Abstract The aim of this study was to evaluate the ability of various clincopathologic variables and staging systems to predict recurrence rates of papillary thyroid carcinoma (PTC) treated with total thyroidectomy and followed by biochemical markers and imaging. We conducted a retrospective review of patients that were treated with total thyroidectomy and radioiodine, and followed by clinical examinations, sonography, and thyroglobulin levels. Cox proportional hazard models were used to identify...
now
Abstract We had introduced ‘SKINTED', a hitherto nameless condition, with a case series describing the condition in the October 2009 issue of this journal. All patients had an eczematous eruption comprising localised xerotic, erythematosquamous or uncommonly, crusted papulovesicular lesions, over and around the surgical incision site of total knee replacement (TKR) surgery.1 SKINTED is an acronym for ‘Surgery of the Knee, injury to the Infrapatellar branch of the saphenous Nerve and Traumatic Eczematous...
37m
Abstract Dupilumab is a human monoclonal IgG4 antibody that inhibits IL‐4 and IL‐13 signalling by binding specifically to the IL‐4Rα subunit, shared by both the IL4 and IL‐13 receptor complexes (1) recently introduced for the treatment of severe atopic dermatitis (AD). We report a case of severe AD associated with cold urticaria that healed shortly after starting Dupilumab therapy. This article is protected by copyright. All rights reserved.
37m
Abstract Cutis verticis gyrata (CVG) is a rare condition of the scalp characterized by skin folds and deep furrows that mimic the outer layer of the brain. CVG is classified in three major forms: primary essential, primary non‐essential and secondary.1 Primary CVG is characterized by a postpuberal onset of parallel symmetrical folds between the vertex and occiput. It can be an isolated finding (primary essential form), or it can be associated with neuropsychiatric conditions such as mental retardation...
37m
Abstract The Mona Lisa has long attracted interest from the general population, and more recently the medical profession. In an attempt to find pathology in her enigmatic appearance, previous clinicians have proposed an underlying diagnosis of hyperlipidaemia or hypothyroidism. This is the first report of features consistent with frontal fibrosing alopecia (FFA) found in the Mona Lisa: namely high forehead, receding frontotemporal hairline, and lack of eyebrows. Given the higher prevalence of autoimmune...
37m
Abstract Acetaminophen (APAP)-induced liver injury is the main cause of acute liver failure. This study investigated the role of microsomal prostaglandin E synthase 2 (mPGES-2), discovered as one of the prostaglandin E2 (PGE2) synthases, in mediating APAP-induced liver injury. Using mPGES-2 wild-type (WT) and knockout (KO) mice, marked resistance to APAP-induced liver damage was found in mPGES-2 KO, as indicated by robust improvement of liver histology, changes in liver enzyme...
39m
In the original publication of this article [1], there is an error in Fig. 4A.
39m
Opinion statement Research into novel therapies for gynecologic cancers is underfunded, and as a result, we are still playing catchup with other solid tumors in the realm of immune checkpoint inhibition. This is despite the fact that two of the most common gynecologic cancers in the USA have strong biologic rationales for response to these agents. Work is now underway to demonstrate safe and effective therapies for our patients. As we better understand the immune system, and...
40m
Abstract Cell‐free DNA (cfDNA) analysis to detect circulating tumor DNA has been focused in monitoring of malignant lymphomas. However, clonal hematopoiesis of indeterminate potential (CHIP)‐associated mutations also can be detected by cfDNA analysis. Our aim is to investigate the origin of mutations detected in cfDNA among B‐cell lymphoma patients. MYD88/CD79B, DNMT3A, and TP53 were chosen as genes of interest, representing each of the following categories: lymphoma driver genes, CHIP‐related genes,...
40m
Summary Safeguarding cerebral function, is of major importance during pediatric anesthesia. Premature, ex premature and full term neonates can be vulnerable to physiological changes that occur during anesthesia and surgery. Data from studies performed during pediatric cardiac surgery and in neonatal/pediatric intensive care units have shown the benefits of near infrared spectroscopy (NIRS) monitoring of regional cerebral oxygenation (c‐rSO2). However, NIRS monitoring is seldom used during non‐cardiac...
42m
Summary Background Prolonged fasting before anesthesia is still common in children. Shortened fasting times may improve the metabolic and hemodynamic condition during induction of anesthesia and the perioperative experience for parents and children and simplify perioperative management. As a consequence, some centers in Germany have reduced fasting requirements, but the national guidelines are still unchanged. Aims This prospective multicenter observational study was initiated by the Scientific...
