hydroxyglutarate, which induces genome-wide hypermethylation, and is thought to be a driver mutation of these tumours. However,...
15h
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