Perioperative dynamic changes in circulating tumor DNA in lung cancer patients (DYNAMIC)Purpose: No study have investigated the precise perioperative dynamic changes in circulating tumor DNA (ctDNA) in any early stage cancer patients. This study (DYNAMIC) investigated perioperative dynamic changes in ctDNA and determine the appropriate detection time of ctDNA-based surveillance for surgical lung cancer patients. Experimental Design: Consecutive patients who underwent curative-intent lung resections were enrolled prospectively (NCT02- Transforming the early drug development paradigm at the National Cancer Institute: The formation of NCI's Experimental Therapeutics Clinical Trials Network (ETCTN)Early drug development for cancer requires broad collaboration and skilled clinical investigators to enable enrollment of patients whose tumors have defined molecular profiles. To respond to these challenges, the National Cancer Institute (NCI) transformed its 60-year old early phase drug development program in 2014 into the Experimental Therapeutics Clinical Trials Network (ETCTN). The ETCTN is a consolidated, national network of 40+ academic in
- Tissue and Plasma EGFR Mutation Analysis in the FLAURA Trial: Osimertinib vs Comparator EGFR-TKI as First-Line Treatment in Patients with EGFR Mutated Advanced NSCLCPurpose: To assess the utility of the cobas® EGFR Mutation Test, with tissue and plasma, for first-line osimertinib therapy for patients with EGFR-mutated (EGFRm) (Ex19del and/or L858R) advanced or metastatic non-small cell lung cancer (NSCLC) from the FLAURA study (NCT02296125). Experimental Design: Tumor tissue EGFRm status was determined at screening using the central cobas tissue test or a local tissue test. Baseline circulating tumor (ct)DNA
- Phase I Trial of Well-Differentiated Neuroendocrine Tumors (NETs) with Radiolabeled Somatostatin Antagonist 177 Lu-Satoreotide TetraxetanPurpose: Radiolabeled somatostatin receptor 2 (SSTR2) antagonists have shown higher tumor uptake and tumor-to-organ ratios than somatostatin agonists in preclinical models of NETs. We performed a phase I study to evaluate the safety and efficacy of SSTR2 antagonist 177Lu-satoreotide tetraxetan. EXPERIMENTAL DESIGN: Twenty patients with advanced SSTR2 positive NETs were treated with 177Lu-satoreotide tetraxetan. Patients first underwent a dosimetr
- A novel mitochondrial inhibitor blocks MAPK pathway and overcomes MAPK inhibitor-resistance in melanoma.Purpose: To determine if inhibition of mitochondrial oxidative phosphorylation (OxPhos) is an effective strategy against MAPK pathway inhibitor (MAPKi)-resistant BRAF-mutant melanomas. Experimental Design: The anti-melanoma activity of IACS-010759 (OPi), a novel OxPhos complex I inhibitor, was evaluated in vitro and in vivo. Mechanistic studies and predictors of response were evaluated using molecularly and metabolically stratified melanoma cell
- Molecular characterization of locally relapsed head and neck cancer after concomitant chemoradiotherapyPurpose: To investigate the pathobiological origin of local relapse after chemoradiotherapy (CRT), we studied genetic relationships of primary tumors (PT) and local relapses (LRs) of patients treated with CRT. Experimental design: First, low coverage whole genome sequencing was performed on DNA from 44 biopsies of resected HNSCC specimen (median 3 biopsies per tumor) to assess suitability of copy number profiles as biomarker for genetic relation
- Chimeric antigen receptor T cells targeting CD79b show efficacy in lymphoma with or without co-targeting CD19Purpose: T cells engineered to express a chimeric antigen receptor (CAR) against CD19 have recently been FDA-approved for the treatment of relapsed or refractory large B cell lymphoma. Despite the success and curative potential of CD19 CAR T cells, several reports describing disease relapse due to antigen loss are now emerging. Experimental design: We developed a novel CAR construct directed against CD79b, a critical receptor for successful B cel
- PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate CancerPurpose: In this study we addressed the underlying mechanisms for the association between enzalutamide treatment and NEPC, and the critical involvement of MYCN, and loss of RB1 function in NED of prostatic epithelial cells, and the development of NEPC. We further sought to determine whether PARP inhibition could suppress NEPC, and to identify molecular determinants of this therapeutic activity. Experimental Design: We utilized a novel prostate ca