42m
Summary While respiratory depression is a known complication of morphine overdose, the neuro‐excitatory side effect of the morphine metabolite morphine‐3‐glucuronide is less widely known. Here we report the case of an infant with neurological excitation after morphine overdose. The neuro‐excitation in this infant was probably induced by an elevated morphine‐3‐glucuronide concentration. This article is protected by copyright. All rights reserved.
23h
Abstract Background and Aims Hypospadias is a common congenital malformation in pediatric patients. Surgical repair of this malformation is a painful procedure and has long‐term effects. Pudendal and penile nerve blocks are commonly preferred techniques for maintaining postoperative analgesia. However, the conventional landmark‐based penile block technique involves numerous potential complications and provides a shorter analgesic period compared to the pudendal block. A promising ultrasound‐guided...
23h
Abstract We appreciate the opportunity to expound on the design of this study describing fluid management for children undergoing large bowel resection and the association of higher volume administration with increased length of stay. The response authors raise several questions including why length of stay was dichotomized for logistic regression, why was the fluid variable normalized to maintenance rate rather than weight, and concerns about accounting for operative time as a confounder for worsened...
23h
Contributors : Petr V Nazarov ; Anke K Wienecke-Baldacchino ; Andrei Zinovyev ; Urszula Czerwińska ; Arnaud Muller ; Dorothée Nashan ; Gunnar Dittmar ; Francisco Azuaje ; Stephanie KreisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe repositories for various “omics” data collected from different cancer types are constantly growing. However, robust diagnostic and/or prognostic conclusions can often not be extracted from mixed transcriptomes or other...
46m
Contributors : Shuo Yang ; Yuqing Wu ; Sheng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe identified that GSDMD was required for the pathogenesis of EAE, and GSDMD deficiency in peripheral myeloid cells impaired the infiltration of immune cells into the CNS , leading to the suppression of neuroinflammation and demyelination.The purpose of this experiment was to identify how GSDMD induces EAE.
7h
GSE133670 Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
7h
Contributor : Yang LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBy performing m6A-seq analysis on the peritoneal macrophages that derived from ALKBH5-/- mice and littermate mice infected with or without vesicular stomatitis virus (VSV), we want to investigate whether ALKBH5 deficiency-mediated m6A RNA methylation contributes to the regulation of its target genes expression. m6A-seq analysis revealed enriched and specific m6A peaks on the transcript of...
10h
Contributor : Yang LiuSeries Type : OtherOrganism : Mus musculusTo investigate whether the ALKBH5-mediated metabolic changes via demethylation of its target mRNA(s) is important in regulating viral response, we mapped the targeting transcripts and binding sites of ALKBH5 in the virus infected cells and uninfected cells by using iCLIP-seq. Biological replicates of iCLIP-seq confirmed that OGDH is the direct targeting transcript of ALKBH5 and the binding capacity of ALKBH5 to OGDH mRNA was decreased...
10h
Contributor : Yang LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBy performing RNA sequencing (RNA-seq) analysis on the peritoneal macrophages that derived from ALKBH5-/- mice and littermate mice infected with or without vesicular stomatitis virus (VSV), we want to investigate whether deficiency of ALKBH5 controls viral replication through a more general mechanism such as enhancing innate response, and if not, what's the critical downstream target(s) of...
10h
Contributors : Kevin C Stein ; Allison Kriel ; Judith FrydmanSeries Type : OtherOrganism : Saccharomyces cerevisiaeFolding newly synthesized proteins relies on the ribosome intricately coordinating mRNA translation with a network of ribosome-associated machinery. The principles that drive the coordination of this diverse machinery remain poorly understood. Here, we use selective ribosome profiling to determine how the essential chaperonin TRiC/CCT and the Hsp70 Ssb are recruited to ribosome-nascent...
11h
Contributors : Sheng-Zhong Duan ; Chao LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNCoR1 played an important role in regulating the expression of many genes. We were wondering what kinds of genes the NCoR1 would regulate in cardiomyocytes. Therefore we generated the cardiomyocyte-specific NCoR1 knockout mice (CMNKO). Then we tried to analyze gene expression of left ventricular from littermate control (LC) and CMNKO mice with an unbiased way. Therefore...
