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Abstract Anticipation of a painful experience can influence brain activity and increase sensitivity to experimental somatosensory stimuli in healthy adults, but this response is poorly understood among individuals with chronic musculoskeletal pain (CMP). Studies of brain and perceptual responses to somatosensory stimuli are used to make inferences about central nervous system dysfunction as a potential mechanism of symptoms. As such, we sought to (a) determine the influence of pain anticipation...
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A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia
Thyroid, Volume 29, Issue 8, Page 1158-1167, August 2019.
Thyroid, Volume 29, Issue 8, Page 1036-1043, August 2019.
Thyroid, Volume 29, Issue 8, Page 1060-1072, August 2019.
Thyroid, Volume 29, Issue 8, Page 1147-1157, August 2019.
Thyroid, Volume 29, Issue 8, Page 1097-1104, August 2019.
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Malassezia furfur is lipophilic and lipid-dependent yeast, inhabitant of human skin microbiota associated with several dermal disorders. In recent years, along with the advances in nanotechnology and the incentiv...
Microbial activity is the main route for cycling mangrove nutrients. In general, microorganisms have abilities to degrade lignocellulosic compounds. Among the biotechnological potential of the microbiota from ...
The responses of denitrifiers and denitrification ability to dissolved oxygen (DO) concent in different layers of surface lake sediments are still poorly understood. Here, the optimal denitrification condition...
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Tissue Engineering Part A, Ahead of Print.
Temporal Impact of Substrate Anisotropy on Differentiating Cardiomyocyte Alignment and Functionality
Tissue Engineering Part A, Ahead of Print.
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Correction of dentofacial deformities via orthodontics is an integral part of oral health as promotes optimal function, periodontal health, aesthetics and overall oral health-related quality of life. The aim o...
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A setup for X-ray beam induced current measurements at synchrotron beamlines is described. It unveils the nanoscale performance of solar cells and extends the suite of techniques for multi-modal X-ray microscopy. From wiring to signal-to-noise optimization, it is shown how to perform state-of-the-art XBIC measurements at a hard X-ray microprobe.
This paper describes real-time electroencephalography-triggered transcranial magnetic stimulation to study and modulate human brain networks.
The goal of this protocol is to outline the design and performance of in vivo experiments in Drosophila melanogaster to assess the functional consequences of rare gene variants associated with human diseases.
Here, we present a protocol for immunofluorescence staining to observe the endothelial cells of the mouse aorta directly. This technique is useful when studying the cellular and molecular phenotype of endothelial cells in different flow patterns and in the development of atherosclerosis.
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Future Oncology, Ahead of Print.
Future Oncology, Ahead of Print.
Future Oncology, Ahead of Print.
Is there a role for carbon therapy in the treatment of gynecological carcinomas? A Systematic Review
Future Oncology, Ahead of Print.
Future Oncology, Ahead of Print.
Future Oncology, Volume 15, Issue 24, Page 2791-2794, August 2019.
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The coexistence of malignancies in a patient may be explained by the tumor-to-tumor metastasis phenomenon or multiple primary malignant tumors, both of which are not common findings. Here, we are going to pres...
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Journal of Neurotrauma, Ahead of Print.
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Surgical Infections, Ahead of Print.
Surgical Infections, Ahead of Print.
Surgical Infections, Ahead of Print.
Surgical Infections, Ahead of Print.
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To evaluate and establish a digital workflow for the custom designing and 3D printing of mouth opening tongue-depressing (MOTD) stents for patients receiving radiotherapy for head and neck cancer.
There is continued debate regarding the optimal combinations of radiation therapy and chemotherapy in the preoperative treatment of locally advanced rectal adenocarcinomas. We report our single-institution exp...
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“Ready-to-use” disinfecting wipes (also known as pre-impregnated disinfecting wipe) are broadly used in food industry and domestic situations. Their application in hospitals and healthcare centres for decontam...
A carbapenem-resistant hypermucoviscous Klebsiella pneumoniae isolate was recovered from human sputum.
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Stem Cells and Development, Ahead of Print.
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25-Hydroxyvitamin D profiles and maternal bone mass during pregnancy and lactation in Japanese women
Abstract Vitamin D deficiency is observed worldwide and represents a health hazard for mothers, infants and elderly persons. We know that many young Japanese women experience vitamin D insufficiency; however, there is a lack of knowledge regarding the serum 25-hydroxyvitamin D [25(OH)D] profile of pregnant Japanese women and of the association between maternal 25(OH)D level and maternal bone mass during pregnancy and lactation. In this longitudinal study, 160 pregnant Japanese...
