A combination of AstraZeneca's lung cancer drug Imfinzi and an experimental treatment failed to extend the lives of patients with advanced non-small cell lung cancer (NSCLC) and high levels of gene mutations, the drugmaker said on Wednesday.Reuters Health Information (Source: Medscape Allergy Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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People who have allergies may be in for a rough ragweed season this summer and fall, thanks to hotter and wetter weather nationwide. (Source: WebMD Health)
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(Natural News) Spring and summer makes flowers bloom, but for people with seasonal allergies, it’s one more reason to hate flower pollen and other allergens. If you’re tired of symptoms like a runny nose and watery eyes, try natural foods and supplements like butterbur or omega-3 fatty acids to relieve your seasonal allergies. At least... (Source: NaturalNews.com)
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You're reading Testicular pain: Everything you need to know as a parent, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Does your of age son often complain about the pain in testicles? Does he feel uncomfortable while riding his bicycles or bike? If yes! It could be testicular pain which mostly occurs among teenage boys. It’s very uncommon to see the pain in boys above 25 years old. Testicular...
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Condition: HIV-1-infection Intervention: Other: This is an observational study only. Sponsors: Massachusetts General Hospital; Africa Health Research Institute; Mbarara University of Science and Technology; National Institute of Allergy and Infectious Diseases (NIAID); Wellcome Trust; ViiV Healthcare; Harvard Medical School; University of KwaZulu; E mory University Recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful...
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Conditions: HIV/AIDS; Adherence, Medication Intervention: Device: Digital Pill Sponsors: University of Colorado, Denver; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Immune Thrombocytopenic Purpura; Splenectomy; Status Intervention: Procedure: Immunolabeling Sponsor: University Hospital, Bordeaux Completed (Source: ClinicalTrials.gov)
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Condition: Chronic Eustachian Salpingitis Intervention: Device: Balloon dilation of the Eustachian tubes Sponsors: Piedmont Ear, Nose, Throat and Related Allergy, PC; Acclarent Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Condition: Hen Egg Allergy Interventions: Biological: AR201 Powder; Biological: Placebo powder Sponsor: Aimmune Therapeutics, Inc. Recruiting (Source: ClinicalTrials.gov)
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Condition: Tuberculosis Intervention: Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
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Authors: Kuziemsky CE, Schwartz DG, Airan-Javia S, Koppel R Abstract Many Electronic Health Record (EHRs) data displays are insensitive to their settings, contexts, and to clinicians' needs. Yet, the contexts in which the data are displayed critically affect EHR usability and patient safety. Medication prescribing is a complex task; especially sensitive to contextual variation in EHR displays as vast variations in formats and logic are often unnecessarily confusing, leading to unwanted...
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Authors: Seo JH, Lee YJ, Lee KH, Gireesh E, Skinner H, Westerveld M Abstract Advances in autoimmune encephalitis studies in the past 10 years have headed to the identification of new syndromes and biomarkers that have transformed the diagnostic approach to the disorder. The disorder or syndrome has been linked to a wide variety of pathologic processes associated with the neural-specific autoantibodies targeting both intracellular and plasma membrane antigens. However, current criteria for...
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Trust for America's Health reported rising levels of obesity contributed to increased disease rates and health care costs (Levi et al., 2013). Factors associated with overweight and obesity rates include lower socioeconomic status, public insurance, and increased chronic disease rates. (Source: Journal of Pediatric Health Care)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained...
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Allium hookeri root extract regulates asthmatic changes through immunological modulation of Th1/Th2‑related factors in an ovalbumin‑induced asthma mouse model. Mol Med Rep. 2019 Aug 06;: Authors: Bok SH, Seo JH, Bae CS, Kang B, Cho SS, Park DH Abstract In 2013, WHO estimated that approximately 235 million people suffered from asthma worldwide. Asthma is a hyper responsive disorder, which is related to an imbalance between the T‑helper type 1 and 2 cells (henceforth, Th1 and...
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Conclusion: We concluded similar efficacy of three medications in relieving symptoms and inefficacy in regressing palpebral and limbal papillae in cases of allergic conjunctivitis. (Source: Indian Journal of Ophthalmology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Publication date: Available online 21 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jean Bousquet, Ignacio J. Ansotegui, Josep M. Anto, Sylvie Arnavielhe, Claus Bachert, Xavier Basagaña, Annabelle Bédard, Anna Bedbrook, Matteo Bonini, Sinthia Bosnic-Anticevich, Fulvio Braido, Vicky Cardona, Wienczyslawa Czarlewski, Alvaro A. Cruz, Pascal Demoly, Govert De Vries, Stephanie Dramburg, Eve Mathieu-Dupas, Marina Erhola, Wytske J. FokkensAbstractSmart devices...
