Abstract Introduction Endoscopic fenestration remains a first-line treatment option for symptomatic arachnoid cysts. After fenestration, the cyst does not collapse but reaches an equilibrium state. The aim of this study was to evaluate the change in cyst volume following successful fenestration and symptomatic improvement. Methods Cyst volume was measured...
Abstract Purpose Previous studies correlating ultrasound (US)-based optic nerve sheath diameter (ONSD) and intracranial pressure (ICP) in children were performed under general anesthesia. To apply ONSD in daily clinical routine, it is necessary to investigate patients awake. It is furthermore essential for ICP-assessment with ONSD to know if ONSD-ICP correlation varies within individuals. In this study, we report on the influence of wakefulness,...
Abstract Decision-making in pediatric neurosurgery routinely involves assessing intracranial pressure (ICP). The level of injury and severity of disease play an important role in determining which method of ICP measurement is preferred. Invasive and non-invasive techniques have described indications, advantages and shortcomings. This collection of papers from some of the world’s leading thinkers in this field is a refreshing perspective on some mundane techniques and a few innovative...
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Publication date: August 2019Source: Clinical Neurology and Neurosurgery, Volume 183Author(s):
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Abstract Introduction Non-invasively distinguishing aggressive from non-aggressive brain tumors is an important clinical challenge. Intracellular pH (pHi) regulation is essential for normal cell function and is normally maintained within a narrow range. Cancer cells are characterized by a reversed intracellular to extracellular pH gradient, compared to healthy cells, that is maintained by several distinct mechanisms. Previous studies have...
Abstract Introduction Glioblastoma multiforme (GBM) is the most lethal form of gliomas. New therapies are currently in development to tackle treatment limitations such as chemotherapy resistance. One mechanism of resistance may be the stress granules (SG) assembly, a stress-related cellular response that allows cells to recruit and protect mRNAs during stress. SG are composed of various proteins, being G3BP1 a core element that enucleates...
Abstract Background Current bevacizumab-based regimens have failed to improve survival in patients with recurrent glioblastoma. To improve treatment efficacy, we evaluated bevacizumab + BKM120, an oral pan-class I PI3K inhibitor, in this patient population. Methods A brief phase I study established the optimal BKM120 dose to administer with standard-dose...
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Publication date: December 2019Source: Current Opinion in Neurobiology, Volume 59Author(s): Masafumi Tsuboi, Yusuke Hirabayashi, Yukiko GotohWhile all the developmental genes are temporarily repressed for future activation in the pluripotent stem cells, non-neural genes become persistently repressed in the course of commitment to the neuronal lineage. Although Polycomb group proteins (PcG) are key factors for both temporary and persistent repression of the developmental genes, how the same group...
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Publication date: Available online 7 August 2019Source: Brain Research BulletinAuthor(s): Mohaddeseh Ebrahimi-Ghiri, Fatemeh Khakpai, Mohammad-Reza ZarrindastAbstractState-dependent memory (SDM) describes a phenomenon that memory is efficiently restored only when the brain state during restoration matches the state during encoding. Some psychoactive drugs such as morphine, ethanol, and cocaine evoke SDM. The scope of this study was to investigate the cross SDM between morphine and norharmane injected...
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Publication date: October 2019Source: World Neurosurgery, Volume 130Author(s): Nathalie Zaidman, Ashirwad Merve, Vittorio RussoBackgroundIntraosseous locations are extremely rare when it comes to schwannomas and account for 0.2% of primary bone tumors. The most common intraosseous locations include the mandible and sacrum, while cervical, thoracic, and lumbar spine lesions are even more uncommon.Case DescriptionWe describe a 56-year-old female patient with incidental finding of an intraosseous lytic...
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Abstract Gait and postural control deficiencies in Parkinson's disease (PD) involve several specific motor aspects. The aim of this study was to identify and compare the main changes in gait kinematics and postural control with dopaminergic loss in the striatum region. This is a cross‐sectional study that included 42 individuals with PD at different motor stages, according to the Hoehn & Yahr scale (H&Y). Motor subsection of the Movement Disorder Society‐Unified Parkinson Disease Rating...
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