Background Sinonasal squamous cell carcinoma (SNSCC) is the most common malignancy of the paranasal sinuses. Surgery is the mainstay of treatment, yet positive surgical margins (PSM) are common and the prognostic impact on overall survival (OS) is mixed. Given the heterogeneity of impact of PSM on OS within the literature, we hypothesized that extent of tumor extirpation (microscopic PSM vs macroscopic PSM) may play a role in OS. Methods Patients with SNSCC were identified in the National...
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A toothache can cause severe pain and prevent a person from falling asleep. Learn about nine different methods to get rid of a toothache at night here.
48m
Home remedies for bad breath include green tea, herbal rinses, and water. People should see a doctor if their breath does not improve. Learn more about home remedies for bad breath here.
1d
What can we do when the patient needing emergency care is the earth? What life support can physicians offer our ailing planet? History can help us understand and answer these pressing questions. A deluge of recent reports document the degradation of Earth’s ecosystems. Local and national…
52m
Abstract Aim Zika virus (ZIKV) outbreak, which started in the year 2015, is considered the fastest and widely spread outbreak reported for this flavivirus. The polymerase domain of NS5 protein is targeted in other viral infections and recognized as a suitable target in ZIKV infection. Different novel modified compounds against ZIKV NS5 are tested in silico. Main methods Few structures are solved for ZIKV polymerase and deposited in the protein data bank website. Two of these solved structures...
52m
I wish to have my set up functions inhabit a different module so I can import them into my numerous test files whenever I want and increase the readability of my actual tests. When I execute the below code I get an error `DETAIL: Key (username)=(SmellyPenguin) already exists.` because it seems to be trying to commit the user to the actual database instead of the test database. Obviously, when I copy the functions contents into the `setUp` method everything works fine as it is being committed to the...
56m
Characterization of the human zinc finger nfx‑1‑type containing 1 encoding ZNFX1 gene and its response to 12‑O‑tetradecanoyl‑13‑acetate in HL‑60 cells. Int J Oncol. 2019 Aug 20;: Authors: Hamada H, Yamamura M, Ohi H, Kobayashi Y, Niwa K, Oyama T, Mano Y, Asai M, Tanuma SI, Uchiumi F Abstract Human promyelocytic HL‑60 cells can be differentiated into macrophage‑like cells by treatment with 12‑O‑tetra decanoylphorbol‑13‑acetate (TPA). Certain 5' upstream regions of the zinc...
57m
TGFBR2‑dependent alterations of microRNA profiles in extracellular vesicles and parental colorectal cancer cells. Int J Oncol. 2019 Aug 19;: Authors: Fricke F, Mussack V, Buschmann D, Hausser I, Pfaffl MW, Kopitz J, Gebert J Abstract In colorectal cancer (CRC) with microsatellite instability (MSI), >90% of cases are affected by inactivating frameshift mutations of transforming growth factor β receptor type 2 (TGFBR2). TGFBR2 deficiency is considered to drive MSI tumor...
57m
Genome‑wide investigation of the clinical implications and molecular mechanism of long noncoding RNA LINC00668 and protein‑coding genes in hepatocellular carcinoma. Int J Oncol. 2019 Aug 14;: Authors: Wang X, Zhou X, Liu J, Liu Z, Zhang L, Gong Y, Huang J, Yu L, Wang Q, Yang C, Liao X, Yu T, Han C, Zhu G, Ye X, Peng T Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of tumor‑related mortalities worldwide. Long noncoding RNAs have been reported to be associated...
57m
Altered DNA methylation is associated with aberrant stemness gene expression in early‑stage HNSCC. Int J Oncol. 2019 Aug 14;: Authors: Suzuki T, Yamazaki H, Honda K, Ryo E, Kaneko A, Ota Y, Mori T Abstract Head and neck squamous cell carcinoma (HNSCC) is characterized by morphological and functional cellular heterogeneity, which are properties of progenitor cells, as opposed to cell alterations caused by accidental expression of stem cell‑related molecules. The expression...
