Proton therapy developer Ion Beam Applications (IBA) posted revenue growth...Read more on AuntMinnieEurope.comRelated Reading: IBA announces ProteusOne contract in Italy IBA posts mixed 2018 financial results IBA secures Belgian ProteusOne contract IBA receives Brazil's OK for proton therapy system Purchase delays affect IBA's 6-month results
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Researchers from Israel have developed a model that compares the water content...Read more on AuntMinnieEurope.comRelated Reading: Novel imaging method tracks brain shrinkage Italians identify key PET marker for memory problems RöKo: Molecular imaging can transform dementia care
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There is a growing list of medications known to adversely affect thyroid function or interpretation of the results of standard thyroid laboratory testing. Many of these drugs are commonly used preparations, ranging from over-the-counter supplements to advanced medical therapy, and include…
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Abstract Background Adolescents and young adult (AYA) women with cancer are at risk of heavy menstrual bleeding (HMB) due to thrombocytopenia, coagulopathy, and/or disruption of the hypothalamic‐pituitary‐gonadal axis. Currently, little is known about current practices to help prevent and treat HMB in AYA women with cancer. Methods We surveyed providers from 100 pediatric oncology centers. Face and content validity were assessed prior to distribution. Descriptive statistics, Chi‐squared...
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Abstract Purpose Cancer‐related fatigue is one of the most distressing side effects of childhood cancer treatment. Physical activity can decrease fatigue and has positive effects on other health outcomes. Most research on physical activity pertains to adults, and the few studies that focus on children have limited follow‐up time. This study evaluates cancer‐related fatigue in children and its association with physical activity over a one‐year time period. Methods Sixty‐eight children with...
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Abstract Background Burkitt lymphoma (BL) is a curable childhood cancer. Treatment adherence is crucial for a good outcome, but is potentially problematic in low‐ and middle‐income countries owing to parental financial constraints. Aims To investigate the association of destitution with treatment adherence and its effect on the survival of patients with BL. Methods Patients received free medical treatment from a twinning programme at two Cameroon Baptist hospitals. A destitution assessment...
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Abstract Chlorogenic acid (CGA) is known to have antioxidant potentials, yet the effect of CGA on brain ischemia has not been sufficiently understood. Brain ischemia such as transient global ischemia disrupts many areas of the brain of rats, including the hippocampus. Male Wistar rats were randomly assigned into 5 groups, i.e. sham operated (SO), bilateral common carotid occlusion (BCCO), BCCO + 15, 30, and 60 mg/kg bw CGA groups (CGA15, CGA30, and CGA60, respectively). Brain ischemia was induced...
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Abstract We used the Land Colour Mondrian experiments in a Bayesian context to test the degree to which subjects vary in categorizing the colour of different patches, when each patch is made to reflect light of the identical wavelength‐energy composition. The brain uses a ratio‐taking mechanism to determine the ratio of light of every waveband reflected from a surface and from its surrounds. Our (Bayesian) hypothesis was that this ratio‐taking mechanism is similar in all humans and therefore leads...
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This study evaluates the impact of ED pediatric readiness on the mortality of critically ill children who initially present to an ED.
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Four girls with epilepsy and mutations in FMR1, the Fragile X gene, are described. Three had DEE, with epileptic spasms seen in 2.
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Abstract Purpose The aim of the present study was to provide predictive factors for survival outcomes of oligometastatic prostate cancer (PC) patients treated with stereotactic body radiation therapy (SBRT) as a metastases-directed therapy (MDT). Methods In this cohort study, endpoints included overall survival (OS), progression-free survival (PFS), distant...
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Contributors : Lei Wang ; Shaoguang SunSeries Type : Non-coding RNA profiling by arrayOrganism : Mus musculusNon-coding circular RNAs (circRNAs) have displayed dysregulated expression in the hippocampus of Nrf2-knockout mice.
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Contributors : Ningning Li ; Kastytis Sidlauskas ; Ying Zhang ; Sebastian BrandnerSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusHuman astrocytomas and oligodendrogliomas are defined by mutations in the metabolic enzyme isocitrate dehydrogenase (IDH) 1 or 2. Mutant IDH1 causes the production and accumulation of the metabolite 2 hydroxyglutarate, which induces genome-wide hypermethylation, and is thought to be a driver mutation of these tumours. However,...
