- Adrenal venous sampling in patients with ACTH-independent hypercortisolismAbstract Purpose To study the usefulness of adrenal venous sampling (AVS) in distinguishing unilateral from bilateral cortisol production in patients with ACTH-independent hypercortisolism and bilateral adrenal lesions, or morphologically normal adrenal glands. Methods A retrospective analysis of ten cons
- Chimeric antigen receptor modified T cell (CAR-T) co-expressed with ICOSL-41BB promote CAR-T proliferation and tumor rejectionPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Wei Hu, Xin Huang, Xingyue Huang, Wenwei Chen, Lidan Hao, Zubing ChenAbstractT cells edited by chimeric antigen receptors (CAR) have shown great potential in the treatment of tumors, especially malignant blood tumors. However, there remain many obstacles in the CAR-T therapy against solid tumors, such as the expansion of CAR-T cells ex vivo and the exhau
- Proteomic analysis of therapeutic effects of Qingyi pellet on rodent severe acute pancreatitis-associated lung injuryPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Zhongwei Sun, Lei Li, Jialin Qu, Hailong Li, Hailong ChenAbstractSevere acute pancreatitis (SAP) is a common acute clinical abdomen syndrome which is characterized by pancreatic self-digestion. As one of the major complication of SAP, acute lung injury is the main reason of high mortality. The traditional Chinese medicine Qingyi pellet (QYT) has been wid
- MiR-377 mediates the expression of Syk to attenuate atherosclerosis lesion development in ApoE<sup>−/−</sup> micePublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Yinsheng Guo, Suli Huang, Yue Ma, Jin Zhang, Ying Wen, Li Zhou, Guanxiang Yuan, Jinquan ChengAbstractAtherosclerosis (AS), a severe disease characterized by an accumulation of lipids and fibers in the large arteries, is the most important contributor to ischemic stroke (IS). Although microRNAs (miRNAs) have been found in circulating blood, the role of mi
- A natural small molecule induces megakaryocytic differentiation and suppresses leukemogenesis through activation of PKCδ/ERK1/2 signaling pathway in erythroleukemia cellsPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Jue Yang, Jianfei Qiu, Yong Hu, Yongqiang Zhang, Li Chen, Qun Long, Juan Chen, Jingrui Song, Qing Rao, Yanmei Li, Wei Gu, Xiaojiang HaoAbstractKaempferol-3-O-rhamnoside (KOR) has multiple potency involved in anti-cancer, anti-inflammatory and antibacterial actions. However, the potential roles of KOR and the analogues isolated from the leaves of Cycloca
- Long non-coding RNA LUCAT1 promotes proliferation and invasion in gastric cancer by regulating miR-134-5p/YWHAZ axisPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Junlin Chi, Tonglei Liu, Chengmin Shi, Huayou Luo, Zhizhong Wu, Binghong Xiong, Shuang Liu, Yujian ZengAbstractPurposeThe aim of this study was to research the function of lncRNA LUCAT1 in gastric cancer.MethodsHuman gastric cancer tissues and paracancer tissues were obtained from 98 patients undergoing surgical resection in our hospital. The human gastr
- LncRNA CPS1-IT1 serves as anti-oncogenic role in gliomaPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Hengsan Chen, Qiang Li, Jin Liang, Ming Jin, Anqing LuAbstractCarbamoyl-phosphate synthetase 1 intronic transcript 1 (CPS1-IT1) is identified recently as a novel tumor suppressive long non-coding RNA (lncRNA). However, the expression status and clinical significance of CPS1-IT1 expression remained unknown in glioma. In our study, we observed CPS1-IT1 le
- Efficacy evaluation of Qingyan formulation in a smoking environment and screening of anti-inflammatory compoundsPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Qingxin Cui, Fang Ma, Jin Tao, Min Jiang, Gang Bai, Guoan LuoAbstractQingyan formulation (QF) is a common preparation that is often used to control inflammation in the haze environment. However, the efficacy and effective constituents of QF are still uncertain and difficult to identify. This paper aims to evaluate the efficacy by simulating a haze envir
- Irisin alleviates pulmonary epithelial barrier dysfunction in sepsis-induced acute lung injury via activation of AMPK/SIRT1 pathwaysPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Xinyi Li, Muhammad Jamal, Peipei Guo, Zhao Jin, Feng Zheng, Xuemin Song, Jia Zhan, Huisheng WuAbstractObjectiveAlveolar epithelial barrier dysfunction in response to inflammatory reaction contributes to pulmonary edema in acute lung injury(ALI).Irisin,a newly-found myokine,exerts the anti-inflammatory effects. This study aims to investigate the protectiv
