• Outcomes associated with peripherally inserted central catheters in hospitalised children: a retrospective 7-year single-centre experience

  ObjectivesThe use of peripherally inserted central catheters (PICCs) are an integral part of caring for hospitalised children. We sought to estimate the incidence of and identify the risk factors for complications associated with PICCs in an advanced registered nurse practitioners (ARNP)-driven programme. DesignRetrospective cohort study. SettingSingle-centre, large quaternary children's hospital. ParticipantsHospitalised children who had PICC

  BMJ Open Current Issue

  2h
• Choosing Healthy Eating for Infant Health (CHErIsH) study: protocol for a feasibility study

  IntroductionChildhood obesity is a public health challenge. There is evidence for associations between parents’ feeding behaviours and childhood obesity risk. Primary care provides a unique opportunity for delivery of infant feeding interventions for childhood obesity prevention. Implementation strategies are needed to support infant feeding intervention delivery. The Choosing Healthy Eating for Infant Health (CHErIsH) intervention is a complex i

  BMJ Open Current Issue

  2h
• Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium

  ObjectiveTo study the association of educational level and risk of death from all causes, cardiovascular disease (CVD) and cancer among Asian populations. DesignA pooled analysis of 15 population-based cohort studies. Setting and participants694 434 Asian individuals from 15 prospective cohorts within the Asia Cohort Consortium. InterventionsNone. Main outcome measuresHRs and 95% CIs for all-cause mortality, as well as for CVD-specific mortal

  BMJ Open Current Issue

  2h
• Learning types and learning success in a structured diabetes education programme for patients with type 2 diabetes: study protocol of a prospective, longitudinal study

  IntroductionDiabetes mellitus (DM) has had a wide-ranging impact on healthcare politics. Secondary diseases and complications caused by diabetes are relevant cost and utilisation factors in the healthcare system. For decades, diabetes self-management education (DSME) has played a major role in the treatment of patients with type 2 DM (T2DM). The aim of this training is to empower patients to actively influence their diabetes process by gaining kn

  BMJ Open Current Issue

  2h
• Efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a protocol for systematic review and individual patient data (IPD) meta-analysis

  IntroductionPregnant women are more vulnerable to malaria leading to adverse impact on both mothers and fetuses. However, knowledge on the efficacy and safety of antimalarials in pregnancy is limited by the paucity of randomised control trials and the lack of standardised protocols in this special subpopulation. Pooling individual patient data (IPD) for meta-analysis could address in part these limitations to summarise accurately the currently av

  BMJ Open Current Issue

  2h
• The joint effect of insomnia symptoms and lifestyle factors on risk of self-reported fibromyalgia in women: longitudinal data from the HUNT Study

  ObjectivesTo investigate the association between insomnia symptoms and risk of self-reported fibromyalgia in women, and to explore whether leisure time physical activity and body mass index (BMI) modify this association. DesignProspective cohort study. SettingWe used longitudinal data from the Norwegian Nord-Trøndelag Health Study collected in 1995–1997 (baseline) and 2006–2008 (follow-up). ParticipantsA total of 14 172 women who reported to b

  BMJ Open Current Issue

  2h
• PCASTt/SPCG-17--a randomised trial of active surveillance in prostate cancer: rationale and design

  IntroductionOvertreatment of localised prostate cancer is substantial despite increased use of active surveillance. No randomised trials help define how to monitor patients or when to initiate treatment with curative intent. Methods and analysisA randomised, multicentre, intervention trial designed to evaluate the safety of an MRI-based active surveillance protocol, with standardised triggers for repeated biopsies and radical treatment. The aim

  BMJ Open Current Issue

  2h
• Optimising neonatal service provision for preterm babies born between 27 and 31 weeks gestation in England (OPTI-PREM), using national data, qualitative research and economic analysis: a study protocol

  IntroductionIn England, for babies born at 23–26 weeks gestation, care in a neonatal intensive care unit (NICU) as opposed to a local neonatal unit (LNU) improves survival to discharge. This evidence is shaping neonatal health services. In contrast, there is no evidence to guide location of care for the next most vulnerable group (born at 27–31 weeks gestation) whose care is currently spread between 45 NICU and 84 LNU in England. This group repre

  BMJ Open Current Issue

  2h
• Physical activity, sedentary time and their associations with clustered metabolic risk among people with type 2 diabetes in Jiangsu province: a cross-sectional study

  ObjectiveInvestigating the association between total physical activity, physical activity in different domains and sedentary time with clustered metabolic risk in patients with type 2 diabetes from Jiangsu province, China. DesignInterview-based cross-sectional study conducted between December 2013 and January 2014. Setting44 selected townships across two cities, Changshu and Huai’an, in Jiangsu province. Participants20 340 participants selecte

