CONCLUSION: Aripiprazole can be a good cytotoxic compound and good candidate for further studies of cancer therapy.RESUMO CONTEXTO: O c âncer gástrico é conhecido como o quarto câncer mais comum. Os tratamentos atuais para o câncer danificaram os tecidos sensíveis do corpo saudável e, em muitos casos, o cancro será recorrente. Portanto, a necessidade de tratamentos que são mais eficazes é desejada. Recentemente, os pesquis adores mudaram sua atenção para os antagonistas antipsicóticos da dopamina...
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CONCLUSION: These preliminaries outcomes could be considered an advance in two-dimensional pit characterization as the whole image processing, comparing to the conventional procedure, takes a few seconds to quantify and charact erize non-pathological colon pits as well as to estimate early pathological stages of colorectal cancer.RESUMO CONTEXTO: O c âncer colorretal é uma das patologias mais prevalentes. Seu prognóstico é ligado à detenção e ao tratamento precoces. Atualmente o diagnóstico é realizado...
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CONCLUSION: Among the nutritional status parameters, only the Patient-Generated Subjective Global Assessment score was significantly different between the groups and was an important predictor of survival in patients with advanced colorectal cancer.RESUMO CONTEXTO: Considerando a alta incid ência de óbitos devido ao câncer coloretal (CCR), estudos investigaram variáveis que podem afetar a sobrevida, com objetivo de prolongar a sobrevida. O estado nutricional desses pacientes também pode predizer...
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CONCLUSION: Enterococcus faecalis in faecal flora of people with colorectal cancer was significantly higher than those with polyps and healthy people. This could potentially signify the ability of this bacterium to induce colorectal cancer. More studies are needed to prove this theory.RESUMO CONTEXTO: O c âncer colorretal é um dos cânceres mais comumente diagnosticados em todo o mundo. Um dos fatores envolvidos no desenvolvimento do câncer colorretal é a mudança na flora normal do intestino. OBJETIVO:...
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ConclusionThis is the first case of robot-assisted laparoscopic retroperitoneal lymph node dissection with concomitant inferior vena cava thrombectomy and reconstruction for metastatic mixed testicular germ cell cancer published to date. This complicated surgical procedure was facilitated by the innovative usage of three-dimensional image reconstruction for defining the vena cava tumor thrombus, a robotic ultrasound probe for intraoperatively defining the vena cava tumor thrombus, and vena cavoscopy...
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ConclusionsCPS was shown to be a more useful assessment method of determining PD-L1 expression than TPS as a prognostic biomarker. This suggests that the total number of PD-L1-expressing cells, including tumor and immune cells, is a more sensitive prognostic biomarker than the number of PD-L1-expressing tumor cells in GC. (Source: Gastric Cancer)
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Sentinel lymph node biopsy (SLNB) is an accurate staging procedure for malignant melanoma but its use in patients with melanoma of the head and neck has been questioned in the past because of a perceived record of poor safety and accuracy. Technical improvements have sought to redress this.Vital structures and variable lymphatic pathways can make its use in the head and neck challenging. In our study we have examined the data and the experiences of clinicians from University Hospital Southampton...
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Clinical Epigenetics
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BMC Microbiology
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BMC Neuroscience
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BMC Medical Informatics and Decision Making
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BMC Psychiatry
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An effective epidermal barrier requires structural and functional integration of adherens junctions, tight junctions, gap junctions (GJ), and desmosomes. Desmosomes govern epidermal integrity while GJs facilitate small molecule transfer across cell membranes. Some patients with Severe dermatitis, multiple Allergies, and Metabolic wasting (SAM) syndrome, caused by biallelic Desmoglein 1 (DSG1) mutations, exhibit skin lesions reminiscent of Erythrokeratodermia Variabilis, caused by mutations in Connexin...
