Brain Sciences, Vol. 9, Pages 215: Effects of Stathmin 1 Gene Knockout on Behaviors and Dopaminergic Markers in Mice Exposed to Social Defeat Stress Brain Sciences doi: 10.3390/brainsci9090215 Authors: Thong Ba Nguyen Vishwanath Vasudev Prabhu Yan Hong Piao Young Eun Oh Rami Fatima Zahra Young-Chul Chung Stathmin (STMN), a microtubule-destabilizing factor, can regulate fear, anxiety, and learning. Social defeat stress (SDS) has detrimental effects on mental health and...
Mon Aug 26, 2019 03:00
Brain Sciences, Vol. 9, Pages 214: Cerebral Vascular Reactivity in Frail Older Adults with Vascular Cognitive Impairment Brain Sciences doi: 10.3390/brainsci9090214 Authors: Sara G. Aguilar-Navarro Alberto José Mimenza-Alvarado Isaac Corona-Sevilla Gilberto A. Jiménez-Castillo Teresa Juárez-Cedillo José Alberto Ávila-Funes Gustavo C. Román Background: Frailty, a state of increased vulnerability, could play a role in the progression of vascular dementia. We aim to describe...
Sat Aug 24, 2019 03:00
Brain Sciences, Vol. 9, Pages 213: Biomarker-Based Signature of Alzheimer’s Disease in Pre-MCI Individuals Brain Sciences doi: 10.3390/brainsci9090213 Authors: Elena Chipi Nicola Salvadori Lucia Farotti Lucilla Parnetti Alzheimer’s disease (AD) pathology begins decades before the onset of clinical symptoms. It is recognized as a clinicobiological entity, being detectable in vivo independently of the clinical stage by means of pathophysiological biomarkers. Accordingly,...
Fri Aug 23, 2019 03:00
Cancers, Vol. 11, Pages 1250: Immune Heterogeneity Between Primary Tumors and Corresponding Metastatic Lesions and Response to Platinum Therapy in Primary Ovarian Cancer Cancers doi: 10.3390/cancers11091250 Authors: Katharina Dötzer Friederike Schlüter Markus Bo Schoenberg Alexandr V. Bazhin Franz Edler von Koch Andreas Schnelzer Sabine Anthuber Dieter Grab Bastian Czogalla Alexander Burges Jens Werner Sven Mahner Barbara Mayer CD3+ and CD8+ lymphocytes...
Mon Aug 26, 2019 03:00
Cancers, Vol. 11, Pages 1248: Gastric Normal Adjacent Mucosa Versus Healthy and Cancer Tissues: Distinctive Transcriptomic Profiles and Biological Features Cancers doi: 10.3390/cancers11091248 Authors: Russi Calice Ruggieri Laurino Rocca Amendola Lapadula Compare Nardone Musto Felice Falco Zoppoli Gastric cancer (GC) is a leading cause of cancer-related deaths in the world. Molecular heterogeneity is a major determinant for the clinical...
Mon Aug 26, 2019 03:00
Cancers, Vol. 11, Pages 1252: BRAF Mutation in Colorectal Rhabdoid and Poorly Differentiated Medullary Carcinomas Cancers doi: 10.3390/cancers11091252 Authors: Bolzacchini Digiacomo Marrazzo Sahnane Maragliano Gill Albarello Sessa Furlan Capella Colorectal rhabdoid carcinomas (CRbCs) are very rare and aggressive cancers. The BRAFmutation and CpG island methylator phenotype have been reported to be common features ofCRbCs. This study reviews the literature...
Mon Aug 26, 2019 03:00
Cancers, Vol. 11, Pages 1249: Potential Role of HLA Class I Antigens in the Glycolytic Metabolism and Motility of Melanoma Cells Cancers doi: 10.3390/cancers11091249 Authors: Peppicelli Ruzzolini Andreucci Bianchini Kontos Yamada Ferrone Calorini Besides playing a crucial role in immune surveillance, human leukocyte antigens (HLA) possess numerous non-immune functions involved in cell communication. In the present study, screening of a panel of HLA class...
