Photodynamic therapy combined with surgery for hidradenitis suppurativa: A case report Publication date: December 2019 Source: Photodiagnosis and Photodynamic Therapy, Volume 28 Author(s): Dan Luo, Yang Tan, Qionghui Cheng, Jinjin Wu, Xia Lei Abstract Hidradenitis Suppurativa (HS) is a distressing painful chronic inflammatory skin follicular condition. It is a challenge to achieve better therapeutic effect and lower recurrence rate. In this report, ALA-PDT combined with surgery for the treatment achieved ulcer healing, pain elimination, with no relapse during our follow-up.

Anti-cancer, anti-biofilm, and anti-inflammatory properties of hen’s albumen: A photodynamic approach Publication date: December 2019 Source: Photodiagnosis and Photodynamic Therapy, Volume 28 Author(s): Justin Sherly Carolyn, Daniel Selva Raj, Balasubramanian Malaikozhundan, Marimuthu Govindarajan, Naiyf S. Alharbi, Shine Kadaikunnan, Jamal M. Khaled, Mohammed N. Al-Anbr, Ahmed S. Alobaidi, Baskaralingam Vaseeharan Abstract The albumen plays a major role in the protection of eggs against microorganisms. It contains an arsenal of natural antimicrobial molecules and antibacterial proteins, including the well-known ovotransferrin and lysozyme, which exert their activities against a range of bacteria. In the present study, the hen’s albumen extract treated with the dried insect body of blister beetle M. pustulata was assessed for antibacterial, antibiofilm, anti-inflammatory and anti-proliferative activity. The zone of inhibition against Gram positive E. faecalis and S. aureus was 10.8 mm and 12.1 mm respectively at 100 μg mL−1. However, it was 13.6 mm and 15.3 mm for Gram negative P. aeruginosa and P. vulgaris respectively. The biofilm of tested bacteria was significantly inhibited at 100 μg mL−1. The hydrophobicity of bacterial biofilms was considerably condensed after treatment with the hen’s albumen extracts at 100 μg mL−1. The anti-inflammatory activity of hen’s albumen extracts was confirmed by the inhibition of cyclooxygenase (COX) enzyme to 84.91% at 100 μg mL−1 with the relative IC50 of 8.26 μg mL−1. The albumen extract effectively inhibited the viability (23.61%) of HepG2 hepatic cancer cells at 100 μg mL−1. The anti-proliferative activity of the albumen extracts was further revealed by the induction of HepG2 apoptotic cell morphology. This study concludes that the hen’s albumen extract treated with M. pustulata is a natural therapeutic agent to treat biofilm associated clinical bacteria, inflammations and human hepatic cancer cells. Graphical abstract

Combination of tacalcitol ointment and photodynamic therapy for the treatment of follicular mucinosis of the scalp Publication date: September 2019 Source: Photodiagnosis and Photodynamic Therapy, Volume 27 Author(s): Roberta Giuffrida, Francesco Borgia, Ilenia Marafioti, Gabriella Riso, Serafinella P. Cannavò Abstract Follicular mucinosis (FM) is a rare inflammatory disorder histologically characterized by mucin deposition in the follicular epithelium. There is no standard therapy for FM and several treatments have been described in the literature. We present the case of a 59 year-old female affected by a recalcitrant FM with diffuse scalp alopecia, in which complete clinical remission was achieved after a combination of topical tacalcitol and photodynamic therapy.

Combination of electrocoagulation and photodynamic therapy for angiolymphoid hyperplasia with eosinophilia in the external ear Publication date: September 2019 Source: Photodiagnosis and Photodynamic Therapy, Volume 27 Author(s): Lisha Wu, Fangfang Li, Wei Shi, Juan Su, Mingliang Chen, Xiang Chen, Shuang Zhao Abstract Angiolymphoid hyperplasia with eosinophilia (ALHE) is an inflamed vascular tumefaction of uncertain pathogenesis and is characterized by higher recurrence rates after surgical excision or other approaches. In the present study, we performed a new approach by combining electrocoagulation with photodynamic therapy (PDT) for the treatment of two ALHE patients. They had multiple treatments in the past and had poor therapeutic effects with relapse each time. After informed consent was obtained, electrocoagulation was used to remove the superficial lesions of ALHE, and the first session of PDT was immediately applied to the lesion. A total of three sessions of PDT were applied to each patient with an interval of 7–10 days. Through more than 12 months of follow-up, the two patients showed complete regression, and no recurrence was observed. Meanwhile, patients were very satisfied with the cost and cosmetic outcomes of the combination treatment. Based on our results, we strongly recommend the combination of electrocoagulation with PDT as a favourable treatment for ALHE, especially in the external ear and other areas that are inconvenient for routine surgery.