- A Phase II Trial of Vandetanib (ZD6474, Caprelsa a) in Children and Adults with Succinate Dehydrogenase Deficient Gastrointestinal Stromal TumorPurpose: Gastrointestinal stromal tumors (GIST) are resistant to cytotoxic and radiation therapy. Most GIST in children are wild-type for KITand PDGFRA (WT GIST) and deficient in expression of succinate dehydrogenase (dSDH GIST). We tested the activity of vandetanib, an oral small molecule inhibitor of VEGFR2, EGFR, and RET, in patients with dSDH GIST. Experimental Design: Phase II study of vandetanib (300 mg orally once daily to patients ≥18 yea
- Acquired Resistance Mutations to ALK-Inhibitors Identified by Single Circulating Tumor Cell Sequencing in ALK-Rearranged Non-Small-Cell Lung CancerPurpose: Anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancer (NSCLC) patients inevitably develop resistance to ALK-inhibitors. New diagnostic strategies are needed to assess resistance mechanisms and provide patients with the most effective therapy. We asked whether single-circulating tumor cell (CTC) sequencing can inform on resistance mutations to ALK-inhibitors and underlying tumor heterogeneity in ALK-rearranged NSCLC. Exp
- POSEIDON phase 1b results: safety, efficacy and ctDNA response of taselisib combined with tamoxifen in hormone receptor positive metastatic breast cancer patientsBackground: The strategy of combining endocrine therapy with PI3K-mTOR inhibition has shown promise in oestrogen-receptor (ER)-positive breast cancer, but new agents and combinations with a better therapeutic index are urgently needed. Taselisib is a potent, selective, beta-isoform sparing PI3 kinase inhibitor. Patients and Methods: 30 patients with ER-positive, metastatic breast cancer who had failed prior endocrine therapy were treated with esc
- ‘Paralysed by anxiety’: researchers speak about life in troubled ancient-DNA labNature, Published online: 23 August 2019; doi:10.1038/d41586-019-02540-5Colleagues of Alan Cooper, who has been suspended as leader of the prestigious Australian Centre for Ancient DNA, describe a toxic work environment.
- DHA-SBT-1214 Taxoid Nanoemulsion and Anti-PD-L1 Antibody Combination Therapy Enhances Anti-Tumor Efficacy in a Syngeneic Pancreatic Adenocarcinoma ModelThe goal of this study was to evaluate combination of a novel taxoid, DHA-SBT-1214 chemotherapy in modulating immune checkpoint marker expression and ultimately in improving antibody-based checkpoint blockade therapy in pancreatic adenocarcinoma (PDAC). DHA-SBT-1214 was encapsulated in an oil-in-water nanoemulsion and administered systemically in Panc02 syngeneic PDAC-bearing C57BL/6 mice. Following treatment with DHA-SBT-1214, PD-L1 expression l
- Tumor intrinsic efficacy by SHP2 and RTK inhibitors in KRAS mutant cancersKRAS, an oncogene mutated in nearly one-third of human cancers, remains a pharmacological challenge for direct inhibition except for recent advances in selective inhibitors targeting the G12C variant. Here, we report that selective inhibition of the protein tyrosine phosphatase, SHP2, can impair the proliferation of KRAS mutant cancer cells in vitro and in vivo using cell line xenografts and primary human tumors. In vitro, sensitivity of KRAS mut
- Targeting PI3K/Akt/mTOR pathway identifies differential expression and functional role of IL-8 in liver cancer stem cell enrichmentActivation of PI3K/Akt/mTOR pathway is an important signaling mechanism involved in the development and the progression of liver cancer stem cell (LCSC) population during acquired Sorafenib resistance in advanced Hepatocellular carcinoma (HCC). Therefore, identification of novel therapeutic targets involving this pathway and acting on LCSCs are highly essential. Here, we analyzed the bioactivities and the molecular pathways involved in the action
- A systematic review of the impact of antifungal stewardship interventions in the United StatesAntimicrobial resistance is a widely recognized public health threat, and stewardship interventions to combat this problem are well described. Less is known about antifungal stewardship (AFS) initiatives and t...
