We report the separation of two small EV sub-populations from a metastatic breast cancer cell line, with biochemical features consistent with different sub-cellular origins. These EV sub-types use different mechanisms of miRNA sorting (selective and non-selective), suggesting that sorting occurs via fundamentally distinct processes, possibly dependent on EV origin. Using biochemical and genetic tools, we identified the Lupus La protein as mediating sorting of selectively packaged miRNAs. We found...
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In this study, we performed transcriptomic analysis by RNA sequencing with next generation sequencing (NGS), a newly developed powerful method that enables the quantification of the expression level of genome-wide genes. Extracellular matrix and immune cell migration genes were mainly upregulated whereas cell cycle genes were downregulated in IDH1-mutant U87 cells but not in IDH1-wildtype U87 cells after adding Bev to TMZ. In vitro and in vivo studies were conducted for further investigations to...
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Conclusions: These findings suggest that YLE is sufficient for application as a promising anti-liver drug in herbal medicine. (Source: Molecules)
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We present a comprehensive review and update of ACC inhibitors. We look at the current advance of ACC inhibitors in clinical studies and the implications in drug discovery. We searched ScienceDirect ( https://www.sciencedirect.com/ ), ACS ( https://pubs.acs.org/ ), Wiley ( https://onlinelibrary.wiley.com/ ), NCBI ( https://www.ncbi.nlm.nih.gov/ ) and World Health Organization ( https://www.who.int/ ). The keywords used were Acetyl-CoA Carboxylase, lipid, inhibitors and metabolic syndrome. All documents...
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ConclusionThis is the typical case of converting dual modality treatment to single modality with the help of knowledge, communication, transparent team work. This also a rare type of neoplasm and by reporting this rare case we are contributing to data pool of nasal tumors where lack of reporting is major obstacle in the formation of uniform treatment guidelines. (Source: International Journal of Surgery Case Reports)MedWorm Message: Have you tried our new medical search engine? More powerful than...
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Cell Death & Disease, Published online: 22 August 2019; doi:10.1038/s41419-019-1866-9Retraction Note: HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation (Source: Cell death and disease)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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ConclusionHC can occur during MW ablation in patients with either primary or metastatic adrenal tumors. Pheochromocytoma, body mass index, tumor size, and pre-procedural systolic blood pressure appear to be significant risk factors for the occurrence of HC. (Source: Journal of Vascular and Interventional Radiology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Publication date: Available online 20 August 2019Source: Social Science & MedicineAuthor(s): Tara Horrill, Janice Linton, Josée G. Lavoie, Donna Martin, Allison Wiens, Annette SchultzAbstractThe inequities in access to healthcare documented and experienced by Indigenous peoples in Canada are startling given Canada's publically funded and ‘equally accessible’ healthcare system, however little is known about access to cancer care, and barriers to accessing cancer care in particular. We conducted...
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ConclusionsIt was concluded that cultural/immigration-related barriers may be the only barrier type that is unique to racial/ethnic minority women. Thus, designing studies of barriers around race and ethnicity is not always appropriate, and other demographic factors are sometimes a more important focus. The variability in ‘barrier’ definitions, how data were collected and reported, and the appropriateness of closed-ended measures was also examined. This literature may benefit from detailed and strategically...
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Conclusion Pleural ultrasound elastography is a better technique than TUS for differentiating MPE from benign pleural disease. (Source: European Respiratory Journal)
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Thoracic ultrasound (TUS) has been incorporated as a routine bedside tool for the diagnosis of pleural diseases and the performance of safe pleural procedures [1]. It is generally accepted that TUS can provide valuable information on the possible malignant nature of a pleural effusion. Ultrasound appearances suggestive of malignancy include parietal or visceral pleural thickening of more than 1 cm, diaphragmatic thickness greater than 7 mm, pleural or diaphragmatic nodules and liver metastases, but...
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Conclusions: Our study indicates that solid nodules have the highest risk of malignancy. Furthermore, the cytological evaluation of subsolid and partially calcified nodules is crucial for the accurate diagnosis and appropriate clinical management of lung nodule patients. (Source: CytoJournal)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Conclusion: Endoscopists at our institutions met/exceeded the quality metrics in the first half of each year from the beginning of the study. Routine reporting may maintain, but not improve, outcomes. Long-term studies to determine if periodic feedback to endoscopists improves the quality of endoscopy as per national standards for detection of early colorectal cancers are required. PMID: 31428145 [PubMed] (Source: Gastroenterology Research and Practice)MedWorm Message: If you are looking to...
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Conclusions Cancer coordinators encounter cognitive, practical, and relational topics that impact their system-focused activities. Adopting a salutogenic focus can help CCs mobilize resources needed to turn challenges into facilitators for system-level work. Implications for Practice Cancer care coordination cannot be undertaken by CCs alone. Cancer coordinators' embedding in multidisciplinary teams, common systems for care provision, meaningful work relations, and professionals' commitment...