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The Crohn’s-like lymphoid reaction (CLR) to colorectal cancer (CRC), a CRC-specific ectopic lymphoid reaction, is thought to play an important role in the host response to CRC. CLR is characterized by peritumoral lymphocytic aggregates that are found at the advancing edge of the tumor. Spatial and molecular characterization of CLR within the tumor microenvironment (TME) have uncovered a spectrum of peritumoral lymphoid aggregates with varying levels of organization and maturation. In early stages...
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In this study, we used LSG sections from pSS patients and human salivary gland cell lines to investigate the relati onship between CXCL10 and MMP-9. Immunofluorescence analyses revealed that CXCL10 and MMP-9 were co-expressed in the LSG of pSS patients, particularly in expanded ductal cells. Furthermore, RT-qPCR analyses on human salivary gland ductal NS-SV-DC cells confirmed thatCXCL10 expression was induced by interferon (IFN)- γ, whereas that ofMMP9 was stimulated by IFN- α, tumor necrosis factor-α,...
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AbstractIschemia-reperfusion injury (IRI) is an inevitable consequence of kidney transplantation (KT). The aim of our study was to investigate the protective effect of a glycogen synthase kinase 3 β (GSK-3β) inhibitor against cold IRI in a rat renal transplantation (RT) model and a rat cold-IRI model through the toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor κ-light-chain-enhancer of the activated B cell (NF-κB) signaling pathway. We treated Sprague D awley (SD)...
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Thus far, the most effective strategy for the prevention of food allergy is early introduction of allergenic solids to at-risk infants. Early skin moisturization may have a role in food allergy prevention. There is insufficient evidence for hydrolyzed formula as a means of allergy prevention. Studies on vitamin D, omega 3, and probiotic supplementation; breastfeeding; early infant dietary diversity; and maternal peanut ingestion during pregnancy and breastfeeding are inconsistent. (Source: Immunology...
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AbstractThe molecular mechanisms of innate immunity are closely associated with the development of non-alcoholic fatty liver disease (NAFLD). TNF- α is a key cytokine involved in the pathogenesis of metabolic inflammation like NAFLD. Melanoma differentiation-associated gene 5 (MDA5) is a member of the intracellular RNA helicase family proteins that play a pivotal role in an antiviral immune response. Previous studies have demonstrated that TN F-α induces the expression of MDA5 in some types of cells....
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Sepsis is a major cause of morbidity and mortality worldwide despite numerous attempts to identify effective therapeutics. While some sepsis deaths are attributable to tissue damage caused by inflammation, most mortality is the result of prolonged immunosuppression. Ex vivo, immunosuppression during sepsis is evidenced by a sharp decrease in the production of pro-inflammatory cytokines by T cells and other leukocytes and increased lymphocyte apoptosis. This allows suppressive cytokines to exert a...
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Endometriosis is an estrogen-dependent disease with symptoms of dysmenorrhea, chronic pain, and infertility that affects 6% to 10% of women of reproductive age. Medical or surgical therapy, such as administration of an anti-gonadotropin or ovarian cystectomy, provide effective pain relief. However, neither therapy can be used for patients wishing to become pregnant. Despite the high morbidity, the pathogenesis of endometriosis has not been well elucidated. Several inflammatory cytokines are reported...
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We read with great interest the article titled “Soil exposure modifies the gut microbiota and supports immune tolerance in a mouse model” by Ottman et al.1 The study investigated the effect and mechanism of soil exposure–induced immune tolerance. However, soil exposure to adults might not be practical in asthma treatment and prevention. (Source: Journal of Allergy and Clinical Immunology)
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Factor XII (FXII) is the zymogen of serine protease, factor XIIa (FXIIa). FXIIa enzymatic activities have been extensively studied and FXIIa inhibition is emerging as a promising target to treat or prevent thrombosis without creating a hemostatic defect. FXII and plasma prekallikrein reciprocally activate each other and result in liberation of bradykinin. Due to its unique structure among coagulation factors, FXII exerts mitogenic activity in endothelial and smooth muscle cells, indicating that zymogen...