57m
Authors: Zhang S, Mo Q, Wang X Abstract The high mobility group A2 (HMGA2) protein is a non‑histone architectural transcription factor that modulates the transcription of several genes by binding to AT‑rich sequences in the minor groove of B‑form DNA and alters the chromatin structure. As a result, HMGA2 influences a variety of biological processes, including the cell cycle process, DNA damage repair process, apoptosis, senescence, epithelial‑mesenchymal transition and telomere restoration....
57m
Construction and characterization of a truncated tissue factor‑coagulation‑based composite system for selective thrombosis in tumor blood vessels. Int J Oncol. 2019 Aug 12;: Authors: Xu P, Zou M, Wang S, Li T, Liu C, Wang L, Wang L, Luo F, Wu T, Yan J Abstract The selective induction of tumor vascular thrombosis using truncated tissue factor (tTF) delivered via a target ligand is a promising novel antitumor strategy. In the present study, an anti‑neuropilin‑1 (NRP‑1) monoclonal...
57m
Authors: Yusufu A, Shayimu P, Tuerdi R, Fang C, Wang F, Wang H Abstract Reports on the roles of the secreted trefoil factor (TFF)1 and 3 in colorectal cancer (CRC) and their underlying mechanisms of action in tumorigenesis are not common and are controversial. In the present study, the mRNA expression and promoter methylation of TFF1 and TFF3 in cancer and adjacent normal tissues were investigated, and their association with other clinical factors and patient prognosis were evaluated. Moreover,...
57m
Authors: Shiozaki A, Yamazato Y, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E Abstract Although peritoneal lavage with distilled water performed after surgery prevents peritoneal seeding, cancer cells may avoid rupture under mild hypotonicity through regulatory volume decrease (RVD), which is the homeostatic regulation of ion and water transport. The aim of the present study was to investigate the effect of low temperature...
57m
Abstract Breast cancer is the commonest malignancy affecting females. Hormone-positive cancers carry a better prognosis. Many adjuvant and palliative endocrine therapies are in use, including surgical ablation. We retrospectively studied seventy-four patients who did bilateral salpingo-oophorectomy (BSO)/bilateral oophorectomy (BO) for factors affecting survival and prognosis. BSO was superior in overall and progression-free survival. Incidental ovarian metastasis carried a grave...
58m
Abstract Total knee arthroplasty with mega-prosthesis in oncologic patients is a painful surgery and may be associated with nerve injury. Epidural analgesia (EA) with local anaesthetics (LA) is routinely used for pain relief in these patients. At our institute, we came across a high incidence of motor weakness in these patients compelling to shift to patient-controlled analgesia (PCA) with intravenous opioids. We retrospectively analysed our data to find the incidence and reasons...
58m
Background Hospitalized pediatric oncology patients are at high risk of clinical decline and mortality, particularly in low‐income and middle‐income countries (LMICs). Pediatric early warning systems (PEWS) assist with the early identification of deterioration. To the authors' knowledge, no studies to date have evaluated the cost‐benefit of PEWS in LMICs. Methods A PEWS was implemented at the National Pediatric Oncology Unit (Unidad Nacional de Oncologia Pediatrica [UNOP]), a pediatric oncology...
1h
Background There are a growing number of cancer survivors in the United States who are at risk for chronic pain due to cancer disease and treatments. The prevalence of chronic pain among cancer survivors has not been comprehensively reported. Methods This study used data from the National Health Interview Survey (2010‐2017) to compare the prevalence of chronic pain between participants with a cancer diagnosis and participants without one. Adjusted odds ratios (AORs) of having chronic pain...