12h
Contributors : Aisha Burton ; Aaron DeLoughery ; Gene-Wei Li ; Daniel KearnsSeries Type : Expression profiling by high throughput sequencingOrganism : Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051Laboratory strains of Bacillus subtilis encodes as many as 16 alternative sigma factors, each dedicated to expressing a unique regulon such as those involved in stress resistance, sporulation, and motility. The ancestral strain of B. subtilis also encodes an additional sigma factor homolog,...
12h
Contributors : Irene Hernando-Herraez ; Brendan Evano ; Thomas Stubbs ; Pierre H CommereSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusAge-related tissue alterations have been associated with a decline in stem cell number and function. Increased cell-to-cell variability in transcription or epigenetic marks has been proposed to be a major hallmark of ageing. Here, using parallel single-cell transcriptome and DNA methylome profiling, we find a global increase...
13h
Series Type : Expression profiling by high throughput sequencing ; Methylation profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
13h
Contributor : Qin AnSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used single-cell RNA-sequencing (scRNA-seq) on human embryonic stem cell (hESC)-derived retinal organoid to deconstruct RPC developmental trajectory in the early retinogenesis, which revealed the fate branchpoint in RPC progression.
14h
Series Type : Expression profiling by arrayOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
14h
Contributors : Kristin G Anderson ; Valentin Voillet ; Raphael Gottardo ; Philip D GreenbergSeries Type : Expression profiling by arrayOrganism : Homo sapiensPurpose: Adoptive T cell therapy using high affinity T cell receptors (TCRs) to target tumor antigens has potential for improving outcomes in high-grade serous ovarian cancer (HGSOC) patients. Ovarian tumors develop a hostile, multicomponent tumor microenvironment containing suppressive cells, inhibitory ligands, and soluble factors that facilitate...
14h
Contributors : Monika A Roy ; Karilyn E Sant ; Olivia L Venezia ; Alix B Shipman ; Stephen D McCormick ; Alicia R Timme-Laragy ; Panithi Saktrakulkla ; Keri C HornbuckleSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerio3,3’-Dichlorobiphenyl (PCB-11) is a non-legacy PCB congener widely detected in environmental samples and has been detected in human serum, but its toxicity potential is poorly understood. Zebrafish statically exposed to 4,500 µg/L PCB-11 at 24 hours...
14h
Contributors : Kristin G Anderson ; Valentin Voillet ; Raphael Gottardo ; Philip D GreenbergSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: Adoptive T cell therapy using high affinity T cell receptors (TCRs) to target tumor antigens has potential for improving outcomes in high-grade serous ovarian cancer (HGSOC) patients. Ovarian tumors develop a hostile, multicomponent tumor microenvironment containing suppressive cells, inhibitory ligands, and soluble...
14h
Contributors : Paolo Kunderfranco ; Marinos Kallikourdis ; Gianluigi CondorelliSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSingle-cell RNA sequencing is revolutionizing the mapping of tissues in physiology and pathology. Whilst immune responses are emerging as key mediators of heart failure, no thorough immune mapping of the ailing heart has been performed so far. Here we examined, at single-cell level, the cardiac immune composition after transverse...
15h
Contributors : Ningning Li ; Kastytis Sidlauskas ; Ying Zhang ; Sebastian BrandnerSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusHuman astrocytomas and oligodendrogliomas are defined by mutations in the metabolic enzyme isocitrate dehydrogenase (IDH) 1 or 2. Mutant IDH1 causes the production and accumulation of the metabolite 2 hydroxyglutarate, which induces genome-wide hypermethylation, and is thought to be a driver mutation of these tumours. However,...
15h
Contributors : Ningning Li ; Kastytis Sidlauskas ; Ying Zhang ; Sebastian BrandnerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHuman astrocytomas and oligodendrogliomas are defined by mutations in the metabolic enzyme isocitrate dehydrogenase (IDH) 1 or 2. Mutant IDH1 causes the production and accumulation of the metabolite 2 hydroxyglutarate, which induces genome-wide hypermethylation, and is thought to be a driver mutation of these tumours. However,...
15h
Contributor : Brigitte Boizet-BonhoureSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNonsteroidal anti-inflammatory drugs such as ibuprofen (IBU) and analgesic drugs, such as acetaminophen (APAP), are the most frequently medications taken by pregnant women, even in combination. They were shown to target fetal gonadal development acting as endocrine disruptors, that might favour genital malformations in new-born boys and reproductive disorders in adults, in...