  BMJ Open Current Issue

  2h
• Readmission and processes of care across weekend and weekday hospitalisation for acute myocardial infarction, heart failure or stroke: an observational study of the National Readmission Database

  ObjectivesVariation in hospital resource allocations across weekdays and weekends have led to studies of the ‘weekend effect’ for ST elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI), heart failure (HF) and stroke. However, few studies have explored the ‘weekend effect’ on unplanned readmission. We aimed to investigate 30-day unplanned readmissions and processes of care across weekend and weekday hospitalisa

  BMJ Open Current Issue

  2h
• Individual and environmental factors associated with death of cyclists involved in road crashes in Spain: a cohort study

  ObjectiveTo quantify the magnitude of associations between cyclist fatalities and both cyclist and environment related characteristics in Spain during the first 24 hours after a crash. DesignCohort study. SettingSpain. Participants65 977 cyclists injured in road crashes recorded between 1993 and 2013 in the Spanish Register of Road Crashes with Victims. Main outcomeDeath within the first 24 hours after the crash. MethodsA multiple imputation

  BMJ Open Current Issue

  2h
• Protocol for a prospective observational diagnostic study: intraoperative simultaneous limb pressure monitoring (INSTANT) study

  IntroductionPeripheral vascular disease (PVD) is a condition caused by arterial blockages causing inadequate blood flow, resulting in pain and gangrene of the legs. Endovascular therapy, such as angioplasty, can be used to treat PVD, however, the operator feedback during surgery is primarily anatomic based on the angiogram. Because physiologic blood perfusion can be difficult to determine based on anatomic images, we propose introducing physiolog

  BMJ Open Current Issue

  2h
• An exploratory spatial analysis of overweight and obesity among children and adolescents in Shandong, China

  ObjectiveIdentifying the spatial patterns of childhood overweight/obesity (OW/OB) can help to guide resource allocation for preventive intervention in China. This study aims to estimate rates of childhood OW/OB across counties within Shandong Province, using geographic techniques to identify sex-specific spatial patterns of childhood OW/OB as well as the presence of spatial clusters. DesignCross-sectional study. SettingShandong Province in Chin

  BMJ Open Current Issue

  2h
• Effect of home-based high-intensity interval training and behavioural modification using information and communication technology on cardiorespiratory fitness and exercise habits among sedentary breast cancer survivors: habit-B study protocol for a randomised controlled trial

  IntroductionMaintaining high levels of physical activity helps to maintain and improve physical health and quality of life, and plays a role in reducing adverse effects due to cancer treatments. Moreover, a greater degree of cardiorespiratory fitness is associated with reduced risk of all-cause mortality. However, there are no home-based programme for improving cardiorespiratory fitness using body weight exercises for breast cancer survivors. Thi

  BMJ Open Current Issue

  2h
• Enriching medical trainees learning through practice: a video reflexive ethnography study protocol

  IntroductionSupporting medical students’ and junior doctors’ development in busy clinical settings is challenging. As opportunities for developing trainees, for example, traditional bedside teaching, are decreasing, teaching outside of clinical practice is increasing. However, evidence suggests that effective learning through practice arises via an interplay between, first, what experiences are afforded by clinical settings and, second, how train

  BMJ Open Current Issue

  2h
• Addressing the polypharmacy challenge in older people with multimorbidity (APOLLO-MM): study protocol for an in-depth ethnographic case study in primary care

  IntroductionPolypharmacy is on the rise. It is burdensome for patients and is a common source of error and adverse drug reactions, especially among older adults. Health policy advises clinicians to practice medicines optimisation—a person-centred approach to safe, effective medicines use. There has been little research exploring older patients’ perspectives and priorities around medicines-taking or their actual practices of fitting medicines into

  BMJ Open Current Issue

  2h
• Exploring geographic variation in acute appendectomy in Ireland: results from a national registry study

  ObjectiveTo explore geographic variations in Irish laparoscopic and open appendectomy procedures. DesignAnalysis based on 2014–2017 administrative hospital data from public hospitals. SettingCounties of Ireland. ParticipantsIrish residents with hospital admissions for an appendectomy as the principal procedure. Main outcome measuresAge and gender standardised laparoscopic and open appendectomy rates for 26 counties. Geographic variation measu

  BMJ Open Current Issue

  2h
• Toxins, Vol. 11, Pages 485: Cytotoxic and Proapoptotic Activity of Sanguinarine, Berberine, and Extracts of Chelidonium majus L. and Berberis thunbergii DC. toward Hematopoietic Cancer Cell Lines

  Toxins, Vol. 11, Pages 485: Cytotoxic and Proapoptotic Activity of Sanguinarine, Berberine, and Extracts of Chelidonium majus L. and Berberis thunbergii DC. toward Hematopoietic Cancer Cell Lines Toxins doi: 10.3390/toxins11090485 Authors: Anna Och Daniel Zalewski Łukasz Komsta Przemysław Kołodziej Janusz Kocki Anna Bogucka-Kocka Isoquinoline alkaloids belong to the toxic secondary metabolites occurring in plants of ma

  Toxins

  2h
• Targeted Temperature Management in Nursing Care

  Therapeutic Hypothermia and Temperature Management, Ahead of Print.