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A landmark study showed that early peanut introduction in high-risk infants, defined as infants with moderate to severe atopic dermatitis or egg allergy, reduced the risk of developing peanut allergy. Since this trial, many international societies have updated feeding guidelines to promote early introduction of peanut, usually around 6 months of age. Implementing these guidelines on a national and international level has been challenging. Furthermore, there is confusion if allergy testing is needed...
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Innate lymphoid cells (ILCs) are specialized immune cells that rapidly respond to environmental challenges, such as infection and tissue damage. ILCs play an important role in organ homeostasis, tissue repair, and host defense in the mucosal tissues intestine and lung. ILCs are sentinels of healthy tissue function, yet it is poorly understood how ILCs are recruited, strategically positioned, and maintained within tissues. Accordingly, ILC migration is an area that has recently come into focus and...
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We report that before start of treatment monocyte and neutrophil counts were higher in GCA and PMR patients than in HCs, while NK- and B-cell counts were lower. C-reactive protein (CRP) levels correlated positively with monocyte counts in GCA, and negatively with B-cell and NK-cell counts in PMR. During glucocorticoid treatment, myeloid subsets remained elevated whereas lymphoid subsets tended to fluctuate. Interestingly, erythrocyte sedimentation rate (ESR) outperformed CRP as marker for relapses...
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Recent studies demonstrate that the stable HIV-1 reservoir in resting CD4+ T cells is mostly formed from viruses circulating when combination antiretroviral therapy (ART) is initiated. Here we explore the immunological basis for these observations. Untreated HIV-1 infection is characterized by a progressive depletion of memory CD4+ T cells which mostly express CD127, the chain of the IL-7 receptor (IL-7R). Depletion results from both direct infection and bystander loss of memory CD4+ T cells in...
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Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structures of convertase bound FP. A structural core formed by three thrombospondin repeats (TSRs) and a TB domain harbors the convertase binding site in FP that mainly interacts with C3b. Stabilization of the interaction between the C3b C-terminus and the MIDAS...
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AbstractDiffuse alveolar hemorrhage (DAH) is a rare but potentially deadly manifestation of systemic lupus erythematosus (SLE). The aim of this study was to investigate the clinical characteristics and risk factors of DAH in SLE. A systematic review and meta-analysis of previous observational studies compared the clinical characteristics and risk factors between DAH-SLE and SLE patients without DAH. A total of 5 observational studies were included in this meta-analysis. Compared with the SLE patients...
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Genetic engineering is an important tool for redirecting the function of various types of immune cells and their use for therapeutic purpose. Although NK cells have many beneficial therapeutic features, genetic engineering of immune cells for targeted therapy focuses mostly on T cells. One of the major obstacles for NK cell immunotherapy is the lack of an efficient method for gene transfer. Lentiviral vectors have been proven to be a safe tool for genetic engineering, however lentiviral transduction...
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We appreciate the interest from Jiang et al1 regarding our article titled “Soil exposure modifies the gut microbiota and supports immune tolerance in a mouse model.”2 The readers' first question addresses the induction of a possible pathology in the intestines of the mice by the soil exposure. This is an important question, and one t hat we did not fully consider in the article. (Source: Journal of Allergy and Clinical Immunology)
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T-cell receptor (TCR) γδ cells are perceived as innate-like effector cells with the possibility of mediating graft-versus-tumor (GVT) without causing graft-versus-host disease (GVHD) in the setting of hematopoietic allogeneic stem cell transplantation (HSCT). We conducted a prospective study to assess the clinical impact of TCR γδ cell immune reconstitution on overall survival, relapse-free-survival, relapse and GVHD. The impact of CD3, CD4, CD8 T cells together with NK cells including subtypes were...
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Current guidelines state that there is insufficient evidence to recommend testing siblings of food allergic children before introduction of potential allergic foods, but the topic continues to remain controversial. Although the proportion of siblings who are sensitized to a food without clinical reactivity is high in comparison to those with a true food allergy, there is still a known increased risk amongst siblings of children with food allergies that has led to much apprehension about management....
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Temperature is one of the major climate factors that affects the outbreak of infectious disease. Lines of evidences have shown that virulence factors can be controlled by thermo-sensors in bacterial pathogens. However, how temperature influence host’s responses to the pathogen is still largely unexplored, and the study on which might pave the way to develop strategies to manage pathogenic bacterial infection. In the present study, we show that finfish Carassius carassius, the crucian carp that is...