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Conclusions Resilience in liver cancer patients undergoing TACE needs to be further improved, which was positively predicted by educational level, time span since diagnosis, family function, social support, hope, self-efficacy, and positive coping strategies, but was negatively predicted by metastasis. Hope had the largest influence on resilience. Implications for Practice Interventions aimed to improve hope are crucial to patients' resilience. Additional attention should be given to patients...
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No abstract available (Source: Cancer Nursing)
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Conclusion Improvement of QOL of patients with head and neck cancer is a long process, which is associated with the clinical and demographic characteristics of patients. Implications for Practice Focusing nursing practice on shoulder and neck function rehabilitation, incision care, and pain management could positively affect QOL among patients with head and neck cancer treated by surgery. (Source: Cancer Nursing)
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Conclusion Results provide insights into modifiable risk factors for morning fatigue. These risk factors can be used to develop more targeted interventions. Implications for Practice Patients in the high and very high morning fatigue classes experienced high symptom and comorbidity burdens and significant decrements in functional status. Using this information, clinicians can identify patients who are at an increased risk for higher levels of morning fatigue and prescribe interventions to improve...
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Conclusions The preparatory intervention facilitated the ability of staff members to conduct their work, although the intervention should be specifically tailored to each child. Meeting children and their families and providing care to both during RT were challenging. The staff strived to provide optimal care for each child and family. Interdisciplinary teamwork and organizational acceptance for the importance of preparation and distraction were essential. Implications for Practice A future...
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Conclusion Medication administration is an activity of great responsibility for nursing; however, in order to achieve a decrease in medication errors, prevention strategies are necessary for the whole health team. Implications for Practice Practice improvements are needed including establishing institutional drug administration protocols and keeping them updated, using a computerized prescription system, and promoting patient safety with staff. (Source: Cancer Nursing)
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Conclusion Cancer-related Internet information plays a crucial role in how people manage their illness and take control of their patient experience. Participants used CRII to learn about their illness, support their efforts to self-manage, and complement information from professionals. Implications for Practice Individuals and institutions can promote and encourage tailored CRII use by engaging patients and suggesting websites based on their needs. Doing so may create efficiencies in service...
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Background Gynecologic cancer can create hopelessness and death anxiety and alter the lifestyle of the affected women and their caregivers. Perceived social support may facilitate coping with this illness. Objective The aim of this study was to determine whether hospitalized patients with gynecologic cancer and their caregivers differ in feelings of hopelessness and death anxiety and how those conditions may be related to their social support. Methods Two hundred patients with gynecologic...
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Conclusions The results of this study can facilitate and encourage health professionals to identify, examine, and solve most of the patient’s sexual problems by using the functional and medical framework of the healthcare system. Implications for Practice One practical recommendation of this study is the incorporation of sexual counseling units into the national healthcare system. Counselors in these units can help breast cancer survivors solve problems and improve sexual satisfaction between...
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Impact of Comorbidity on Symptoms and Quality of Life Among Patients Being Treated for Breast Cancer
Background Cancer patients often have other noncancer medical conditions. Presence of comorbidities negatively affects cancer survival. Objective The aim of this study was to investigate comorbidity, risk factors for comorbidity, and how comorbidity was associated with symptoms and quality of life in patients being treated for breast cancer. Methods One hundred and one breast cancer chemotherapy outpatients completed this study. Comorbid conditions, weight, height, and smoking status were...
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No abstract available (Source: Cancer Nursing)
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Background Depressive symptoms are prevalent in patients with cancer and are heterogeneous; however, existing methods of grouping patients with heterogeneous symptoms have limitations. Objectives The purpose of this study was to identify depressive symptom clusters in patients with cancer using a data-driven method and to explore their relationships with symptoms of anxiety and posttraumatic stress disorder. Methods Data from 247 patients were analyzed in this cross-sectional study. Latent...
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Conclusion Nurses caring for women receiving endocrine therapy for breast cancer should assess the 5 key symptoms identified. There remain substantial gaps in the science related to the symptom experience during endocrine therapy for breast cancer. Future studies should focus on the domains of symptom intensity and distress, specific understudied symptoms, symptom clusters, and development of symptom assessment instruments specific to symptoms associated with endocrine therapy. Implications for...
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Conclusions The CBT-E protocol tested among this highly selected sample was fairly well received and suggested positive outcomes in some patients, particularly those with an insomnia complaint alone. Implications Efforts should be pursued to adapt CBT-E and develop other nonpharmacological interventions, in order to provide an alternative to pharmacotherapy for sleep-wake difficulties in this population. (Source: Cancer Nursing)
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Conclusions Findings confirm the importance of focusing on both positive and negative well-being, their associated factors, and mediators. Implications for practice The authors discuss practice implications to enhance self-transcendence such as journaling, mindfulness techniques, activities to connect with nature, and others. (Source: Cancer Nursing)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales...