- The Comfort of the Ordinary — On Dying as We’ve LivedYears ago, I heard about the death of an old family friend whom I’d loved as a child for her eccentric cooking habits, feeding her parakeets saliva-soaked crumbs from her lips, and letting me rap my knuckles on her wooden leg. Although I wasn’t with her at the end of her colorful life, I can almost…
- Reconstruction of mandibular defects using vascularized fibular osteomyocutaneous flap combined with nonvascularized fibular flap.Related ArticlesReconstruction of mandibular defects using vascularized fibular osteomyocutaneous flap combined with nonvascularized fibular flap. Med Oral Patol Oral Cir Bucal. 2019 Aug 19;: Authors: Wang W, Zhu J, Xu B, Xia B, Liu Y, Shao S Abstract BACKGROUND: The height of single-layer fibular flap is not long enough to return to the ideal height of the mandible. While the double-layer vasculariz
- Assessment of the capacity of a pyrophosphate-based mouth rinse to inhibit the formation of supragingival dental calculus. a randomized double-blind placebo-controlled clinical trial.Related ArticlesAssessment of the capacity of a pyrophosphate-based mouth rinse to inhibit the formation of supragingival dental calculus. a randomized double-blind placebo-controlled clinical trial. Med Oral Patol Oral Cir Bucal. 2019 Aug 19;: Authors: Fons-Badal C, Agustín-Panadero R, Solá-Ruíz MF, Alpiste-Illueca F, Font-Fons A Abstract BACKGROUND: This study aimed to analyze the efficacy of an an
- Validation of microRNA expression profile in Oral Lichenoid Disease through cytological samples.Related ArticlesValidation of microRNA expression profile in Oral Lichenoid Disease through cytological samples. Med Oral Patol Oral Cir Bucal. 2019 Aug 19;: Authors: Setién-Olarra A, Marichalar-Mendia X, Fernández-Pacheco JA, Fernández-Barriales-López M, Gainza-Cirauqui ML, Aguirre-Urizar JM Abstract BACKGROUND: To validate oral exfoliative cytology in the analysis of the microRNA expression profile
- Oral and dental health status in patients with eating disorders in Madrid, Spain.Related ArticlesOral and dental health status in patients with eating disorders in Madrid, Spain. Med Oral Patol Oral Cir Bucal. 2019 Aug 19;: Authors: Garrido-Martínez P, Domínguez-Gordillo A, Cerero-Lapiedra R, Burgueño-García M, Martínez-Ramírez MJ, Gómez-Candela C, Cebrián-Carretero JL, Esparza-Gómez G Abstract BACKGROUND: The aim of the present study was to describe and compare the oral and dent
- The accuracy of three-dimensional rapid prototyped surgical template guided anterior segmental osteotomy.Related ArticlesThe accuracy of three-dimensional rapid prototyped surgical template guided anterior segmental osteotomy. Med Oral Patol Oral Cir Bucal. 2019 Aug 19;: Authors: Qu M, Zhu S, Hu Z, Li Y, Abotaleb B, Bi R, Jiang N Abstract BACKGROUND: Surgical guiding templates provided a reliable way to transfer the simulation to the actual operation. However, there was no template designed for anterior
- Epigenetics and periodontics: A systematic review.Related ArticlesEpigenetics and periodontics: A systematic review. Med Oral Patol Oral Cir Bucal. 2019 Aug 19;: Authors: Almiñana-Pastor PJ, Boronat-Catalá M, Micó-Martinez P, Bellot-Arcís C, Lopez-Rolda A, Alpiste-Illueca FM Abstract BACKGROUND: Despite decades of research, our knowledge of several important aspects of periodontal pathogenesis remains incomplete. Epigenetics allows to perform dynami
- Impact of crestal and subcrestal implant placement upon changes in marginal peri-implant bone level. A systematic review.Related ArticlesImpact of crestal and subcrestal implant placement upon changes in marginal peri-implant bone level. A systematic review. Med Oral Patol Oral Cir Bucal. 2019 Aug 19;: Authors: Pellicer-Chover H, Díaz-Sanchez M, Soto-Peñaloza D, Peñarrocha-Diago MA, Canullo L, Peñarrocha-Oltra D Abstract BACKGROUND: To systematically assess studies analyzing peri-implant bone loss in implants placed in
- Trends of maxillofacial trauma: An update from the prospective register of a multicenter study in emergency services of Chile.Related ArticlesTrends of maxillofacial trauma: An update from the prospective register of a multicenter study in emergency services of Chile. Med Oral Patol Oral Cir Bucal. 2019 Aug 19;: Authors: Werlinger F, Villalón M, Duarte V, Acevedo R, Aguilera R, Alcocer D, Badillo O, Briones R, Condal C, Del Río M, García R, Herrera M, Jaramillo J, Merchan F, Nasi M, Osbén R, Rivera A, Riviello S, Rojas P, Vidal C, Rodríguez
- Orofacial features and medical profile of eight individuals with Kabuki syndrome.Related ArticlesOrofacial features and medical profile of eight individuals with Kabuki syndrome. Med Oral Patol Oral Cir Bucal. 2019 Aug 19;: Authors: Silva-Andrade N, López-Ortega S, Gallottini M Abstract BACKGROUND: To evaluate oral, craniofacial and systemic characteristics of eight patients with Kabuki syndrome (KS), aged between 3 and 16 years old. MATERIAL AND METHODS: in this retrosp