Mon Aug 26, 2019 03:00
Cancers, Vol. 11, Pages 1251: Tumor Transcriptome Reveals High Expression of IL-8 in Non-Small Cell Lung Cancer Patients with Low Pectoralis Muscle Area and Reduced Survival Cancers doi: 10.3390/cancers11091251 Authors: Sarah Santiloni Cury Diogo de Moraes Paula Paccielli Freire Grasieli de Oliveira Douglas Venâncio Pereira Marques Geysson Javier Fernandez Maeli Dal-Pai-Silva Érica Nishida Hasimoto Patricia Pintor dos Reis Silvia Regina Rogatto Robson Francisco...
Mon Aug 26, 2019 03:00
Cancers, Vol. 11, Pages 1247: Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions Cancers doi: 10.3390/cancers11091247 Authors: Tian Liu Yiwei Wang Yubing Wang Andrew M. Chan Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor gene frequently found to be inactivated in over 30% of human cancers. PTEN encodes a 54-kDa lipid phosphatase that serves as a gatekeeper of the phosphoinositide 3-kinase pathway involved...
Mon Aug 26, 2019 03:00
Cancers, Vol. 11, Pages 1246: A Multi-Center Study of BRCA1 and BRCA2 Germline Mutations in Mexican-Mestizo Breast Cancer Families Reveals Mutations Unreported in Latin American Population Cancers doi: 10.3390/cancers11091246 Authors: Oliver Millan Catalan Alma D. Campos-Parra Rafael Vázquez-Romo David Cantú de León Nadia Jacobo-Herrera Fermín Morales-González César López-Camarillo Mauricio Rodríguez-Dorantes Eduardo López-Urrutia Carlos Pérez-Plasencia The...
Mon Aug 26, 2019 03:00
Cancers, Vol. 11, Pages 1244: Review and Comparison of Cancer Biomarker Trends in Urine as a Basis for New Diagnostic Pathways Cancers doi: 10.3390/cancers11091244 Authors: Bax Lotesoriere Sironi Capelli Cancer is one of the major causes of mortality worldwide and its already large burden is projected to increase significantly in the near future with a predicted 22 million new cancer cases and 13 million cancer-related deaths occurring annually by 2030. Unfortunately, current...
Sun Aug 25, 2019 03:00
Cancers, Vol. 11, Pages 1245: Novel Carbazole-Piperazine Hybrid Small Molecule Induces Apoptosis by Targeting BCL-2 and Inhibits Tumor Progression in Lung Adenocarcinoma in Vitro and Xenograft Mice Model Cancers doi: 10.3390/cancers11091245 Authors: Mongre Mishra Prakash Jung Lee Kumari Hong Lee Lung cancer is a type of deadly cancer and a leading cause of cancer associated death worldwide. BCL-2 protein is considered as an imperative target for the treatment...
Sun Aug 25, 2019 03:00
Cancers, Vol. 11, Pages 1243: Lactate Dehydrogenase (LDH) Response to First-Line Treatment Predicts Survival in Metastatic Breast Cancer: First Clues for A Cost-Effective and Dynamic Biomarker Cancers doi: 10.3390/cancers11091243 Authors: Giacomo Pelizzari Debora Basile Silvia Zago Camilla Lisanti Michele Bartoletti Lucia Bortot Maria Grazia Vitale Valentina Fanotto Serena Barban Marika Cinausero Marta Bonotto Lorenzo Gerratana Mauro Mansutti Francesco...
Sat Aug 24, 2019 03:00
Cancers, Vol. 11, Pages 1241: The Diverse Contributions of Fucose Linkages in Cancer Cancers doi: 10.3390/cancers11091241 Authors: Tyler S. Keeley Shengyu Yang Eric Lau Fucosylation is a post-translational modification of glycans, proteins, and lipids that is responsible for many biological processes. Fucose conjugation via α(1,2), α(1,3), α(1,4), α(1,6), and O’- linkages to glycans, and variations in fucosylation linkages, has...
Sat Aug 24, 2019 03:00
Cancers, Vol. 11, Pages 1240: Role of the Microenvironment in Regulating Normal and Cancer Stem Cell Activity: Implications for Breast Cancer Progression and Therapy Response Cancers doi: 10.3390/cancers11091240 Authors: Vasudeva Bhat Alison L. Allan Afshin Raouf The epithelial cells in an adult woman’s breast tissue are continuously replaced throughout their reproductive life during pregnancy and estrus cycles. Such extensive epithelial cell turnover is governed by the...