16h
Contributors : Lei Wang ; Shaoguang SunSeries Type : Non-coding RNA profiling by arrayOrganism : Mus musculusNon-coding circular RNAs (circRNAs) have displayed dysregulated expression in the hippocampus of Nrf2-knockout mice.
16h
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
16h
Contributors : Alyssa A Lombardi ; Andrew A Gibb ; John W ElrodSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusFibroblast to myofibroblast differentiation is crucial for the initial healing response but excessive myofibroblast activation leads to pathological fibrosis. Therefore, it is imperative to understand the mechanisms underlying myofibroblast formation. Here we report that mitochondrial calcium (mCa2+) signaling is a regulatory mechanism...
16h
Contributors : Alyssa A Lombardi ; Andrew A Gibb ; John W ElrodSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFibroblast to myofibroblast differentiation is crucial for the initial healing response but excessive myofibroblast activation leads to pathological fibrosis. Therefore, it is imperative to understand the mechanisms underlying myofibroblast formation. Here we report that mitochondrial calcium (mCa2+) signaling is a regulatory mechanism in myofibroblast...
16h
Contributors : Lei Wang ; Shaoguang SunSeries Type : Non-coding RNA profiling by array ; Expression profiling by arrayOrganism : Mus musculusNon-coding long noncoding RNAs (lncRNAs) and mRNA have displayed dysregulated expression in the hippocampus of Nrf2-knockout mice.
16h
Contributors : Serfling Edgar ; Khalid MuhammadSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBy co-culturing murine keratinocytes with splenic T cells we show here that T cells affect the synthesis and secretion of chemokines by keratinocytes.
16h
Contributor : Jeffrey J BednarskiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusRAG DSBs trigger ATM-dependent induction of SPIC, an ETS family transcriptional repressor with significant homology to PU.1. RAG DSB-mediated expression of SPIC results in displacement of PU.1 throughout the genome and induction of broad transcriptional changes in pre B cells. SPIC also binds and recruits a unique partner, BCLAF1 to gene regulatory elements that regulate...
16h
Contributors : Zachary S Lorsch ; Peter J Hamilton ; Li Shen ; Rosemary C Bagot ; Eric J NestlerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusStress resilience involves numerous brain-wide transcriptional changes. Determining the organization and orchestration of these transcriptional events may reveal novel antidepressant targets, but this remains unexplored. Here, we characterize the resilient transcriptome with co-expression analysis and identify a single...
16h
Contributors : Byungyong Ahn ; Shibiao Wan ; Kyong-Jae Won ; Daniel P KellySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIt is well known that insulin resistance in the obese state is associated with accumulation of neutral lipid in extra-adipose tissues. This phenomenon is particularly well-documented in skeletal muscle. The mechanistic underpinnings of this linkage are not fully understood. To define new MondoA target gene and pathway in human myotubes,...
16h
Contributor : Santanu DasguptaSeries Type : Expression profiling by arrayOrganism : Homo sapiensSH3GL2 acts as a tumor suppressor. Our aim was to idenfy SH3GL2 regulatory pathways.We stably introduced SH3GL2 in SUM159 cells, exhibiting reduced cancer growth and pulmonary metastasis
16h
Contributors : Won-Hee Jung ; Eunsoo Do ; MinJi Park ; Yong-Joon Cho ; Dong-Hyeun KimSeries Type : Expression profiling by high throughput sequencingOrganism : Cryptococcus neoformans var. grubii H99 ; Malassezia restrictaPurpose: Understanding the mechanism of action of lauryl betaine against Cryptococcus neoformans and Malassezia restricta.Methods: The transcriptome profile of the lauryl betaine-treated cells compared to that of untreated cells were generated by RNA-seq Illumina Hiseq.Results:...
16h
Series Type : Methylation profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
16h
Contributors : Xiaoyang Dou ; Jerome D Boyd-Kirkup ; Jing-dong J HanSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensHow individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in human and other animals were strongly biased to light (L)-strand non-CpG methylation with conserved peak loci preferentially...
