Antibiotics, Vol. 8, Pages 129: Antibiotic Resistance: From the Bench to Patients Antibiotics doi: 10.3390/antibiotics8030129 Authors: Márió Gajdács Fernando Albericio The discovery and subsequent clinical introduction of antibiotics is one of the most important game-changers in the history of medicine [...]
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Antibiotics, Vol. 8, Pages 128: Staphylococcus aureus Infections in Malaysia: A Review of Antimicrobial Resistance and Characteristics of the Clinical Isolates, 1990–2017 Antibiotics doi: 10.3390/antibiotics8030128 Authors: Ainal Mardziah Che Hamzah Chew Chieng Yeo Suat Moi Puah Kek Heng Chua Ching Hoong Chew Staphylococcus aureus is an important nosocomial pathogen and its multidrug resistant strains, particularly methicillin-resistant S. aureus (MRSA), poses a serious threat...
Mon Aug 26, 2019 03:00
Antibiotics, Vol. 8, Pages 127: Direct Measurement of Performance: A New Era in Antimicrobial Stewardship Antibiotics doi: 10.3390/antibiotics8030127 Authors: Majdi N. Al-Hasan Hana Rac Winders P. Brandon Bookstaver Julie Ann Justo For decades, the performance of antimicrobial stewardship programs (ASPs) has been measured by incidence rates of hospital-onset Clostridioides difficile and other infections due to multidrug-resistant bacteria. However, these represent indirect and...
Sat Aug 24, 2019 03:00
Antibodies, Vol. 8, Pages 45: Back-To-Germline (B2G) Procedure for Antibody Devolution Antibodies doi: 10.3390/antib8030045 Authors: Schrade Bujotzek Spick Wagner Goerl Wezler Georges Kontermann Brinkmann Bispecific antibodies (bsAbs) with avidity-enhanced specificity can be used to address target cells with increased specificity, ideally binding efficiently to cells that express two cognate antigens, yet not to cells that express only one of those. Building...
Mon Aug 26, 2019 03:00
Antibodies, Vol. 8, Pages 44: Phage Display Libraries for Antibody Therapeutic Discovery and Development Antibodies doi: 10.3390/antib8030044 Authors: Juan C. Almagro Martha Pedraza-Escalona Hugo Iván Arrieta Sonia Mayra Pérez-Tapia Phage display technology has played a key role in the remarkable progress of discovering and optimizing antibodies for diverse applications, particularly antibody-based drugs. This technology was initially developed by George Smith in the mid-1980s...
Fri Aug 23, 2019 03:00
Antioxidants, Vol. 8, Pages 342: Anti-Inflammatory, Anti-Arthritic and Anti-Nociceptive Activities of Nigella sativa Oil in a Rat Model of Arthritis Antioxidants doi: 10.3390/antiox8090342 Authors: Cinzia Nasuti Donatella Fedeli Laura Bordoni Marco Piangerelli Maurizio Servili Roberto Selvaggini Rosita Gabbianelli This study investigated the preventive efficacy of the crude oil extracted from Nigella sativa seeds in a rat model of arthritis induced by using complete...
Sun Aug 25, 2019 03:00
Antioxidants, Vol. 8, Pages 341: Vitamin D Attenuates Oxidative Damage and Inflammation in Retinal Pigment Epithelial Cells Antioxidants doi: 10.3390/antiox8090341 Authors: Ali Mohammad Tohari Reem Hasaballah Alhasani Lincoln Biswas Sarita Rani Patnaik James Reilly Zhihong Zeng Xinhua Shu Age-related macular degeneration (AMD), the most common visual disorder in elderly people, is characterized by the formation of deposits beneath the retinal pigment epithelium (RPE)...
Sat Aug 24, 2019 03:00
Antioxidants, Vol. 8, Pages 340: Increase of 4-Hydroxybenzoic, a Bioactive Phenolic Compound, after an Organic Intervention Diet Antioxidants doi: 10.3390/antiox8090340 Authors: Sara Hurtado-Barroso Paola Quifer-Rada María Marhuenda-Muñoz Jose Fernando Rinaldi de Alvarenga Anna Tresserra-Rimbau Rosa M. Lamuela-Raventós Consumption of organic products is increasing yearly due to perceived health-promoting qualities. Several studies have shown higher amounts of phytochemicals...