1h
Background The rates of contralateral prophylactic mastectomy (CPM) are increasing in women with breast cancer. Previous retrospective research has examined clinical and demographic predictors of the uptake of CPM. However, to the authors' knowledge, there has been very little prospective research to date that has examined psychosocial functioning prior to breast cancer surgery to determine whether psychosocial functioning predicts uptake of CPM. The current study was conducted to evaluate demographic,...
1h
Robust and scalable synthesis of functionalized 1,3‐disubstituted pyridylcyclobutanes (including nicotine analogues) is developed, which relies on double alkylation of pyridylacetonitriles. An approach to all isomeric 3‐pyridylcyclobutane‐derived building blocks, i.e. ketones, alcohols and amines, is described. Synthesis of the title compounds relied on the five‐step reaction sequence including alkylation of isomeric pyridyl acetonitriles with 1,3‐dibromo‐2,2‐dimethoxypropane. Hydrolysis, decarboxylation...
1h
Azlactones, a potent building block for the synthesis of complex molecules, have been explored in an organocatalytic Mannich reaction with protected imines. In this study, azlactones containing a propargyl substituent were employed for the first time in organocatalysis so far. The catalytically active species responsible for high enantioselectivity with substrate containing such a small linear substituent is assembled in situ from a bifunctional thiourea, prone to dimerization, and an organic acid,...
1h
Abstract: One‐pot sulfenylation/selenylation reaction have been developed to access 3‐sulfenyl/selenylimidazo[1,5‐a]quinolines from 2‐methylquinolines, aliphatic amines/ aminoacids and dichalcogenides. This developed method gives direct access to 3‐chalcogenylimidazo[1,5‐a]quinolines in moderate to good yields with good functional group tolerance from readily available starting materials. Moreover, this protocol can avoid the prior synthesis of fused imidazoles as starting materials for the synthesis...
1h
An TEMPO promoted oxidative aza‐Diels‐Alder reaction of ketohydrazones with 3‐methyleneoxindoles or 2‐arylidene‐1,3‐indanediones were successfully developed, This reaction provided an efficient synthetic protocol for novel functionalized spiro[indoline‐3,3'‐pyridazines] and spiro[indene‐2,3'‐pyridazines]. This reaction showed high diastereoselectivity and strict substituent’s electron effect, which might be due to the reaction mechanisms process including sequential oxidative generation of 1,2‐diaza‐1,3‐dien...
1h
Selection of linkers connecting two phenyl rings as a part of molecular design of diarylnitroxides with increased kinetic stability of redox forms was performed using quantum chemical estimation of the geometry and oxidation potential values. It revealed that introduction of the carbon bridge cannot be considered as efficient “instrument” for structural tuning of the nitroxide properties since altering neither the length of the bridge nor its position results in significant changes in the oxidation...
1h
A density functional theory approach has been used to shed light on the mechanism of a recently discovered rearrangement reaction for the conversion of spirocyclic indolenines into cyclopentanone‐fused quinolines. A new base‐mediated variant of this unusual rearrangement reaction has also been developed, that operates at much lower temperatures than those required in the analogous acidic reactions. A Density functional theory (DFT) approach has been used to shed light on the mechanism of a...
1h
Tris(4‐azido‐2,6‐dimethylphenyl)borane was readily synthesized from an amino‐substituted triarylborane using tert ‐butyl nitrite and trimethylsilylazide. This compound can easily be converted into triarylboranes bearing various π‐conjugated moieties with triazole ring π‐linkers through a Huisgen cycloaddition. UV–vis absorption spectra and DFT calculations suggested that constructing a triazole linker successfully extended the π‐conjugated system of triarylboranes. Triarylboranes obtained using...
1h
The direct and stereocontrolled addition of (S)‐4‐isopropyl‐N‐(2‐pivaloyloxyacetyl)‐1,3‐thiazolidine‐2‐thione to dialkyl acetals of aromatic and α,β‐unsaturated aldehydes catalyzed by 2.5–5 mol% of a nickel(II) complex permits the synthesis of diastereomerically pure and fully protected anti aldol adducts in good to high yields. The catalytic species is formed in situ from commercially available and easy to handle (Me3P)2NiCl2, which makes this reaction a direct, catalytic, and experimentally simple...