Sat Aug 24, 2019 03:00
Cancers, Vol. 11, Pages 1242: The PI3K/AKT/mTOR and CDK4/6 Pathways in Endocrine Resistant HR+/HER2− Metastatic Breast Cancer: Biological Mechanisms and New Treatments Cancers doi: 10.3390/cancers11091242 Authors: Daniele Presti Erica Quaquarini Endocrine-based treatments are the normal standard-of-care in women with hormone receptor-positive/Human Epidermal growth factor Receptor 2-negative metastatic breast cancer. Despite the well-known efficacy of these drugs as first-line therapies,...
Sat Aug 24, 2019 03:00
Cancers, Vol. 11, Pages 1238: Enrichment of Aldolase C Correlates with Low Non-Mutated IDH1 Expression and Predicts a Favorable Prognosis in Glioblastomas Cancers doi: 10.3390/cancers11091238 Authors: Chang Tsai Huang Chen Hsiao Tsai The aldolases family is one of the main enzymes involved in the process of glycolysis. Aldolase C (ALDOC), which belongs to the aldolase family, is found in normal brain tissue and is responsible for the repair of injured tissue. However,...
Fri Aug 23, 2019 03:00
Cancers, Vol. 11, Pages 1239: Trends in Overall Survival and Treatment Patterns in Two Large Population-Based Cohorts of Patients with Breast and Colorectal Cancer Cancers doi: 10.3390/cancers11091239 Authors: Abbema Vissers Vos-Geelen Lemmens Janssen-Heijnen Tjan-Heijnen Previous studies showed substantial improvement of survival rates in patients with cancer in the last two decades. However, lower survival rates have been reported for older patients compared to...
Fri Aug 23, 2019 03:00
Cancers, Vol. 11, Pages 1237: Risk Assessment of kINPen Plasma Treatment of Four Human Pancreatic Cancer Cell Lines with Respect to Metastasis Cancers doi: 10.3390/cancers11091237 Authors: Sander Bekeschus Eric Freund Chiara Spadola Angela Privat-Maldonado Christine Hackbarth Annemie Bogaerts Anke Schmidt Kristian Wende Klaus-Dieter Weltmann Thomas von Woedtke Claus-Dieter Heidecke Lars-Ivo Partecke André Käding Cold physical plasma has limited tumor...
Fri Aug 23, 2019 03:00
Cancers, Vol. 11, Pages 1236: Relevance of Non-Targeted Effects for Radiotherapy and Diagnostic Radiology; A Historical and Conceptual Analysis of Key Players Cancers doi: 10.3390/cancers11091236 Authors: Carmel Mothersill Andrej Rusin Colin Seymour Non-targeted effects (NTE) such as bystander effects or genomic instability have been known for many years but their significance for radiotherapy or medical diagnostic radiology are far from clear. Central to the issue are reported...
Fri Aug 23, 2019 03:00
Cancers, Vol. 11, Pages 1235: Cancer Diagnosis Using Deep Learning: A Bibliographic Review Cancers doi: 10.3390/cancers11091235 Authors: Khushboo Munir Hassan Elahi Afsheen Ayub Fabrizio Frezza Antonello Rizzi In this paper, we first describe the basics of the field of cancer diagnosis, which includes steps of cancer diagnosis followed by the typical classification methods used by doctors, providing a historical idea of cancer classification techniques to the readers. These...
Fri Aug 23, 2019 03:00
Cancers, Vol. 11, Pages 1234: Involvement of the Anterior Commissure in Early Glottic Cancer (Tis-T2): A Review of the Literature Cancers doi: 10.3390/cancers11091234 Authors: Martine Hendriksma Elisabeth V. Sjögren Background: The impact of the anterior commissure (AC) involvement on prognosis in laryngeal cancer remains a topic of discussion with inconsistent results in the literature. This review examines AC involvement as a prognostic factor in patients with early glottic cancer...
Fri Aug 23, 2019 03:00
Cancers, Vol. 11, Pages 1231: Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance Cancers doi: 10.3390/cancers11091231 Authors: Weihua Zhou Daniel R. Wahl Glioblastoma (GBM) is the most common and aggressive primary brain tumor and is nearly universally fatal. Targeted therapy and immunotherapy have had limited success in GBM, leaving surgery, alkylating chemotherapy and ionizing radiation as the standards of care. Like most cancers, GBMs...