- Effects of locally applied Insulin-like Growth Factor-I on osseointegration.Related ArticlesEffects of locally applied Insulin-like Growth Factor-I on osseointegration. Med Oral Patol Oral Cir Bucal. 2019 Aug 19;: Authors: López-Quiles J, Forteza-López A, Montiel M, Clemente C, Fernández-Tresguerres JA, Fernández-Tresguerres I Abstract BACKGROUND: The aim of this study was to assess the effect of local application of IGF-I on osseointegration of dental implants placed in ost
- Is the re-use of sterilized implant abutments safe enough? (Implant abutment safety).Related ArticlesIs the re-use of sterilized implant abutments safe enough? (Implant abutment safety). Med Oral Patol Oral Cir Bucal. 2019 Aug 19;: Authors: Sánchez-Garcés MA, Jorba M, Ciurana J, Vinas M, Vinuesa MT Abstract BACKGROUND: The reuse of implant healing abutments is common in dental practice. Effective elimination of bacteria and viruses is accomplished by conventional sterilization. The a
- Stomatological disorders in older people: An epidemiological study in the brazil southern.Related ArticlesStomatological disorders in older people: An epidemiological study in the brazil southern. Med Oral Patol Oral Cir Bucal. 2019 Aug 19;: Authors: Fattori E, Teixeira DS, de Figueiredo MA, Cherubini K, Salum FG Abstract BACKGROUND: The aim of this retrospective, cross-sectional and observational study was to perform a survey of the stomatological conditions of elderly patients seen in a
- Environmental Association Identifies Candidates for Tolerance to Low Temperature and DroughtBarley (Hordeum vulgare ssp. vulgare) is cultivated from the equator to the Arctic Circle. The wild progenitor species, Hordeum vulgare ssp. spontaneum, occupies a relatively narrow latitudinal range (~30 - 40° N) primarily at low elevation (< 1,500 m). Adaptation to the range of cultivation has occurred over ~8,000 years. The genetic basis of adaptation is amenable to study through environmental association. An advantage of environmental asso
- Genomic Data Reveal Conserved Female Heterogamety in Giant Salamanders with Gigantic Nuclear GenomesSystems of genetic sex determination and the homology of sex chromosomes in different taxa vary greatly across vertebrates. Much progress remains to be made in understanding systems of genetic sex determination in non-model organisms, especially those with homomorphic sex chromosomes and/or large genomes. We used reduced representation genome sequencing to investigate genetic sex determination systems in the salamander family Cryptobranchidae (ge
- Forthcoming IssuesAnesthesia for Otolaryngology
- Not Just Smaller Ears, Noses, Throats, and NecksOn the first day of my clinical rotation in Pediatrics as a third-year medical student, I was handed the Harriet Lane Handbook and told, with some ferocity, that “children are not just little adults.” Similarly, otolaryngologic problems in children are not just smaller versions of those problems in adults. Although otolaryngologists have always cared for children, and the fundamental nature of their specialty is conducive to treating diseases in
- ContributorsSUJANA S. CHANDRASEKHAR, MD, FACS, FAAOHNS
- Updates in Pediatric OtolaryngologyOTOLARYNGOLOGIC CLINICS OF NORTH AMERICA
- [ASAP] Exploiting Excited-State Aromaticity To Design Highly Stable Singlet Fission MaterialsJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b06346
- [ASAP] Förster Resonance Energy Transfer-Based Fluorescent Probe for the Selective Imaging of Hydroxylamine in Living CellsAnalytical ChemistryDOI: 10.1021/acs.analchem.9b02737
- [ASAP] Detection of Anti-<italic toggle="yes">Toxoplasma gondii</italic> Antibodies in Human Sera Using Synthetic Glycosylphosphatidylinositol Glycans on a Bead-Based Multiplex AssayAnalytical ChemistryDOI: 10.1021/acs.analchem.9b02154
- [ASAP] Dual-Functional Titanium(IV) Immobilized Metal Affinity Chromatography Approach for Enabling Large-Scale Profiling of Protein Mannose-6-Phosphate Glycosylation and Revealing Its Predominant SubstratesAnalytical ChemistryDOI: 10.1021/acs.analchem.9b01698
- [ASAP] A Generic Liquid Chromatography-Tandem Mass Spectrometry Exposome Method for the Determination of Xenoestrogens in Biological MatricesAnalytical ChemistryDOI: 10.1021/acs.analchem.9b02446
- Case 26-2019: A 27-Year-Old Woman with Opioid Use Disorder and Suicidal IdeationPresentation of Case. Dr. Andrew Cruz (Psychiatry): A 27-year-old woman was evaluated at this hospital because of a suicide attempt. Approximately 3 months before admission, the patient became homeless and was staying intermittently with friends. Two months before admission, she began to ingest…
- Population genomics of Vibrionaceae isolated from an endangered oasis reveals local adaptation after an environmental perturbation. [NEW RESULTS]Background: In bacteria, pan-genomes are the result of the evolutionary "tug of war" between selection and horizontal gene transfer (HGT). High rates of HGT increase the genetic pool and the effective population size, resulting in open pan-genomes. In contrast, selective pressures can lead to local adaptation by purging the variation introduced by HGT, resulting in closed pan-genomes and clonal lineages. In this study, we explored both hypotheses