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Publication date: Available online 26 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Kenneth A. Michelson, Timothy E. Dribin, David Vyles, Mark I. Neuman (Source: The Journal of Allergy and Clinical Immunology: In Practice)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Intravenous immunoglobulin (IVIg) serves as the first line therapy in Guillain-Barr é syndrome (GBS), however, its action mechanism remains unknown. We hereby stimulated peripheral blood mononuclear cells (PBMCs) from patients with GBS and healthy controls using IVIg and an IgG-derived natural Treg epitopes, namely Tregitopes. Our results showed that IVIg significantly promoted bo th the expansion of CD4+CD25+Foxp3+ regulatory T cells (Tregs) and secretion of IL-10 and TGF-β1 while Tregitopes promoted...
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TNFA, IL1B, HMGB1, IL10, CXCL8, CCL2 and CCR5 gene polymorphisms were investigated in 183 Japanese Encephalitis (JE) cases and 361 healthy controls from North India. Higher frequency of TNFA rs1800629 G/A, CCR5 rs1799987 genotypes with A allele and lower frequency of combination lacking TNFA rs1800629 A, CCR5 rs333 Δ32, andCCR5 rs1799987 A alleles and CCL2 rs1024611 G/G genotype was observed in JE cases. TNFA rs1800629 A and CCR5 rs1799987 A alleles were associated with susceptibility while combination...
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Authors: Janke T, Schwaiger K, Ege M, Fahn C, von Mutius E, Bauer J, Mayer M Abstract The original version of this article contained a mistake in the co-author's conflict of interest statement. Erika von Mutius wishes to add the following disclosures: "E. von Mutius is listed as an inventor on the following patents: publication number EP 1411977, composition containing bacterial antigens used for the prophylaxis and the treatment of allergic diseases, granted on 18 April 2007; publication...
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ConclusionIn contrast to traditional therapy, DC-CIK immunotherapy not only shows improved short-term effect, long-term effect and immunologic function, but also reduces mortality and negative immunoregulatory index, and shows mild adverse reactions. This is the first study to evaluate the clinical effect and safety of DC-CIK immunotherapy for PC, and it indicated that DC-CIK immunotherapy may be suitable for patients with advanced PC or intolerance to radiotherapy and chemotherapy. (Source: Cytotherapy)
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ConclusionHerein, we provide guidance on IT gadolinium usage and a framework for IT pump malfunction in iodine allergic patients. (Source: Neuromodulation: Technology at the Neural Interface)
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We report the presence of C. jejuni from potential transmission sources including egg shells, poultry waste, waste water and migratory bird droppings with a prevalence rate of 78%, 66%, 86% and 70% respectively. Antibiotic resistance profile showed high number of isolates resistant to multiple antibiotics including 4th generation cephalosporins. C. jejuni isolates were further screened for presence of T6SS, an important virulence determinant. None of the C. jejuni isolates from migratory birds carried...
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(Source: Journal of Inflammation Research)
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Background: The choice of anesthetic technique for ischemic stroke patients undergoing endovascular thrombectomy is controversial. Intravenous propofol and volatile inhalational general anesthetic agents have differing effects on cerebral hemodynamics, which may affect ischemic brain tissue and clinical outcome. We compared outcomes in patients undergoing endovascular thrombectomy with general anesthesia who were treated with propofol or volatile agents. Methods: Consecutive endovascular...
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Background: Anesthetic technique affects the neuroendocrine stress response to surgery. In this retrospective study, we compared the neuroendocrine stress response in patients undergoing endoscopic transsphenoidal pituitary adenoma surgery (ETSPAS) with total intravenous anesthesia (TIVA) with propofol-remifentanil or balanced anesthesia (BAL) with sevoflurane-remifentanil. Materials and Methods: Eighty-nine patients undergoing ETSPAS were anesthetized with either propofol-remifentanil (TIVA...
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Laryngopharyngeal reflux (LPR), a growing issue in ear, nose, and throat (ENT) and pediatric medicine, is the backflow of stomach contents into the laryngopharynx. Patients present with frequent upper and/or lower respiratory tract infections and coughs, associated with acid- and pepsin-mediated injury to the mucosae of the larynx and pharynx. LPR is associated with rhinosinusitis, laryngitis, pneumonia, and asthma. Children with LPR often fail to exhibit classic gastroesophageal reflux disease symptoms,...