Fri Aug 23, 2019 03:00
Cancers, Vol. 11, Pages 1233: The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing Cancers doi: 10.3390/cancers11091233 Authors: Hayley J. Luxton Benjamin S. Simpson Ian G. Mills Nicola R. Brindle Zeba Ahmed Vasilis Stavrinides Susan Heavey Stefan Stamm Hayley C. Whitaker Oncogenic metadherin is a key contributor to tumourigenesis with metadherin expression and cytoplasmic...
Fri Aug 23, 2019 03:00
Cells, Vol. 8, Pages 979: Neutrophil Extracellular Traps: Current Perspectives in the Eye Cells doi: 10.3390/cells8090979 Authors: Gibrán Alejandro Estúa-Acosta Rocío Zamora-Ortiz Beatriz Buentello-Volante Mariana García-Mejía Yonathan Garfias Neutrophil extracellular traps (NETs) have been the subject of research in the field of innate immunity since their first description more than a decade ago. Neutrophils are the first cells recruited at sites of inflammation, where...
03:00
Cells, Vol. 8, Pages 978: The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine Cells doi: 10.3390/cells8090978 Authors: Shiina Blancher Among the non-human primates used in experimental medicine, cynomolgus macaques (Macaca fascicularis hereafter referred to as Mafa) are increasingly selected for the ease with which they are maintained and bred in captivity. Macaques belong to Old World monkeys and are phylogenetically much closer to humans than rodents, which are still...
Mon Aug 26, 2019 03:00
Cells, Vol. 8, Pages 976: Physiology, Pathology and Regeneration of Salivary Glands Cells doi: 10.3390/cells8090976 Authors: Porcheri Mitsiadis Salivary glands are essential structures in the oral cavity. A variety of diseases, such as cancer, autoimmune diseases, infections and physical traumas, can alter the functionality of these glands, greatly impacting the quality of life of patients. To date, no definitive therapeutic approach can compensate the impairment of salivary glands,...
Mon Aug 26, 2019 03:00
Cells, Vol. 8, Pages 977: A Novel Computational Model for Predicting microRNA–Disease Associations Based on Heterogeneous Graph Convolutional Networks Cells doi: 10.3390/cells8090977 Authors: Li Liu Hu Que Yao Identifying the interactions between disease and microRNA (miRNA) can accelerate drugs development, individualized diagnosis, and treatment for various human diseases. However, experimental methods are time-consuming and costly. So computational approaches to predict...
Mon Aug 26, 2019 03:00
Cells, Vol. 8, Pages 975: Insights into Early Recovery from Influenza Pneumonia by Spatial and Temporal Quantification of Putative Lung Regenerating Cells and by Lung Proteomics Cells doi: 10.3390/cells8090975 Authors: Ong Tan Ler Gunaratne Choi Seet Chow During influenza pneumonia, the alveolar epithelial cells of the lungs are targeted by the influenza virus. The distal airway stem cells (DASCs) and proliferating alveolar type II (AT2) cells are reported to...
Mon Aug 26, 2019 03:00
Cells, Vol. 8, Pages 974: Lipid Droplets in Disease Cells doi: 10.3390/cells8090974 Authors: Paul Dalhaimer Lipid droplets (LDs) are a crucial part of lipid storage; thus, they are important players in a variety of diseases that are affected by lipid imbalances such as obesity, fatty liver disease, type 2 diabetes, Alzheimer’s disease, cardiovascular disease, and cancer [...]
Mon Aug 26, 2019 03:00
Cells, Vol. 8, Pages 973: Mechanisms and Pathophysiological Roles of the ATG8 Conjugation Machinery Cells doi: 10.3390/cells8090973 Authors: Lystad Simonsen Since their initial discovery around two decades ago, the yeast autophagy-related (Atg)8 protein and its mammalian homologues of the light chain 3 (LC3) and γ-aminobutyric acid receptor associated proteins (GABARAP) families have been key for the tremendous expansion of our knowledge about autophagy, a process in which...