- Modelling the niches of wild and domesticated Ungulatespecies using deep learning [NEW RESULTS]Knowledge of global biodiversity remains limited by geographic and taxonomic sampling biases. The scarcity of species data restricts our understanding of the underlying environmental factors shaping distributions, and the ability to draw comparisons among species. Species distribution models (SDMs) were developed in the early 2000s to address this issue. Although SDMs based on single layered Neural Networks have been experimented with in the past
- The impact of local adaptation and biological invasion on the geographical distribution of Aedes aegypti in Panama [NEW RESULTS]Local adaptation is an important consideration when predicting arthropod-borne disease risk because it can impact on individual vector fitness and vector population persistence. However, the extent that populations are adapted to local environmental conditions remains unknown. Using sequence capture technology and Environmental Association Analysis of 371,307 SNPs we show that local adaptation of Aedes aegypti mosquito populations across relative
- Convergent genomic signatures of high altitude adaptation among domestic mammals [NEW RESULTS]Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we utilized 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparati
- Here's how early humans evaded immunodeficiency virusesThe cryoEM structure of a simian immunodeficiency virus protein bound to primate proteins shows how a mutation in early humans allowed our ancestors to escape infection while monkeys and apes did not. SIV's Nef protein forms a solid link between two primate proteins, tetherin and AP-2, forcing the destruction of tetherin, which normally prevents new SIV virions from budding off. A mutation in human tetherin disrupted binding, thwarting SIV buddi
- Here's how early humans evaded immunodeficiency virusesThe cryoEM structure of a simian immunodeficiency virus protein bound to primate proteins shows how a mutation in early humans allowed our ancestors to escape infection while monkeys and apes did not. SIV's Nef protein forms a solid link between two primate proteins, tetherin and AP-2, forcing the destruction of tetherin, which normally prevents new SIV virions from budding off. A mutation in human tetherin disrupted binding, thwarting SIV buddi
- A single gene determines whether a fly has a good sense of sight or a good sense of smellTrade-offs in the sizes of visual and olfactory organs are a common feature of animal evolution, but the underlying genetic and developmental mechanisms have not been clear. A study reveals that a single DNA variant that affects the timing of sensory organ development in fruit flies could explain the size trade-off between eyes and antennae, potentially providing a quick route to behavioral changes and adaptation.
- Higher Dose Starting Protocols In Coronary Artery Disease Patients With Aspirin HypersensitivityAspirin is first-line treatment in coronary artery disease (CAD) patients, but in patients with acute coronary syndrome (ACS) or who require dual antiplatelet therapy after myocardial revascularization, aspirin therapy becomes critical and time-sensitive1. Approximately 1.5% of CAD patients report aspirin allergy2. Most reactions are considered non-immunologic, related to aspirin’s inhibition of cyclo-oxygenase causing allergic-like symptoms3. A
- Unexpected and Unintended Cure of Habit Cough by ProxyIn 1966, Dr. Bernie Berman, a Boston allergist, described 6 children with a chronic cough that could be stopped by “the art of suggestion.” Dr. Berman called this a Habit Cough. This disorder has been repeatedly described, sometimes with different terminology, but with the same description of the characteristic sound of the cough, barking or honking, and the absence of the cough once asleep.2,3,4,5,6,7,8 The frequency of Habit Cough diagnoses wer
- Fornix-Region Deep Brain Stimulation–Induced Memory Flashbacks in Alzheimer’s DiseaseTo the Editor: In a randomized trial involving 42 patients, we assessed deep brain stimulation targeting the fornix to improve cognition in patients with Alzheimer’s disease (ClinicalTrials.gov number, NCT01608061; the protocol for the trial is available with the published article). Although the…
- EvoFreq: Visualization of the Evolutionary Frequencies of Sequence and Model Data [NEW RESULTS]High throughput sequence data has provided in depth means of molecular characterization of populations. When recorded at numerous time steps, such data can reveal the evolutionary dynamics of the population under study by tracking the changes in genotype frequencies over time. This necessitates a simple and flexible means of visualizing an increasingly complex set of data. Here we offer EvoFreq as a comprehensive tool set to visualize the evoluti
- Human Health on an Ailing Planet — Historical Perspectives on Our FutureWhat can we do when the patient needing emergency care is the earth? What life support can physicians offer our ailing planet? History can help us understand and answer these pressing questions. A deluge of recent reports document the degradation of Earth’s ecosystems. Local and national…