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Background: Deep learning (DL) has demonstrated human expert levels of performance for medical image classification in a wide array of medical fields, including ophthalmology. In this article, we present the results of our DL system designed to determine optic disc laterality, right eye vs left eye, in the presence of both normal and abnormal optic discs. Methods: Using transfer learning, we modified the ResNet-152 deep convolutional neural network (DCNN), pretrained on ImageNet, to determine...
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No abstract available
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Background: Through transcranial magnetic stimulation (TMS) it is possible to change cortical excitability of the visual cortex, and to influence binocular balance. The main goal of our study is to assess the effect of transcranial magnetic stimulation, specifically theta burst stimulation (TBS), in a group of amblyopic volunteers measuring several visual parameters: visual acuity, suppressive imbalance, and stereoacuity. Methods: Thirteen volunteers aged 19 to 24 years, randomly split in...
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No abstract available
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Background: The benefit of thymectomy in reducing requirement for corticosteroids, symptom severity, need for immunosuppression, and hospitalization rates in patients with seropositive generalized myasthenia has recently been established. It is unclear whether this benefit applies to patients with myasthenia and purely ocular manifestations (ocular myasthenia gravis [OMG]). Methods: We conducted a retrospective single-center cohort study of patients with OMG. Patients were included if their...
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No abstract available
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Background: The relation of retinal thickness to neuropsychological indexes of cognitive impairment in patients with Alzheimer disease (AD) remains an area of investigation. The scope of this investigation was to compare volume and thickness changes of neuronal retinal layers in subjects with AD with those of age-matched healthy controls and to estimate the relation between cognitive functioning evaluated by neuropsychological assessment and thickness changes of the retina. Methods: This...
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Objective: The King-Devick (K-D) test is a rapid visual screening tool that can assess underlying brain trauma such as concussion via impairments in saccadic rhythm. A new tablet version of the K-D test using randomized numbers is now available, but reliability for this new version and comparison to the traditional K-D test has not yet been reported. Known for learning effects in the test, the aim of this study was to determine test–retest reliability and to compare performance of the new “randomized”...
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Abstract: Lisch nodules are melanocytic hamartomas that have been hypothesized to grow larger in the presence of sunlight. A 17-year-old boy with neurofibromatosis Type 1 and congenital ptosis in one eye presented and was found to have a distinct asymmetry of Lisch nodules between eyes with less under the ptotic lid. This case supports the theory that Lisch nodules form at least partially due to a direct trophic effect of sunlight. Address correspondence to Robert A. Egan, MD, MultiCare Rockwood...
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No abstract available
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Background: Although the nonaffected side appears to be clinically normal in hemifacial spasm (HFS), it is not known whether this side can be considered normal regarding histopathological findings. The purpose of this study was to objectively evaluate and compare orbicularis oculi samples of patients with HFS (not previously treated with botulinum toxin) and control patients undergoing cosmetic upper eyelid blepharoplasty. Methods: Orbicularis oculi samples from 22 eyelids were evaluated....
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No abstract available
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Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) is a causative agent of severe-to-fatal pneumonia especially in patients with pre-existing conditions, such as smoking and chronic obstructive pulmonary disease (COPD). MERS-CoV transmission continues to be reported in the Saudi Arabian Peninsula since its discovery in 2012. However, it has rarely been epidemic outside the area except one large outbreak in South Korea in May 2015. The genome of the epidemic MERS-CoV...
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Abstract The phytopathogenic Burkholderia species B. glumae and B. plantarii are the causal agents of bacterial wilt, grain rot, and seedling blight, which threaten the rice industry globally. Toxoflavin and tropolone are produced by these phytopathogens and are considered the most hostile biohazards with a broad spectrum of target organisms. However, despite their nonspecific toxicity, the effects of toxoflavin and tropolone on bacteria remain unknown. RNA-seq based transcriptome...
