Potential role of autofluorescence imaging in determining biopsy of oral potentially malignant disorders: A large prospective diagnostic study
Author links open overlay panelLinjunShia1ChenxiLia1XueminShenaZengtongZhouaWeiLiubGuoyaoTanga
a
Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China
b
Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Received 22 May 2019, Revised 27 July 2019, Accepted 7 August 2019, Available online 12 August 2019.
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https://doi.org/10.1016/j.oraloncology.2019.08.006Get rights and content
Highlights
•
The diagnostic value of VELscop was examined in a large prospective study of 517 patients with OPMD.
•
High NPV and sensitivity were in distinguishing high-risk lesions from low-risk lesions.
•
Our data indicate the cases without LAF substantially rule out the presence of high-risk lesions.
•
A no biopsy strategy may be appropriate for OPMD without LAF using VELscope.
Abstract
Autofluorescence examination of oral tissues using the VELscope has been suggested as an adjunctive tool for cancer detection and diagnosis. This study aimed to determine the diagnostic value of VELscope in a large prospective study of 517 patients with oral potentially malignant disorders (OPMD). For the outcome assessments of discrimination of carcinoma form general OPMD and distinguishing high-risk lesions (moderate/severe dysplasia and carcinoma) from low-risk lesions (no/mild dysplasia), high sensitivity (100% and 95.9% respectively) and negative predictive value (100% and 98.2% respectively) were observed. All the carcinoma and showed loss of autofluorescence (LAF) and only 3 (0.6%) moderate/severe dysplasia were observed without LAF.
These data indicate that the cases without LAF using VELscope substantially rule out the presence of high-risk lesions including cancer. This may prove to be useful specially to alleviate patient anxiety regarding a clinically suspicious oral lesion without the LAF, and to avoid a unnecessary biopsy for these cases. Collectively, a perspective to highlight was that a no biopsy strategy may be appropriate for OPMD without LAF using VELscope after conventional oral examination.
Keywords
VELscopeTissue autofluorescenceDysplasiaOral cancerOral potentially malignant disorder
1
LS and CL contributed equally to this work.
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© 2019 Elsevier Ltd. All rights reserved.
Author links open overlay panelLinjunShia1ChenxiLia1XueminShenaZengtongZhouaWeiLiubGuoyaoTanga
a
Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China
b
Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Received 22 May 2019, Revised 27 July 2019, Accepted 7 August 2019, Available online 12 August 2019.
Show less
https://doi.org/10.1016/j.oraloncology.2019.08.006Get rights and content
Highlights
•
The diagnostic value of VELscop was examined in a large prospective study of 517 patients with OPMD.
•
High NPV and sensitivity were in distinguishing high-risk lesions from low-risk lesions.
•
Our data indicate the cases without LAF substantially rule out the presence of high-risk lesions.
•
A no biopsy strategy may be appropriate for OPMD without LAF using VELscope.
Abstract
Autofluorescence examination of oral tissues using the VELscope has been suggested as an adjunctive tool for cancer detection and diagnosis. This study aimed to determine the diagnostic value of VELscope in a large prospective study of 517 patients with oral potentially malignant disorders (OPMD). For the outcome assessments of discrimination of carcinoma form general OPMD and distinguishing high-risk lesions (moderate/severe dysplasia and carcinoma) from low-risk lesions (no/mild dysplasia), high sensitivity (100% and 95.9% respectively) and negative predictive value (100% and 98.2% respectively) were observed. All the carcinoma and showed loss of autofluorescence (LAF) and only 3 (0.6%) moderate/severe dysplasia were observed without LAF.
These data indicate that the cases without LAF using VELscope substantially rule out the presence of high-risk lesions including cancer. This may prove to be useful specially to alleviate patient anxiety regarding a clinically suspicious oral lesion without the LAF, and to avoid a unnecessary biopsy for these cases. Collectively, a perspective to highlight was that a no biopsy strategy may be appropriate for OPMD without LAF using VELscope after conventional oral examination.
Keywords
VELscopeTissue autofluorescenceDysplasiaOral cancerOral potentially malignant disorder
1
LS and CL contributed equally to this work.
View full text
© 2019 Elsevier Ltd. All rights reserved.
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