MicroRNA‑208a directly targets Src kinase signaling inhibitor 1 to facilitate cell proliferation and invasion in non‑small cell lung cancer. Mol Med Rep. 2019 Jul 31;: Authors: Liu L, Wang W, Gao S, Wang X Abstract The abnormal expression of microRNAs (miRNAs/miRs) has a critical function in the formation and progression of non‑small cell lung cancer (NSCLC). Therefore, understanding the association between NSCLC and dysregulated miRNAs may allow for the identification of...
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MicroRNA‑330 is downregulated in retinoblastoma and suppresses cell viability and invasion by directly targeting ROCK1. Mol Med Rep. 2019 Aug 01;: Authors: Wang L, Wang L, Li L, Zhang H, Lyu X Abstract Abnormal expression of microRNAs (miRNAs/miRs) has been previously reported in various types of human cancer, such as retinoblastoma (RB). Dysregulated miRNAs have been demonstrated to be important epigenetic regulators of numerous biological events associated with RB. Therefore,...
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ConclusionSevere anemia was not uncommon during sofosbuvir plus ribavirin therapy for chronic hepatitis C genotype 2 patients. Careful monitoring of anemia is necessary in patients with chronic kidney disease and low baseline hemoglobin level and platelet count. (Source: Journal of the Formosan Medical Association)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate...
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Discussion and conclusionOSNA is effective in detecting lymph node metastases of PTC. Considering the high risk of complications in CLND, and the uncertain prognostic value of lymph node metastases of PTC, OSNA seems to be a promising tool to identify intraoperatively patients who may benefit from CLND. (Source: Annals of Medicine and Surgery)
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Conclusions: In this simulation, the incremental costs of FN-related hospitalization due to PEG-OBI failure in cycle 1 compared to assured prophylaxis with reference pegfilgrastim, reference filgrastim, and biosimilar filgrastim-sndz varied depending upon the PEG-OBI failure rate and the alternative G-CSF prophylaxis option. Biosimilar filgrastim-sndz offers the greatest cost-efficiency. PMID: 31433700 [PubMed - as supplied by publisher] (Source: Journal of Medical Economics)MedWorm Message:...
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CONCLUSION: Downregulation of CIP2A can inhibit cancer cell proliferation and vascularization in renal clear cell carcinoma through inactivation of the Akt pathway and its downstream VEGF. PMID: 31431792 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
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ConclusionsCXPA is a rare salivary malignancy that has a reported increased incidence in the last decade. Tumor size>4 cm, multiple positive lymph nodes, and distant metastatic disease are predictors of disease-specific mortality. Further research should be conducted to improve early detection and survival strategies for this salivary cancer.Level of Evidence: 4. (Source: American Journal of Otolaryngology)MedWorm Message: Have you tried our new medical search engine? More powerful than before....
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In this study, an electrochemical method for detecting cell viability and cytotoxicity was discussed with the intracellular small molecule metabolite purines as indexes.MethodsThe electrochemical behaviors of Balb/c 3T3, CHO, PC-12 and V79 cell suspensions were studies by cyclic voltammetry, and cell viability and cytotoxicity of four cell lines were compared by electrochemical, cell counting, 3-(4,5-dimethyl-2-Thiazyl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) and trypan blue exclusion methods.ResultsFour...
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ConclusionsThese results verified the molecular mechanism of ERJR that has been used in traditional anti-cancer remedy and suggest that it can be developed as a promising therapy for cancer metastasis in the future.Graphical abstract (Source: Journal of Ethnopharmacology)
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ConclusionsAccumulating reports suggested that the bioactive extracts (e.g., Huachansu) and bufadienolide monomers (including bufalin, gamabufotalin, bufotalin, cinobufagin, resibufogenin and arenobufagin) isolated from Chanpi or Chansu could be promising drug candidates for cancer patients due to their potent and broad-spectrum of anti-tumor activity. However, it is crucial to elucidate in-depth molecular mechanisms, structure-activity relationships and potential side-effects of active constituents...
