- Neratinib-based therapy in patients with metastatic HER2-positive breast cancer from Asia.Neratinib-based therapy in patients with metastatic HER2-positive breast cancer from Asia. Future Oncol. 2019 Aug 21;: Authors: Xu B, Kim SB, Inoue K, Lee J, Zhang B, Bryce R, Chow LW Abstract Aim: To evaluate the safety and efficacy of neratinib-based therapy in Asian patients with HER2-positive metastatic breast cancer (MBC). Patients & methods: We performed a pooled analysis of seven early-pha
- Long-term outcome with targeted therapy in advanced/metastatic HER2-positive breast cancer: The Royal Marsden experience.Related ArticlesLong-term outcome with targeted therapy in advanced/metastatic HER2-positive breast cancer: The Royal Marsden experience. Breast Cancer Res Treat. 2019 Aug 20;: Authors: Battisti NML, Tong D, Ring A, Smith I Abstract PURPOSE: Agents targeting the human epidermal growth factor receptor 2 (HER2) have improved outcomes of advanced HER2-positive breast cancer with durable responses. We ev
- Pharmacogenetics of medication-related osteonecrosis of the jaw: a systematic review and meta-analysisPublication date: Available online 22 August 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): Z. Guo, W. Cui, L. Que, C. Li, X. Tang, J. LiuAbstractMedication-related osteonecrosis of the jaw (MRONJ) is a severe complication that can develop in patients treated with anti-resorptive drugs. Although the pathogenesis of MRONJ is still unclear, genetic factors have a demonstrated important role. Thus, the aim of this stu
- Welcome address for the 15th REMPAN meeting in Geneva WHO HEADQUARTERS-3-5 July, 2017.Welcome address for the 15th REMPAN meeting in Geneva WHO HEADQUARTERS-3-5 July, 2017. Radiat Prot Dosimetry. 2019 Aug 01;184(2):137 Authors: Charrière R PMID: 31433486 [PubMed - in process]
- Detection and verification of 2.3 million cancer mutations in NCI60 cancer cell lines with a cloud search enginePublication date: Available online 21 August 2019Source: Journal of ProteomicsAuthor(s): Amol Prakash, Swetaketu Majumder, Shadab Ahmad, Manu Varkey, T.A. Anish, Conor Jenkins, Megan Rigby, Benjamin OrsburnAbstractToday we have unprecedented access to human genomic and proteomic data that appear to be rapidly approaching our current understanding of comprehensive coverage. Combining genomic information with shotgun proteomics remains challenging
- Comparison of metaproteomics workflows for deciphering the functions of gut microbiota in an animal model of obesityPublication date: Available online 21 August 2019Source: Journal of ProteomicsAuthor(s): Maria Guirro, Pol Herrero, Andrea Costa, Andreu Gual-Grau, Adrià Ceretó-Massagué, Adrià Hernández, Helena Torrell, Lluís Arola, Núria CanelaAbstractMetaproteomics has emerged as a new, revolutionary approach to study gut microbiota functionality, but the lack of consistent studies in this field due to the grea
- A digital anatomic investigation of the safe triangle areas for L1–5 percutaneous minimally invasive discectomyAbstract Purpose To reconstruct the three-dimensional safe triangle areas at L1–5 based on the computed tomography digital data, analyze the safe scopes for the puncture location and angles, and provide anatomic references for percutaneous lumbar discectomy. Methods Computed tomography data from patients
- Stathmin 1 is highly expressed and associated with survival outcome in malignant adrenocortical tumoursAdrenocortical carcinoma (ACC) is an aggressive endocrine cancer with few molecular predictors of malignancy and survival, especially in paediatric patients. Stathmin 1 (STMN1) regulates microtubule dynamics and has been involved in the malignant phenotype of cancer cells. Recently, it was reported that STMN1 is highly expressed in ACC patients, and STMN1 silencing reduces the clonogenicity and migration of ACC cell lines. However, the prognostic
- Goblet cell tumors of the appendix: A reviewPublication date: Available online 21 August 2019Source: Annals of Diagnostic PathologyAuthor(s): Sara A.J. Sinno, Nawaf M.H. JurdiAbstractGoblet cell tumors are rare tumors of the appendix that exhibit both neuroendocrine and mucinous differentiation. This dual differentiation has led to a controversy regarding the proper classification of these neoplasms as to whether they should be considered neuroendocrine tumors or adenocarcinomas. Multiple
- A survey of prescribing practices by general dentists in AustraliaAbstract Background Numerous studies of dental antibiotic prescribing show that overprescribing is a worldwide occurrence. The aim of this study was to assess prescribing practices of general dentists in Australia for antibiotics, analgesics and anxiolytics and to determine the extent to which prescribing is in accordance with current guidelines.
- Biocompatibility of new bioactive resin composite versus calcium silicate cements: an animal studyAbstract Background The purpose of this study was to compare the biocompatibility of three bioactive materials, namely ACTIVA bioactive restorative resin composite, iRoot BP plus and Mineral Trioxide Aggregate (MTA) Angelus-HP. Methods Seventy-five Wistar male rats were subjected to subcutan
- Incidence and Risk Factors for Dysphagia Following Non-traumatic Subarachnoid Hemorrhage: A Retrospective Cohort Study.Related ArticlesIncidence and Risk Factors for Dysphagia Following Non-traumatic Subarachnoid Hemorrhage: A Retrospective Cohort Study. Dysphagia. 2019 04;34(2):229-239 Authors: Dunn K, Rumbach A Abstract The aim of the study is to investigate dysphagia incidence and establish factors which may reliably predict dysphagia risk in individuals presenting with non-traumatic subarachnoid hemorrhage (SAH
- [Pathophysiology of obstructive sleep apnea].Related Articles[Pathophysiology of obstructive sleep apnea]. HNO. 2019 Aug 20;: Authors: Heiser C, Eckert D Abstract The prevalence of obstructive sleep apnea (OSA) is considered to be very high in western industrialized countries. There are conservative and surgical forms of treatment for OSA; however, the pathophysiology is largely unexplained and cannot be explained by anatomical abnormalities al
- Role of Omega-3 Polyunsaturated Fatty Acids in Treatment of Nasal Polyposis.Role of Omega-3 Polyunsaturated Fatty Acids in Treatment of Nasal Polyposis. Am J Rhinol Allergy. 2019 Aug 21;:1945892419871802 Authors: Attia TM PMID: 31433665 [PubMed - as supplied by publisher]
- Sam68 Promotes the Progression of Human Breast Cancer through Inducing Activation of EphA3.Sam68 Promotes the Progression of Human Breast Cancer through Inducing Activation of EphA3. Curr Cancer Drug Targets. 2019 Jul 18;: Authors: Chen X, Zhang L, Kuang Z, Zou Y, Tang T, Zhang W, Hu X, Xia T, Cao T, Jia H, Yuan M Abstract BACKGROUND: Src-associated in mitosis of 68 kDa (Sam68), is often elevated expressing in human cancers. Overexpression of Sam68 has been shown to be correlated with poor
- Hepatic NPC1L1 overexpression attenuates alcoholic autophagy in mice.Related ArticlesHepatic NPC1L1 overexpression attenuates alcoholic autophagy in mice. Mol Med Rep. 2019 Aug 01;: Authors: Wang Y, Yang P, Zhang B, Ding Y, Lei S, Hou Y, Guan X, Li Q Abstract Alcohol consumption causes liver steatosis in humans. Metabolic disorders of lipids are one of the factors that cause liver steatosis in hepatocytes. Hepatic Niemann‑Pick C1‑like 1 (NPC1L1) regulates lipid homeos
- Characterization of the species-specific acid-base equilibria of adrenaline and noradrenaline.Related ArticlesCharacterization of the species-specific acid-base equilibria of adrenaline and noradrenaline. J Pharm Biomed Anal. 2019 Jun 05;170:215-219 Authors: Mirzahosseini A, Pálla T, Orgován G, Tóth G, Noszál B Abstract Adrenaline, noradrenaline, the biogenic catecholamines of vital importance, and four closely related compounds were studied by 1H NMR-pH titratio
- Minimum Data Elements for Radiation Oncology: An ASTROPublication date: Available online 21 August 2019Source: Practical Radiation OncologyAuthor(s): James A. Hayman, Andre Dekker, Mary Feng, Sameer R. Keole, Todd R. McNutt, Mitchell Machtay, Neil E. Martin, Charles S. Mayo, Todd Pawlicki, Benjamin D. Smith, Randi Kudner, Samantha Dawes, James B. Yu
- Forecasting annual incidence and mortality rate for prostate cancer in Australia until 2022 using autoregressive integrated moving average (ARIMA) models.Related ArticlesForecasting annual incidence and mortality rate for prostate cancer in Australia until 2022 using autoregressive integrated moving average (ARIMA) models. BMJ Open. 2019 Aug 19;9(8):e031331 Authors: Earnest A, Evans SM, Sampurno F, Millar J Abstract OBJECTIVES: Prostate cancer is the second most common cause of cancer-related death in males after lung cancer, imposing a significant bu
- Adrenal venous sampling in patients with ACTH-independent hypercortisolism Abstract Purpose...Adrenal venous sampling in patients with ACTH-independent hypercortisolismAbstract Purpose To study the usefulness of adrenal venous sampling (AVS) in distinguishing unilateral from bilateral cortisol production in patients with ACTH-independent hypercortisolism and bilateral adrenal lesions, or morphologically normal adrenal glands. Methods A retrospective analysis of ten consInternational journal of basic and clinical endocrinologyWed Aug 21,
- Characterising the gut microbiome in veterans with Gulf War Illness: a protocol for a longitudinal, prospective cohort study.Related ArticlesCharacterising the gut microbiome in veterans with Gulf War Illness: a protocol for a longitudinal, prospective cohort study. BMJ Open. 2019 Aug 19;9(8):e031114 Authors: Keating JA, Shaughnessy C, Baubie K, Kates AE, Putman-Buehler N, Watson L, Dominguez N, Watson K, Cook DB, Rabago D, Suen G, Gangnon R, Safdar N Abstract INTRODUCTION: Approximately 25%-35% of the 1991 Gulf War Vetera
- Effects of lumbar extensor muscle strengthening and neuromuscular control retraining on disability in patients with chronic low back pain: a protocol for a randomised controlled trial.Related ArticlesEffects of lumbar extensor muscle strengthening and neuromuscular control retraining on disability in patients with chronic low back pain: a protocol for a randomised controlled trial. BMJ Open. 2019 Aug 19;9(8):e028259 Authors: Farragher JB, Pranata A, Williams G, El-Ansary D, Parry SM, Kasza J, Bryant A Abstract INTRODUCTION: Chronic low back pain (CLBP) is the leading cause of disa
- Decision-making dilemmas of paediatricians: a qualitative study in Japan.Related ArticlesDecision-making dilemmas of paediatricians: a qualitative study in Japan. BMJ Open. 2019 Aug 19;9(8):e026579 Authors: Sasazuki M, Sakai Y, Kira R, Toda N, Ichimiya Y, Akamine S, Torio M, Ishizaki Y, Sanefuji M, Narama M, Itai K, Hara T, Takada H, Kizawa Y, Ohga S Abstract OBJECTIVE: To delineate the critical decision-making processes that paediatricians apply when treating children wi
- Anti-infective potential of hydroalcoholic extract of Phyllanthus emblica seeds against selected human-pathogenic bacteria.Anti-infective potential of hydroalcoholic extract of Phyllanthus emblica seeds against selected human-pathogenic bacteria. Infect Disord Drug Targets. 2019 Aug 21;: Authors: Patel P, Joshi C, Kothari V Abstract INTRODUCTION: In context of the global threat of antimicrobial resistance among pathogenic bacteria against conventional bactericidal antibiotics, investigation on complementary/ alternative
- Salvage surgery for recurrent larynx cancer.Salvage surgery for recurrent larynx cancer. Head Neck. 2019 Aug 21;: Authors: Mimica X, Hanson M, Patel SG, McGill M, McBride S, Lee N, Dunn LA, Cracchiolo JR, Shah JP, Wong RJ, Ganly I, Cohen MA Abstract BACKGROUND: Despite advances in treatment, the recurrence rates for laryngeal cancer range from 16% to 40%. METHODS: Patients with recurrent laryngeal cancer treated at Memorial Sloan Kett
- Electroglottographic and acoustic analysis of voice in children with vocal nodules.Related ArticlesElectroglottographic and acoustic analysis of voice in children with vocal nodules. Int J Pediatr Otorhinolaryngol. 2019 Jul;122:82-88 Authors: Szklanny K, Gubrynowicz R, Ratyńska J, Chojnacka-Wądołowska D Abstract PURPOSE: Vocal fold nodules are usually caused by voice overuse or vocal hyperfunction, and their symptoms include persistent hoarseness - a disturbance i
- human homeostasis; +26 new citations26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2019/08/22PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
- human physiology; +73 new citations73 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/08/22PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
- Bilingual children access multiplication facts from semantic memory equivalently across languages: Evidence from the N400Publication date: November 2019Source: Brain and Language, Volume 198Author(s): Vanessa R. Cerda, Amandine E. Grenier, Nicole Y.Y. WichaAbstractTypically, bilinguals learn multiplication facts in only one instruction language. Consequently, these facts may be represented and/or accessed as language-specific memories, requiring a qualitatively different retrieval process in their other language. Indeed, behavioral studies reveal that bilinguals ve
- Association of long-term sleep habits and hypertension: a cross-sectional study in Chinese adults.Related ArticlesAssociation of long-term sleep habits and hypertension: a cross-sectional study in Chinese adults. J Hum Hypertens. 2019 Aug 20;: Authors: Zhao H, Gui W, Huang H, Liu Y, Ding H, Fan W, Huang S, Yang W, Wang X, Chen G Abstract Poor sleep has been associated with risk of hypertension, but previous studies were limited by treating one or two sleep factors as predictor. Our previous study
- A new genus and species of pinworm (Nematoda, Oxyuridae) from the gray mouse opossum, Tlacuatzin canescens.A new genus and species of pinworm (Nematoda, Oxyuridae) from the gray mouse opossum, Tlacuatzin canescens. Parasite. 2019;26:50 Authors: Jiménez FA, Caspeta-Mandujano JM, Albino-Miranda S Abstract Tlacuatzoxyuris simpsoni n. gen. n. sp. is described from the cecum of the gray opossum, Tlacuatzin canescens, a species endemic to the deciduous dry forest of Mexico. The digestive tracts of four specimen
- Prevention of the transmission of Babesia rossi by Haemaphysalis elliptica in dogs treated with Nexgard®.Prevention of the transmission of Babesia rossi by Haemaphysalis elliptica in dogs treated with Nexgard®. Parasite. 2019;26:49 Authors: Beugnet F, Lebon W, de Vos C Abstract This experimental study aimed to determine the efficacy of Afoxolaner (NexGard®) to prevent Babesia rossi transmission by Haemaphysalis elliptica ticks on dogs. The study included three groups of seven dogs each. Groups 1 and 2 r
- The Frequency of Cranial Base Fractures in Lethal Head Trauma.The Frequency of Cranial Base Fractures in Lethal Head Trauma. J Forensic Sci. 2019 Aug 21;: Authors: Crudele GDL, Merelli VG, Vener C, Milani S, Cattaneo C Abstract The interpretation of cranial base injuries has never been investigated from a purely anthropological perspective. Very little exists in forensic literature in order to interpret the significance of cranial base fractures. We analyzed 29
- Incidence and patterns of retropharyngeal lymph node involvement in oropharyngeal carcinoma.Related ArticlesIncidence and patterns of retropharyngeal lymph node involvement in oropharyngeal carcinoma. Radiother Oncol. 2019 Aug 17;: Authors: Iyizoba-Ebozue Z, Murray LJ, Arunsingh M, Vaidyanathan S, Scarsbrook AF, Prestwich RJD Abstract INTRODUCTION: The aim was to evaluate in oropharyngeal carcinoma the: (1) incidence and predictors of retropharyngeal (RP) lymph node (LN) involvement, (2) pa
- Realignment of Basilar Invagination by C1-C2 Joint Distraction: A Modified Approach to a Paradigm Shift.Related ArticlesRealignment of Basilar Invagination by C1-C2 Joint Distraction: A Modified Approach to a Paradigm Shift. Acta Neurochir Suppl. 2019;125:273-277 Authors: Cacciola F, Boszczyk B, Perrini P, Gallina P, Di Lorenzo N Abstract BACKGROUND: Distraction of the C1-C2 joint and maintenance thereof by introduction of spacers into the articular cavity can successfully and durably reduce basilar in
- Stability-Sparing Endoscopic Endonasal Odontoidectomy in a Malformative Craniovertebral Junction: Case Report and Biomechanical Considerations.Related ArticlesStability-Sparing Endoscopic Endonasal Odontoidectomy in a Malformative Craniovertebral Junction: Case Report and Biomechanical Considerations. Acta Neurochir Suppl. 2019;125:229-233 Authors: Vitali M, Canevari FR, Cattalani A, Somma T, Grasso VM, Barbanera A Abstract BACKGROUND: The craniovertebral junction (CVJ) is often involved in a wide range of congenital, developmental and acqu
- The High Cervical Anterolateral Retropharyngeal Approach.Related ArticlesThe High Cervical Anterolateral Retropharyngeal Approach. Acta Neurochir Suppl. 2019;125:147-149 Authors: Alshafai NS, Gunness VRN Abstract The first high cervical anterolateral retropharyngeal (HCALR) approach was reported by Stevenson et al. for a clivus chordoma in 1966. Anterior approaches to the spine have often been developed in response to problems presented by tuberculous spon
- The Relationship Between Basilar Invagination and Chiari Malformation Type I: A Narrative Review.Related ArticlesThe Relationship Between Basilar Invagination and Chiari Malformation Type I: A Narrative Review. Acta Neurochir Suppl. 2019;125:111-118 Authors: Liao C, Visocchi M, Zhang W, Li S, Yang M, Zhong W, Liu P Abstract Basilar invagination (BI) and Chiari malformation type I CM-I) are the most common adult craniovertebral junction malformations, and they are frequently associated with each
- Atlantoaxial Fixation for Treatment of Chiari Formation and Syringomyelia with No Craniovertebral Bone Anomaly: Report of an Experience with 57 Cases.Related ArticlesAtlantoaxial Fixation for Treatment of Chiari Formation and Syringomyelia with No Craniovertebral Bone Anomaly: Report of an Experience with 57 Cases. Acta Neurochir Suppl. 2019;125:101-110 Authors: Goel A, Kaswa A, Shah A Abstract AIM: In this paper we evaluate the role of atlantoaxial instability in the pathogenesis of Chiari formation type I and the role of atlantoaxial stabilizati
- The Craniovertebral Junction in Rheumatoid Arthritis: State of the Art.Related ArticlesThe Craniovertebral Junction in Rheumatoid Arthritis: State of the Art. Acta Neurochir Suppl. 2019;125:79-86 Authors: Ferrante A, Ciccia F, Giammalva GR, Iacopino DG, Visocchi M, Macaluso F, Maugeri R Abstract Rheumatoid arthritis (RA) is a chronic inflammatory disorder, characterized by polyarticular inflammation causing progressive joint damage and disability. The mechanisms underly
- Ossification of the Posterior Longitudinal Ligament: Analysis of the Role of Craniovertebral and Spinal Instability.Related ArticlesOssification of the Posterior Longitudinal Ligament: Analysis of the Role of Craniovertebral and Spinal Instability. Acta Neurochir Suppl. 2019;125:63-70 Authors: Goel A Abstract BACKGROUND: This paper reviews an experience of surgically treating ossification of the posterior longitudinal ligament (OPLL) with fixation of the involved spinal segments alone, without resorting to any bon
- Ventral Brainstem Anatomy: An Endoscopic Transoral Perspective.Related ArticlesVentral Brainstem Anatomy: An Endoscopic Transoral Perspective. Acta Neurochir Suppl. 2019;125:45-50 Authors: de Divitiis O, Conti A, Somma T, Angileri F, Cappabianca P Abstract In recent years the use of the endoscope through the transclival route has gained new attention as a minimally invasive operative method to successfully treat numerous clival pathologies such as chordomas, men
- Endonasal and Transoral Approaches to the Craniovertebral Junction: A Quantitative Anatomical Study.Related ArticlesEndonasal and Transoral Approaches to the Craniovertebral Junction: A Quantitative Anatomical Study. Acta Neurochir Suppl. 2019;125:37-44 Authors: Doglietto F, Belotti F, Qiu J, Roca E, Radovanovic I, Agur A, Kucharczyk W, Schreiber A, Villaret AB, Nicolai P, Gentili F, Fontanella MM Abstract BACKGROUND: The endoscopic endonasal approach has recently been added to the surgical armamen
- The Endoscopic Endonasal Approach to Craniovertebral Junction Pathologies: Surgical Skills and Anatomical Study.Related ArticlesThe Endoscopic Endonasal Approach to Craniovertebral Junction Pathologies: Surgical Skills and Anatomical Study. Acta Neurochir Suppl. 2019;125:25-36 Authors: Pacca P, Tardivo V, Pecorari G, Garbossa D, Ducati A, Zenga F Abstract INTRODUCTION: Surgical anterior decompression is the treatment of choice for symptomatic irreducible ventral craniovertebral junction (CVJ) compression. Alon
- Mastering Craniovertebral Junction Surgical Approaches: The Dissection Laboratory Experience at the Catholic University of Rome.Related ArticlesMastering Craniovertebral Junction Surgical Approaches: The Dissection Laboratory Experience at the Catholic University of Rome. Acta Neurochir Suppl. 2019;125:13-15 Authors: Signorelli F, Stumpo V, Oliva A, Pascali VL, Olivi A, Visocchi M Abstract The craniovertebral junction is an intricate anatomical region frequently affected by neoplastic, vascular, traumatic, congenital and dege
- The Craniovertebral Junction and Laboratory Experience: The Italian Paradox.Related ArticlesThe Craniovertebral Junction and Laboratory Experience: The Italian Paradox. Acta Neurochir Suppl. 2019;125:11-12 Authors: Signorelli F Abstract Current neurosurgical training can rely on innovative methods that have been provided, especially in recent years, by the remarkable and constant evolution of surgical techniques, instruments and additional dedicated tools. Moreover, the incr
- Pulmonary Edema Following Intrathecal Fluorescein Injection; a Case Report.Related ArticlesPulmonary Edema Following Intrathecal Fluorescein Injection; a Case Report. Arch Acad Emerg Med. 2019;7(1):e18 Authors: Behnaz F, Ebrahimy Dehkordy M, Azizi Faresani H, Shahmohammadi M Abstract Intrathecal Fluorescein has been used widely for detection of cerebrospinal fluid (CSF) leakage. After administration of fluorescein many serious complications may happen. Pulmonary edema is on
- Endoscopic Endonasal Approaches for Treatment of Craniovertebral Junction Tumours.Related ArticlesEndoscopic Endonasal Approaches for Treatment of Craniovertebral Junction Tumours. Acta Neurochir Suppl. 2019;125:209-224 Authors: Locatelli D, Karligkiotis A, Turri-Zanoni M, Canevari FR, Pozzi F, Castelnuovo P Abstract Tumours involving the craniovertebral junction (CVJ) are challenging because of their local invasiveness and high recurrence rates, as well as their proximity to crit
- Comparison of temporal muscle fascia and tragal cartilage perichondrium in endoscopic type 1 tympanoplasty with limited elevation of tympanomeatal flap.Related ArticlesComparison of temporal muscle fascia and tragal cartilage perichondrium in endoscopic type 1 tympanoplasty with limited elevation of tympanomeatal flap. Braz J Otorhinolaryngol. 2019 Jul 27;: Authors: Özdamar K, Sen A Abstract INTRODUCTION: Elevation of a tympanomeatal flap is one of the basic steps of tympanoplasty. A satisfactory level of anatomic and functional success can be achie
- A Cribriform Cancer Metastatic to Liver: Case Report and Literature ReviewMetastasis from salivary gland tumors to liver is exceedingly uncommon. Reported is the first case of a mammary analog secretory carcinoma (MASC) of salivary gland origin metastasized to the liver, even after complete surgical resection. A 76 year old female, with past history of a completely extirpated right parotid gland MASC, presented 2 years after right superficial parotidectomy and right neck dissection, with back and flank pain. Subsequent
- Checking InIlana Gershon asked seven editors for their insights on questions that authors commonly ask. Five are press editors (Berghahn, Chicago, Indiana, Princeton, Stanford) and two are series editors. This month’s column explores the following question: How long should a nervous author wait before asking you if the manuscript’s reviews are in yet? Fred Appel: Ideally the acquisitions editor should inform the author when her manuscript has been succes
- Apoptotic activity of xanthoquinodin JBIR-99, from Parengyodontium album MEXU 30054, in PC-3 human prostate cancer cells.Apoptotic activity of xanthoquinodin JBIR-99, from Parengyodontium album MEXU 30054, in PC-3 human prostate cancer cells. Chem Biol Interact. 2019 Aug 18;:108798 Authors: Anaya-Eugenio GD, Rebollar-Ramos D, González MDC, Raja H, Mata R, Carcache de Blanco EJ Abstract Natural products are a valuable source of anticancer agents, with many naturally derived compounds currently used in clinical and precl
- Amentoflavone Promotes Apoptosis in Non-small Cell Lung Cancer by Modulating Cancerous Inhibitor of PP2A.Amentoflavone Promotes Apoptosis in Non-small Cell Lung Cancer by Modulating Cancerous Inhibitor of PP2A. Anat Rec (Hoboken). 2019 Aug 21;: Authors: Shen F, Chen Y, Chen L, Qin J, Li Z, Xu J Abstract Non-small-cell lung cancer (NSCLC) is one of the most common human malignancies. Amentoflavone (AF) is one of bioflavonoid compounds isolated from Selaginella tamariscina Spring. This study was designed
- Pereskia bleo Leaves Extract Induces Cell Death via Cell Cycle Arrest and Apoptosis in Cervical Cancer Cells HeLa.Pereskia bleo Leaves Extract Induces Cell Death via Cell Cycle Arrest and Apoptosis in Cervical Cancer Cells HeLa. Nutr Cancer. 2019 Aug 21;:1-9 Authors: Mohd-Salleh SF, Wan-Ibrahim WS, Ismail N Abstract Introduction: Pereskia bleo is a leafy and edible plant, locally known as "Pokok Jarum Tujuh Bilah" which has anticancer properties. This study purposed to determine the cytotoxic effects of P. bleo
- Quinalizarin induces cycle arrest and apoptosis via reactive oxygen species-mediated signaling pathways in human melanoma A375 cells.Related ArticlesQuinalizarin induces cycle arrest and apoptosis via reactive oxygen species-mediated signaling pathways in human melanoma A375 cells. Drug Dev Res. 2019 Aug 20;: Authors: Luo YH, Li JQ, Zhang Y, Wang JR, Xu WT, Zhang Y, Feng YC, Li SZ, Jin CH Abstract Quinalizarin, a bioactive and highly selective compound, is known to promote apoptosis in colon and lung cancer cells. However, studies
- Downregulation of lncRNA NR2F2 Antisense RNA 1 Induces G1 Arrest of Colorectal Cancer Cells by Downregulating Cyclin-Dependent Kinase 6.Related ArticlesDownregulation of lncRNA NR2F2 Antisense RNA 1 Induces G1 Arrest of Colorectal Cancer Cells by Downregulating Cyclin-Dependent Kinase 6. Dig Dis Sci. 2019 Aug 20;: Authors: Li F, Jiang Z, Shao X, Zou N Abstract AIMS: Long non-coding RNA (lncRNA) NR2F2 antisense RNA 1 (NR2F2-AS1) is an oncogenic lncRNA in lung cancer. This study aimed to investigate the role of NR2F2-AS1 in colorectal
- Mcl-1 Inhibitor Induces Cells Death in BRAF-Mutant Amelanotic Melanoma Trough GSH Depletion, DNA Damage and Cell Cycle Changes.Related ArticlesMcl-1 Inhibitor Induces Cells Death in BRAF-Mutant Amelanotic Melanoma Trough GSH Depletion, DNA Damage and Cell Cycle Changes. Pathol Oncol Res. 2019 Aug 20;: Authors: Respondek M, Beberok A, Rzepka Z, Rok J, Wrześniok D Abstract Mcl-1 is a potent antiapoptotic protein and amplifies frequently in many human cancer. Currently, it is considered that the extensively expressed of Mcl-1 p
- Yeast extract inhibits the proliferation of renal cell carcinoma cells via regulation of iron metabolism.Related ArticlesYeast extract inhibits the proliferation of renal cell carcinoma cells via regulation of iron metabolism. Mol Med Rep. 2019 Aug 20;: Authors: Moon D, Kim J, Yoon SP Abstract The microbiome has recently attracted research interest in a variety of subjects, including cancer. In the present study, it was determined that reinforced clostridium media (RCM) for microbiome culture, exerts an
- Curcumin inhibits cell proliferation and migration in NSCLC through a synergistic effect on the TLR4/MyD88 and EGFR pathways.Related ArticlesCurcumin inhibits cell proliferation and migration in NSCLC through a synergistic effect on the TLR4/MyD88 and EGFR pathways. Oncol Rep. 2019 Aug 14;: Authors: Zhang L, Tao X, Fu Q, Ge C, Li R, Li Z, Zhu Y, Tian H, Li Q, Liu M, Hu H, Zeng B, Lin Z, Li C, Luo R, Song X Abstract Despite the increasing number of available therapeutic methods, the prognosis of non‑small cell lung cancer (
- Role of miR‑34 in gastric cancer: From bench to bedside (Review).Related ArticlesRole of miR‑34 in gastric cancer: From bench to bedside (Review). Oncol Rep. 2019 Aug 16;: Authors: Xiong S, Hu M, Li C, Zhou X, Chen H Abstract Gastric cancer (GC) is a prevalent digestive system malignancy that is associated with a poor prognosis specifically for advanced‑stage patients. MicroRNAs (miRNAs) are small, non‑coding RNAs that have been reported to play roles as oncogenes
- The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 kinase via pyrimidine depletion.Related ArticlesThe ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 kinase via pyrimidine depletion. J Biol Chem. 2019 Aug 20;: Authors: Dembitz V, Tomic B, Kodvanj I, Simon JA, Bedalov A, Visnjic D Abstract Metabolic pathways play important roles in proliferation and differentiation of malignant cells. 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr),
- MicroRNA-206 serves as a tumor suppressor in pediatric acute myeloid leukemia by targeting Cyclin D1.Related ArticlesMicroRNA-206 serves as a tumor suppressor in pediatric acute myeloid leukemia by targeting Cyclin D1. Pathol Res Pract. 2019 Jul 23;:152554 Authors: Liu H, Wu H, Qin X Abstract Pediatric acute myeloid leukemia (AML) is a complex and heterogeneous disease. Several studies have shown the regulatory functions of microRNAs (miRNAs) in pediatric AML progression, and in this study, we aimed
- Anti-Colorectal Cancer Effects of Probiotic-Derived p8 Protein.Related ArticlesAnti-Colorectal Cancer Effects of Probiotic-Derived p8 Protein. Genes (Basel). 2019 Aug 19;10(8): Authors: An BC, Hong S, Park HJ, Kim BK, Ahn JY, Ryu Y, An JH, Chung MJ Abstract Recently, we reported a novel therapeutic probiotic-derived protein, p8, which has anti-colorectal cancer (anti-CRC) properties. In vitro experiments using a CRC cell line (DLD-1), anti-proliferation activity
- [Combinations of chemotherapy or radiotherapy with checkpoint inhibitors].Related Articles[Combinations of chemotherapy or radiotherapy with checkpoint inhibitors]. Biol Aujourdhui. 2018;212(3-4):77-79 Authors: Ghiringhelli F Abstract Recent advances in cancer immunotherapy with the development of anti-PD1/PD-L1 antibodies are revolutionizing cancer care. Nevertheless, the efficacy of these treatments in monotherapy is limited to a subpopulation representing about 25-30% o
- Orofacial features and medical profile of eight individuals with Kabuki syndrome.Orofacial features and medical profile of eight individuals with Kabuki syndrome. Med Oral Patol Oral Cir Bucal. 2019 Aug 19;: Authors: Silva-Andrade N, López-Ortega S, Gallottini M Abstract BACKGROUND: To evaluate oral, craniofacial and systemic characteristics of eight patients with Kabuki syndrome (KS), aged between 3 and 16 years old. MATERIAL AND METHODS: in this retrospective study, me
- Congenital human cytomegalovirus infection and neurologic diseases in newborns.Congenital human cytomegalovirus infection and neurologic diseases in newborns. Chin Med J (Engl). 2019 Aug 19;: Authors: Zhang XY, Fang F Abstract OBJECTIVE: This review aimed to summarize research progress regarding congenital cytomegalovirus (cCMV) infection-related nervous system diseases and their mechanisms. DATA SOURCES: All literature quoted in this review was retrieved from PubMed a
- Insights into the mechanisms of epilepsy from structural biology of LGI1-ADAM22.Related ArticlesInsights into the mechanisms of epilepsy from structural biology of LGI1-ADAM22. Cell Mol Life Sci. 2019 Aug 20;: Authors: Yamagata A, Fukai S Abstract Epilepsy is one of the most common brain disorders, which can be caused by abnormal synaptic transmissions. Many epilepsy-related mutations have been identified in synaptic ion channels, which are main targets for current antiepileptic
- Autoimmune Encephalitis and Epilepsy: Evolving Definition and Clinical Spectrum.Related ArticlesAutoimmune Encephalitis and Epilepsy: Evolving Definition and Clinical Spectrum. Korean J Pediatr. 2019 Aug 16;: Authors: Seo JH, Lee YJ, Lee KH, Gireesh E, Skinner H, Westerveld M Abstract Advances in autoimmune encephalitis studies in the past 10 years have headed to the identification of new syndromes and biomarkers that have transformed the diagnostic approach to the disorder. The
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- Is it a Tie at This Point in the Game? Efficacy of Levetiracetam and Phenytoin for the Second-Line Treatment of Convulsive Status Epilepticus.Related ArticlesIs it a Tie at This Point in the Game? Efficacy of Levetiracetam and Phenytoin for the Second-Line Treatment of Convulsive Status Epilepticus. Epilepsy Curr. 2019 Aug 21;:1535759719868180 Authors: Vossler DG Abstract Levetiracetam Versus Phenytoin for Second-Line Treatment of Pediatric Convulsive Status Epilepticus (EcLiPSE): A Multicentre, Open-Label, Randomized Trial Lyttle MD, Rain
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- Asparagine-linked glycosylation is not directly coupled to protein translocation across the endoplasmic reticulum in Saccharomyces cerevisiae.Asparagine-linked glycosylation is not directly coupled to protein translocation across the endoplasmic reticulum in Saccharomyces cerevisiae. Mol Biol Cell. 2019 Aug 21;:mbcE19060330 Authors: Shrimal S, Cherepanova NA, Mandon EC, Venev SV, Gilmore R Abstract Mammalian cells express two oligosaccharyltransferase complexes (STT3A and STT3B) that have distinct roles in N-linked glycosylation. The STT3A
- Clinicians' views of using cortical auditory evoked potentials (CAEP) in the permanent childhood hearing impairment patient pathway.Clinicians' views of using cortical auditory evoked potentials (CAEP) in the permanent childhood hearing impairment patient pathway. Int J Audiol. 2019 Aug 21;:1-9 Authors: Mehta K, Mahon M, Van Dun B, Marriage J, Vickers D Abstract Objective: To obtain clinicians' views on the use of cortical auditory evoked potentials (CAEP) in the clinical pathway. Design: A questionnaire aimed at clinicians who u
- Method for spatial overlap estimation of electroencephalography and functional magnetic resonance imaging responsesPublication date: Available online 21 August 2019Source: Journal of Neuroscience MethodsAuthor(s): N. Heugel, E. Liebenthal, S.A. BeardsleyAbstractBackgroundSimultaneous functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) measurements may represent activity from partially divergent neural sources, but this factor is seldom modeled in fMRI-EEG data integration.New MethodThis paper proposes an approach to estimate the spa
- Optimised lyophilisation-based method for different biomolecule single-extractions from the same rat brain sample: suitability for RNA and protein expression analyses after ischemic strokePublication date: Available online 21 August 2019Source: Journal of Neuroscience MethodsAuthor(s): Alicia Aliena-Valero, Sergio Rius-Pérez, Salvador Pérez, Germán Torregrosa, Juan B. SalomAbstractBackgroundOptimisation of tissue processing procedures in preclinical studies reduces the number of animals used and allows integrated multilevel study in the same sample. Multiple extraction of different biomolecules from the same
- A kinematic study of skilled reaching movement in RatPublication date: Available online 21 August 2019Source: Journal of Neuroscience MethodsAuthor(s): Pierantonio Parmiani, Cristina Lucchetti, Claudio Bonifazzi, Gianfranco FranchiAbstractBackgroundIn the rat, the single-pellet reaching task includes orienting, reaching, grasping and retracting movements. It has previously been described by notation techniques, high-speed video and cineradiographic recordings. Recently, high-definition cameras hav
- Vestibular rehabilitation exercises programs to improve the postural control, balance and gait of children with sensorineural hearing loss: A systematic reviewPublication date: Available online 21 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Renato S. Melo, Andrea Lemos, Giselle S. Paiva, Lucas Ithamar, Marília C. Lima, Sophie Helena Eickmann, Karla Mônica Ferraz, Rosalie Barreto BelianAbstractBackgroundSeveral studies have demonstrated that children with sensorineural hearing loss (SNHL) exhibit postural instabilities, as well as balance and gait di
- Bacteriology and resistance patterns of otitis media with effusionPublication date: Available online 21 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Hye Kyu Min, Seok Huyn Kim, Myung Jin Park, Sung Su Kim, Sang Hoon Kim, Seung Geun YeoAbstractObjectivesFollowing the increased use of antibiotics, the emergence of antibiotic-resistant species in pediatric patients with otitis media has become a problem in recent years. The aim of this study was to investigate change in bact
- Early Detection of Neonatal Hearing Loss by Otoacoustic Emissions and Auditory Brainstem Response over 10 Years of ExperiencePublication date: Available online 21 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Fredy A. Escobar-Ipuz, C. Soria-Bretones, María Ángeles García-Jiménez, Elisa M. Cueto, Ana María Torres Aranda, Jorge Mateo SotosAbstractObjectivesA number of different screening protocols for detecting neonatal hearing loss currently exist. We present our 10 years of experience with using
- Unilateral Acute Cervical Lymphadenitis in Children: can we predict the need for surgery?Publication date: Available online 21 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Ricardo Matos, Sónia Martins, Pedro Marques, Margarida SantosIntroductionPaediatric acute cervical lymphadenitis is a frequent diagnosis in the emergency department. Traditionally, suppurative cervical lymphadenitis (SCL) is associated with a higher need of surgical drainage. However, a great variability in the managem
- Pediatric Hard Palate Foreign Bodies:Case Report and Systematic Review of the LiteraturePublication date: Available online 21 August 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): M. Khalaf, H. Smaily, S. RassiAbstractIntroductionForeign body impaction in the pediatric hard palate is a rarely described otolaryngologic entity. It is often misdiagnosed as a neoplastic or an inflammatory lesion causing much stress to parents. The aim of this paper is to report a case managed in our department and to prese
- EPOS2020 and beyond.Related ArticlesEPOS2020 and beyond. Rhinology. 2019 Jun 01;57(3):161 Authors: Hellings PW Abstract The EPOS2020 Steering group is proud to introduce the EPOS2020 logo, the key goals, the core stakeholders, the planned methodology and the dissemination strategies for EPOS2020. This article is an introduction to the EPOS2020 project and presents the ambitions goals of the latest European Position Pape
- Ask an Editor: When Should You Contact an Editor about Whether Reviews are In?Ilana Gershon asked seven editors for their insights on questions that authors commonly ask. Five are press editors (Berghahn, Chicago, Indiana, Princeton, Stanford) and two are series editors. This month’s column explores the following question: How long should a nervous author wait before asking you if the manuscript’s reviews are in yet? Fred Appel: Ideally the acquisitions editor should inform the author when her manuscript has been succes
ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
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00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis
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