- Embelin can protect mice from thioacetamide-induced acute liver injuryPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Huafeng Wang, Huan Zhang, Yanxia Wang, Luhong Yang, Dong WangAbstractBackground/aimsEmbelin is an active component isolated from Embelia ribes Burm. In this study, we explored the protective effects of embelin on acute liver injury.MethodsAn animal model of acute liver injury was established via administration of a single injection of thioacetamide (TAA
- MicroRNA-375 regulates oocyte <em>in vitro</em> maturation by targeting ADAMTS1 and PGR in bovine cumulus cellsPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Jianrui Zhang, Yichun Guan, Chunyan Shen, Luwen Zhang, Xingling WangAbstractMicroRNAs (miRNAs) have attracted increasing attention for their function in oocyte in vitro maturation (IVM). In this study, we aimed to explore the functional role and underlying mechanism of miR-375 in oocyte IVM. Cumulus-oocyte complexes (COCs) were cultured in standard cell
- Ricolinostat (ACY-1215) inhibits VEGF expression <em>via</em>PI3K/AKT pathway and promotes apoptosis in osteoarthritic osteoblastsPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Li lei, Yin zongshengAbstractOsteoarthritis (OA) is involved in these pathophysiological changes of articular cartilage, subchondral bone and synovium. As a selective HDAC6 inhibitor, Ricolinostat (ACY-1215) has demonstrated chondroprotective effects in OA. However, its efficacy remains unclear in subchondral bone. In this study, we found that the mRNA a
- Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in micePublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): João Rocha, Rosa Direito, Ana Lima, Joana Mota, Margarida Gonçalves, Maria Paula Duarte, João Solas, Bruno Felício Peniche, Adelaide Fernandes, Rui Pinto, Ricardo Boavida Ferreira, Bruno Sepodes, Maria-Eduardo FigueiraAbstractPurposeLittle is known about the pharmacological effects of the phenolic compounds of Pennyroyal (Men
- <em>Guizhi-Shaoyao-Zhimu</em> decoction possesses anti-arthritic effects on type II collagen-induced arthritis in rats <em>via</em> suppression of inflammatory reactions, inhibition of invasion & migration and induction of apoptosis in synovial fibroblastsPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Qing Zhang, Wei Peng, Shujun Wei, Daneng Wei, Ruolan Li, Jia Liu, Lanyu Peng, Shuang Yang, Yongxiang Gao, Chunjie Wu, Xufeng PuAbstractBackgroundRheumatoid arthritis (RA) is a known intractable chronic inflammatory disease of synovial joints characterized by hyperplasia and consecutive inflammation with a high prevalence.Guizhi-Shaoyao-Zhimu (GSZD) is th
- RAD54B potentiates tumor growth and predicts poor prognosis of patients with luminal A breast cancerPublication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Zeyu Zhang, Xiaoting Li, Yingyan Han, Teng Ji, Xiaoyuan Huang, Qinglei Gao, Ding MaAbstractRAD54B, a human paralog of RAD54 L, belongs to the SW12/SNF2 superfamily of helicases. Up to now, few studies have reported the role of RAD54B in breast cancer (BC). In this study, we reported that RAD54B was amplified and the expression of RAD54B was elevat
- Common variable immunodeficiency-associated endotoxemia promotes early commitment to the T follicular lineagePublication date: Available online 22 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Carole Le Coz, Bertram Bengsch, Caroline Khanna, Melissa Trofa, Takuya Ohtani, Brian E. Nolan, Sarah E. Henrickson, Michele P. Lambert, Taylor Olmsted Kim, Jenny M. Despotovic, Scott Feldman, Olajumoke O. Fadugba, Patricia Takach, Melanie Ruffner, Soma Jyonouchi, Jennifer Heimall, Kathleen E. Sullivan, E.John Wherry, Neil RombergAbstract
- No Marked Manuscript has been provided as this manuscript has been reformatted from an Original Article to a Letter to the Editor.Publication date: Available online 22 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Jian Luo, Yanqiu Wu, Rahul Shrimanker, Simei Go, Yuan Ye, Clare Hardman, Janina Nahler, Yi-Ling Chen, Linda Stöger, Ni Zeng, Wei Liu, Lara Reed, Aviva M. Tolkovsky, Paul Klenerman, Graham Ogg, Ian D. Pavord, Luzheng Xue