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ConclusionsLncRNA LUCAT1 could promote proliferation and invasion of gastric cancer by regulating miR-134-5p/YWHAZ axis. (Source: Biomedicine and Pharmacotherapy)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Wei Hu, Xin Huang, Xingyue Huang, Wenwei Chen, Lidan Hao, Zubing ChenAbstractT cells edited by chimeric antigen receptors (CAR) have shown great potential in the treatment of tumors, especially malignant blood tumors. However, there remain many obstacles in the CAR-T therapy against solid tumors, such as the expansion of CAR-T cells ex vivo and the exhaustion of CAR-T cells in vivo. In order to solve these...
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Jue Yang, Jianfei Qiu, Yong Hu, Yongqiang Zhang, Li Chen, Qun Long, Juan Chen, Jingrui Song, Qing Rao, Yanmei Li, Wei Gu, Xiaojiang HaoAbstractKaempferol-3-O-rhamnoside (KOR) has multiple potency involved in anti-cancer, anti-inflammatory and antibacterial actions. However, the potential roles of KOR and the analogues isolated from the leaves of Cyclocarya paliurus in anti-erythroleukemia remain unclear....
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ConclusionsTaking into consideration the central role of inflammation in the pathophysiology of CRC and the recognised connection between inflammatory events and cancer, these results enlighten the relevance of the phenolic constituents of pennyroyal as important pharmacological sources in the investigation of new treatment options for patients with inflammatory bowel diseases.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
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RAD54B potentiates tumor growth and predicts poor prognosis of patients with luminal A breast cancer
In this study, we reported that RAD54B was amplified and the expression of RAD54B was elevated in BC, as identified through a bioinformatics analysis of open databases (cBioPortal and Oncomine) and an immunohistochemical analysis of a tissue microarray (TMA). Analysis of Kaplan-Meier plotter (KM plotter) showed that high RAD54B transcription activity was critically linked with poor prognosis of BC patients, in particular those with the luminal A subtype. Gene set enrichment analysis (GSEA) performed...
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Publication date: Available online 21 August 2019Source: BurnsAuthor(s): Mazaher Gholipourmalekabadi, Behrouz Farhadihosseinabadi, Mehdi Faraji, Mohammad Reza NouraniAbstractHuman amniotic membrane (AM) has been widely used for tissue engineering and regenerative medicine applications. AM has many favorable characteristics such as high biocompatibility, antibacterial activity, anti-scarring property, immunomodulatory effects, anti-cancer behavior and contains several growth factors that make it an...
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This case report describes a patient with a medical history of symptomatic primary hyperparathyroidism who was found to have an atypical parathyroid neoplasm at the right skull base with an infiltrating pattern, which was treated by transnasal-transpterygoid endoscopic removal. (Source: JAMA Otolaryngology - Head and Neck Surgery)
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ConclusionDifferentially expressed in tumors, PLA2G4A, PRKCB, PIK3R1, KDR, PLA2G1B and PTGS2 are potential therapeutic targets of Yupingfengsan in the treatment of LAD, and MAPK, VEGF and ErbB signaling pathways are involved. (Source: European Journal of Integrative Medicine)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Publication date: Available online 21 August 2019Source: Seminars in Cancer BiologyAuthor(s): Btissame El Hassouni, Carlotta Granchi, Andrea Vallés-Martí, I Gede Putu Supadmanaba, Giulia Bononi, Tiziano Tuccinardi, Niccola Funel, Connie R. Jimenez, Godefridus J. Peters, Elisa Giovannetti, Filippo MinutoloAbstractCancer metastasis to distant organs is initiated by tumor cells that disseminate from primary heterogeneous tumors. The subsequent growth and survival of tumor metastases depend on different...
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This article reviews endogenous- and exogenous-based stimulus-responsive drug delivery systems designed to overcome the limitations of conventional therapies. The article also summarizes the study of nanomaterials, including polymeric, gold, silver, magnetic, and quantum dot nanoparticles. Though an array of drug delivery systems has so far been proposed, there remain many challenges and concerns that should be addressed in order to fill the gaps in the field. Prominence is given to drug delivery...