Sat Aug 24, 2019 03:00
Antioxidants, Vol. 8, Pages 339: Polyphenolic Composition and Antioxidant Activity of Uncaria tomentosa Commercial Bark Products Antioxidants doi: 10.3390/antiox8090339 Authors: Mirtha Navarro Elizabeth Arnaez Ileana Moreira Alonso Hurtado Daniela Monge Maria Monagas Uncaria tomentosa, which is widely commercialized as an herbal medicine, constitutes an important source of secondary metabolites with diverse biological activities. For instance, we have previously reported,...
Fri Aug 23, 2019 03:00
Antioxidants, Vol. 8, Pages 338: Impact of Melatonin Supplementation in Women with Unexplained Infertility Undergoing Fertility Treatment Antioxidants doi: 10.3390/antiox8090338 Authors: Javier Espino María Macedo Graciela Lozano Águeda Ortiz Carmina Rodríguez Ana B. Rodríguez Ignacio Bejarano Unexplained infertility occurs when common causes for a couple’s inability to conceive have been excluded. Although origins of idiopathic infertility are still unclear,...
Fri Aug 23, 2019 03:00
Arts, Vol. 8, Pages 108: Weegee, Standing By Arts doi: 10.3390/arts8030108 Authors: Jason Hill Informed by an interesting recent infrastructuralist turn in media studies and by an expanding sense among historians and theorists of photography of what might properly delimit the photographer’s toolkit, this essay considers aspects of the photography of Weegee, as these can be observed to issue from that photographer’s deep professional embeddedness in specific media-infrastructural...
Mon Aug 26, 2019 03:00
Arts, Vol. 8, Pages 107: Situational Ecumenism: The Architecture of Jewish Student Centers on American University Campuses Arts doi: 10.3390/arts8030107 Authors: Jeremy Kargon Since the start of the 20th century, the presence of Jewish students on American university campuses required accommodation of their religious practices. Jewish activities, including prayer, took place in existing campus buildings designed for other purposes. Eventually, at some universities, facilities were built...
Fri Aug 23, 2019 03:00
Atmosphere, Vol. 10, Pages 495: Use of Citizen Science-Derived Data for Spatial and Temporal Modeling of Particulate Matter near the US/Mexico Border Atmosphere doi: 10.3390/atmos10090495 Authors: Graeme N. Carvlin Humberto Lugo Luis Olmedo Ester Bejarano Alexa Wilkie Dan Meltzer Michelle Wong Galatea King Amanda Northcross Michael Jerrett Paul B. English Jeff Shirai Michael Yost Timothy Larson Edmund Seto This paper describes the use of citizen...
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Atmosphere, Vol. 10, Pages 494: Spatio-Temporal Variations of Multiple Primary Air Pollutants Emissions in Beijing of China, 2006–2015 Atmosphere doi: 10.3390/atmos10090494 Authors: Yifeng Xue Shihao Zhang Zhen Zhou Kun Wang Kaiyun Liu Xiaoyan Wang Aijun Shi Kangli Xu Hezhong Tian Air pollution in Beijing, China has attracted continuous worldwide public attention along with the rapid urbanization of the city. By implementing a set of air pollution mitigation measures,...
Mon Aug 26, 2019 03:00
Atmosphere, Vol. 10, Pages 491: Wind Stress in the Coastal Zone: Observations from a Buoy in Southwestern Norway Atmosphere doi: 10.3390/atmos10090491 Authors: Martin Flügge Mostafa Bakhoday-Paskyabi Joachim Reuder Omar El Guernaoui Several studies have focused on the investigation of the wind stress in open ocean conditions where coastal processes were negligible. However, the direction and magnitude of the wind stress vector in coastal areas are still not fully known due to...
Mon Aug 26, 2019 03:00
Atmosphere, Vol. 10, Pages 493: New Particle Formation: A Review of Ground-Based Observations at Mountain Research Stations Atmosphere doi: 10.3390/atmos10090493 Authors: Karine Sellegri Clemence Rose Angela Marinoni Angelo Lupi Alfred Wiedensohler Marcos Andrade Paolo Bonasoni Paolo Laj New particle formation (NPF) was predicted to contribute to a major fraction of free tropospheric particle number and cloud condensation nuclei (CCN) concentrations by global models....