1d
Azlactones have been extensively explored due to their intrinsic reactivity, providing valuable synthetic products. The use of azlactone core, is a simple way to mask free amino acids and perform several chemical transformations. This review covers examples from the last four years, including mechanism and reactivity discussions, as well as some selected applications. Azlactones, also known as oxazolones, are versatile building blocks in organic synthesis due to the presence of multiple pro‐nucleophilic...
1d
An efficient procedure for the Pd‐catalyzed olefination of 4H‐benzo[d][1,3]oxazin‐4‐ones with activated alkenes has been achieved via C‐H activation. The site selectivity of the reaction was explained by a DFT study. A palladium‐catalyzed chelation‐assisted selective ortho C‐H bond olefination of biologically active 4H‐benzo[d][1,3] oxazin‐4‐one derivatives with activated olefins has been achieved. The products are obtained in good yields with high regio‐ and stereoselectivities. This new protocol...
1d
A tandem reaction consisting of (1) the in situ generation of functionalized aromatic and electron‐deficient heteroaromatic Grignard reagents, (2) trifluoroacetylation with diphenylmethyl trifluoroacetate, and (3) successive Meerwein–Ponndorf–Verley type reductions giving α‐aryl‐ and α‐heteroaryl‐α‐trifluoromethyl alcohols is reported. We have developed a new one‐pot synthesis of α‐aryl‐ and α‐heteroaryl‐α‐trifluoromethyl alcohols carrying not only arenes with electron‐withdrawing groups but...
1d
No metal, no cry! Macrocyclic polyamines (MPAs) are important chelating agents for cations, anions, and neutral molecules; cyclen and DOTA are well‐known contrast agents for MR or PET/SPECT imaging. Their unique properties also make them attractive multivalent molecular platforms for applications far beyond conventional metal chelation. Their use in materials chemistry, medicinal chemistry, and chemical biology is discussed. Recent advances in the use of radiometals for both imaging and therapy...
1d
A versatile catalytic asymmetric strategy for the total synthesis of quinuclidine natural products and the completed asymmetric synthesis of the classical targets quinine and quinidine is disclosed. A catalytic asymmetric strategy for the total synthesis of quinuclidine natural products, which includes the completed enantioselective synthesis of the classical targets quinine and quinidine is disclosed. It is based on catalytic asymmetric cascade transformations, which paves the road for the...
1d
A novel Michael Addition and subsequent 4‐exo‐tet ring closure sequence with easily accessible N‐unsubstituted or N‐alkyl‐substituted oxindoles and phenyl vinyl selenone in aqueous basic conditions is described. An unprecedented Michael/intramolecular etherification cascade reaction of phenyl vinyl selenone with 3‐hydroxyoxindoles under aqueous basic conditions at room temperature is described. The method provides a domino access to new spirooxindole 2,2‐disubstituted oxetanes in moderate to...
1d
Background and Objectives The eyelids are susceptible to a number of skin cancers, which are challenging to excise radically without sacrificing excessive healthy tissue. Photoacoustic (PA) imaging is an emerging non‐invasive biomedical imaging modality that could potentially be used for intraoperative micrographic control of the surgical margins of eyelid tumors. In this study, non‐cancerous human eyelid tissue was characterized using PA as a first step in the development of this technique. ...
1h
An 80-year-old man with a history of hypertension presented to the emergency department with a 2-day history of abdominal pain in the right upper quadrant. The patient was febrile. On physical examination, he had abdominal tenderness in the right upper quadrant, and Murphy’s sign was positive.…
1h
A 73-year-old man presented to the emergency department with the acute onset of severe lower abdominal pain. He recalled eating yellowtail fish the day before the onset of the pain. His temperature was 38°C, blood pressure 122/69 mm Hg, and heart rate 77 beats per minute. On physical examination,…
1h
Abstract An adverse outcome pathway (AOP) network is an attempt to represent the complexity of systems toxicology. This study illustrates how an AOP network can be derived and analysed in terms of its topological features to guide research and support chemical risk assessment. A four-step workflow describing general design principles and applied design principles was established and implemented. An AOP network linking nine linear AOPs was mapped and made available in AOPXplorer....