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Publication date: Available online 21 August 2019Source: Seminars in Cancer BiologyAuthor(s): Yue Zhao, Jiahui Li, Dai Li, Zhefang Wang, Jiangang Zhao, Xiaolin Wu, Qiye Sun, Peter Ping Lin, Patrick Plum, Menglong Zhou, Zhen Zhang, Hans Schlösser, Peter J. Nelson, Christiane J. BrunsAbstractMore than 70% of gastrointestinal (GI) cancers are diagnosed with metastases, leading to poor prognosis. For some cancer patients with limited sites of metastatic tumors, the term oligometastatic disease (OMD)...
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Publication date: Available online 21 August 2019Source: Seminars in Cancer BiologyAuthor(s): Carlos S. MorenoAbstractSOX4 is an essential developmental transcription factor that regulates stemness, differentiation, progenitor development, and multiple developmental pathways including PI3K, Wnt, and TGFβ signaling. The SOX4 gene is frequently amplified and overexpressed in over 20 types of malignancies, and multiple lines of evidence support that notion that SOX4 is an oncogene. Its overexpression...
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Publication date: Available online 21 August 2019Source: Seminars in Cancer BiologyAuthor(s): Francesco Spagnolo, Andrea Boutros, Enrica Tanda, Paola QueiroloAbstractThe past 5 years have witnessed the results of many practice-changing studies that have dramatically improved the landscape of adjuvant therapy in patients with resected, high-risk melanoma. After a 20-year era of adjuvant interferon, the anti-CTLA-4 and anti-PD-1 immune-checkpoint inhibitors, and MAPK-directed targeted therapy brought...
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Publication date: Available online 21 August 2019Source: Practical Radiation OncologyAuthor(s): James A. Hayman, Andre Dekker, Mary Feng, Sameer R. Keole, Todd R. McNutt, Mitchell Machtay, Neil E. Martin, Charles S. Mayo, Todd Pawlicki, Benjamin D. Smith, Randi Kudner, Samantha Dawes, James B. Yu (Source: Practical Radiation Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income...
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ConclusionPatients with cardiovascular comorbidities were more likely to have a PDI. A higher number of PDIs may be an independent risk factor for early unplanned hospitalization. (Source: Journal of Geriatric Oncology)
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Publication date: Available online 21 August 2019Source: Cancer GeneticsAuthor(s): Nicoletta Coccaro, Luisa Anelli, Paola Orsini, Antonella Zagaria, Angela Minervini, Luciana Impera, Giuseppina Tota, Crescenzio Francesco Minervini, Cosimo Cumbo, Elisa Parciante, Maria Rosa Coserva, Immacolata Attolico, Giorgina Specchia, Francesco AlbanoAbstractMyeloid neoplasms with eosinophilia and abnormalities of the PDGFRA gene can benefit from therapy with tyrosine kinase inhibitors, therefore revealing the...
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ConclusionPPI use was associated with an increased risk of gastric and oesophageal cancer and the risk remained increased over follow-up. These results support our original hypothesis that use of PPIs may be a risk factor for gastric and oesophageal cancer in the general population of maintenance users, independent of underlying indications. (Source: Cancer Epidemiology)
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Conclusion: This present study provides the exact prevalence of EML4-ALK rearrangement in different variants for NSCLC patients with ALK positive. PMID: 31432686 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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T-cell receptor (TCR) γδ cells are perceived as innate-like effector cells with the possibility of mediating graft-versus-tumor (GVT) without causing graft-versus-host disease (GVHD) in the setting of hematopoietic allogeneic stem cell transplantation (HSCT). We conducted a prospective study to assess the clinical impact of TCR γδ cell immune reconstitution on overall survival, relapse-free-survival, relapse and GVHD. The impact of CD3, CD4, CD8 T cells together with NK cells including subtypes were...