Mon Aug 26, 2019 03:00
Atmosphere, Vol. 10, Pages 492: Characterising Particulate Organic Nitrogen at A Savannah-Grassland Region in South Africa Atmosphere doi: 10.3390/atmos10090492 Authors: Wanda Booyens Pieter G. Van Zyl Johan P. Beukes Jose Ruiz-Jimenez Matias Kopperi Marja-Liisa Riekkola Ville Vakkari Miroslav Josipovic Markku Kulmala Lauri Laakso Although atmospheric organic N compounds are considered to be important, especially in new particle formation and their contribution...
Mon Aug 26, 2019 03:00
Atmosphere, Vol. 10, Pages 490: Spatial Predictability of Heavy Rainfall Events in East China and the Application of Spatial-Based Methods of Probabilistic Forecasting Atmosphere doi: 10.3390/atmos10090490 Authors: Xiaoran Zhuang Haonan Zhu Jinzhong Min Liu Zhang Naigen Wu Zhipeng Wu Shiqi Wang One of the major issues in developing convective-scale ensemble forecasts is what is widely known as under-dispersion. This can be addressed through the consideration of spatial...
Mon Aug 26, 2019 03:00
Atmosphere, Vol. 10, Pages 489: Water Pathways for the Hindu-Kush-Himalaya and an Analysis of Three Flood Events Atmosphere doi: 10.3390/atmos10090489 Authors: Robert Boschi Valerio Lucarini The climatology of major sources and pathways of moisture for three locales along the Hindu-Kush-Himalayan region are examined, by use of Lagrangian methods applied to the ERA-Interim dataset, over the period from 1980 to 2016 for both summer (JJA) and winter (NDJ) periods. We also investigate...
Sun Aug 25, 2019 03:00
Atmosphere, Vol. 10, Pages 488: VAPOR: A Visualization Package Tailored to Analyze Simulation Data in Earth System Science Atmosphere doi: 10.3390/atmos10090488 Authors: Shaomeng Li Stanislaw Jaroszynski Scott Pearse Leigh Orf John Clyne Visualization is an essential tool for analysis of data and communication of findings in the sciences, and the Earth System Sciences (ESS) are no exception. However, within ESS, specialized visualization requirements and data models, particularly...
Sun Aug 25, 2019 03:00
Atmosphere, Vol. 10, Pages 487: Measuring Regional Atmospheric CO2 Concentrations in the Lower Troposphere with a Non-Dispersive Infrared Analyzer Mounted on a UAV, Ogata Village, Akita, Japan Atmosphere doi: 10.3390/atmos10090487 Authors: Takashi Chiba Yumi Haga Makoto Inoue Osamu Kiguchi Takeshi Nagayoshi Hirokazu Madokoro Isamu Morino We have developed a simple measuring system prototype that uses an unmanned aerial vehicle (UAV) and a non-dispersive infrared (NDIR)...
Fri Aug 23, 2019 03:00
Behavioral Sciences, Vol. 9, Pages 92: Sequential Multilingualism and Cognitive Abilities: Preliminary Data on the Contribution of Language Proficiency and Use in Different Modalities Behavioral Sciences doi: 10.3390/bs9090092 Authors: Marlijne Boumeester Marije C. Michel Valantis Fyndanis This exploratory study focuses on sequential bi-/multilinguals (specifically, nonimmigrant young Dutch native speakers who learned at least one foreign language (FL) at or after the age of 5)...
Mon Aug 26, 2019 03:00
Bioengineering, Vol. 6, Pages 74: Biotechnological Production of Poly(3-Hydroxybutyrate-co-4-Hydroxybutyrate-co-3-Hydroxyvalerate) Terpolymer by Cupriavidus sp. DSM 19379 Bioengineering doi: 10.3390/bioengineering6030074 Authors: Kucera Novackova Pernicova Sedlacek Obruca The terpolymer of 3-hydroxybutyrate (3HB), 3-hydroxyvalerate (3HV), and 4-hydroxybutyrate (4HB) was produced employing Cupriavidus sp. DSM 19379. Growth in the presence of γ-butyrolactone,...
Mon Aug 26, 2019 03:00
Bioengineering, Vol. 6, Pages 73: Metastasis of Cancer Stem Cells Developed in the Microenvironment of Hepatocellular Carcinoma Bioengineering doi: 10.3390/bioengineering6030073 Authors: Said M. Afify Ghmkin Hassan Amira Osman Anna Sanchez Calle Hend M Nawara Maram Hussein Zahra Samah EL-Ghlban Hager Mansour Md Jahangir Alam Hagar A Abu Quora Juan Du Akimasa Seno Yoshiaki Iwasaki Masaharu Seno Metastasis develops when cancer cells spread from the...