- A T cell-myeloid IL-10 axis regulates pathogenic IFN-γ-dependent immunity in a mouse model of type 2-low asthmaPublication date: Available online 22 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): William J. Branchett, Helen Stölting, Robert A. Oliver, Simone A. Walker, Franz Puttur, Lisa G. Gregory, Leona Gabryšová, Mark S. Wilson, Anne O’Garra, Clare M. LloydBackgroundAlthough originally defined as a type 2 (T2) immune-mediated condition, non-T2 cytokines, such as IFN-γ and IL-17A, have been implic
- Deriving individual threshold doses from clinical food challenge data for population risk assessment of food allergensPublication date: Available online 22 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Joost Westerhout, Joseph L. Baumert, W. Marty Blom, Katrina J. Allen, Barbara Ballmer-Weber, René W.R. Crevel, Anthony E.J. Dubois, Montserrat Fernández-Rivas, Matthew J. Greenhawt, Jonathan O’B Hourihane, Jennifer J. Koplin, Astrid G. Kruizinga, Thuy-My Le, Hugh A. Sampson, Wayne G. Shreffler, Paul J. Turner, Steve L
- Osteomalacia secondary to delayed diagnosis of a maxillary mesenchymal tumourPublication date: Available online 21 August 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): L. Nakhleh, S. Zink, J.M. Raguin, T. Raguin
- Tamoxifen and Sulphoraphane for the breast cancer management: A synergistic nanomedicine approachPublication date: Available online 22 August 2019Source: Medical HypothesesAuthor(s): Bharti Mangla, Yub Raj Neupane, Archu Singh, Kanchan KohliAbstractBreast cancer is second most leading cause of death in all over the world and not only limited to the females. Tamoxifen has been considered as the gold line therapy for estrogen receptor positive breast cancer. However, this chemopreventive approach has been focused at individuals in high risk g
- NAD+ cleavage activity by animal and plant TIR domains in cell death pathways SARM1 (sterile...NAD+ cleavage activity by animal and plant TIR domains in cell death pathwaysSARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (NAD+) during Wallerian degeneration associated with neuropathies. Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors recognize pathogen effector proteins and trigger localized cell death to restrict pathogen infection.
- Selective Targeting of Signet Ring Cell AdenocarcinomasPublication date: Available online 22 August 2019Source: Medical HypothesesAuthor(s): Abdullah OlgunAbstractMany epithelial tumors, especially signet-ring cell adenocarcinomas, produce huge amounts of mucin glycoproteins that fill cytoplasm and push nucleus to the periphery, giving a signet ring like structure to the cell. Mucin proteins are very rich of l-threonine which is essential in humans. L-threonine content can reach up to 35% of total a
- Pulmonary Lymphangioleiomyomatosis: A proposed state of neoplastic senescencePublication date: Available online 21 August 2019Source: Medical HypothesesAuthor(s): Charles M. LombardAbstractPulmonary lymphangioleiomyomatosis (PLAM) is a disease strongly associated with tuberous sclerosis. In PLAM patients, with and without clinical tuberous sclerosis, mutations in the tuberous sclerosis complex involving the proteins hamartin and tuberin have been found. These proteins are key regulators of the MTor pathway. MTor activati
- Tourette Syndrome Treated with Functional MRIResearchers at Yale University have for the first time showed that it is possible to control the symptoms of Tourette Syndrome using functional magnetic resonance imaging (fMRI). The researchers recruited twenty one 11 to 19 year-olds and used real-time fMRI neurofeedback (rt-fMRI-NF), a technology that lets patients monitor their own brain activity, to control the frequency of tics. While rt-fMRI-NF is a relatively new tec
- Use and Cost of a Hypoglossal Nerve Stimulator Device for Obstructive Sleep ApneaThis economic evaluation based on publicly available data assesses the use and cost of an implantable device, approved by the US Food and Drug Administration in 2014, that offers a unique alternative to patients with moderate to severe obstructive sleep apnea and poor response to continuous positive airway pressure.
- Anatomic Distribution of the Morphologic Variation of the Upper Lip Frenulum Among Healthy NewbornsThis cross-sectional study examines the variations in morphology of the maxillary labial frenulum in healthy newborns to identify which anatomic measurements may be associated with neonatal breastfeeding difficulty.