  Therapeutic Hypothermia and Temperature Management

  2h
• Incidental Finding of Thrombus by Ultrasonography in a Trauma Patient with an Intravascular Cooling Device

  Therapeutic Hypothermia and Temperature Management, Ahead of Print.

  Therapeutic Hypothermia and Temperature Management

  2h
• Fall Is in the Air

  Therapeutic Hypothermia and Temperature Management, Ahead of Print.

  Therapeutic Hypothermia and Temperature Management

  2h
• Optimization of phosphate recovery as struvite from synthetic distillery wastewater using a chemical equilibrium model

  Abstract This study investigates the feasibility of recovery of phosphorus via struvite precipitation from a synthetic anaerobically treated distillery spent wash by optimizing the process using a chemical equilibrium model, namely Visual MINTEQ. Process parameters such as Mg2+, \( {\mathrm{PO}}_4^{3-} \) , and

  Latest Results

  2h
• Drug Effects on the Thyroid

  There is a growing list of medications known to adversely affect thyroid function or interpretation of the results of standard thyroid laboratory testing. Many of these drugs are commonly used preparations, ranging from over-the-counter supplements to advanced medical therapy, and include…

  http://search.nejm.org/search?cnt=20&start_month=9&start_year=2005&w=*&restrict=doctype%3Aarticle&srt=0&isort=date&ts=rss&af=topic:6

  2h
• GSE118989 KCNH2-3.1 mediates aberrant complement activation to impair hippocampal-medial prefrontal pathway associated with schizophrenia

  Contributors : Ming Ren ; Zhonghua Hu ; Qiang Chen ; Andrew Jaffe ; Yingbo Li ; Vijay Sadashivaiah ; Shujuan Zhu ; Nina Rajpurohit ; Joo-Heon Shin ; Wei Xia ; Yankai Jia ; Jingxian Wu ; Sunny L Qin ; Xinjian Li ; Jian Zhu ; Qingjun Tian ; Daniel Parades ; Fengyu Zhang ; Kuan H Wang ; S V Mattay ; H J Callicott ; Karen F Berman ; Daniel R Weinberger ; Feng YangSeries Type : Expression profiling by high throughput sequencingOrgani

  New GEO Series

  2h
• GSE136214 Gene expression from ErbB2-driven mamamry tumors (MMTV-NIC model) with beta 1 integrin KO, beta 3 integrin KO or beta 1/beta 3 double KO

  Contributor : Tung BuiSeries Type : Expression profiling by arrayOrganism : Mus musculusIn this study, we used conditional knockout and gene expression approaches to understand global molecular and transciptional changes due to ablation of each integrin subunit.Affymetrix MoGene-2_0-st-v1 gene chip

  New GEO Series

  2h
• GSE119045 Apoptosis in the fetal testis eliminates developmentally defective germ cell clones

  Contributors : D H Nguyen ; D J LairdSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMammalian egg and sperm are produced by germ cells (GCs) that develop in the embryo long before reproductive maturity. Many GCs that begin this process do not contribute their genes to the next generation, although it remains unclear what determines GC fitness. Here, we examined how the composition of GCs in the fetal testis

  New GEO Series

  2h
• GSE136212 Paternal knockout of Slc38a4/SNAT4 causes placental hypoplasia associated with intrauterine growth restriction in mice

  Contributors : Shogo Matoba ; Shoko Nakamuta ; Kento Miura ; Michiko Hirose ; Hirosuke Shiura ; Takashi Kohda ; Nobuaki Nakamuta ; Atsuo OguraSeries Type : Expression profiling by arrayOrganism : Mus musculusThe placenta is critical for mammalian embryonic development because the embryo’s supply of nutrients, including amino acids, depends solely on mother-to-embryo transport through the placenta. However, the molecular mechanisms underly

  New GEO Series

  2h
• GSE136225 Dach1 downregulation marks a lymphoid-primed progenitor in early haematopoiesis

  Contributors : Luyi Tian ; Daniela Amann-Zalcenstein ; Jaring Schreuder ; Shalin H NaikSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA classical view of blood cell development is that multipotent haematopoietic stem and progenitor cells (HSPCs) become lineage-restricted at defined stages. The Lin–c-kit+Sca1+Flt3+ stage, termed lymphoid-primed multipotent progenitors (LMPPs), have lost megakaryocyte and

  New GEO Series

  2h
• GSE136211 Regulation of Drosophila intestinal stem cell proliferation by enterocyte mitochondrial pyruvate metabolism

  Contributors : Dona R Wisidagama ; Carl S ThummelSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterPurpose: The goals of this study was to compare differentially expressed transcripts when MPC expression is supressed in the adult intestines or enterocyte. The NCBI gene ID for dMPC1 is 42268.