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Studying cognition in the wild is a challenge. Field researchers and their study animals face many factors that can easily interfere with their variables of interest and that many say are 'impossible' to control for. A novel observational approach for field research can now guide young scholars, who want to study cognition in the field before this opportunity disappears.
Researchers who rush in after storms to study the behavior of spiders have found that extreme weather events such as tropical cyclones may have an evolutionary impact on populations living in storm-prone regions, where aggressive spiders have the best odds of survival.
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Cancers, Vol. 11, Pages 1215: Fluorescence-Guided Surgery for Hepatoblastoma with Indocyanine Green Cancers doi: 10.3390/cancers11081215 Authors: Yohei Yamada Michinobu Ohno Akihiro Fujino Yutaka Kanamori Rie Irie Takako Yoshioka Osamu Miyazaki Hajime Uchida Akinari Fukuda Seisuke Sakamoto Mureo Kasahara Kimikazu Matsumoto Yasushi Fuchimoto Ken Hoshino Tatsuo Kuroda Tomoro Hishiki Fluorescence-guided surgery with indocyanine green (ICG) for...
Cancers, Vol. 11, Pages 1214: Determination of the Potential Tumor-Suppressive Effects of Gsdme in a Chemically Induced and in a Genetically Modified Intestinal Cancer Mouse Model Cancers doi: 10.3390/cancers11081214 Authors: Lieselot Croes Erik Fransen Marieke Hylebos Kimberly Buys Christophe Hermans Glenn Broeckx Marc Peeters Patrick Pauwels Ken Op de Beeck Guy Van Camp Gasdermin E (GSDME), also known as deafness autosomal dominant 5 (DFNA5) and previously...
Cancers, Vol. 11, Pages 1211: RAC1B Suppresses TGF-β-Dependent Chemokinesis and Growth Inhibition through an Autoregulatory Feed-Forward Loop Involving PAR2 and ALK5 Cancers doi: 10.3390/cancers11081211 Authors: Hannah Otterbein Koichiro Mihara Morley D. Hollenberg Hendrik Lehnert David Witte Hendrik Ungefroren The small GTPase RAC1B functions as a powerful inhibitor of transforming growth factor (TGF)-β1-induced epithelial-mesenchymal transition, cell motility,...
Cancers, Vol. 11, Pages 1212: Circulating Tumor Cell Enumeration and Characterization in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Cabazitaxel Cancers doi: 10.3390/cancers11081212 Authors: de Kruijff Sieuwerts Onstenk Kraan Smid Van van der Vlugt-Daane Hoop Mathijssen Lolkema de Wit Hamberg Meulenbeld Beeker Creemers Martens Sleijfer (1) Background: Markers identifying which patients with metastatic,...
Cancers, Vol. 11, Pages 1213: LAG3: The Biological Processes That Motivate Targeting This Immune Checkpoint Molecule in Human Cancer Cancers doi: 10.3390/cancers11081213 Authors: Cinzia Solinas Edoardo Migliori Pushpamali De Silva Karen Willard-Gallo The programmed cell death 1 (PD-1) pathway is an important regulator of immune responses in peripheral tissues, including abnormal situations such as the tumor microenvironment. This pathway is currently the principal target for...
Cancers, Vol. 11, Pages 1209: Involvement of Actin in Autophagy and Autophagy-Dependent Multidrug Resistance in Cancer Cancers doi: 10.3390/cancers11081209 Authors: Magdalena Izdebska Wioletta Zielińska Marta Hałas-Wiśniewska Alina Grzanka Currently, autophagy in the context of cancer progression arouses a lot of controversy. It is connected with the possibility of switching the nature of this process from cytotoxic to cytoprotective and vice versa depending on the treatment....
Cancers, Vol. 11, Pages 1210: The Importance of Gender-Related Anticancer Research on Mitochondrial Regulator Sodium Dichloroacetate in Preclinical Studies In Vivo Cancers doi: 10.3390/cancers11081210 Authors: Donatas Stakišaitis Milda Juknevičienė Eligija Damanskienė Angelija Valančiūtė Ingrida Balnytė Marta Maria Alonso Sodium dichloroacetate (DCA) is an investigational medicinal product which has a potential anticancer preparation as a metabolic regulator in cancer...
Cancers, Vol. 11, Pages 1208: Antioxidant Defenses: A Context-Specific Vulnerability of Cancer Cells
Cancers, Vol. 11, Pages 1208: Antioxidant Defenses: A Context-Specific Vulnerability of Cancer Cells Cancers doi: 10.3390/cancers11081208 Authors: Jordan A. Cockfield Zachary T. Schafer Reactive oxygen species (ROS) are well known for their capacity to cause DNA damage, augment mutagenesis, and thereby promote oncogenic transformation. Similarly, agents that reduce ROS levels (antioxidants) are frequently thought to have anti-cancer properties given their propensity to minimize DNA...