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Abstract Salterns are hypersaline extreme environments with unique physicochemical properties such as a salinity gradient. Although the investigation of microbiota in salterns has focused on archaea and bacteria, diverse fungi also thrive in the brine and soil of salterns. Fungi isolated from salterns are represented by black yeasts (Hortaea werneckii, Phaeotheca triangularis, Aureobasidium pullulans, and Trimmatostroma salinum), Cladosporium, Aspergillus, and Penicillium species....
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Abstract Most commercialized virus-like particle (VLP) vaccines use aluminum salt as adjuvant, even though VLPs provoke adequate antibody responses without adjuvant. We do not have detailed knowledge of how adjuvant affects the profile of anti-VLP antibodies. Meanwhile, there is evidence that differences between vaccination protocols influence the glycosylation of antibodies, which may alter their effector functions. In the present study a murine model was used to investigate...
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FDA issues draft guidance encouraging the inclusion of male patients in breast cancer clinical trials (Source: FDA Center for Drug Evaluation and Research - What's New)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Draft guidance for industry: Male Breast Cancer: Developing Drugs for Treatment. (Source: FDA Center for Drug Evaluation and Research - What's New)
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Men are often excluded from clinical trials of breast cancer drugs on the basis of sex. The US Food and Drug Administration wants to change that.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
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(Source: The Doctors Lounge - Oncology)
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Exposure to ≥ 250 mg/m ² doxorubicin - equivalent anthracycline chemo tied to risk for CVD, heart failure (Source: The Doctors Lounge - Oncology)
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Atezolizumab is an immune-checkpoint inhibitor, which has been approved by the US Food and Drug Administration (FDA) in various combinations for a number of cancer types in recent years. (Source: CancerNetwork)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Prostate cancer is the most frequent cancer found in American men, and the second leading cause of cancer death in this population. Currently, scores of reputable clinical trials are underway and recruiting patients. (Source: CancerNetwork)
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[Ghanaian Times] The Child Health Department of the Korle Bu Teaching Hospital in Accra needs Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) scan machine at its Paediatric Oncology Unit (POU) where childhood cancers are treated. (Source: AllAfrica News: Health and Medicine)
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The genetic condition is one of the most common in the UK and may be a leading cause of infertility in men. Why does it so often go untreated?Three years ago, Paul (not his real name), now 31, went to the doctor with stomach pains. His blood test came back with low testosterone levels. “We went to see a urologist and he said bluntly that we wouldn’t have any options to have kids with my sperm – we would have to use a donor or adopt,” he says. “My wife immediately burst into tears.” The couple had...
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Has genomic medicine realized all its potential over the past decade? Yes and no, says Dr David Kerr.Medscape Oncology (Source: Medscape Today Headlines)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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When most people think about sun-related damage, they probably worry about their skin. But the sun’s ultraviolet rays also pose a threat to a person’s eyes. According to a 2014 study funded by the U.S. National Eye Institute, part of the National Institutes of Health, UV radiation can damage proteins in the eye’s lens. Over time, this damage can raise a person’s risk for cataracts, which impair vision. “When you don’t wear protection, ultraviolet radiation you cannot see is penetrating the eye,...
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When Robert Fuller found out he had throat cancer, he decided to finish out his life and then end it with fatal drugs (Source: ABC News: Health)
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Freddie Burgess-Shardlow has an ectomesenchymoma, a rare and fast-growing tumour of the nervous system or soft tissue. He is receiving treatment in Nottingham. (Source: the Mail online | Health)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Artificial intelligence (AI) may create new opportunities to improve outcomes...Read more on AuntMinnie.comRelated Reading: Data biases for AI could worsen healthcare disparities Preparing healthcare IT architecture for AI: Part 2 Preparing healthcare IT architecture for AI: Part 1 AI can improve reproducibility of radiomics in CT AI, radiomics can help predict chemotherapy response (Source: AuntMinnie.com Headlines)
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Abstract Purpose In the mandible, the condylar neck vascularization is commonly described as mainly periosteal; while the endosteal contribution is still debated, with very limited anatomical studies. Previous works have shown the contribution of nutrient vessels through accessory foramina and their contribution in the blood supply of other parts of the mandible. Our aim was to study the condylar neck’s blood supply from nutrient foramina....
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SurgRob
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