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Contributors : Lei Wang ; Shaoguang SunSeries Type : Non-coding RNA profiling by array ; Expression profiling by arrayOrganism : Mus musculusNon-coding long noncoding RNAs (lncRNAs) and mRNA have displayed dysregulated expression in the hippocampus of Nrf2-knockout mice.
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Contributors : Ningning Li ; Kastytis Sidlauskas ; Ying Zhang ; Sebastian BrandnerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHuman astrocytomas and oligodendrogliomas are defined by mutations in the metabolic enzyme isocitrate dehydrogenase (IDH) 1 or 2. Mutant IDH1 causes the production and accumulation of the metabolite 2 hydroxyglutarate, which induces genome-wide hypermethylation, and is thought to be a driver mutation of these tumours. However,...
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Contributors : Serfling Edgar ; Khalid MuhammadSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBy co-culturing murine keratinocytes with splenic T cells we show here that T cells affect the synthesis and secretion of chemokines by keratinocytes.
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Contributor : Santanu DasguptaSeries Type : Expression profiling by arrayOrganism : Homo sapiensSH3GL2 acts as a tumor suppressor. Our aim was to idenfy SH3GL2 regulatory pathways.We stably introduced SH3GL2 in SUM159 cells, exhibiting reduced cancer growth and pulmonary metastasis
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Contributors : Seung-Jae V Lee ; Dongyeop Lee ; Seon-Woo A An ; Yoonji JungSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansTo determine the role of MDT-15 in mRNA expression changes at different temperatures, we sequenced mRNAs obtained from day 1 adult Caenorhabditis elegans. Bristol N2 (wild-type) and mdt-15(tm2182) mutant animals that cultured at 25oC or 15oC were used.
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Contributor : Brigitte Boizet-BonhoureSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNonsteroidal anti-inflammatory drugs such as ibuprofen (IBU) and analgesic drugs, such as acetaminophen (APAP), are the most frequently medications taken by pregnant women, even in combination. They were shown to target fetal gonadal development acting as endocrine disruptors, that might favour genital malformations in new-born boys and reproductive disorders in adults, in...
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Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
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Contributors : Alyssa A Lombardi ; Andrew A Gibb ; John W ElrodSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusFibroblast to myofibroblast differentiation is crucial for the initial healing response but excessive myofibroblast activation leads to pathological fibrosis. Therefore, it is imperative to understand the mechanisms underlying myofibroblast formation. Here we report that mitochondrial calcium (mCa2+) signaling is a regulatory mechanism...
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Contributors : Alyssa A Lombardi ; Andrew A Gibb ; John W ElrodSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFibroblast to myofibroblast differentiation is crucial for the initial healing response but excessive myofibroblast activation leads to pathological fibrosis. Therefore, it is imperative to understand the mechanisms underlying myofibroblast formation. Here we report that mitochondrial calcium (mCa2+) signaling is a regulatory mechanism in myofibroblast...
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Series Type : Methylation profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
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Contributors : Xiaoyang Dou ; Jerome D Boyd-Kirkup ; Jing-dong J HanSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensHow individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in human and other animals were strongly biased to light (L)-strand non-CpG methylation with conserved peak loci preferentially...
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Contributors : Xiaoyang Dou ; Jerome D Boyd-Kirkup ; Jing-dong J HanSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensHow individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in human and other animals were strongly biased to light (L)-strand non-CpG methylation with conserved peak loci preferentially...
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Contributors : Xiaoyang Dou ; Joseph McDermott ; Jing-dong J HanSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensHow individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in human and other animals were strongly biased to light (L)-strand non-CpG methylation with conserved peak loci preferentially...
16h
Contributors : Xiaoyang Dou ; Jerome D Boyd-Kirkup ; Jing-dong J HanSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensHow individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in human and other animals were strongly biased to light (L)-strand non-CpG methylation with conserved peak loci preferentially...
16h
Contributors : Won-Hee Jung ; Eunsoo Do ; MinJi Park ; Yong-Joon Cho ; Dong-Hyeun KimSeries Type : Expression profiling by high throughput sequencingOrganism : Cryptococcus neoformans var. grubii H99 ; Malassezia restrictaPurpose: Understanding the mechanism of action of lauryl betaine against Cryptococcus neoformans and Malassezia restricta.Methods: The transcriptome profile of the lauryl betaine-treated cells compared to that of untreated cells were generated by RNA-seq Illumina Hiseq.Results:...