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Publication date: Available online 19 August 2019Source: Reports of Practical Oncology & RadiotherapyAuthor(s): A. Tullio, A. Magli, E. Moretti, F. ValentAbstractAimThe aim of the present study is to evaluate and quantify the bias of competing risks in an Italian oncologic cohort comparing results from different statistical analysis methods.BackgroundCompeting risks are very common in randomized clinical trials and observational studies, in particular oncology and radiotherapy ones, and their...
Publication date: Available online 19 August 2019Source: Reports of Practical Oncology & RadiotherapyAuthor(s): Haris Vakil, Lena Tran, Gary D. Lewis, Matthew D. Cykowski, E. Brian Butler, Bin S. TehAbstractMeningiomas are the most common type of benign tumor found in the brain and are typically benign, slow-growing lesions. The current standard of care consists of surgical resection and subsequent postoperative radiotherapy to prevent local recurrence. Because of their indolent nature, meningiomas...
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Current Anthropology, Ahead of Print.
16h
Current Anthropology, Ahead of Print.
1d
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Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11653-4Quantification of shale gas reserves is critical to shape the energy policies of countries. Here, the authors present a new procedure to estimate gas in place and show that important UK gas reserves are actually much lower than previously thought.
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11311-9Biomarkers that predict mortality are of interest for clinical as well as research applications. Here, the authors analyze metabolomics data from 44,168 individuals and identify key metabolites independently associated with all-cause mortality risk.
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11705-9The genome of double-stranded DNA bacteriophages is delivered to host cells through the viral portal and tail structures. Here the authors describe structures of the bacteriophage T7 portal and the 1.5 MDa tail complex formed by the portal protein, adaptor protein and nozzle, providing insight into how the portal and tail machinery work during DNA packaging and ejection.
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11672-1Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11559-1The authors introduce ACT-seq: a Tn5-based method for rapidly profiling epigenetic marks in bulk-cell and single-cell samples. ACT-seq avoids many laborious or time-consuming steps required for similar techniques including chromatin fragmentation and end repair.
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11730-8The limited efficacy of current immunotherapy suggests low antigen-specific T cells and immunosuppressive factors in tumor microenvironment (TME). Here, the authors develop a syringeable immunomodulatory multi-domain nanogel that can reprogram the TME and induce enhanced cancer immunotherapy.
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11387-3Air pollution has become a major health risk in China. Here Zhang et al. report that maternal and neonatal exposure to particulate matter increases the risk of neonatal jaundice based on the study of 25,782 newborns born in China between 2014 and 2017.
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11276-9The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Here, Alcala and colleagues present a multi-omics analysis of these tumours, revealing distinct molecular and prognostic subgroups.
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11733-5The transient receptor potential channel member 2 (TRPM2) ion channel has a function in redox-dependent signaling. Here the authors present the cryo-EM structures of zebrafish TRPM2 in the ligand-free form, with Ca2+ and both ADP-ribose/Ca2+ and observe two-fold symmetric quaternary structure rearrangements in the ligand-bound structures that likely represent intermediate gating states.
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11737-1Controlling the rotation direction of individual molecular machines requires precise design and manipulation. Here, the authors describe a surface-adsorbed molecular propeller that, upon excitation with a scanning tunneling microscope tip, can rotate clockwise or anticlockwise depending on its chirality, and directly visualize its stepwise rotation with STM images.
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Publication date: Available online 19 August 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Kevin Vu, Karen KowalskeAbstractObjectiveTo review the effectiveness of Botulinum Toxin A (BTX-A) for treating the loss of maximum ankle dorsiflexion range of motion after burn injuryDesignRetrospective chart reviewSettingLarge urban burn centerParticipants5 patients with major burn injury and loss of ankle dorsiflexion range while hospitalizedInterventionBTX-A treatment in addition...
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Publication date: Available online 19 August 2019Source: Practical Radiation OncologyAuthor(s): Barry S. Rosenstein
Publication date: Available online 19 August 2019Source: Practical Radiation OncologyAuthor(s): James Loudon, Natalie Rozanec, Ashley Clement, Rachel Woo, Anne Grant, Judy Murray, Woodrow WellsAbstract:PurposePalliative radiation therapy (PRT) has an essential role in cancer symptom control but is under-utilized in Ontario. This initiative aimed to implement an educational outreach intervention to improve knowledge of and access to PRT among inter-professional palliative healthcare teams across an...