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Conclusions The Chinese version of BCSES appears to be culturally appropriate, reliable, and valid for assessing self-efficacy among patients with breast cancer in China. Implication for Practice The Chinese version of BCSES could help measure the breast cancer patients' self-efficacy and provide evidence to develop culturally sensitive interventions for Chinese patients. (Source: Cancer Nursing)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on...
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ConclusionsIn view of the fact that cystic angiomatosis is a heterogeneous disorder of unpredictable prognosis and uncertain treatment, it is necessary to disseminate new cases so that further studies may be undertaken to obtain further physiopathological findings and an effective treatment. (Source: Journal of Medical Case Reports)
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Erratum to "Melatonin Suppresses the Expression of 45S Preribosomal RNA and Upstream Binding Factor and Enhances the Antitumor Activity of Puromycin in MDA-MB-231 Breast Cancer Cells". Evid Based Complement Alternat Med. 2019;2019:5741476 Authors: Jung JH, Sohn EJ, Shin EA, Lee D, Kim B, Jung DB, Kim JH, Yun M, Lee HJ, Park YK, Kim SH Abstract [This corrects the article DOI: 10.1155/2013/879746.]. PMID: 31428174 [PubMed - in process] (Source: Evidence-based Complementary...
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AbstractLong QT syndrome (LQTS) is an inherited primary arrhythmia syndrome that may present with malignant arrhythmia and, rarely, risk of sudden death. The clinical symptoms include palpitations, syncope, and anoxic seizures secondary to ventricular arrhythmia, classicallytorsade de pointes. This predisposition to malignant arrhythmia is from a cardiac ion channelopathy that results in delayed repolarization of the cardiomyocyte action potential. The QT interval on the surface electrocardiogram...
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(Source: OncoTargets and Therapy)
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(Source: Cancer Management and Research)
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(Source: Cancer Management and Research)
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(Source: OncoTargets and Therapy)
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(Source: Cancer Management and Research)
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(Source: Cancer Management and Research)
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(Source: OncoTargets and Therapy)
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(Source: OncoTargets and Therapy)
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(Source: Cancer Management and Research)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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(Source: Cancer Management and Research)
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(Source: OncoTargets and Therapy)
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In this study, total circulating CD4 T cells were sorted into CD25+CXCR5− Treg-like, CD25+CXCR5+ Tfr-like, and CD25−CXCR5+ Tfh-like subsets. Data showed that the Tfr-like subset presented intermediate levels of both Foxp3 and Bcl-6, while the Treg-like subset was high in Foxp3 and low in Bcl-6, and the Tfh-like was high in Bcl-6 and low in Foxp3. Of note, the frequencies of Tfr-like and Treg-like cells were significantly elevated in breast cancer (BC) patients than in non-cancer (NC) controls. Tfr-like...
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Authors: Silvia Schmidtova Katarina Kalavska Katarina Gercakova Zuzana Cierna Svetlana Miklikova Bozena Smolkova Verona Buocikova Viera Miskovska Erika Durinikova Monika Burikova Michal Chovanec Miroslava Matuskova Michal Mego Lucia Kucerova Cisplatin resistance in testicular germ cell tumors (TGCTs) is a clinical challenge. We investigated the underlying mechanisms associated with cancer stem cell (CSC) markers and modalities circumventing the chemoresistance....
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Authors: Yoshitaro Shindo Shoichi Hazama Ryouichi Tsunedomi Nobuaki Suzuki Hiroaki Nagano Cancer immunotherapy has emerged as a novel and effective treatment strategy for several types of cancer. Immune checkpoint inhibitors (ICIs) have recently demonstrated impressive clinical benefit in some advanced cancers. Nonetheless, in the majority of patients, the successful use of ICIs is limited by a low response rate, high treatment cost, and treatment-related toxicity. Therefore,...