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The Crohn’s-like lymphoid reaction (CLR) to colorectal cancer (CRC), a CRC-specific ectopic lymphoid reaction, is thought to play an important role in the host response to CRC. CLR is characterized by peritumoral lymphocytic aggregates that are found at the advancing edge of the tumor. Spatial and molecular characterization of CLR within the tumor microenvironment (TME) have uncovered a spectrum of peritumoral lymphoid aggregates with varying levels of organization and maturation. In early stages...
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AbstractThe molecular mechanisms of innate immunity are closely associated with the development of non-alcoholic fatty liver disease (NAFLD). TNF- α is a key cytokine involved in the pathogenesis of metabolic inflammation like NAFLD. Melanoma differentiation-associated gene 5 (MDA5) is a member of the intracellular RNA helicase family proteins that play a pivotal role in an antiviral immune response. Previous studies have demonstrated that TN F-α induces the expression of MDA5 in some types of cells....
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ConclusionsThe results indicate the importance of finding incentives and creating an environment that fosters autonomy, competence and relatedness to motivate persons to exercise during oncological treatment. Some BCTs appear particularly useful and may be used by health professionals to increase patients ’ motivation to exercise. (Source: International Journal of Behavioral Medicine)
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ConclusionsCytotechnologists performed at a high level of competency in providing ROSE and allocating specimens for ancillary testing, which were performed successfully in majority of cases. Implementation of a standardized protocol for tissue management/prioritization is of paramount importance to maximize tissue preservation and minimize wastage. (Source: Journal of the American Society of Cytopathology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com...
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Contributors : Ryan D Chow ; Sidi ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCD8+ cytotoxic T cells play essential roles in anti-tumor immune responses. Here, we performed in vivo screens in CD8+ T cells and identified regulators of tumor infiltration and killing, which are directly relevant to cancer immunotherapy. Unlike in vitro screens, the in vivo screen robustly re-ident ified canonical immunotherapy targets such as PD-1 and Tim-3, along with...
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Contributor : Santanu DasguptaSeries Type : Expression profiling by arrayOrganism : Homo sapiensSH3GL2 acts as a tumor suppressor. Our aim was to idenfy SH3GL2 regulatory pathways.We stably introduced SH3GL2 in SUM159 cells, exhibiting reduced cancer growth and pulmonary metastasis (Source: GEO: Gene Expression Omnibus)
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Contributors : Guillermo Peluffo ; Ashim Subedee ; Nicholas W Harper ; Natalie Kingston ; Bojana Jovanovic ; Felipe Flores ; Francisco Beca ; Anne Trinh ; Chandra S Chilamakuri ; Eva Papachristou ; Ying Su ; Andriy Marusyk ; Clive D'Santos ; Andrew Beck ; Carlos Caldas ; Jason Carroll ; Kornelia PolyakSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo define transcriptional dependencies of TNBCs,...
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Contributors : W Zhang ; J Wang ; B Chiu ; L Hou ; Z Zhang ; C ZengSeries Type : Methylation profiling by arrayOrganism : Homo sapiensGenome wide DNA hydroxymethylation profiling of tumor and adjacent tissue samples in pancreatic cancer. The Illumina Infinium MethylationEPIC BeadChip was used to obtain DNA hydroxymethylation profiles across approximately 850,000 CpGs in paired tumor and tumor adjacent tissues in 17 adult patients with primary pancreatic adenocarcionoma . (Source: GEO: Gene Expression...
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Contributor : Zheng ZhangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapienscircRNA sequencing for 6 samples (Source: GEO: Gene Expression Omnibus)
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Contributors : Xiaohu Zheng ; Haiming WeiSeries Type : Expression profiling by arrayOrganism : Homo sapiensAnalysis of the gene expression profiles of NK cells from liver cancer patients and normal donors (Source: GEO: Gene Expression Omnibus)
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Conclusions: Treatment with engineered T cells may have clinical applicability in patients with advanced-stage HGSOC. (Source: GEO: Gene Expression Omnibus)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Contributors : Ryan D Chow ; Sidi ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCD8+ cytotoxic T cells play essential roles in anti-tumor immune responses. Here, we performed in vivo screens in CD8+ T cells and identified regulators of tumor infiltration and killing, which are directly relevant to cancer immunotherapy. Unlike in vitro screens, the in vivo screen robustly re-ident ified canonical immunotherapy targets such as PD-1 and Tim-3, along with...