16h
Contributors : Jeff Molkentin ; Hadi Khalil ; Vikram PrasadSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOverall goal: To elucidate fibroblast-specific role of Hsp47 in fibroblast activation, collagen production, and cardiac fibrosis and their differentiation to myofibroblasts. Purpose of analysis: To generate transcriptional profile of HSP47-deficient fibroblasts in the context of pathological cardiac remodeling associated with chronic pressure-overload.
16h
Contributors : Xiaoyang Dou ; Jerome D Boyd-Kirkup ; Jing-dong J HanSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensHow individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in human and other animals were strongly biased to light (L)-strand non-CpG methylation with conserved peak loci preferentially...
16h
Contributor : Jeffrey J BednarskiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRAG DSBs trigger ATM-dependent induction of SPIC, an ETS family transcriptional repressor with significant homology to PU.1. RAG DSB-mediated expression of SPIC results in displacement of PU.1 throughout the genome and induction of broad transcriptional changes in pre B cells. SPIC also binds and recruits a unique partner, BCLAF1 to gene regulatory elements that regulate expression...
16h
Contributors : Xiaoyang Dou ; Joseph McDermott ; Jing-dong J HanSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensHow individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in human and other animals were strongly biased to light (L)-strand non-CpG methylation with conserved peak loci preferentially...
16h
Contributors : Seung-Jae V Lee ; Dongyeop Lee ; Seon-Woo A An ; Yoonji JungSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansTo determine the role of MDT-15 in mRNA expression changes at different temperatures, we sequenced mRNAs obtained from day 1 adult Caenorhabditis elegans. Bristol N2 (wild-type) and mdt-15(tm2182) mutant animals that cultured at 25oC or 15oC were used.
16h
Contributors : Xiaoyang Dou ; Jerome D Boyd-Kirkup ; Jing-dong J HanSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensHow individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in human and other animals were strongly biased to light (L)-strand non-CpG methylation with conserved peak loci preferentially...
16h
Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
16h
Contributors : Xiaoyang Dou ; Joseph McDermott ; Jing-dong J HanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHow individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in human and other animals were strongly biased to light (L)-strand non-CpG methylation with conserved peak loci preferentially...
16h
Contributors : Byungyong Ahn ; Shibiao Wan ; Kyong-Jae Won ; Daniel P KellySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensIt is well known that insulin resistance in the obese state is associated with accumulation of neutral lipid in extra-adipose tissues. This phenomenon is particularly well-documented in skeletal muscle. The mechanistic underpinnings of this linkage are not fully understood. To define direct MondoA target genes, we performed...
16h
Contributors : Xiaoyang Dou ; Jerome D Boyd-Kirkup ; Jing-dong J HanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHow individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in human and other animals were strongly biased to light (L)-strand non-CpG methylation with conserved peak loci preferentially...
16h
GSE133958 The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A [HEK293T_MeDIP]
Contributors : Xiaoyang Dou ; Jerome D Boyd-Kirkup ; Jing-dong J HanSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensHow individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in human and other animals were strongly biased to light (L)-strand non-CpG methylation with conserved peak loci preferentially...
16h
Contributors : W Zhang ; J Wang ; B Chiu ; L Hou ; Z Zhang ; C ZengSeries Type : Methylation profiling by arrayOrganism : Homo sapiensGenome wide DNA hydroxymethylation profiling of tumor and adjacent tissue samples in pancreatic cancer. The Illumina Infinium MethylationEPIC BeadChip was used to obtain DNA hydroxymethylation profiles across approximately 850,000 CpGs in paired tumor and tumor adjacent tissues in 17 adult patients with primary pancreatic adenocarcionoma .
16h
Contributors : Alan P Fields ; Ning Yin ; E A Thompson ; Xue WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA-seq analysis of KP and KPI lung adenocarcinoma cells. Analysis revealed activation of Wnt signaling in KPI tumor cells.
16h
Contributors : Shuuji Mawaribuchi ; Yuzuru ItoSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensWe established two different substates in human ES cell line, H9 cells, by changing the extracellular matrices. To examine a global miRNA expression comparison between the substate 1 and substate 2 cells, miRNA microarray was performed.
17h
Contributors : Bo He ; Shuangbo Kong ; Haibin WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImplantation of the blastocyst into the uterus is a developmental milestone in mammalian embryonic development, which is the gateway for further development of fetus. At this time, remodeling of the blastocyst to an implantation competent status, which is known as blastocyst activation, is indispensable for embryo implantation.This RNA sequence data is from the...