- Do We Really Need Another Time-Series Study of the PM2.5–Mortality Association?The link between particulate pollution and mortality was originally recognized in the context of severe episodes of poor air quality in the 20th century, such as the London Fog of 1952. These episodes showed clear evidence that the number of deaths increased in association with high levels of…
- Prioritizing Health in a Changing ClimateAs medical professionals navigate busy days in temperature-controlled hospitals and seemingly indestructible health care systems, it can be easy to lose sight of the environmental chaos unfolding outside. The stark reality is that high levels of greenhouse gases caused by the combustion of fossil…
- Ambient Particulate Air Pollution and Daily Mortality in 652 CitiesThe adverse health effects of short-term exposure to ambient air pollution are well documented. Particulate matter (PM), especially, arouses public health concerns because of its toxicity and the widespread human exposure to this pollutant. PM, which includes inhalable particles with an aerodynamic…
- Prescription Drug Monitoring Programs — Friend or Folly in Addressing the Opioid-Overdose Crisis?Virtually every U.S. state has implemented a prescription drug monitoring program (PDMP) to address high-risk opioid-prescribing and opioid-seeking behaviors that have contributed to the opioid-overdose crisis. PDMPs — electronic databases that track dispensing of controlled substances — are…
- A New Era of Climate Medicine — Addressing Heat-Triggered Renal DiseaseWith a rising death toll from chronic kidney disease of unknown origin (CKDu) — also known in Central America as Mesoamerican nephropathy — and with greenhouse gas emissions driving global temperature increases, we are woefully short of early screening tools and treatment options for tens of…
- New approach to the treatment of persistent lagophthalmosInability to close the eyelid completely (lagophthalmos) is a devastating complication of facial nerve palsy. Excessive evaporation of the tear film secondary to corneal exposure will result in corneal abrasion, ulceration, and severe distress to the affected patient.1 Various weights for upper eyelid loading have been used effectively in the treatment of paralytic lagophthalmos. Rigid gold, platinum implants, and platinum-iridium alloy chains ar
- Results of flap reconstruction: categorisation to reflect outcomes and process in the management of head and neck defectsThe reporting of the outcomes of flap reconstruction is often based on numerical success rates. Whilst this remains a useful variable with which to measure success, it is limited in its ability to reflect the complex processes involved. The lack of consistency in the categorisation of outcomes of flap reconstruction in the head and neck could potentially lead us to lose the opportunity to fully capture the implications of its success or failure,
- Multicenter study of surgical and oncologic outcomes of extra-levator versus conventional abdominoperineal excision for lower rectal cancerPublication date: Available online 21 August 2019Source: European Journal of Surgical OncologyAuthor(s): Zhanlong Shen, Zhaode Bu, Ang Li, Junyang Lu, Liyu Zhu, Choon Seng Chong, Zhidong Gao, Kewei Jiang, Shan Wang, Fei Li, Yi Xiao, Jiafu Ji, Yingjiang YeAbstractBackgroundThe surgical and oncological outcome of extra-levator abdominoperineal excision (ELAPE) procedure remains unclear in low rectal cancer.MethodsA total of 194 cases of rectal can
- Ultrasonography with the colonic segment-approach for colonic polyps in childrenAbstract Background Ultrasonography (US) has been widely applied and has validated efficacy in the diagnosis of colonic polyps in children. However, little attention has been paid to improving the detection rate of polyps, optimizing the ultrasonic examination process and reducing misdiagnosis. Objective
- Pharmacogenetics of medication-related osteonecrosis of the jaw: a systematic review and meta-analysisMedication-related osteonecrosis of the jaw (MRONJ) is a severe complication that can develop in patients treated with anti-resorptive drugs. Although the pathogenesis of MRONJ is still unclear, genetic factors have a demonstrated important role. Thus, the aim of this study was to perform a systematic review on the pharmacogenetics of MRONJ. Studies published until March 2019 were retrieved from eight databases and were selected by two independen
- William S. SimmonsSeptember 10, 1938–June 2, 2018 William S. Simmons, professor of anthropology at Brown University, passed away on June 2, 2018. Simmons (or Bill, as most knew him) was born on September 10, 1938 in Providence. He earned a BA cum laude with highest honors in human biology from Brown University in 1960, and master’s and doctoral degrees in anthropology from Harvard University in 1963 and 1967. He joined the Anthropology Department fa