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(Source: Frontiers in Immunology)
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Contributors : Nicholas Collins ; Seong-Ji Han ; Michel Enamorado ; Verena M Link ; Yasmine BelkaidSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMammals evolved in the face of fluctuating food availability. How the immune system adapts to transient nutritional stress remains poorly understood. Here, we show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow...
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Conclusions: Treatment with engineered T cells may have clinical applicability in patients with advanced-stage HGSOC. (Source: GEO: Gene Expression Omnibus)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Conclusions: Treatment with engineered T cells may have clinical applicability in patients with advanced-stage HGSOC. (Source: GEO: Gene Expression Omnibus)
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ConclusionsThe incidence of neonatal listeriosis is increasing, especially in preterm neonates. Maternal listeriosis should be adequately treated with appropriate empirical antibiotics. (Source: Journal of Microbiology, Immunology and Infection)
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Publication date: 15 October 2019Source: Biosensors and Bioelectronics, Volume 143Author(s): Xianbao Sun, Yongkang Ye, Shudong He, Zeyu Wu, Junyang Yue, Hanju Sun, Xiaodong CaoAbstract:As a well-known allergenic indicator in kidney beans, lectins have always been the serious threats for human health. Herein, we introduced a new label-free voltammetric immunosensor for the direct determination of kidney bean lectin (KBL) with potential allergenic activity. Gold nanoparticles-polyethyleneimine-multiwalled...
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Conclusions: Taken together, MPA synergized with LPS to induce the release of IL-18 via activating the NLRP3 inflammasome and increasing the degradation of pro-IL-18, rather than by enhancing the production of pro-IL-18. PMID: 31429348 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Conclusions: HHV6 primary infection may be associated with unilateral retinal granuloma in otherwise healthy patients. Antiviral drugs may be helpful in the treatment of this condition. PMID: 31430214 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
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Conclusion: We describe the first case of fungal necrotising scleritis without intraocular inflammation following pars plana vitrectomy (PubMed Search). Infection should be kept in the differential diagnosis of post-operative necrotising scleritis even in the absence of risk factors like hypopyon or diabetes. Early recognition improves final outcome. Medical therapy should be continued even after presumed cure to take care of residual fungi and prevent recurrences. PMID: 31429609 [PubMed - as...
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Conclusions: Corneal DCs respond differently in terms of shape and distribution during local and systemic inflammation. These features can serve as in vivo indicators in ocular and systemic diseases. PMID: 31429614 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
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Conclusion: Anterior uveitis was the most common pattern found among uveitis patients. Herpes simplex and toxoplasmic chorioretinitis were the most common-identified infectious causes. PMID: 31429610 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
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Conclusion: Both formulations improved ocular surface parameters. Group 2 showed more reduction in tear cytokines and Demodex count. PMID: 31429629 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Conclusions: Sub-tenon sustained controllable delivery of DXM effectively suppresses severe acute inflammation in a rabbit model of uveitis. The proposed minimal invasive system might be a promising candidate for managing severe ocular diseases. PMID: 31429619 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
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Authors: Menzies FM, Oldham RS, Waddell C, Nelson SM, Nibbs RJB Abstract Homeostatic leukocyte trafficking into and within the female reproductive tract (FRT) contributes to fertility and reproductive health. It is unclear how this process is regulated in the anatomically distinct reproductive tissues, or whether the genes involved are affected by cyclical changes in reproductive hormones. In tissues such as skin and intestine, mouse studies have defined evolutionarily conserved molecular...
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In conclusion, the results show that salmon were able to mount a robust adaptive response to different PAA doses and exposure times, and a combined exposure to stress and PAA. These results underscore the potential of PAA as a chemotherapeutant for salmon at PAA concentrations commonly applied to control parasitic infestations. (Source: Fish and Shellfish Immunology)
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We report transcriptome sequencing of gill, head kidney, and spleen of bester sturgeon (a hybrid of beluga Huso huso and sterlet Acipenser ruthenus) injected with synthetic double-stranded RNA (polyI:C). The composition of transcriptome and responses to treatment were examined in the context of comparative genomics with focus on immune genes. Sturgeon transcripts matched to 21.5 k different proteins (blastx). With reference to Atlantic salmon, the functional groups and pathways of the immune system...