Sun Aug 25, 2019 03:00
Cells, Vol. 8, Pages 972: Somatic Mutations of lats2 Cause Peripheral Nerve Sheath Tumors in Zebrafish Cells doi: 10.3390/cells8090972 Authors: Zachary J. Brandt Paula N. North Brian A. Link The cellular signaling pathways underlying peripheral nerve sheath tumor (PNST) formation are poorly understood. Hippo signaling has been recently implicated in the biology of various cancers, and is thought to function downstream of mutations in the known PNST driver, NF2. Utilizing CRISPR-Cas9...
Sun Aug 25, 2019 03:00
Cells, Vol. 8, Pages 970: JNK1 Induces Notch1 Expression to Regulate Genes Governing Photoreceptor Production Cells doi: 10.3390/cells8090970 Authors: Pan Hu Wang Zhou Zhang Wang Wang c-Jun N-terminal kinases (JNKs) regulate cell proliferation and differentiation via phosphorylating such transcription factors as c-Jun. The function of JNKs in retinogenesis remains to be elucidated. Here, we report that knocking out Jnk1, but not Jnk2, increased the number of...
Sat Aug 24, 2019 03:00
Cells, Vol. 8, Pages 971: PI3K (Phosphatidylinositol 3-Kinase) Activation and Endothelial Cell Proliferation in Patients with Hemorrhagic Hereditary Telangiectasia Type 1 Cells doi: 10.3390/cells8090971 Authors: Adriana Iriarte Agnes Figueras Pau Cerdà José María Mora Anna Jucglà Rosa Penín Francesc Viñals Antoni Riera-Mestre Hemorrhagic hereditary telangiectasia (HHT) type 2 patients have increased activation of the phosphatidylinositol 3-kinase (PI3K) signaling...
Sat Aug 24, 2019 03:00
Cells, Vol. 8, Pages 969: TGFβ/BMP Signaling Pathway in Cartilage Homeostasis Cells doi: 10.3390/cells8090969 Authors: Nathalie G.M. Thielen Peter M. van der Kraan Arjan P.M. van Caam Cartilage homeostasis is governed by articular chondrocytes via their ability to modulate extracellular matrix production and degradation. In turn, chondrocyte activity is regulated by growth factors such as those of the transforming growth factor β (TGFβ) family. Members of this...
Sat Aug 24, 2019 03:00
Cells, Vol. 8, Pages 968: Extracellular Vesicles: A Possible Link between HIV and Alzheimer’s Disease-Like Pathology in HIV Subjects? Cells doi: 10.3390/cells8090968 Authors: Sunitha Kodidela Kelli Gerth Sanjana Haque Yuqing Gong Saifudeen Ismael Ajay Singh Ishrat Tauheed Santosh Kumar The longevity of people with HIV/AIDS has been prolonged with the use of antiretroviral therapy (ART). The age-related complications, especially cognitive deficits, rise as HIV patients...
Sat Aug 24, 2019 03:00
Cells, Vol. 8, Pages 967: Targeting Metabolic Reprogramming in Acute Myeloid Leukemia Cells doi: 10.3390/cells8090967 Authors: Isabel Castro Belém Sampaio-Marques Paula Ludovico The cancer metabolic reprogramming allows the maintenance of tumor proliferation, expansion and survival by altering key bioenergetics, biosynthetic and redox functions to meet the higher demands of tumor cells. In addition, several metabolites are also needed to perform signaling functions that further...
Sat Aug 24, 2019 03:00
Cells, Vol. 8, Pages 966: Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics Cells doi: 10.3390/cells8090966 Authors: Katarina Psenakova Klara Kohoutova Veronika Obsilova Michael Ausserlechner Vaclav Veverka Tomas Obsil FOXO transcription factors regulate cellular homeostasis, longevity and response to stress. FOXO1 (also known as FKHR) is a key regulator of hepatic glucose production and lipid metabolism, and its specific inhibition...
Sat Aug 24, 2019 03:00
Cells, Vol. 8, Pages 965: Adipose Mesenchymal Extracellular Vesicles as Alpha-1-Antitrypsin Physiological Delivery Systems for Lung Regeneration Cells doi: 10.3390/cells8090965 Authors: Bari Ferrarotti Di Silvestre Grisoli Barzon Balderacchi Torre Rossi Mauri Corsico Perteghella Accumulating evidence shows that Mesenchymal Stem/Stromal Cells (MSCs) exert their therapeutic effects by the release of secretome, made of both soluble proteins and nano/microstructured...
Fri Aug 23, 2019 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου