Contributors : Razvan V Chereji ; Peter R Eriksson ; Josefina Ocampo ; David J ClarkSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDNA accessibility is thought to be of major importance in regulating gene expression. We test this hypothesis using a restriction enzyme as a probe of chromatin structure and as a proxy for transcription factors. We measured the digestion rate and the fraction of accessible DNA at all genomic AluI sites in budding...
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Contributors : Razvan V Chereji ; Peter R Eriksson ; Josefina Ocampo ; David J ClarkSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeDNA accessibility is thought to be of major importance in regulating gene expression. We test this hypothesis using a restriction enzyme as a probe of chromatin structure and as a proxy for transcription factors. We measured the digestion rate and the fraction of accessible DNA at all genomic AluI sites...
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Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculus ; Saccharomyces cerevisiaeThis SuperSeries is composed of the SubSeries listed below.
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Contributors : Razvan V Chereji ; Peter R Eriksson ; Josefina Ocampo ; David J ClarkSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeDNA accessibility is thought to be of major importance in regulating gene expression. We test this hypothesis using a restriction enzyme as a probe of chromatin structure and as a proxy for transcription factors. We measured the digestion rate and the fraction of accessible DNA at all genomic AluI sites...
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Contributors : Razvan V Chereji ; Peter R Eriksson ; Josefina Ocampo ; David J ClarkSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeDNA accessibility is thought to be of major importance in regulating gene expression. Here we test this hypothesis, using a restriction enzyme as a probe of chromatin structure and as a proxy for transcription factors. We measured the digestion rate and the fraction of accessible DNA at all genomic AluI...
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Kaposi sarcoma (KS) is an angioproliferative disorder that is commonly associated with human herpes virus 8 as well as the HIV. In fact, KS is one of the most common AIDS-defining illnesses. KS typically presents with diffuse, violaceous cutaneous nodules, and may have concomitant visceral involvement. However, visceral involvement rarely occurs without skin manifestations. A rare case of localised bronchopulmonary KS without skin involvement is described in a patient with previously undiagnosed...
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A 52-year-old male patient with hyaluronic acid-based dermal fillers injected in his cheeks was diagnosed with glossotonsillary malignancy, and managed with concurrent cetuximab (epidermal growth factor receptor inhibitor) and radiation therapy. He developed significant inflammation around the dermal filler sites after first cycle of cetuximab which improved with dissolution of the dermal fillers with hyaluronidase. This suggests that cetuximab can lead to inflammation around the dermal filler sites,...
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We present a rare and unusual case of a 16-year-old girl, with no significant medical history, presenting with right nasal obstruction and suspected sinusitis with occasional epistaxis and haemoptysis. On examination, she had a mass lesion in the right nasal cavity, with no evidence of other pathology on assessment of the ears, nose, throat or head and neck. A CT scan revealed an opacified right maxillary sinus with polypoidal mucosa, extending and passing through the accessory ostium into the right...
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This report discusses a case of superior mesenteric artery (SMA) syndrome in a previously healthy 15-year-old boy with no weight loss or other common risk factors. The patient presented to the emergency department with acute bilious vomiting and epigastric pain after acute consumption of a meal and excessive quantities of water. The patient was diagnosed with SMA syndrome based on the findings of contrasted CT of the abdomen. In early puberty, boys have a significant increase in lean body mass and...
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Electrical injuries are a common occurrence and can be minor or even fatal depending on the voltage to which an individual has been exposed to. Electrical current causes tissue damage by producing heat due to local tissue resistance. Serious electrocution may manifest with cutaneous burns, visceral injuries, organ perforation, and cardiac and respiratory effects. Pneumothorax as a complication of electrical injury is a very rare entity. We report one such case of electrical burn injury with right-sided...
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A 16-year-old female patient showed up at the orthopaedics unit complaining of intolerable pain on her left hip. While being questioned and her clinical history written down, she shared that as part of her daily exercise routine, she ran 10 miles (16 km) daily at a speed of 9.5–10.5 mph (15–17 km/hour). MRI was consequently ordered, confirming the presence of a stress fracture. Therefore, immediate suspension of physical activity was indicated, followed by the prescription of crutches as well as...
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We report a case of primary pulmonary cryptococcosis in a 59-year-old female patient with a history of systemic lupus erythematosus, interstitial lung disease and glaucoma. She presented with a cough, severe fatigue, unintentional weight loss, shortness of breath (increase in home oxygen use from baseline) and pleuritic chest pain of 2 months duration. During these 2 months, her symptoms had worsened despite multiple hospital visits, empirical antibiotics and empirical increase of her steroid dosage....
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Mycobacterium tuberculosisis highly endemic in the Philippines. The diagnosis is challenging with its non-specific presentation and the organism could extend to any of the organs. Interestingly, bacterial peritonitis arising spontaneously from gastrointestinal tuberculosis (TB) in an otherwise healthy, non-cirrhotic patient is quite unusual. In this paper, we discuss the case of a 27-year-old HIV-seronegative woman with massive intraperitoneal mixed bacterial and tuberculous abscess presenting 20...
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Acute appendicitis is the most common cause of the acute abdomen syndrome and can be treated either surgically or conservatively with antibiotics. This case demonstrates the first time use of mechanics based MRI by tomoelastography with generation of quantitative maps of tissue stiffness (shear wave speed in m/s) and tissue fluidity (shear modulus loss angle, in rad) in a case of uncomplicated acute appendicitis with antibiotic treatment at (i) baseline, (ii) the end of treatment (EOT) and (iii)...
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A 42-year-old man reported to our service with a 1-week history of vague cervical neck pain on a background history of a gelastic seizure disorder. Radiological imaging confirmed a type II hangman’s fracture through the C2 pedicle. A CT angiogram of carotid and vertebral arteries was normal, and the patient was managed with an occipitocervical fusion. The patient had no neurological insult and was discharged on day 5 with a Miami-J collar for 6 weeks. Although there are case report evidence of lumbar...
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A 62-year-old previously healthy male was admitted with new onset generalised tonic-clonic seizures. Treatment was initiated with the antiepileptic levetiracetam and he had no further episodes of seizures. Creatine kinase (CPK) level was 1812 IU/L 12-hour postadmission. Despite good hydration, his CPK levels continued to rise dramatically and reached a level of 19 000 IU/L on day 5. This rise was unexplained as he did not have any further seizures and had a normal renal function. In the absence of...
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A 92-year-old woman developed sudden consciousness disturbance, global aphasia and right hemiparesis. She had atrial fibrillation and cardioembolic stroke was diagnosed. Tissue plasminogen activator was administered, and endovascular treatment was initiated. The left middle cerebral artery was occluded and complete recanalisation was achieved after direct aspiration first-pass technique. However, MRI immediately after treatment showed reocclusion. Endovascular treatment was repeated and complete...
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Publication date: Available online 26 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Jong-Mok Lee, Ju-Hyun Kim, Seock Hwan Choi
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Abstract Since the 1960s there has been an escalation in the purposeful utilization of altitude to enhance endurance athletic performance. This has been mirrored by a parallel intensification in research pursuits to elucidate hypoxia-induced adaptive mechanisms and substantiate optimal altitude protocols (e.g., hypoxic dose, duration, timing, and confounding factors such as training load periodization, health status, individual response, and nutritional considerations). The majority...
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A polymer that breaks down in sunlight has been used to create a glider that can transport objects behind enemy lines at night, then disappear without a trace
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Ugandan inventor Brian Gitta created a way to test for malaria without a blood sample. He hopes it will help people get vital treatment faster, and enable us to track and ultimately beat the disease
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Related ArticlesDecompressive craniectomy in malignant middle cerebral artery infarction: family perception, outcome and prognostic factors. Neurocirugia (Astur). 2019 Aug 21;: Authors: García-Feijoo P, Isla A, Díez-Tejedor E, Mansilla B, Palpan Flores A, Sáez-Alegre M, Vivancos C Abstract OBJECTIVE: The prognosis of one hemisphere malignant infarction creates doubt among neurosurgeons about decompressive hemicraniectomy indication. What results are...
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Related ArticlesOral squamous cell cancer in a patient with Lynch syndrome. Oral Oncol. 2019 Aug 21;: Authors: Sorscher S, Lycan T Abstract For patients with Lynch Syndrome (LS) (formerly known as hereditary nonpolyposis colorectal cancer or HNPCC), inheritance of one of several mutated mismatch repair genes (MMR) results in an increased risk for a variety of malignancies including colon, rectal, endometrial, urinary tract, gastric, small bowel and others...
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Related ArticlesResults of portosystemic shunts during extended pancreatic resections. Langenbecks Arch Surg. 2019 Aug 24;: Authors: Oehme F, Distler M, Müssle B, Kahlert C, Weitz J, Welsch T Abstract PURPOSE: Patients with borderline resectable pancreatic cancer are increasingly explored after neoadjuvant treatment protocols. A complete resection, then, frequently includes the resection of the mesentericoportal axis. Portosystemic shunting for advanced...
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Related ArticlesA comparison of non-absorbable polymeric clips and staplers for laparoscopic appendiceal stump closure: analysis of 618 adult patients. Langenbecks Arch Surg. 2019 Aug 24;: Authors: Kliuchanok K, Keßler W, Partecke I, Walschus U, Schulze T, Heidecke CD, Patrzyk M Abstract PURPOSE: The aim of this long-term study was the comparison of appendiceal stump closure with polymeric clips or staplers with respect to perioperative costs and surgical...
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Related ArticlesCentromedian thalamic nuclei deep brain stimulation and Anakinra treatment for FIRES - Two different outcomes. Eur J Paediatr Neurol. 2019 Aug 08;: Authors: Sa M, Singh R, Pujar S, D'Arco F, Desai N, Eltze C, Hughes E, Al Obaidi M, Eleftheriou D, Tisdall M, Selway R, Cross JH, Kaliakatsos M, Valentin A Abstract Febrile infection-related epilepsy syndrome (FIRES) is a severe epilepsy disorder that affects previously healthy children. It...
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Publication date: Available online 26 August 2019Source: Journal of ProteomicsAuthor(s): Carlos Fajardo, Francisco Amil-Ruiz, Carlos Fuentes Almagro, Marcos De Donato, Gonzalo Martinez-Rodriguez, Almudena Escobar Niño, Rafael Carrasco, Juan Miguel Mancera, Francisco Javier Fernandez-AceroAbstractPyrocystis lunula (Schutt) is a photoautotrophic dinoflagellate without armored form, frequently found in marine environments. Today, there are several biotechnological applications derived from the bioluminescent...
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Related ArticlesPatterns of bone metastases from head and neck squamous cell carcinoma. Auris Nasus Larynx. 2019 Aug 21;: Authors: Suzuki A, Kashiwagi N, Doi H, Ishii K, Doi K, Kitano M, Kozuka T, Hyodo T, Tsurusaki M, Yagyu Y, Nakanishi K Abstract OBJECTIVE: To report clinical features of bone metastases (BM) from head and neck squamous cell carcinoma (HNSCC). METHODS: Among 772 patients with HNSCC diagnosed at our hospital over 9 years, 30...
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Abstract Rural public health still faces serious challenges in China. These challenges in rural public health reduce peasants’ well-being and social satisfaction. Examining the social factors of rural public health helps improve the public health in rural areas. This study attempts to characterize the relationship between social deprivation and rural public health in China. In particular, 14 indicators are integrated for assessing social deprivation, which is described from five...
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CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
AbstractNeuroinflammation and microglial activation are significant processes in Alzheimer’s disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in association with Alzheimer’s disease, and experimental data have demonstrated microglial proliferation as a significant component of the neuropathology. In this study, we tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 (JNJ-527) in the P301S mouse tauopathy model. We first demonstrated...