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British Journal of Cancer, Published online: 22 August 2019; doi:10.1038/s41416-019-0553-zFXYD5 (Dysadherin) upregulation predicts shorter survival and reveals platinum resistance in high-grade serous ovarian cancer patients (Source: British Journal of Cancer)
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Home remedies for bad breath include green tea, herbal rinses, and water. People should see a doctor if their breath does not improve. Learn more about home remedies for bad breath here. (Source: Health News from Medical News Today)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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(Natural News) Ginseng, referred to by some as the “king of all herbs,” is a widely used herbal medicine and health supplement. Numerous benefits are associated with the use of ginseng, most notably the enhancement of male reproductive function, the improvement of general well-being, and the prevention of cancer. While different varieties of ginseng exist, each... (Source: NaturalNews.com)
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(Natural News) Electroacupuncture can greatly improve symptoms of postoperative urinary retention in women, according to a review published in the journal Evidence-Based Complementary and Alternative Medicine. In the article, researchers from Guangzhou University of Chinese Medicine in China looked at data from randomized control trials that used electroacupuncture for treating postoperative urinary retention, a complication usually associated with... (Source: NaturalNews.com)
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My name is Kayla Gasbarro, and following breast implant surgery, I have lived with breast implant illness for the last 7 years. This is my story. (Source: Health News from Medical News Today)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Brown fat helps protect against obesity and diabetes by filtering branched-chain amino acids from the blood, according to research published inNature.Medical Xpress (Source: Society for Endocrinology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Researchers say that physical activity or eating oily fish is more beneficial Related items fromOnMedica Type 2 diabetes in 10 times more young people than realised Sugary drinks linked to risk of overall and breast cancer Should we recognise obesity as a disease? One person diagnosed with diabetes every three minutes Diabetes will soon cost NHS £16.9bn (Source: OnMedica Latest News)
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Active middle aged and older adults at lower risk of premature death Related items fromOnMedica How a ‘grumpy’ GP can have a disproportionate effect on a young person’s health The star fish and the link worker Surgery should be a last resort for obese children Measles warning as vaccination rates fall Public health chiefs set out NHS plan targets (Source: OnMedica Latest News)
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A new study from Rutgers University has found that brown fat is essentiall for filtering out amino acids called BCAAs from the blood that have been linked to diabetes and obesity (Source: the Mail online | Health)
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Conclusion â The Eversense real-world data showed excellent glycemic results, sensor accuracy, and safety. This data demonstrates that the Eversense CGM System is a valuable tool for diabetes management. âThis real-world data reflects how the Eversense CGM functions for people who choose this innovative, implantable system to manage their diabetes,â Francine R. Kaufman, MD, Endocrinologist and Chief Medical Officer at Senseonics, said in a release. âThe data shows that glucose control, as measured...
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TYPE 2 diabetes is a life-long condition that requires making certain lifestyle changes to reduce the risk. Seven sugar snacks often consumed during the day can be a healthier alternative. (Source: Daily Express - Health)
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THURSDAY, Aug. 22, 2019 -- The health risks of sugary drinks, from juice to soda, are well known. They can lead to overweight and diabetes, stroke and other problems in the brain, including poorer memory and smaller brain volume. But diet sodas... (Source: Drugs.com - Daily MedNews)
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Higher levels of total physical activity, less time spent sedentary linked to lower mortality risk (Source: The Doctors Lounge - Oncology)
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Targeting adenosine receptor A2B in a mouse model of osteoporosis reversed bone degradation, according to a study published inScience Advances.Science Daily (Source: Society for Endocrinology)
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Chronic inflammation in type 2 diabetes is driven by mitochondrial cells in response to fat exposure, according to research published inCell Metabolism.Science Daily (Source: Society for Endocrinology)
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A report, published in theEuropean Journal of Clinical Nutrition, suggests that supplementing flour with vitamin D could avoid deficiency and improve health, particularly in countries with less sunlight.BBC News (Source: Society for Endocrinology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Do children receiving growth hormone treatment realize improvements in health-related quality of life?Clinical Endocrinology (Source: Medscape Today Headlines)
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TYPE 2 diabetes is a life-long condition that requires careful management to mitigate the risks associated. Certain lifestyle choices are well understood to raise blood sugar levels, it may come as a surprise that a popular activity could play havoc to blood sugar regulation. (Source: Daily Express - Health)
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People with type 2 diabetes "should not be encouraged" to take omega-3, researchers say. (Source: BBC News | Health | UK Edition)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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A family is hoping a seven-month-old golden retriever will help their daughter manage her type 1 diabetes. (Source: BBC News | Health | UK Edition)
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Researchers at the University of East Anglia, commissioned by the World Health Organization, concluded people who took more of them were no less likely to be diagnosed with the condition. (Source: the Mail online | Health)
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WEDNESDAY, Aug. 21, 2019 -- It would be welcome news to millions if fish oil supplements were proven to help prevent diabetes. But new research delivers very disappointing data on the prospect. Previous research has hinted that fish oil supplements... (Source: Drugs.com - Daily MedNews)
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Families with a history of diabetes have a higher bone density than those who don't, which can put them at a higher risk for bone fragility or fractures, new research suggests. (Source: Health News - UPI.com)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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One in Four Patients Concerned About Diabetes Drug Costs (Source: eMedicineHealth.com)
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Title: Study Finds Diabetes, Heart Failure a Dangerous DuoCategory: Health NewsCreated: 8/21/2019 12:00:00 AMLast Editorial Review: 8/21/2019 12:00:00 AM (Source: MedicineNet Heart General)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Findings seen among those taking buprenorphine and any of five other drug classes (Source: The Doctors Lounge - Psychiatry)
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