1h
Abstract Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder, characterized by the formation, aggregation and accumulation of amyloid beta, perturbed metal (copper, iron and zinc) homeostasis, metal-induced oxidative stress, neuroinflammation, aberrant activity of acetylcholinesterase (AChE) and other pathologies. The aim of this review is to discuss the current therapies based on the “combination-drugs-multitargets” strategy to target multiple pathologies to...
1d
Abstract The procedures based on simulation have become a feasible testing method that does not require investing valuable resources to create a concrete prototype, especially with the increasing computational power of computers. Thus, design changes can be adopted and design errors can be fixed before it is too late. Simulation turns to be a cheap, safe and often more acceptable from an ethical perspective. In our work we summarize the results from the analysis with the help of...
1h
Abstract An exhaustive overview of heavy metal pollution in Chaohu Lake illustrating enrichment intensity, temporal and spatial distribution, chemical speciation, and ecological risk under natural and anthropogenic changes was conducted. Low concentrations of heavy metals excluding Hg were found in water whereas high Hg might be ascribed to surrounding coal-fired power plants. Copper, Pb, Zn, Cd, and Hg were enriched in sediment whereas Cr and Ni were comparable to background values....
10h
Abstract Due to increasingly serious deterioration of surface water quality, effective water quality prediction technique for real-time early warning is essential to guarantee the emergency response ability in advance for sustainable water management. In this study, an effective data-driven model for surface water quality prediction is developed to analyze the inherent water quality variation tendencies and provide real-time early warnings according to the historical observation...
10h
Abstract This study has assessed the influence of the origin of air mass on levels of particulate matter (PM10) and chemical composition (SO42− and NO3−) in the air basin of Madrid. A data set of back-trajectories of air mass arriving to this area of study from 15 June 15 2009 to 8 July 2011 has been analyzed. Firstly, the cluster analysis statistical method has been used to group the back-trajectories into 5 sets according to the angle, direction, and speed of the air mass. Afterwards,...
16h
Abstract The present study was carried out to determine the contamination levels of heavy metals in road dust of the National Capital Territory of Delhi (NCT), India and its consequent effect on human and environment. The levels of heavy metals (Pb, Zn, Cu, Cr, Ni, Mn, and Fe) in 9 districts (Z1–Z9) of NCT were monitored and the corresponding human health risk was estimated. District-wise evaluation of heavy metal pollution in the road dust was performed. The mean concentrations...
16h
Abstract A study of the impact of an abandoned lead (Pb) mine (“Las Musas”), located in SW Spain, on the contamination of the surface soil and pastures in its vicinity revealed the presence of widely distributed, high levels of Pb contamination. The total Pb concentrations in soils sampled at distances from 3 to 998 m from the mine ranged between 129 and 1053 mg/kg, when it has been reported that non-polluted soils have concentrations of 29–40 mg/kg. These exceed the maximum tolerable...
18h
Abstract Heavily chromium-polluted areas, where people are prohibited from entering, are paradises for stray dogs. In this study, stray dogs were used to study the effects of chromium exposure on the heart of dogs in severely Cr(VI)-contaminated rural areas of China. The dogs were given water (control), low dose (L, 0.92 mg/kg), medium dose (M, 1.15 mg/kg), and high dose (H, 1.38 mg/kg) of Cr(VI). The changes of electrocardiogram (ECG), myocardial enzyme parameters, inflammatory...