Fri Aug 23, 2019 03:00
Biology, Vol. 8, Pages 61: Microsyntenic Clusters Reveal Conservation of lncRNAs in Chordates Despite Absence of Sequence Conservation Biology doi: 10.3390/biology8030061 Authors: Carlos Herrera-Úbeda Marta Marín-Barba Enrique Navas-Pérez Jan Gravemeyer Beatriz Albuixech-Crespo Grant N. Wheeler Jordi Garcia-Fernàndez Homologous long non-coding RNAs (lncRNAs) are elusive to identify by sequence similarity due to their fast-evolutionary rate. Here we develop LincOFinder,...
Sat Aug 24, 2019 03:00
Biomedicines, Vol. 7, Pages 63: Herbal Tea for the Management of Pharyngitis: Inhibition of Streptococcus pyogenes Growth and Biofilm Formation by Herbal Infusions Biomedicines doi: 10.3390/biomedicines7030063 Authors: Niluni M. Wijesundara H. P. Vasantha Rupasinghe Herbal teas are becoming popular as functional beverages due to their various health promotional properties. This study aimed at assessing 13 hot water infusions (HWIs) from different herbs against streptococcal pharyngitis...
Sat Aug 24, 2019 03:00
Biomolecules, Vol. 9, Pages 415: Polysaccharide Fraction Extracted from Endophytic Fungus Trichoderma atroviride D16 Has an Influence on the Proteomics Profile of the Salvia miltiorrhiza Hairy Roots Biomolecules doi: 10.3390/biom9090415 Authors: Peng Ming Zhai Zhang Rahman Wu Qin Han Trichoderma atroviride develops a symbiont relationship with Salvia miltiorrhiza and this association involves a number of signaling pathways and proteomic responses between...
Mon Aug 26, 2019 03:00
Biomolecules, Vol. 9, Pages 416: The Therapeutic Potential of Nanoparticles to Reduce Inflammation in Atherosclerosis Biomolecules doi: 10.3390/biom9090416 Authors: Gorabi Kiaie Reiner Carbone Montecucco Sahebkar Chronic inflammation is one of the main determinants of atherogenesis. The traditional medications for treatment of atherosclerosis are not very efficient in targeting atherosclerotic inflammation. Most of these drugs are non-selective, anti-inflammatory...
Mon Aug 26, 2019 03:00
Biomolecules, Vol. 9, Pages 414: The Inhibitory Effect of Cordycepin on the Proliferation of MCF-7 Breast Cancer Cells, and its Mechanism: An Investigation Using Network Pharmacology-Based Analysis Biomolecules doi: 10.3390/biom9090414 Authors: Lee Lee Jung Kwon Kim Hwang Kim Lee Kang Cordyceps militaris is a well-known medicinal mushroom. It is non-toxic and has clinical health benefits including cancer inhibition. However, the anticancer effects of...
Mon Aug 26, 2019 03:00
Biomolecules, Vol. 9, Pages 412: Procyanidin B2 3″-O-gallate Isolated from Reynoutria elliptica Prevents Glutamate-Induced HT22 Cell Death by Blocking the Accumulation of Intracellular Reactive Oxygen Species Biomolecules doi: 10.3390/biom9090412 Authors: Ji Hoon Song Sil Kim Jae Sik Yu Do Hwi Park Song-Yi Kim Ki Sung Kang Sullim Lee Ki Hyun Kim In this study, we examined the neuroprotective effects of MeOH extract and bioactive compounds obtained from Reynoutria...
Mon Aug 26, 2019 03:00
Biomolecules, Vol. 9, Pages 413: Serum Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) Level as a Potential Biomarker of Cholangiocarcinoma Biomolecules doi: 10.3390/biom9090413 Authors: Doungdean Tummanatsakun Tanakorn Proungvitaya Sittiruk Roytrakul Temduang Limpaiboon Sopit Wongkham Chaisiri Wongkham Atit Silsirivanit Ongart Somintara Sakkarn Sangkhamanon Siriporn Proungvitaya Diagnostic and/or prognostic biomarkers for cholangiocarcinoma (CCA) are...