- [ASAP] Metal-Free Selective Borylation of Arenes by a Diazadiborinine via C–H/C–F Bond Activation and DearomatizationJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b06022
- [ASAP] Catalytic Enantioselective House–Meinwald Rearrangement: Efficient Construction of All-Carbon Quaternary StereocentersJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b07514
- [ASAP] Synthesis of Belt- and Möbius-Shaped Cycloparaphenylenes by Rhodium-Catalyzed Alkyne CyclotrimerizationJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b06197
- [ASAP] A Domino 10-Step Total Synthesis of FR252921 and Its Analogues, Complex Macrocyclic ImmunosuppressantsJournal of the American Chemical SocietyDOI: 10.1021/jacs.9b07185
- Fornix-Region Deep Brain Stimulation–Induced Memory Flashbacks in Alzheimer’s DiseaseTo the Editor: In a randomized trial involving 42 patients, we assessed deep brain stimulation targeting the fornix to improve cognition in patients with Alzheimer’s disease (ClinicalTrials.gov number, NCT01608061; the protocol for the trial is available with the published article). Although the…
- Human Health on an Ailing Planet — Historical Perspectives on Our FutureWhat can we do when the patient needing emergency care is the earth? What life support can physicians offer our ailing planet? History can help us understand and answer these pressing questions. A deluge of recent reports document the degradation of Earth’s ecosystems. Local and national…
- Surgical treatment of intraperitoneal metastases from lung cancer: two case reports and a review of the literaturePeritoneal metastases are often reported in several abdominal tumors. Peritoneal diffusion from extra-abdominal tumors is thought to be rare. Lung cancer is one of the most common cancers in the world with ear...
- Measurement of Chitinase Activity in Biological SamplesPresented here is a simple method to measure chitinase activity in biological fluids such as bronchoalveolar lavage or serum.
- Lightest neutrino is at least 6 million times lighter than an electronNature, Published online: 22 August 2019; doi:10.1038/d41586-019-02538-zResearchers established the limits by combining data from surveys of the cosmos and particle-physics experiments.
- Cuba’s untold Zika outbreak uncoveredNature, Published online: 22 August 2019; doi:10.1038/d41586-019-02510-xAn unreported spike in cases from 2017 is revealed through international travellers, a technique that could help with early detection in other epidemics.
- Working Scientist podcast: Switching scientific disciplinesNature, Published online: 22 August 2019; doi:10.1038/d41586-019-02500-zMoving to a new branch of science is scary, but learning new skills and collaborating with different colleagues can be exhilarating, Julie Gould discovers.
- Daily briefing: Cryptographers fight a future without secretsNature, Published online: 22 August 2019; doi:10.1038/d41586-019-02544-1Preparing for the day quantum computers bring down public-key encryption, huge US study will offer genetic counselling and how consciousness arose from 3.8 billion years of trying to survive.
- CRISPR cuts turn gels into biological watchdogsNature, Published online: 22 August 2019; doi:10.1038/d41586-019-02542-3Wunderkind gene-editing tool used to trigger smart materials that can deliver drugs and sense biological signals.
- Language, neurodevelopment, and behavior in Angelman syndrome: a case reportRESUMO Objetivo O objetivo deste estudo é apresentar achados de linguagem, comportamento e neurodesenvolvimento de uma menina com diagnóstico da Síndrome de Angelman, avaliada aos três e aos oito anos. Método Os instrumentos de avaliação foram Observação do Comportamento Comunicativo, Early Language Milestone Scale (ELM) e Teste de Screening de Desenvolvimento DENVER-II (TSDD-II). Resultados No caso apresentado, verifica-se a presença dos sina
- The Comfort of the Ordinary — On Dying as We’ve LivedYears ago, I heard about the death of an old family friend whom I’d loved as a child for her eccentric cooking habits, feeding her parakeets saliva-soaked crumbs from her lips, and letting me rap my knuckles on her wooden leg. Although I wasn’t with her at the end of her colorful life, I can almost…
- Prescription Drug Monitoring Programs — Friend or Folly in Addressing the Opioid-Overdose Crisis?Virtually every U.S. state has implemented a prescription drug monitoring program (PDMP) to address high-risk opioid-prescribing and opioid-seeking behaviors that have contributed to the opioid-overdose crisis. PDMPs — electronic databases that track dispensing of controlled substances — are…
- Drug Effects on the ThyroidThere is a growing list of medications known to adversely affect thyroid function or interpretation of the results of standard thyroid laboratory testing. Many of these drugs are commonly used preparations, ranging from over-the-counter supplements to advanced medical therapy, and include…