- Transnasal-Transpterygoid Endoscopic Removal of an 18 F–Choline-Avid Parathyroid Carcinoma in the Skull BaseThis case report describes a patient with a medical history of symptomatic primary hyperparathyroidism who was found to have an atypical parathyroid neoplasm at the right skull base with an infiltrating pattern, which was treated by transnasal-transpterygoid endoscopic removal.
- Vaping Among Adolescents in the United StatesOn December 18, 2018, the US Surgeon General declared e-cigarette vaping among adolescents an “epidemic.” This declaration coincided with a report in The New England Journal of Medicine highlighting a 10% increase in youth vaping between 2017 and 2018, the equivalent of an additional estimated 1.3 million teenagers. In a public hearing in January 2019, the former US Food and Drug Administration (FDA) Commissioner, Scott Gottlieb, stated that e-ci
- Mucocutaneous Lesions in an Adult Man Who Recently Moved From MexicoA 66-year-old man presented to the emergency department for painful and pruritic ulcerative cutaneous lesions involving his back, nose, lips, and mucosal lesions involving his oral cavity and oropharynx. What is your diagnosis?
- Endoscopic Endonasal Approaches for Treatment of Craniovertebral Junction Tumours.Related ArticlesEndoscopic Endonasal Approaches for Treatment of Craniovertebral Junction Tumours. Acta Neurochir Suppl. 2019;125:209-224 Authors: Locatelli D, Karligkiotis A, Turri-Zanoni M, Canevari FR, Pozzi F, Castelnuovo P Abstract Tumours involving the craniovertebral junction (CVJ) are challenging because of their local invasiveness and high recurrence rates, as well as their proximity to crit
- Sprachverstehen und kognitive Leistungen in akustisch schwierigen SituationenZusammenfassung Das Verstehen von Sprache hängt stark von sensorischen Prozessen („bottom-up“) ab. Allerdings spielen insbesondere in akustisch schwierigen Situationen auch kognitive Prozesse („top-down“), wie z. B. Aufmerksamkeit und Arbeitsgedächtnis, eine Rolle. Im Alter nehmen typischerweise sowohl das Hörvermögen als auch bestimmte kognitive Leistungen ab. Dies hat Konsequenzen für die Alltagskommunikation. In der Praxis i
- Quality of Life of Couples Living with SarcoidosisBackground: Consequences of sarcoidosis are wide ranging, and the symptom burden has a great impact on patients’ quality of life (QoL). However, the QoL of couples living with sarcoidosis has not yet been studied. Objectives: Our aim was to assess the QoL of couples living with sarcoidosis and to evaluate whether living with a partner with sarcoidosis influences the partner’s QoL. Furthermore, we aimed to assess whether nonspecific s
- Sputum Microbiome Dynamics in Chronic Obstructive Pulmonary Disease Patients during an Exacerbation Event and Post-StabilizationBackground: Chronic obstructive pulmonary disease (COPD) affects up to 65 million people worldwide, and COPD exacerbation causes tissue damage and subsequent loss of lung function. It is a multifactorial event in which respiratory infections are involved, but little is known about its dynamics. Objectives: The objective of our study was to determine the microbiome composition during an exacerbation event and post-stabilization. Methods: We conduc
- A Single Enhanced Dual-Energy CT Scan May Distinguish Lung Squamous Cell Carcinoma From Adenocarcinoma During the Venous phasePublication date: Available online 22 August 2019Source: Academic RadiologyAuthor(s): Zhaotao Zhang, Hongye Zou, Aimei Yuan, Fei Jiang, Baolin Zhao, Yin Liu, Jinghua Chen, Minjing Zuo, Lianggeng GongRationale and ObjectivesTo investigate whether iodine quantification extracted from enhanced dual energy-computed tomography (DE-CT) is useful for distinguishing lung squamous cell carcinoma from adenocarcinoma and to evaluate whether a single scan e
- The Value of Numerical USMLE Step 1 Scores in Radiology Resident SelectionPublication date: Available online 21 August 2019Source: Academic RadiologyAuthor(s): Charles M Maxfield, Lars J. GrimmRationale and ObjectivesIn response to a recent proposal to change scoring on the United States Medical Licensing (USMLE) Step 1 exam to pass/fail, we sought to determine the value of numerical Step 1 scores in predicting success in our radiology residency program.Materials and MethodsResidency applications for 157 residents ent
- Outcomes After Onyx Embolization as Primary Treatment for Cranial Dural Arteriovenous Fistula in the Past DecadePublication date: Available online 21 August 2019Source: Academic RadiologyAuthor(s): Christoph Moenninghoff, Ewelina Pohl, Cornelius Deuschl, Karsten Wrede, Ramazan Jabbarli, Alexander Radbruch, Ulrich Sure, Michael Forsting, Isabel WankeRationale and ObjectivesThis retrospective single-center study aims to evaluate endovascular therapy (EVT) of cranial dural arteriovenous fistulas (dAVF) with ethylene vinyl alcohol (EVOH) copolymer (Onyx) rega