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Conclusions: Treatment with engineered T cells may have clinical applicability in patients with advanced-stage HGSOC. (Source: GEO: Gene Expression Omnibus)
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GSE136105 Gene expression profiling in lung and breast cancer cells treated by Bloom-specific siRNAs
Contributors : Bin Shan ; Simon AlsagerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA549 and MDA-MB-231 cells were transfected with the Bloom-specific siRNA. Total RNA was extracted using Trizol at 48 hours after transfection. RNA-SEQ was carried out to profile the gene expression in both culture conditions. (Source: GEO: Gene Expression Omnibus)
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Series Type : Expression profiling by arrayOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
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Contributors : Alison Hirukawa ; William J MullerSeries Type : Expression profiling by arrayOrganism : Mus musculusMonoclonal antibodies (mAbs) targeting the oncogenic receptor tyrosine kinase ERBB2/HER2, such as Trastuzumab, are the standard of care therapy for breast cancers driven by ERBB2 overexpression and activation. However, a substantial proportion of patients exhibits de novo resistance. Here, by comparing matched Trastuzumab-na ïve and post-treatment patient samples from a neoadjuvant trial,...
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Cancer cells often rewire their metabolic pathways for adaption to nutrient deficiency within tumors. Wang et al. demonstrate here that GDH1 interacts with IKK complex and provides a local source of α-KG, which directly activates IKKβ and NF-κB signaling, thereby promoting glucose uptake, tumor cell survival, and brain tumor development. (Source: Molecular Cell)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best...
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This study examined whether cancer-associated fibroblasts (CAFs), a major component of a tumor microenvironment, promote cancer cell regrowth after chemotherapy. First, we treated human lung adenocarcinoma cell line A549 and CAFs from four patients with cisplatin. Cisplatin treatment inhibited the viable cell number of A549 cells and induced epithelial –mesenchymal transition. After cisplatin was removed, A549 cells continued to manifest the mesenchymal phenotype and proliferated 2.2-fold in 4 days...
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Publication date: Available online 21 August 2019Source: Clinica Chimica ActaAuthor(s): Seyed Mohammad Hosseini, Isobel Okoye, Mitra Ghasemi Chaleshtari, Bita Hazhirkarzar, Javad Mohamadnejad, Gholamreza Azizi, Mohammad Hojjat-Farsangi, Hamed Mohammadi, Siamak Sandoghchian Shotorbani, Farhad Jadidi-NiaraghAbstractDespite the medical advances of the 21st century, the incidence of cancer continues to increase and the search for a universal cure remains a major health challenge. Our lack of understanding...
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Authors: Duffy IR, Boyle AJ, Vasdev N Abstract Machine learning (ML) algorithms have found increasing utility in the medical imaging field and numerous applications in the analysis of digital biomarkers within positron emission tomography (PET) imaging have emerged. Interest in the use of artificial intelligence in PET imaging for the study of neurodegenerative diseases and oncology stems from the potential for such techniques to streamline decision support for physicians providing early...