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In this study, nine truncated CyHV-2 membrane glycoproteins (ORF25, ORF25C, ORF25D, ORF30, ORF124, ORF131, ORF136, ORF142A, ORF146) and a GFP reporter protein were respectively expressed using baculovirus surface displaying system. Western blot showed that the proteins were successfully packaged in the recombinant virus particles. In baculovirus transduced gibel carp kidney cells, the target proteins were expressed and displayed on the fish cell surface. Healthy gibel carp were immunized by immersion...
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This article is protected by copyright. All rights reserved. (Source: FEBS Letters)
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Exposures to pollen and air pollutants commonly occur simultaneously and have been linked to eliciting or exacerbating the allergic response in susceptible individuals [1, 2]. The risk of co-exposure was recently confirmed in a study from Copenhagen, Denmark [3] indicating that pollen and ozone concentration peaks coincide both diurnally and seasonally. Ozone exposures are able to prime the airways and exacerbate respiratory symptoms [4]. However, this effect is debated, especially regarding lower...
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The clinical effects of Aspergillus fumigatus in the cystic fibrosis (CF) airway, with the exception of allergic bronchopulmonary aspergillosis, is unclear. (Source: Journal of Cystic Fibrosis)
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The objectives of our study were to (1) establish the prevalence of hypersensitivity to components of knee prostheses in patients referred to our contact dermatitis clinic, (2) determine if patients with post-surgery dermatitis have become sensitized, and (3) describe the outcome of patients with and without hypersensitivity. We reviewed the charts of patients referred from 2007 to 2018 and extracted demographic information, date, type, and site of implant, clinical presentation, and results of patch...
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Over 2.6 million ED visits across the United States result in a primary diagnosis of urinary tract infection.1 While much attention has been paid to reducing blood culture contamination rates in the emergency department,2-9 a substantial gap remains in projects aimed at reducing contamination in clean-catch urine specimens obtained in the ED setting. Obtaining an adequate urine culture is clinically important to the care of several vulnerable patient groups, including patients with diabetes or compromised...
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Immunological aging is related to the development of cancer, but factors that impact this relationship are only partially understood. Several studies demonstrated that aging correlates with increased peripheral blood T lymphocyte (PBTL) expression of p16INK4a [1,2], a molecular marker associated with cellular senescence and irreversible cell cycle arrest [3]. PBTL p16INK4a levels not only increase with chronological age, but are influenced by physiologic stress caused by smoking, chemotherapy, and...
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Publication date: September 2019Source: Autoimmunity Reviews, Volume 18, Issue 9Author(s): (Source: Autoimmunity Reviews)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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In this study, total circulating CD4 T cells were sorted into CD25+CXCR5− Treg-like, CD25+CXCR5+ Tfr-like, and CD25−CXCR5+ Tfh-like subsets. Data showed that the Tfr-like subset presented intermediate levels of both Foxp3 and Bcl-6, while the Treg-like subset was high in Foxp3 and low in Bcl-6, and the Tfh-like was high in Bcl-6 and low in Foxp3. Of note, the frequencies of Tfr-like and Treg-like cells were significantly elevated in breast cancer (BC) patients than in non-cancer (NC) controls. Tfr-like...
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Recently, we have shown that microparticles (MPs) levels derived from leukocytes (LMPs), endothelium (EMPs), neurons (NMPs) and those expressing tissue factor (TFMPs) were higher in Alzheimer's Disease (AD) patients when compared to cognitively healthy subjects. Therefore, in this study we proposed to investigate the correlation between MPs levels, cognitive performance and functional status in a sample of elderly individuals. We evaluated MPs derived from platelets (PMPs), LMPs, EMPs, NMPs and TFMPs...
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A 21-year-old man with chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and comorbid asthma the last ten years was referred for allergy evaluation. The diagnosis of CRSwNP was based on the patient ’s symptomatology (nasal congestion, atypical facial pain, hyposmia/anosmia), nasal endoscopy, and the objective evidence of mucosal inflammation (complete opacification of the paranasal sinuses on CT-scan that revealed marked mucosal thickening with partial opacification of right maxillary sinus,...