- Protective microbiomes can limit the evolution of host pathogen defense [NEW RESULTS]The evolution of host immunity occurs in the context of the microbiome, but little theory exists to predict how resistance against pathogens might be influenced by the need to tolerate and regulate commensal microbiota. We present a general model to explore the optimal investment in host immunity under conditions in which the host can, versus cannot easily distinguish among commensal versus pathogenic bacteria; and when commensal microbiota can,
- Oral Functional Behaviors and Neurosensation after Long-term Adult Maxillomandibular Advancement for Obstructive Sleep ApneaPublication date: Available online 22 August 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Joseph E. Cillo, David J. DattiloABSTRACTPurposeEvaluate and correlate long-term subjective peri-oral neurosensory deficit intensity and oral functional behavior difficulty after maxillomandibular advancement (MMA) in adult obstructive sleep apnea (OSA).Subjects and methodsA long-term retrospective cohort study of adult subjects who had M
- Nasal Sebaceous Carcinoma; A Case Report and Review of the Literature.Publication date: Available online 21 August 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Omar Kholaki, Dongkun Chang, Roderick Y. KimAbstractSebaceous carcinoma arising from the nasal vestibule is exceedingly rare, with 3 cases published in the literature. This report illustrates a case of a 69-year-old man with an indolent exophytic growth on the medial aspect of his right nasal vestibule. Incisional biopsy demonstrated seba
- Are oral and maxillofacial surgeons prescribing fewer opioids and more non-narcotic analgesics for post-operative pain after third molar removal?Publication date: Available online 21 August 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Jesse T. Han, Srinivas M. Susarla, Thomas B. Dodson, Melanie S. LangAbstract:PurposeIn response to the national opioid epidemic crisis, this study’s purpose was to measure changes in opioid and non-narcotic analgesic (NNA) prescribing practices over time after third molar (M3) removal.Materials and MethodsThe investigators used a re
- Immediate of Impact Prosthetic Graft Replacement of the Ascending Aorta on Circumferential Strain in the Descending AortaPublication date: Available online 21 August 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Lisa Q. Rong, Maria C. Palumbo, Mohamed M. Rahouma, Massimiliano Meineri, Gabriel R. Arguelles, Jiwon Kim, Christopher Lau, Richard B. Devereux, Kane O. Pryor, Leonard N. Girardi, Alberto Redaelli, Mario F.L. Gaudino, Jonathan W. WeinsaftObjectivesProsthetic replacement of the ascending aorta (AA) can potentially modify energy
- Cancers, Vol. 11, Pages 1230: Predictive Factors of Recurrence in Patients with Differentiated Thyroid Carcinoma: A Retrospective Analysis on 579 PatientsCancers, Vol. 11, Pages 1230: Predictive Factors of Recurrence in Patients with Differentiated Thyroid Carcinoma: A Retrospective Analysis on 579 Patients Cancers doi: 10.3390/cancers11091230 Authors: Medas Canu Boi Lai Erdas Calò Differentiated thyroid carcinoma (DTC) is usually associated with a favorable prognosis. Nevertheless, up to 30% of patients present a local or distant recurrence. The aim of this study
- Mesenchymal stem cells in allergic diseases: Current statusPublication date: Available online 21 August 2019Source: Allergology InternationalAuthor(s): He Li, Yunzhe Tian, Lihui Xie, Xiuxing Liu, Zhaohao Huang, Wenru SuAbstractAllergic diseases, which include asthma, allergic skin diseases, allergic rhinitis and allergic conjunctivitis, have already garnered worldwide public health attention over recent decades. Mesenchymal stem cells (MSCs) have gradually emerged as a potential method for treating aller
- Breaking the Curse: Opening Students’ Eyes to Pathology and Oncology ResearchAbstract Research is a particularly underexplored professional activity for physicians, leaving many medical students compelled to pursue a clinical career. However, the XXI century requires that physicians innovate and perform research that fuels their practice; students should have early exposure to research to explore it as a career path. It should be encouraged in the undergraduate program by having students take part in ca
- Stathmin 1 is highly expressed and associated with survival outcome in malignant adrenocortical tumoursAdrenocortical carcinoma (ACC) is an aggressive endocrine cancer with few molecular predictors of malignancy and survival, especially in paediatric patients. Stathmin 1 (STMN1) regulates microtubule dynamics and has been involved in the malignant phenotype of cancer cells. Recently, it was reported that STMN1 is highly expressed in ACC patients, and STMN1 silencing reduces the clonogenicity and migration of ACC cell lines. However, the prognostic
- There are way more species of horseshoe bats than scientists thoughtHorseshoe bats are bizarre-looking animals with giant ears and elaborate flaps of skin on their noses that they use like satellite dishes. There are about a hundred different species of horseshoe bats -- and that number is only going to grow. By studying the DNA of horseshoe bat specimens in museum collections, scientists have discovered that there are probably a dozen new species of horseshoe bat that haven't been officially described yet.