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ConclusionsAlthough cardiopulmonary complications can accompany salvage surgery, the procedure is generally safe. Survival outcome is encouraging, especially in cases with good response to initial treatment. (Source: The Annals of Thoracic Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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ConclusionsPulmonary metastasectomy is safe and effective treatment for well-selected patients with pulmonary metastasis of HCC. Liver recurrence at the time of pulmonary metastasectomy and the number of metastatic sites were identified as independent prognostic factors. The number of risk factors significantly influenced patient survival. (Source: The Annals of Thoracic Surgery)
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ConclusionThis study represents the largest analysis of paediatric pineoblastomas to date. The only clinically relevant prognostic factor was older age at diagnosis. The role of surgery and adjuvant radiotherapy on overall survival remains to be defined. (Source: Acta Neurochirurgica)
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Publication date: Available online 22 August 2019Source: Trends in Food Science & TechnologyAuthor(s): Ning Fang, Chunkai Wang, Xiaofeng Liu, Xue Zhao, Yanhua Liu, Xinmin Liu, Yongmei Du, Zhongfeng Zhang, Hongbo ZhangAbstractBackgroundAstaxanthin is a ketocarotenoid with stronger antioxidant activity than vitamin E and coenzyme Q10, and with pharmacological effects against cancer, cardiovascular disease, diabetes, inflammation, and others. Increased astaxanthin supplementation in food, nutraceuticals,...
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Publication date: Available online 22 August 2019Source: LWTAuthor(s): Shunmugavel Uma Maheshwari, Sundarajan Amutha, Rangasamy Anandham, Ganapathyswamy Hemalatha, Natesan Senthil, Soon Woo Kwon, Natesan SivakumarAbstract:Panchamirtham is a fermented fruit mix made from natural fermentation of fruits (banana, brown sugar, seedless dates, sugar candy, honey, cardamom and ghee), which offers multiple health benefits to human. Research on fermented foods for probiotic microorganisms remains scarce compared...
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Publication date: Available online 22 August 2019Source: Veterinary MicrobiologyAuthor(s): Sante Roperto, Francesca De Falco, Antonella Perillo, Cornel Catoi, Franco RopertoAbstractAutophagy is a powerful tool that host cells use to defend against viral infection. Mitophagy, the selective autophagic removal of dysfunctional mitochondria was upregulated in urothelial cancer cells harbouring bovine papillomavirus (BPV) infection, as detected by the expression of BPV E5 protein, the major oncoprotein...
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Publication date: Available online 21 August 2019Source: Artificial Intelligence in MedicineAuthor(s): Sebastian Spänig, Agnes Emberger-Klein, Jan-Peter Sowa, Ali Canbay, Klaus Menrad, Dominik HeiderAbstractArtificial intelligence (AI) will pave the way to a new era in medicine. However, currently available AI systems do not interact with a patient, e.g., for anamnesis, and thus are only used by the physicians for predictions in diagnosis or prognosis. However, these systems are widely used, e.g.,...
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This study reviews current prevalence of gastric cancer in the word and China, as well as the characteristics and functions of circRNA and common laboratory detection methods involving circRNA in gastric cancer. PMID: 31428168 [PubMed - in process] (Source: Mol Biol Cell)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Authors: Riancho J, Santurtun A, Sánchez-Juan P Abstract Micro-RNAs (miRNAs) are small endogenous noncoding ribonucleic acids that modulate gene expression at a post-transcriptional level. miRNAs have been postulated as potential biomarkers and therapeutic targets in a wide list of human diseases including cancer, autoimmune, cardiovascular, and neurodegenerative diseases. miRNAs are secreted by the cells into exosomes. These are small cell-derived membrane vesicles that can be isolated...
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Authors: Jacquemet G, Hamidi H, Ivaska J Abstract Filopodia are fingerlike membrane protrusions that are extended by cells in vitro and in vivo. Due to important roles in sensing the extracellular microenvironment, filopodia and filopodia-like protrusions have been implicated in numerous biological processes including epithelial sheet zippering in development and wound healing and in cancer progression. Recently, there has been an explosion in the number of software available to analyze...
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Publication date: Available online 21 August 2019Source: Molecular Aspects of MedicineAuthor(s): Luis Enrique Cortés-Hernández, Zahra Eslami-S, Catherine Alix-PanabièresAbstractMetastasis is the main cause of death in patients with cancer. The molecular mechanisms underlying the different metastasis steps are not yet fully known, partly because most studies have been focusing only on cancer cells within the tumor. Currently, with the development of technologies for the enrichment and capture of circulating...