- Case 26-2019: A 27-Year-Old Woman with Opioid Use Disorder and Suicidal IdeationPresentation of Case. Dr. Andrew Cruz (Psychiatry): A 27-year-old woman was evaluated at this hospital because of a suicide attempt. Approximately 3 months before admission, the patient became homeless and was staying intermittently with friends. Two months before admission, she began to ingest…
- Emphysematous CholecystitisAn 80-year-old man with a history of hypertension presented to the emergency department with a 2-day history of abdominal pain in the right upper quadrant. The patient was febrile. On physical examination, he had abdominal tenderness in the right upper quadrant, and Murphy’s sign was positive.…
- Fish Bone PerforationA 73-year-old man presented to the emergency department with the acute onset of severe lower abdominal pain. He recalled eating yellowtail fish the day before the onset of the pain. His temperature was 38°C, blood pressure 122/69 mm Hg, and heart rate 77 beats per minute. On physical examination,…
- Prescription Drug Monitoring Programs — Friend or Folly in Addressing the Opioid-Overdose Crisis?Virtually every U.S. state has implemented a prescription drug monitoring program (PDMP) to address high-risk opioid-prescribing and opioid-seeking behaviors that have contributed to the opioid-overdose crisis. PDMPs — electronic databases that track dispensing of controlled substances — are…
- Case 26-2019: A 27-Year-Old Woman with Opioid Use Disorder and Suicidal IdeationPresentation of Case. Dr. Andrew Cruz (Psychiatry): A 27-year-old woman was evaluated at this hospital because of a suicide attempt. Approximately 3 months before admission, the patient became homeless and was staying intermittently with friends. Two months before admission, she began to ingest…
- Immediate Reconstruction of Oncologic Spinal Wounds Is Cost-Effective Compared to Conventional Primary Wound ClosureBackground: Several studies have demonstrated a reduced wound complication rate when immediate soft tissue reconstruction is performed after complex spine instrumentations in high-risk patients; however, the cost-effectiveness of this technique is not known. We hypothesized that immediate soft tissue reconstruction of oncologic spine wounds would be a cost-effective strategy compared to the standard of care (oncologic spine surgery with conven
- The Supercharged Pedicled Jejunal Flap (SPJ) for Total Esophageal Reconstruction: A Retrospective Review of 100 CasesBackground: When gastric pull-up is unsuccessful or unsuitable for total esophageal reconstruction, a supercharged pedicled jejunum (SPJ) can be used to re-establish gastrointestinal continuity. We reviewed our technique and outcomes of the SPJ for total esophageal reconstruction. Methods: A retrospective review of a prospectively maintained database was performed of 100 patients who underwent SPJ for total esophageal reconstruction betwe
- Comparative study of meshed and non-meshed acellular dermal matrix in immediate breast reconstructionBackground: Acellular dermal matrices (ADM) are commonly used to support implant-based breast reconstruction. Meshing may enhance integration, reduce drain time and seroma, and decrease surgical costs. Methods: This was a retrospective, single-center analysis of 83 adult women (115 breasts) undergoing one-stage (84.3%) or two-stage (15.7%) immediate breast reconstruction with bovine-derived ADM (SurgiMend) meshed at 2:1 ratio. Outcomes we
- Can a Partially Injured Donor Nerve Restore Elbow Flexion in an Acute Brachial Plexus Injury in Rats?Background: Loss of elbow flexion commonly occurs following acute brachial plexus injury. The double fascicular transfer (DFT) is often used in acute C5-C6 and C5-C7 root injuries, but rarely applied in cases involving concomitant C8 or T1 root injury. We designed a rat model using varying severities of lower trunk (LT) injury to determine whether partial injury to the LT affects nerve transfers for elbow flexion. Methods: There were four
- Hyperparathyroidism Due to Concurrent Parathyroid Carcinoma and Parathyroid AdenomaParathyroid carcinoma is uncommon, and its coexistence with parathyroid adenoma is extremely rare. A 28-year-old woman with hyperparathyroidism underwent dual-phase 99mTc-sestamibi SPECT/CT scan for presurgical evaluation. The images showed intense activity inside the left side thyroid and mild activity inside the right side of the thyroid. The histopathologic findings showed intrathyroidal parathyroid carcinoma on the left side and intrathyroid
- Extremely Rapid and Specific Metabolic Labelling of RNA In Vivo with 4-Thiouracil (Ers4tU)The use of thiolated uracil to sensitively and specifically purify newly transcribed RNA from the yeast Saccharomyces cerevisiae.
- Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell PopulationsThe BSelex method to identify and recover individual antigen-specific antibodies from human peripheral blood mononuclear cells combines flow cytometry with single cell PCR and cloning.
ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
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Πέμπτη 22 Αυγούστου 2019
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis
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