18h
Abstract As the largest emitter of CO2 emissions, the installed capacity of thermal power generation in China is facing more and more strict restrictions, since the Chinese government proposed to dissolve overcapacity and intends to solve the problem of continuous reduction in utilization rate of electricity sector. Regretfully, the impact of power-generating capacity and its utilization on carbon emissions in the power sector has not yet been addressed. In this study, we incorporate...
18h
Abstract Southeast Asia has undergone rapid developments in terms of urbanization, economic and population growth. The progress in sewerage treatment infrastructure has not kept pace with such developments. The inadequacy and inefficiency of sewerage systems has prompted the release of untreated sewage into the aquatic environment of Southeast Asia causing many waterborne illnesses since surface water is utilized for recreational, agricultural and aquaculture purposes and, above...
1d
Abstract Diabetes mellitus (DM) and neurosyphilis (NS) may both damage the blood-brain barrier (BBB). It seems that non-neurosyphilis (non-NS) patients with high HbA1c levels are likely to develop into NS. However, the correlation of HbA1c level with BBB disruption in syphilis (non-NS) patients is unclear. In this study, we used dynamic contrast-enhanced (DCE) MRI to quantify regional BBB permeability in syphilis (non-NS) patients and detected several molecular biomarkers of cerebrospinal...
1d
Abstract We describe analytically the nonlinear surface waves at the interface between two nonlinear media with different characteristics. We use one-dimensional nonlinear Schrödinger equation with cubic nonlinearity differing on the opposite sides of the interface. We take into account the interaction of excitations with media interface. We consider the interaction of the wave with the interface using the local potential approximated by Dirac delta function. We derive and analyse...
17h
Abstract In this paper, the proposed dark energy, Tsallis holographic dark energy (THDE), infrared cut-off with the Hubble horizon has been investigated in the Bianchi-I (axially symmetric) anisotropic model with a hybrid expansion law. It has been observed that the THDE is in tune with the accelerating Universe with equation of state (EoS) parameter ( \(\omega _{\mathrm {T}}<-1/3\) ...
17h
Abstract Primary mucinous cystadenocarcinoma of the spleen is an extremely rare tumour. Only 7 cases have been reported in the literature. Mucinous cystadenocarcinoma of the spleen presenting as pseudomyxoma peritonei has been reported only once. Our patient was initially managed as a case of a hydatid cyst of the spleen. Following splenectomy, histopathology reported it as mucinous cystadenocarcinoma. In view of the fact that metastatic cystadenocarcinoma is more common, investigations...
7h
Abstract Although thermal injuries are common, burns due to coal tar are rare and enigmatic. One of the problems encountered is removal of tar without injuring the underlying tissue. The present article describes a successful attempt of removing the tar from burnt tissue using turpentine oil, with minimal tissue trauma.
7h
Abstract Compared with warfarin, the direct-acting oral anticoagulants (DOAC) have fewer pharmacokinetic drug interactions. However, significant drug interactions do exist with documented changes in DOAC concentrations, which can exceed 100%. Unlike warfarin, DOACs have no validated surrogate test to monitor the intensity of anticoagulation. However, several analyses of major outcomes trials with DOACs have demonstrated that serum concentrations do affect both the thrombotic benefits...
19h
Abstract We present a numerical procedure for elastic and nonlinear analysis (including fracture situations) of solid materials and structures using the discrete element method. It can be applied to strongly cohesive frictional materials such as concrete and rocks. The method consists on defining nonlocal constitutive equations at the contact interfaces between discrete particles using the information provided by the stress tensor over the neighbor particles. The method can be...
17h
Toxins, Vol. 11, Pages 484: Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates Toxins doi: 10.3390/toxins11090484 Authors: Gonçalves Lesport Kuylle Stura Ciolek Mourier Servent Bourinet Benoit Gilles Over the two last decades, venom toxins have been explored as alternatives to opioids to treat chronic debilitating pain. At present, approximately 20 potential analgesic toxins, mainly from...
16h
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