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Publication date: Available online 21 August 2019Source: Life SciencesAuthor(s): Xuan Rong, Wei Gao, Xiaomei Yang, Junjun GuoAbstractAimsHsa_circ_0007534 has been reported to be a novel cancer-related circRNA affecting multiple cancers. However, little is known about the role of hsa_circ_0007534 in cervical cancer specifically. In the current study, we aimed to explore the expression and function of hsa_circ_0007534 in cervical cancer.Main methodsThe expression of circRNA, miRNA and mRNA was measured...
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Publication date: Available online 21 August 2019Source: Life SciencesAuthor(s): Chen Shao, Bingbing Yu, Yanan LiuAbstractIn prostate cancer development, the androgen receptor (AR) signaling plays a crucial role during both formation of early prostate lesions and progression to the lethal, incurable castration resistant stage. Accordingly, numerous approaches have been developed to inhibit AR activity including androgen deprivation therapy, application of the AR antagonists as well as the use of...
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Thorough understanding of growth and evolution of tissue vasculature is fundamental to many fields of medicine including cancer therapy, wound healing, and tissue engineering. Angiogenesis, the growth of new vessels from existing ones, is dynamically influenced by a variety of environmental factors, including mechanical and biophysical factors, chemotactic factors, proteolysis, and interaction with stromal cells. Yet, dynamic interactions between neovessels and their environment are difficult to...
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Publication date: 15 November 2019Source: Sensors and Actuators B: Chemical, Volume 299Author(s): Gao-Chao Fan, Zimeng Li, Yanwei Lu, Linzheng Ma, Huan Zhao, Xiliang LuoAbstractResulting from nonspecific adsorption or obvious biofouling, target detection in real biological media is a potential challenge for most of the biosensors. Herein, we first report an antifouling photoelectrochemical (PEC) cytosensor by using zwitterionic peptide. The typical cervical carcinoma Henrietta Lacks (HeLa) cell was...
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Publication date: Available online 21 August 2019Source: Journal of Organometallic ChemistryAuthor(s): Georges Dahm, Mathilde Bouché, Corinne Bailly, Lydia Karmazin, Stéphane Bellemin-LaponnazAbstractA series of platinum (II) complexes bearing N-heterocyclic carbene NHC ligands functionalized by various benzyl moieties were synthesized and characterized. The molecular structure of two complexes has been confirmed by X-ray diffraction studies on single crystals. Investigation of in vitro cytotoxic...
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We describe extensions of the iterated reweighted least-squares algorithm for fitting generalized linear regression models using the proposed framework. Based on the same moment equations, we also develop a diagnostic test for detecting violations of underlying model assumptions, such as those arising from heterogeneity in the underlying study populations. The proposed methods are illustrated with extensive simulation studies and a real-data example involving the development of a breast cancer risk...
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Publication date: 15 January 2020Source: Journal of Hazardous Materials, Volume 382Author(s): Long Peng, Lei Li, Qinhao Lin, Mei Li, Guohua Zhang, Xinhui Bi, Xinming Wang, Guoying ShengAbstractA single particle aerosol mass spectrometry (SPAMS) was deployed to investigate the mixing state and chemical processing of Pb-rich particles in suburban Beijing. Based on a large dataset of mass spectra, Pb-rich particles were classified into Pb-O-Cl-N-S (55%), Pb-N (17%), Pb-N-S (15%), and Pb-EC (7%). Residual...
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We report a new 7-nitrobenzo-2-oxa-1, 3-diazolyl (NBD)-based chemosensor containing a piperazine derivative, NBDP, for detection of mercury ions in almost 100% aqueous medium. The chemosensor shows sensing exclusively toward Hg2+ with a switch-on fluorescence response at 543 nm, which could be attributed to the blocking of PET (photo-induced electron transfer) process upon complexation with mercury ions. The molar ratio of Hg(Ⅱ) to NBDP in the complex is 1:1 based on the Job’s plot and HRMS studies....
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