- Dual-source computed tomography coronary artery imaging in childrenAbstract Computed tomography (CT) has a well-established diagnostic role in the assessment of coronary arteries in adults. However, its application in a pediatric setting is still limited and often impaired by several technical issues, such as high heart rates, poor patient cooperation, and radiation dose exposure. Nonetheless, CT is becoming crucial in the noninvasive approach of children affected by coronary abnormalities and
- Phase lag index and spectral power as QEEG features for identification of patients with mild cognitive impairment in Parkinson's diseasePublication date: October 2019Source: Clinical Neurophysiology, Volume 130, Issue 10Author(s): Menorca Chaturvedi, Jan Guy Bogaarts, Vitalii V. Kozak (Cozac), Florian Hatz, Ute Gschwandtner, Antonia Meyer, Peter Fuhr, Volker RothAbstractObjectivesTo identify quantitative EEG frequency and connectivity features (Phase Lag Index) characteristic of mild cognitive impairment (MCI) in Parkinson’s disease (PD) patients and to investigate if these featu
- Neuroprotection for ischemic stroke in the endovascular era: A brief report on the future of intra-arterial therapy.Related ArticlesNeuroprotection for ischemic stroke in the endovascular era: A brief report on the future of intra-arterial therapy. J Clin Neurosci. 2019 Aug 17;: Authors: Griauzde J, Ravindra VM, Chaudhary N, Gemmete JJ, Pandey AS Abstract Mechanical thrombectomy is now at the forefront of the treatment of large vessel acute ischemic stroke (AIS). Selective intra-arterial (IA) access has opened a n
- Anterior versus posterior approach in traumatic thoracolumbar burst fractures deemed for surgical management: Systematic review and meta-analysis.Related ArticlesAnterior versus posterior approach in traumatic thoracolumbar burst fractures deemed for surgical management: Systematic review and meta-analysis. J Clin Neurosci. 2019 Aug 17;: Authors: Tan T, Rutges J, Marion T, Gonzalvo A, Mathew J, Fitzgerald M, Dvorak M, Schroeder G, Tee J Abstract Uncertainties remain regarding the optimal surgical approach in the treatment of traumatic thoracol
- OLIG2 gene polymorphisms are associated with nasty, unpleasant and uncontrollable thoughts in obsessive-compulsive disorder.Related ArticlesOLIG2 gene polymorphisms are associated with nasty, unpleasant and uncontrollable thoughts in obsessive-compulsive disorder. J Clin Neurosci. 2019 Aug 17;: Authors: Vieira-Fonseca T, Fontenelle LF, Kohlrausch FB Abstract Obsessive-compulsive disorder (OCD) is one of 10 major debilitating neuropsychiatric disorders, according to the World Health Organization (WHO), affecting around 2.3
- Predicting extended hospital stay after deep brain stimulation surgery in Parkinson's patients.Related ArticlesPredicting extended hospital stay after deep brain stimulation surgery in Parkinson's patients. J Clin Neurosci. 2019 Aug 17;: Authors: Young NA, Brown MP, Peng J, Kline D, Reider C, Deogaonkar M Abstract BACKGROUND: The goal of deep brain stimulation (DBS) is to achieve maximal benefit for the patient while minimizing the likelihood of adverse effects. Currently, no standardized crit
- Efficacy of nicergoline treatment in Parkinson's disease associated with dementia.Related ArticlesEfficacy of nicergoline treatment in Parkinson's disease associated with dementia. J Clin Neurosci. 2019 Aug 17;: Authors: Lee S, Na SH, Chung YA, Jeong H, Song IU Abstract Parkinson's disease (PD) has a variable spectrum of cognitive impairment. However, there are no clear evident-based management guidelines for PD with dementia (PDD). Alternative treatments for PDD are therefore req
- Topically applied adipose-derived mesenchymal stem cell treatment in experimental focal cerebral ischemia.Related ArticlesTopically applied adipose-derived mesenchymal stem cell treatment in experimental focal cerebral ischemia. J Clin Neurosci. 2019 Aug 17;: Authors: Lam PK, Wang KKW, Chin DWC, Tong CSW, Wang Y, Lo KKY, Lai PBS, Ma H, Zheng VZY, Poon WS, Wong GKC Abstract In this study, the neuro-modulation effect of topical mesenchymal stem cells (MSCs) was tested in a rodent middle carotid artery occl
- Direct trans-pedicular screw fixation for atypical hangman's fracture: A minimally invasive technique using the tubular retractor system.Related ArticlesDirect trans-pedicular screw fixation for atypical hangman's fracture: A minimally invasive technique using the tubular retractor system. J Clin Neurosci. 2019 Aug 17;: Authors: Man Kyu C, Youngseok K, Ki Hong K, Dae-Hyun K Abstract The ideal treatment strategy of atypical hangman's fracture (AHF) is debatable. If surgical treatment is needed, direct trans-pedicular fixation technique
- A potential novel drug combination for adjuvant therapy in lung cancer: reflections on an early phase of clinical development.A potential novel drug combination for adjuvant therapy in lung cancer: reflections on an early phase of clinical development. J Chemother. 2019 Aug 21;:1-2 Authors: Roviello G, Nobili S, Mini E PMID: 31432747 [PubMed - as supplied by publisher]
- The possible neuroprotective role of grape seed extract on the histopathological changes of the cerebellar cortex of rats prenatally exposed to Valproic Acid: animal model of autism.Related ArticlesThe possible neuroprotective role of grape seed extract on the histopathological changes of the cerebellar cortex of rats prenatally exposed to Valproic Acid: animal model of autism. Acta Histochem. 2019 Aug 17;: Authors: Arafat EA, Shabaan DA Abstract Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disease characterized by defect in verbal and nonverbal communica
- Antimicrobial use in acute care hospitals: national point prevalence survey on healthcare-associated infections and antimicrobial use, Switzerland, 2017.Related ArticlesAntimicrobial use in acute care hospitals: national point prevalence survey on healthcare-associated infections and antimicrobial use, Switzerland, 2017. Euro Surveill. 2019 Aug;24(33): Authors: Zingg W, Metsini A, Gardiol C, Balmelli C, Behnke M, Troillet N, Widmer A, Pittet D, On Behalf Of The Swissnoso Network Abstract BackgroundA point prevalence survey (PPS) on healthcare-associa
- Intense interseasonal influenza outbreaks, Australia, 2018/19.Related ArticlesIntense interseasonal influenza outbreaks, Australia, 2018/19. Euro Surveill. 2019 Aug;24(33): Authors: Barr IG, Deng YM, Grau ML, Han AX, Gilmour R, Irwin M, Markey P, Freeman K, Higgins G, Turra M, Komadina N, Peck H, Booy R, Maurer-Stroh S, Dhanasekaran V, Sullivan S Abstract BackgroundInterseasonal influenza outbreaks are not unusual in countries with temperate climates and well-d
- Angiostrongylus cantonensis in North African hedgehogs as vertebrate hosts, Mallorca, Spain, October 2018.Related ArticlesAngiostrongylus cantonensis in North African hedgehogs as vertebrate hosts, Mallorca, Spain, October 2018. Euro Surveill. 2019 Aug;24(33): Authors: Paredes-Esquivel C, Sola J, Delgado-Serra S, Puig Riera M, Negre N, Miranda MÁ, Jurado-Rivera JA Abstract In October 2018, two Atelerix algirus hedgehogs were admitted to the Wildlife Rehabilitation Hospital in Mallorca (Balearic Islands,
- Strong correlation between the rates of intrinsically antibiotic-resistant species and the rates of acquired resistance in Gram-negative species causing bacteraemia, EU/EEA, 2016.Related ArticlesStrong correlation between the rates of intrinsically antibiotic-resistant species and the rates of acquired resistance in Gram-negative species causing bacteraemia, EU/EEA, 2016. Euro Surveill. 2019 Aug;24(33): Authors: Jarlier V, Diaz Högberg L, Heuer OE, Campos J, Eckmanns T, Giske CG, Grundmann H, Johnson AP, Kahlmeter G, Monen J, Pantosti A, Rossolini GM, van de Sande-Bruinsma N, Vatopoulos A, Żab