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Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Yingzhe Cui, Lulu Chang, Chunbo Wang, Xudong Han, Lili Mu, Yue Hao, Chonghui Liu, Jiarui Zhao, Tongshuai Zhang, Haiyu Zhang, Yao Zhang, Yumei Liu, Wei Zhao, Jinghua Wang, Xijun Liu, Bo Sun, Guangyou Wang, Qingfei Kong, Junwei Han, Hulun LiAbstractMetformin, the most widely used medicine for type 2 diabetes, displays anti-inflammatory functions via activating AMP-activated protein kinase (AMPK). Circulating...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Gaowa Bai, Takashi Matsuba, Haruhisa Kikuchi, Haorile Chagan-Yasutan, Hirotoshi Motoda, Ryo Ozuru, Osamu Yamada, Yoshiteru Oshima, Toshio HattoriAbstractPlasma osteopontin (OPN) levels are elevated in tuberculosis patients and may involve granuloma formation. New inhibitors using brefelamide, an aromatic amide isolated from Dictyostelium cellular slime molds that may inhibit OPN transcription in A549 cells...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Jianlin He, Bihong Hong, Mianli Bian, Huanhuan Jin, Junde Chen, Jiangjuan Shao, Feng Zhang, Shizhong ZhengAbstractDocosahexaenoic acid (DHA) has been found to have a hepatoprotective effect. In this study, we investigated the role of peroxisome proliferator-activated receptor γ (PPARγ) in DHA regulation of liver fibrosis. DHA was found to inhibit hepatic stellate cell (HSC)-LX2 cell viability and downregulate...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Ji-ye Lim, Ji-Hyun Lee, Dong-Hyun Lee, Jeong-Heon Lee, Dae-Ki KimAbstractUmbelliferone (UMB) is a coumarin derivative present in roots and barks of plants, such as Angelica decursiva, Artemisia capillaris, and orange. UMB has been previously reported to exhibit anti-inflammatory, anti-diabetic, and anti-cancer effects. However, the effect of UMB on atopic dermatitis (AD) remains unknown. The purpose of this...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Mengyun Ke, Zhenhai Zhang, Biyi Xu, Shidi Zhao, Yiming Ding, Xiaoning Wu, Rongqian Wu, Yi Lv, Jian DongAbstractBlocking the PD-L1/PD-1 pathway to prevent the immune evasion of tumor cells is a powerful approach for treating multiple cancers, including hepatocellular carcinoma (HCC). Previous studies have shown that baicalein and baicalin are directly cytotoxic to some tumors, here we demonstrate that in addition...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Kuo Jiang, Jia Li, Jitao Zhang, Lei Wang, Qianfeng Zhang, Junli Ge, Yunshan Guo, Biao Wang, Yi Huang, Tuanmin Yang, Dingjun Hao, Lequn ShanAbstractImmune checkpoint inhibitors, such as anti-PD-1/PD-L1, are a novel class of inhibitors that function as a tumor suppressing factor via modulation of immune cell-tumor cell interaction. To date, PD-1/PD-L1 inhibitors have been approved for the treatment of specific...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Song Xue, Qing Shao, Li-Bo Zhu, Ya-Fei Jiang, Cong Wang, Bao Xue, Hai-Ming Lu, Wei-Lin Sang, Jin-Zhong MaAbstractBone homeostasis requires a dynamic balance between osteogenesis and osteoclastogenesis, and osteolytic disorders are mainly attributed to aberrant osteoclastogenesis and bone resorption. Accumulating evidence has demonstrated that cyclin-dependent kinase 9 (CDK9) regulates some inflammatory diseases...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Zhipeng Sun, Fuquan Wang, Yiyi Yang, Jingxu Wang, Shujun Sun, Haifa Xia, Shanglong YaoAbstractMechanical ventilation (MV) is a major support for patients with severe clinical disease, surgery and anesthesia. However, complications of mechanical ventilation especially ventilator-induced lung injury(VILI) can make the course and prognosis worse. Resolvin D1(RvD1) is a class of endogenous polyunsaturated fatty...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Zohre Sadeghi, Mahdi Fasihi-Ramandi, Saeid BouzariAbstractBrucellosis is a worldwide zoonotic disease affecting domestic animals and humans. Due to several safety problems associated with live attenuated vaccines (Rev1 and RB51), it is necessary to produce an efficient and safer vaccine against Brucella. In this study, we evaluated efficacy of two novel multi-peptide vaccine candidates of FliC, 7α-HSDH, BhuA...
Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Hong-zhong Jin, Xiao-jia Yang, Kai-liang Zhao, Fang-chao Mei, Yu Zhou, Yun-dong You, Wei-xing WangAbstractMounting evidence has demonstrated that acute pancreatitis (AP) is one of the causes of multiple organ damage. NADPH (nicotinamide adenine dinucleotide phosphate) act as a substrate of NADPH oxidase (NOX) to generate reactive oxygen species (ROS), but the role NADPH oxidase signaling pathway plays in AP-induced...
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Abstract Purpose To compare the fracture resistance of implant‐supported milled zirconia, milled lithium disilicate, and additively manufactured zirconia crowns. Materials and Methods : Maxillary cast with a dental implant replacing right second bicuspid was obtained. Custom abutments and full‐contour crowns for milled zirconia, milled lithium disilicate, and additively manufactured zirconia crowns (n = 10/group) were digitally designed and fabricated. The crowns were cemented to implant...
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Publication date: September 2019Source: Gait & Posture, Volume 73Author(s):
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Conversion surgery has been reported but few cases have undergone surgical R0 resection after second-line chemotherapy. We report a case of an unresectable locally advanced gastric cancer in a patient who finally underwent the operation (R0) after second-line chemotherapy. The 77-year-old male was diagnosed with gastric cancer (cT4 [SI; Skin, Liver] N0M0 c Stage IIIA) with invasion to the skin of the abdominal wall, and chemotherapy was initially performed because of his poor performance status and...
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Publication date: Available online 20 August 2019Source: Gene Expression PatternsAuthor(s): Ryo D. Shiraishi, Sathoshi Miyashita, Mariko Yamashita, Toma Adachi, Mana M. Shimoda, Tomoo Owa, Mikio HoshinoAbstractCerebellar granule cell precursors (GCPs) and granule cells (GCs) constitute a good model system to investigate proliferation of neural precursors and differentiation of neurons. During development, GCPs proliferate in the outer external granule cell layer (outer EGL) and then exit the cell...
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Abstract Background This study aimed to evaluate the prevalence of tooth wear among preschool children in Jakarta, Indonesia, and examine the risk factors associated with its occurrence. Methods An epidemiological survey was conducted with a cross-sectional study design. The participants were recruited via cluster sampling. Tooth wear was clinically...
Abstract Background Enterococcus faecalis is a bacterium frequently isolated after failed root canal therapy. This study analyzed the antibacterial and antibiofilm effects in vitro of sustained-release fillers (SRF) containing cetylpyridinium chloride (CPC) against vancomycin resistant E. faecalis. Methods First, the solidification capability...
Abstract Background Studies in high-income countries have reported associations between oral health and diabetes. There is however a lack of evidence on this association from low and middle-income countries, especially India. The current study aimed to assess the prevalence of common oral diseases and their association with diabetes. Methods ...
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Researchers at Ecole Polytechnique Fédérale de Lausanne in Switzerland have developed a new type of intraneural electrode to bypass the eyeball and send messages directly to the brain through the optic nerve. The technique could provide a visual aid for permanently blind people. Using retinal implants to treat blindness is a developing field. The concept involves allowing users to have the sensation of observing light, which is experienced as white patterns. While this isn’t the same as full...
The company EXO Imaging out of Redwood City, CA recently emerged from stealth mode to announce the development of a novel technology called Piezoelectric Micromachined Ultrasonic Transducers (pMUT) for ultrasound imaging. EXO Imaging is bringing together advances in micromachined materials and artificial intelligence to enhance both the ultrasound probe as well as the receiver that a clinician uses to visualize the ultrasound images. Traditional ultrasound transducers are built from bulk piezoelectric...
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Publication date: Available online 19 August 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Lorenz Epprecht, Alexander M. HuberVestibular neurectomy for Meniere's disease is considered as a treatment option when conservative methods fail to control debilitating vestibular symptoms. Most common surgical approaches today consist of transtemporal supralabyrinthine (middle fossa), retrolabyrinthine and retrosigmoid craniotomies. The aim of this article is to describe...
Publication date: Available online 19 August 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Jenny X. Chen, Zizi Yu, Steven D. RauchMeniere's disease is characterized by idiopathic progressive fluctuating hearing loss, tinnitus, and episodic vertigo. Intratympanic gentamicin injection is the preferred therapeutic option for those who have failed conservative management including lifestyle modifications and oral medications. The procedure is simple and can be performed...
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Publication date: Available online 20 August 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Jens H. Højvig, Henrik Kehlet, Christian T. Bonde
Publication date: Available online 20 August 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Eric R. Carlson, R. John Tannyhill
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