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AbstractAstroglia are multifunctional cells that regulate neuroinflammation and maintain homeostasis within the brain. Astroglial α-synuclein-positive cytoplasmic accumulations have been shown post-mortem in patients with Parkinson’s disease and therefore astroglia may play an important role in the initiation and progression of Parkinson’s disease. Imidazoline 2 binding sites are expressed on activated astroglia in the cortex, hippocampus, basal ganglia and brainstem; therefore, by measuring imidazoline...
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Abstract Two studies were conducted to examine how self-compassion relates to beliefs about failure. Study 1 (N = 252) showed that, after controlling for self-esteem, trait self-compassion correlated positively with the belief that failures are learning opportunities and part of life, and negatively with the belief that failures are aversive and something that must be avoided. In Study 2, participants (N = 124) first recalled their weaknesses, then wrote either (a) a compassionate...
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Related ArticlesSerenoCemTM Granules in mastoid obliteration surgery: a 2 year follow up case series of 55 patients to determine the risk of progressive bone resorption. Clin Otolaryngol. 2019 Aug 25;: Authors: Cherko M, Harrison L, Chawdhary G, Bull M, Bottrill I, Aldren C Abstract SerenoCemTM granules (Corinthian Medical Ltd, Nottingham, UK) are a pre-set version of SerenoCemTM ionomeric cement, which is a bone-bonding and bioactive material marketed...
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Publication date: October 2019Source: Advances in Applied Mathematics, Volume 111Author(s): Peter L. Guo, Sophie C.C. SunAbstractGustafson and Milne proved an identity which can be used to express a Schur function sμ(x1,x2,…,xn) with μ=(μ1,μ2,…,μk) in terms of the Schur function sλ(x1,x2,…,xn), where λ=(λ1,λ2,…,λk) is a partition such that λi=μi+n−k for 1≤i≤k. On the other hand, Fehér, Némethi and Rimányi found an identity which relates sμ(x1,x2,…,xn) to the Schur function sλ(x1,x2,…,xℓ), where λ=(λ1,λ2,…,λℓ)...
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Related ArticlesRadiosensitivity-related postirradiation hypothyroidism in Graves' disease patients. Hormones (Athens). 2019 Aug 24;: Authors: Jia X, Guo K, Gao R, Yu Y, Yang A Abstract PURPOSE: The cumulative incidence of hypothyroidism, in 131I-treated patients with hyperthyroidism caused by Graves' disease, has been gradually increasing each year. Meanwhile, the role of the genes that control radiation sensitivity (GCRS) involved in 131I therapy is...
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Objective. IL-35 was reported as a crucial anti-inflammatory cytokine and could efficiently regulate bone metabolism in murine collagen-induced arthritis model. However, the relationship between IL-35 and bone health in human rheumatoid arthritis (RA) has not been clarified. In this study, the aim was to explore the correlations between IL-35 and bone loss in postmenopausal women with RA. Methods. The study included 76 postmenopausal women with RA and 53 healthy postmenopausal women as healthy controls...
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Abstract Core body temperature is maintained within a narrow range around 37 °C in normal individual. Hypothalamus acts as the body’s thermostat which regulates heat balance. Increased body temperature results from excessive heat production or interference with heat dissipation. Fever is elevation of core body temperature resulting from upward resetting of the hypothalamic thermostatic set-point caused by pyrogens. Hyperthermia is elevation of body temperature beyond the unchanged...
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Abstract Musculoskeletal system consists of bones, skeletal muscles, ligaments, tendons, cartilages and other connective tissues, and joints are the fundamental functional unit. The primary methods used for physical examination of musculoskeletal system are inspection and palpation. Percussion and auscultation are only used in special situations such as percussion pain of vertebrae, auscultation for bone crepitus. The examination should include assessment of muscle strength and...
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Abstract Arthralgia is the pain in the area of joints which is a subjective symptom of patient with or without joint tenderness. Arthralgia could be a result of articular or periarticular disorders and also be a part of systemic diseases with joint involvement.
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Abstract Low back pain is the pain that occurs in the area between the lowest ribs and the crease of the buttocks. It is extremely common which affects about 80% of the population at least once in lifetime. It is also one of the most common causes of disability and the history is used to highlight potentially serious or treatable causes of the pain.
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