- NTCP model validation method for DAHANCA patient selection of protons versus photons in head and neck cancer radiotherapy.NTCP model validation method for DAHANCA patient selection of protons versus photons in head and neck cancer radiotherapy. Acta Oncol. 2019 Aug 21;:1-6 Authors: Hansen CR, Friborg J, Jensen K, Samsøe E, Johnsen L, Zukauskaite R, Grau C, Maare C, Johansen J, Primdahl H, Bratland Å, Kristensen CA, Andersen M, Eriksen JG, Overgaard J Abstract Introduction: Prediction models using logistic regression may
- Pembrolizumab in lung cancer: current evidence and future perspectives.Pembrolizumab in lung cancer: current evidence and future perspectives. Future Oncol. 2019 Aug 21;: Authors: Palumbo G, Carillio G, Manzo A, Montanino A, Sforza V, Costanzo R, Sandomenico C, Manna C, Luca G, Piccirillo MC, Daniele G, Cecio R, Botti G, Totaro G, Muto P, Picone C, Esposito G, Normanno N, Morabito A Abstract Pembrolizumab is a humanized monoclonal antibody against PD-1 capable of enhanc
- Glasdegib in the treatment of acute myeloid leukemia.Glasdegib in the treatment of acute myeloid leukemia. Future Oncol. 2019 Aug 21;: Authors: Wolska-Washer A, Robak T Abstract Pharmacologic inhibition of the Hedgehog pathway significantly enhanced the sensitivity of leukemic cells to cytotoxic drugs. Glasdegib (PF-04449913; DAURISMO™) is a potent and selective oral inhibitor of the Hedgehog signaling pathway with clinical activity in patients with ac
- Neratinib-based therapy in patients with metastatic HER2-positive breast cancer from Asia.Neratinib-based therapy in patients with metastatic HER2-positive breast cancer from Asia. Future Oncol. 2019 Aug 21;: Authors: Xu B, Kim SB, Inoue K, Lee J, Zhang B, Bryce R, Chow LW Abstract Aim: To evaluate the safety and efficacy of neratinib-based therapy in Asian patients with HER2-positive metastatic breast cancer (MBC). Patients & methods: We performed a pooled analysis of seven early-pha
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- Intraoperative Visible Air Bubbling Recorded as a Sign of Massive Venous Air Embolism During Prone Position Surgery for Extensive Ossification of Spinal Ligaments: A Case Report with a Video ClipPublication date: November 2019Source: World Neurosurgery, Volume 131Author(s): Naohisa Miyakoshi, Michio Hongo, Yuji Kasukawa, Yoshinori Ishikawa, Daisuke Kudo, Yoichi ShimadaBackgroundVenous air embolism (VAE) is a rare but, frequently, fatal complication that can occur during surgery. Several reported studies have shown visible bubbling of air at the surgical site as the first clinical indication of VAE-induced cardiovascular collapse during p
- Minimally Invasive Syringe Brain Port for Deep-Seated Lesions: How to Make the System and Surgical VideoPublication date: November 2019Source: World Neurosurgery, Volume 131Author(s): Abdulelah Alluhaybi, Sami Khairy, Yasser Orz, Abdullah Alobaid, Mohammed BafaquhBrain retraction is crucial for adequate exposure during many intracranial procedures. It facilitates the access to the area of interest inside the brain and gives the surgeon the ability to create a corridor to visualize the deeply seated lesions. Retraction-related injury is a well-known
- Endoscopic-Assisted Spinal Arachnoiditis Adhesiolysis and Placement of a Spinal Cysto-Subarachnoid ShuntPublication date: November 2019Source: World Neurosurgery, Volume 131Author(s): David Chi Hau Tan, Kerry A. Vaughan, Helge KoeckBackgroundSpinal arachnoiditis and associated arachnoid adhesions can cause debilitating neurological symptoms due to nerve root and spinal cord compression or tethering. Adhesiolysis using a microscopic approach has traditionally been used for this condition. This procedure has been further refined in recent years with
ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis
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