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Contributors : Xiaoyang Dou ; Joseph McDermott ; Jing-dong J HanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHow individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in human and other animals were strongly biased to light (L)-strand non-CpG methylation with conserved peak loci preferentially...
16h
Contributors : Xiaoyang Dou ; Jerome D Boyd-Kirkup ; Jing-dong J HanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHow individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in human and other animals were strongly biased to light (L)-strand non-CpG methylation with conserved peak loci preferentially...
16h
GSE133958 The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A [HEK293T_MeDIP]
Contributors : Xiaoyang Dou ; Jerome D Boyd-Kirkup ; Jing-dong J HanSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensHow individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in human and other animals were strongly biased to light (L)-strand non-CpG methylation with conserved peak loci preferentially...
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Contributor : Jeffrey J BednarskiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRAG DSBs trigger ATM-dependent induction of SPIC, an ETS family transcriptional repressor with significant homology to PU.1. RAG DSB-mediated expression of SPIC results in displacement of PU.1 throughout the genome and induction of broad transcriptional changes in pre B cells. SPIC also binds and recruits a unique partner, BCLAF1 to gene regulatory elements that regulate expression...
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Contributors : Shuuji Mawaribuchi ; Yuzuru ItoSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensWe established two different substates in human ES cell line, H9 cells, by changing the extracellular matrices. To examine a global miRNA expression comparison between the substate 1 and substate 2 cells, miRNA microarray was performed.
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Contributors : Byungyong Ahn ; Shibiao Wan ; Kyong-Jae Won ; Daniel P KellySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIt is well known that insulin resistance in the obese state is associated with accumulation of neutral lipid in extra-adipose tissues. This phenomenon is particularly well-documented in skeletal muscle. The mechanistic underpinnings of this linkage are not fully understood. To define new MondoA target gene and pathway in human myotubes,...
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Contributors : Jeff Molkentin ; Hadi Khalil ; Vikram PrasadSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOverall goal: To elucidate fibroblast-specific role of Hsp47 in fibroblast activation, collagen production, and cardiac fibrosis and their differentiation to myofibroblasts. Purpose of analysis: To generate transcriptional profile of HSP47-deficient fibroblasts in the context of pathological cardiac remodeling associated with chronic pressure-overload.
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Contributors : Bo He ; Shuangbo Kong ; Haibin WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImplantation of the blastocyst into the uterus is a developmental milestone in mammalian embryonic development, which is the gateway for further development of fetus. At this time, remodeling of the blastocyst to an implantation competent status, which is known as blastocyst activation, is indispensable for embryo implantation.This RNA sequence data is from the...
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Contributor : Jeffrey J BednarskiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusRAG DSBs trigger ATM-dependent induction of SPIC, an ETS family transcriptional repressor with significant homology to PU.1. RAG DSB-mediated expression of SPIC results in displacement of PU.1 throughout the genome and induction of broad transcriptional changes in pre B cells. SPIC also binds and recruits a unique partner, BCLAF1 to gene regulatory elements that regulate...
17h
Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
17h
Contributors : Byungyong Ahn ; Shibiao Wan ; Kyong-Jae Won ; Daniel P KellySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensIt is well known that insulin resistance in the obese state is associated with accumulation of neutral lipid in extra-adipose tissues. This phenomenon is particularly well-documented in skeletal muscle. The mechanistic underpinnings of this linkage are not fully understood. To define direct MondoA target genes, we performed...
17h
Contributors : Shuuji Mawaribuchi ; Yuzuru ItoSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensWe established two different substates in human ES cell line, H9 cells, by changing the extracellular matrices. To examine a global miRNA expression comparison between the substate 1 and substate 2 cells, miRNA microarray was performed.
17h
Contributors : Shuuji Mawaribuchi ; Yuzuru ItoSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe established two different substates in human ES cell line, H9 cells, by changing the extracellular matrices. To examine a global gene expression comparison between the substate 1 and substate 2 cells, DNA microarray was performed.