17h
Contributors : Guillermo Peluffo ; Ashim Subedee ; Nicholas W Harper ; Natalie Kingston ; Bojana Jovanovic ; Felipe Flores ; Francisco Beca ; Anne Trinh ; Chandra S Chilamakuri ; Eva Papachristou ; Ying Su ; Andriy Marusyk ; Clive D'Santos ; Andrew Beck ; Carlos Caldas ; Jason Carroll ; Kornelia PolyakSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo define transcriptional dependencies...
17h
Contributors : Shuuji Mawaribuchi ; Yuzuru ItoSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensWe established two different substates in human ES cell line, H9 cells, by changing the extracellular matrices. To examine a global miRNA expression comparison between the substate 1 and substate 2 cells, miRNA microarray was performed.
17h
Contributors : Shuuji Mawaribuchi ; Yuzuru ItoSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe established two different substates in human ES cell line, H9 cells, by changing the extracellular matrices. To examine a global gene expression comparison between the substate 1 and substate 2 cells, DNA microarray was performed.
17h
Contributors : Lital Sever ; Idit Shachar ; Gilgi FriedlanderSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSLAMF9 belongs to the conserved lymphocytic activation molecule family (SLAMF). Unlike other SLAMs, which have been extensively studied, the role of SLAMF9 in the immune system remained mostly unexplored. By generating CRISPR/CAS9 SLAMF9 knockout mice, we analyzed the role of this receptor in plasmacytoid dendritic cells (pDCs), which preferentially...
17h
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
17h
Series Type : Methylation profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
19h
Contributors : Emil Andersen ; Ali Altıntaş ; Ulrika Andersson-Hall ; Agneta Holmäng ; Romain BarrèsSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensHere we investigated the degree by which epigenetic signatures in children from mothers with obesity or gestational diabetes mellitus are influenced by environmental factors. We profiled the DNA methylation signature of whole blood from lean, obese and gestational diabetes mellitus mothers and their respective...
19h
Contributors : Danielle Hiam ; David Simar ; Rhianna Laker ; Ali Altıntaş ; Romain Barres ; Nigel SteptoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTranscriptomic and genome-wide DNA methylation was performed on T helper cells using RNA-sequencing and Reduced Representation Bisulfite Sequencing, respectively. Specific genome-wide DNA methylation analysis of T helper cells from women with PCOS identified 5,581 differentially methylated CpG sites. Interestingly,...
19h
Contributors : Danielle Hiam ; David Simar ; Rhianna Laker ; Ali Altıntaş ; Romain Barres ; Nigel SteptoSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensTranscriptomic and genome-wide DNA methylation was performed on T helper cells using RNA-sequencing and Reduced Representation Bisulfite Sequencing, respectively. Specific genome-wide DNA methylation analysis of T helper cells from women with PCOS identified 5,581 differentially methylated CpG sites. Interestingly,...
19h
Contributors : Julia Schumann ; Claudia Roessler ; Knut KrohnSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusWe report the miRNA profiles of macrophages (cell line: RAW264.7) and endothelial cells (cell line: TIME) after supplementation with polyunsaturated fatty acids (PUFA) and stimulation with LPS/pro-inflammatory cytokines. The fatty acids docosahexaenoic acid (DHA, C22:6n3) or arachidonic acid (AA, C20:4n6) were included in the culture...
20h
Contributors : Xiaohu Zheng ; Haiming WeiSeries Type : Expression profiling by arrayOrganism : Homo sapiensAnalysis of the gene expression profiles of NK cells from liver cancer patients and normal donors
22h
Contributors : Hai Li ; Shengwang LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusWe sequenced mRNA from ILTV uninfected or infected LMH cells with or without Src inhibition.
1d
Abstract Purpose Mental nerve (MN) injury can be caused by transoral endoscopic thyroidectomy vestibular approach (TOETVA). The purpose of this experimental study was to determine the location and distribution pattern of MN structures in relation to oral vestibular incisions. Methods Ten cadaver specimens were included, yielding a total of 20 MNs. The difference...
48m
A toothache can cause severe pain and prevent a person from falling asleep. Learn about nine different methods to get rid of a toothache at night here.
48m
Home remedies for bad breath include green tea, herbal rinses, and water. People should see a doctor if their breath does not improve. Learn more about home remedies for bad breath here.
1d
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