Mon Aug 26, 2019 03:00
Biomolecules, Vol. 9, Pages 411: Synthesis and Characterization of FITC Labelled Ruthenium Dendrimer as a Prospective Anticancer Drug Biomolecules doi: 10.3390/biom9090411 Authors: Sylwia Michlewska Małgorzata Kubczak Marta Maroto-Díaz Natalia Sanz del Olmo Paula Ortega Dzmitry Shcharbin Rafael Gomez Ramirez Francisco Javier de la Mata Maksim Ionov Maria Bryszewska Metallodendrimers—dendrimers with included metals—are widely investigated...
Sun Aug 25, 2019 03:00
Biomolecules, Vol. 9, Pages 410: The Breakthrough of Biosimilars: A Twist in the Narrative of Biological Therapy Biomolecules doi: 10.3390/biom9090410 Authors: Eva Rahman Kabir Shannon Sherwin Moreino Mohammad Kawsar Sharif Siam The coming wave of patent expiries of first generation commercialized biotherapeutical drugs has seen the global market open its doors to close copies of these products. These near perfect substitutes, which are termed as “biosimilars”,...
Sat Aug 24, 2019 03:00
Biomolecules, Vol. 9, Pages 409: Carbidopa Alters Tryptophan Metabolism in Breast Cancer and Melanoma Cells Leading to the Formation of Indole-3-Acetonitrile, a Pro-Proliferative Metabolite Biomolecules doi: 10.3390/biom9090409 Authors: Diana Duarte Filipa Amaro Isabel Silva Dany Silva Paula Fresco José C. Oliveira Henrique Reguengo Jorge Gonçalves Nuno Vale Carbidopa is used for the treatment of Parkinson’s disease (PD) as an inhibitor of DOPA decarboxylase,...
Sat Aug 24, 2019 03:00
Biomolecules, Vol. 9, Pages 408: Antioxidative Properties of Melanins and Ommochromes from Black Soldier Fly Hermetia illucens Biomolecules doi: 10.3390/biom9090408 Authors: Nina Ushakova Alexander Dontsov Natalia Sakina Alexander Bastrakov Mikhail Ostrovsky A comparative study of melanin and ommochrome-containing samples, isolated from the black soldier fly (BSF) by enzymatic hydrolysis, alkaline and acid alcohol extraction or by acid hydrolysis, was carried out. Melanin...
Fri Aug 23, 2019 03:00
Biomolecules, Vol. 9, Pages 407: The Inhibitory Effect of Cordycepin on the Proliferation of MCF-7 Breast Cancer Cells, and its Mechanism: An Investigation Using Network Pharmacology-Based Analysis Biomolecules doi: 10.3390/biom9090407 Authors: Lee Lee Jung Kwon Kim Hwang Kim Lee Kang Cordyceps militaris is a well-known medicinal mushroom. It is non-toxic and has clinical health benefits including cancer inhibition. However, the anticancer effects of...
Fri Aug 23, 2019 03:00
Biomolecules, Vol. 9, Pages 405: Antibacterial Effect of Carbosilane Metallodendrimers in Planktonic Cells of Gram-Positive and Gram-Negative Bacteria and Staphylococcus aureus Biofilm Biomolecules doi: 10.3390/biom9090405 Authors: Celia Llamazares Natalia Sanz del Olmo Paula Ortega Rafael Gómez Juan Soliveri F. Javier de la Mata Sandra García-Gallego José Luis Copa-Patiño Antibiotic resistance is currently one of the main threats to public health security. Biofilm...
Fri Aug 23, 2019 03:00
Biomolecules, Vol. 9, Pages 406: Creatine for the Treatment of Depression Biomolecules doi: 10.3390/biom9090406 Authors: Brent M. Kious Douglas G. Kondo Perry F. Renshaw Depressed mood, which can occur in the context of major depressive disorder, bipolar disorder, and other conditions, represents a serious threat to public health and wellness. Conventional treatments are not effective for a significant proportion of patients and interventions that are often beneficial for treatment-refractory...
Fri Aug 23, 2019 03:00
Biosensors, Vol. 9, Pages 102: Overview of Optical and Electrochemical Alkaline Phosphatase (ALP) Biosensors: Recent Approaches in Cells Culture Techniques Biosensors doi: 10.3390/bios9030102 Authors: Balbaied Moore Alkaline phosphatase (ALP), which catalyzes the dephosphorylation process of proteins, nucleic acids, and small molecules, can be found in a variety of tissues (intestine, liver, bone, kidney, and placenta) of almost all living organisms. This enzyme has been extensively...
Fri Aug 23, 2019 03:00
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