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Contributors : Alan P Fields ; Ning Yin ; E A Thompson ; Xue WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA-seq analysis of KP and KPI lung adenocarcinoma cells. Analysis revealed activation of Wnt signaling in KPI tumor cells.
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Contributors : Lital Sever ; Idit Shachar ; Gilgi FriedlanderSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSLAMF9 belongs to the conserved lymphocytic activation molecule family (SLAMF). Unlike other SLAMs, which have been extensively studied, the role of SLAMF9 in the immune system remained mostly unexplored. By generating CRISPR/CAS9 SLAMF9 knockout mice, we analyzed the role of this receptor in plasmacytoid dendritic cells (pDCs), which preferentially...
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Contributors : Zachary S Lorsch ; Peter J Hamilton ; Li Shen ; Rosemary C Bagot ; Eric J NestlerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusStress resilience involves numerous brain-wide transcriptional changes. Determining the organization and orchestration of these transcriptional events may reveal novel antidepressant targets, but this remains unexplored. Here, we characterize the resilient transcriptome with co-expression analysis and identify a single...
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Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
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Contributors : Guillermo Peluffo ; Ashim Subedee ; Nicholas W Harper ; Natalie Kingston ; Bojana Jovanovic ; Felipe Flores ; Francisco Beca ; Anne Trinh ; Chandra S Chilamakuri ; Eva Papachristou ; Ying Su ; Andriy Marusyk ; Clive D'Santos ; Andrew Beck ; Carlos Caldas ; Jason Carroll ; Kornelia PolyakSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo define transcriptional dependencies...
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Series Type : Methylation profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
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Contributors : Danielle Hiam ; David Simar ; Rhianna Laker ; Ali Altıntaş ; Romain Barres ; Nigel SteptoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTranscriptomic and genome-wide DNA methylation was performed on T helper cells using RNA-sequencing and Reduced Representation Bisulfite Sequencing, respectively. Specific genome-wide DNA methylation analysis of T helper cells from women with PCOS identified 5,581 differentially methylated CpG sites. Interestingly,...
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Contributors : Danielle Hiam ; David Simar ; Rhianna Laker ; Ali Altıntaş ; Romain Barres ; Nigel SteptoSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensTranscriptomic and genome-wide DNA methylation was performed on T helper cells using RNA-sequencing and Reduced Representation Bisulfite Sequencing, respectively. Specific genome-wide DNA methylation analysis of T helper cells from women with PCOS identified 5,581 differentially methylated CpG sites. Interestingly,...
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Contributors : Emil Andersen ; Ali Altıntaş ; Ulrika Andersson-Hall ; Agneta Holmäng ; Romain BarrèsSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensHere we investigated the degree by which epigenetic signatures in children from mothers with obesity or gestational diabetes mellitus are influenced by environmental factors. We profiled the DNA methylation signature of whole blood from lean, obese and gestational diabetes mellitus mothers and their respective...
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Contributors : Julia Schumann ; Claudia Roessler ; Knut KrohnSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusWe report the miRNA profiles of macrophages (cell line: RAW264.7) and endothelial cells (cell line: TIME) after supplementation with polyunsaturated fatty acids (PUFA) and stimulation with LPS/pro-inflammatory cytokines. The fatty acids docosahexaenoic acid (DHA, C22:6n3) or arachidonic acid (AA, C20:4n6) were included in the culture...
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Contributors : Xiaohu Zheng ; Haiming WeiSeries Type : Expression profiling by arrayOrganism : Homo sapiensAnalysis of the gene expression profiles of NK cells from liver cancer patients and normal donors
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Contributors : Hai Li ; Shengwang LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusWe sequenced mRNA from ILTV uninfected or infected LMH cells with or without Src inhibition.
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Contributors : A Jiménez-Leiva ; J J Cabrera ; E Bueno ; M J Torres ; S Salazar ; E J Bedmar ; M J Delgado ; S MesaSeries Type : Expression profiling by arrayOrganism : Bradyrhizobium diazoefficiens ; Bradyrhizobium diazoefficiens USDA 110Genome-wide transcription profiling of B. diazoefficiens (formerly B. japonicum) wild type and nnrR mutant strain which were grown in free-living anoxic denitrifying conditions (using nitrate as final electron aceptor). This study includes also the expression...
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