Photodynamic therapy induced pemphigus: Atypical clinical, pathological and immunological features Publication date: September 2019 Source: Photodiagnosis and Photodynamic Therapy, Volume 27 Author(s): D. Ortega-Quijano, C.M. Garcia del Real, J. Jimenez-Cauhe, D. Fernandez-Nieto, A. Ballester-Martinez, M. Fernandez-Guarino

Successful treatment of kerion with itraconazole and ALA-PDT: A case report Publication date: September 2019 Source: Photodiagnosis and Photodynamic Therapy, Volume 27 Author(s): Jiejie Lu, Wen Li, Wen’ai Zheng, Ruiye Huang, Weiwei Wu Abstract Kerion refers to the severe inflammatory reaction which occurs in some cases of fungal infection of the hair or hair follicles. Successful treatment is a challenge for the small number of kerion patients who show poor efficacy of oral antifungal agents. In recent years, photodynamic therapy (PDT) has been proven to be a useful treatment for a variety of fungal infections. In this case report, a 9-year-old Chinese girl presented with erythema, pustular and tender plaques on her scalp for 2 month. The diagnosis of kerion was made based on clinical features and positive mycological findings. After the disease relapsed with oral administration of itraconazole for 6 weeks, she was successfully cured by three sessions of ALA-PDT combined with itraconazole. This case report suggests that ALA-PDT provides a good alternative and adjutant choice for kerion with safety, less side effects, and good repeatability.

The fluorescein angiographic photodiagnosis of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome: Outcome of combined therapy Publication date: September 2019 Source: Photodiagnosis and Photodynamic Therapy, Volume 27 Author(s): Buğra Karasu, Derya Özkan, Gürkan Erdoğan, Özgür Artunay Abstract Idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN) syndrome is a disease characterized by multiple retinal macroanurysms, neuroretinitis and ischemia in peripheral vessels, which are difficult to diagnose and cause visual loss if delayed. It consists of 5 stages and causes irreversible vision loss with severe complications after stage 2. In this report, photodiagnosis and combined treatment are defined in a Turkish patient with IRVAN syndrome during 6 months of follow-up. Fundus fluorescein angiography (FFA) showed that bilateral aneurysms in retinal vessels as well as aneurysms and ischemic regions were observed in the inferotemporal retina of the left eye. Argon laser photocoagulation was performed to ischemic regions at the left eye. 2 months later best corrected visual acuities were 20/20 and counting fingers from 1 m in the right and left eyes, respectively. Fundus and OCT images showed that an increase in exudations was observed at the left eye and intravitreal injection of dexametasone implant was considered. Three months after initial presentation, best corrected visual acuities were 20/20 and counting fingers from 2 m in right and left eyes, consequetively. In the last fundus and OCT images, the exudations decreased and disappeared on left eye. In this patient, we could not detect an increase in vision due to damage of photoreceptor cells because of subretinal exudation. In the shed-light of this case, the combination therapy seems to improved the anatomical and functional outcomes in IRVAN syndrome however close follow-up and frequent examinations should be prioritized.

Atypical polypoid adenomyoma treated by hysteroscopy with photodynamic diagnosis using 5-aminolevulinic acid: A case report Publication date: September 2019 Source: Photodiagnosis and Photodynamic Therapy, Volume 27 Author(s): Yusuke Matoba, Kouji Banno, Yusuke Kobayashi, Iori Kisu, Daisuke Aoki Abstract Surgical resection for atypical polypoid adenomyoma (APA) is an option for fertility preservation. Due to the high recurrence rate of APA, studies have been conducted to improve total resection of tumors. Photodynamic diagnosis (PDD) using 5-aminolevulinic acid (5-ALA) improves tumor resection, but this has not been applied for APA. The patient was 35-year-old. After initial treatment, the APA lesion did not disappear. We performed hysteroscopic tumor resection using 5-ALA-PDD. Only one PDD-positive lesion was found and histopathologically diagnosed as APA. Other areas were PDD-negative and showed no histopathologic APA or malignant findings. This is the first report of hysteroscopic 5-ALA-PDD for APA. This method makes it easy to identify morbid lesions, and may lead to improved total resection and decreased recurrence.

Recurrent chondroblastic osteosarcoma of the right mandible subjected to photochemical internalization Publication date: September 2019 Source: Photodiagnosis and Photodynamic Therapy, Volume 27 Author(s): Waseem Jerjes, Zaid Hamdoon, Kristian Berg, Anders Høgset, Colin Hopper

Successful treatment of recalcitrant plantar warts: Pretreatment with superficial shaving is vital before photodynamic therapy Publication date: September 2019 Source: Photodiagnosis and Photodynamic Therapy, Volume 27 Author(s): Kai Huang, Yixin Li, Wenjie Zeng, Zixi Jiang, Wu Zhu, Mingliang Chen, Bo Deng, Juan Su, Shuang Zhao