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Viral Immunology, Ahead of Print. (Source: Viral Immunology)
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Mucosal Immunology, Published online: 21 August 2019; doi:10.1038/s41385-019-0195-8Neutrophils express pro- and anti-inflammatory cytokines in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques (Source: Mucosal Immunology)
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Mucosal Immunology, Published online: 21 August 2019; doi:10.1038/s41385-019-0193-xAntibiotic-induced dysbiosis of gut microbiota impairs corneal development in postnatal mice by affecting CCR2 negative macrophage distribution (Source: Mucosal Immunology)
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Conclusion Bromocriptine may stimulate dopamine receptors in cochlear cells with potential therapeutic role in patients with cochlear hydrops. There are no widely accepted and effective treatments for endolymphatic hydrops, and identifying potential new and efficacious therapeutics is of high relevance. PMID: 31430172 [PubMed - as supplied by publisher] (Source: American Journal of Audiology)
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Conclusions Results from this study suggest support for the predominant clinical view that patients with tinnitus and hyperacusis have higher levels of anxiety and depression than the general population. The extent of the suffering described and patterns of coping strategies suggest clinical practice patterns and the need for research in implementing improved practice plans. PMID: 31430190 [PubMed - as supplied by publisher] (Source: American Journal of Audiology)MedWorm Message: Have you tried...
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Conclusion Important hearing aid maintenance tasks, such as listening checks, are not completed regularly for many children, even when families own the necessary equipment. Ensuring that children who are hard of hearing have an IEP or 504 plan throughout elementary school may support self-advocacy and encourage children to take responsibility for their hearing aids, which may lead to more consistent hearing aid functioning. PMID: 31430182 [PubMed - as supplied by publisher] (Source: American...
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Conclusions Young AHL experience more effortful listening than their normal hearing peers. This increased effort is associated with increased reports of listening-related fatigue. However, diurnal cortisol profiles were not significantly different between groups nor were they associated with these perceived differences. PMID: 31430174 [PubMed - as supplied by publisher] (Source: American Journal of Audiology)
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Conclusion Most surveyed facilities measure productivity at the individual and/or department levels. However, there is no standard method. Current productivity measures include time-based measures based on appointment length, time-based measures assigned to Current Procedural Terminology codes, relative value units, combined approaches, and individual site developed programs. Many variables impact productivity measurements. Further study and discussion are needed to develop an optimal method for...
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Conclusions: The results show that a sloping hearing loss is related to altered resting-state brain organization. Effects were shown in attention and cognitive control networks, as well as visual and sensorimotor regions. Specifically, we found that even in a partial hearing deficit (affecting only some of the hearing frequency ranges), the age at the onset affects the brain function differently, pointing to the role of sensitive periods in brain development. (Source: Frontiers in Human Neuroscience)
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Conclusion: There are different reasons for disuse of hearing aids in elderly patients. Audiologists should ensure that hearing aids selection is patient specific and inclusive. Expectations of the elderly regarding hearing aids benefits and limitations should also be addressed by audiologists before fitting hearing aids.Keywords: Elderly, hearing aids, hearing loss, audiologists. (Source: African Health Sciences)
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Conclusion: Parental involvement was not associated with academic achievement among deaf children in Kampala. Other factors associated with academic achievement need to be identified to enhance deaf children's performance at school.Keywords: Parental involvement, academic achievement, deaf children, Mulago school for the deaf, Kampala, Uganda. (Source: African Health Sciences)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory...
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Axonal sprouting in the dorsal cochlear nucleus affects gap‑prepulse inhibition following noise exposure. Int J Mol Med. 2019 Aug 19;: Authors: Han KH, Mun SK, Sohn S, Piao XY, Park I, Chang M Abstract One of the primary theories of the pathogenesis of tinnitus involves maladaptive auditory‑somatosensory plasticity in the dorsal cochlear nucleus (DCN), which is assumed to be due to axonal sprouting. Although a disrupted balance between auditory and somatosensory inputs may...
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We report a potential association between these two rare anomalies that, to our knowledge, has not been reported. Two brothers presented with sensorineural hearing loss and almost identical inner ear and hypothalamic abnormalities, consistent with a diagnosis of X-linked stapes gusher syndrome and hypothalamic hamartoma. Genetic testing revealed identical mutations in thePOU3F4 gene associated with X-linked stapes gusher syndrome. Furthermore, multiple vestibular diverticula were seen in both brothers,...
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Conclusions: The findings reported here warrant further, more substantive, methodologically-sound research that is fully powered to show a reliable difference. Findings may be useful for both clinicians and researchers in better identification and understanding of communication disorders. PMID: 31426435 [PubMed - in process] (Source: Medicina (Kaunas))
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Telemedicine and e-Health, Ahead of Print. (Source: Telemedicine and e-Health)
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