  New GEO Series

  2h
• GSE119042 Thermo Fisher Scientific OncoScan expression array data for undifferentiated uterine sarcomas (CNV)

  Series Type : Genome variation profiling by arrayOrganism : Homo sapiensThermo Fisher Scientific OncoScan expression array data for undifferentiated uterine sarcoma

  New GEO Series

  2h
• GSE136205 H3K27me3 ChIP-Seq analysis of ErbB2-driven mouse mammary tumour cells treated with GSK-126

  Contributors : Alison Hirukawa ; William J MullerSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMonoclonal antibodies (mAbs) targeting the oncogenic receptor tyrosine kinase ERBB2/HER2, such as Trastuzumab, are the standard of care therapy for breast cancers driven by ERBB2 overexpression and activation. However, a substantial proportion of patients exhibits de novo resistance. Here, by compa

  New GEO Series

  2h
• GSE115460 Expression data from Saccharomyces cerevisiae F12 cells in the presence of insoluble solids at high concentration

  Contributors : Antonio D Moreno ; Elia Tomás-PejóSeries Type : Expression profiling by arrayOrganism : Saccharomyces cerevisiae ; Schizosaccharomyces pombeThe implementation of a cost-effective lignocellulosic ethanol production requires developing efficient high gravity processes (i.e. working at high substrate concentrations). During the fermentation processes, the presence of high concentration of insoluble solids leads to lower glucose consu

  New GEO Series

  2h
• GSE136194 miRNA profiling from different histological subtypes of colorectal carcinoma

  Contributors : Angel Esteban-Gil ; Fernando Pérez-Sanz ; José García-Solano ; Begoña Alburquerque-González ; María A Parreño-González ; María del Carmen Legaz-García ; Edith Rodriguez-Braun ; Paola Pimentel ; Ondrej Slaby ; Pablo Conesa-ZamoraSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; synthetic constructColorectal cancer (CRC) is the third leading cause of cancer mortality worldwide. Different pathological p

  New GEO Series

  2h
• GSE122466 Transcriptional logic of cell fate specification and axon guidance in early born retinal neurons revealed by single-cell mRNA profiling [10X]

  Contributors : Quentin L Lo Giudice ; Marion L Leuleu ; Pierre F FabreSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusApplication of single-cell sequencing technology "10X" to obtain neural retinal transcriptomes. This resource highlight transcriptional sequences that establish the hierarchical ordering of early cell fate specification in the retina.

  New GEO Series

  2h
• GSE136178 Bacillus velezensis LG37: Transcriptome profiling and functional verification of GlnK and NmtA in ammonia (NH4+) assimilation

  Contributors : Guangxin Liu ; Li LinSeries Type : Expression profiling by high throughput sequencingOrganism : Bacillus velezensisnot provided; requested

  New GEO Series

  2h
• GSE119043 Thermo Fisher Scientific OncoScan expression array data for undifferentiated uterine sarcomas

  Series Type : Expression profiling by array ; Genome variation profiling by arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.

  New GEO Series

  2h
• GSE136098 Identification of AIA-related genes

  Contributors : Weijie Li ; Xia MaoSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusTo obtain AIA-related genes [the significant differentially expressed genes (DEGs) of AIA model group vs. Normal control group], the microarray analysis was carried out.

  New GEO Series

  2h
• GSE119041 Thermo Fisher Scientific OncoScan expression array data for undifferentiated uterine sarcomas (expression)

  Series Type : Expression profiling by arrayOrganism : Homo sapiensThermo Fisher Scientific OncoScan expression array data for undifferentiated uterine sarcoma

  New GEO Series

  2h
• GSE126820 Transcriptional logic of cell fate specification and axon guidance in early born retinal neurons revealed by single-cell mRNA profiling

  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.

  New GEO Series

  2h
• GSE118894 An Aspergillus niger colony locally adapts its molecular responses to spatially separated substrates

  Contributors : Hugh Mitchell ; Meng Markillie ; Paul Daly ; Mao Peng ; Ronald P de VriesSeries Type : Expression profiling by high throughput sequencingOrganism : Aspergillus nigerSaprotrophic fungi, such as Aspergillus niger, grow as mycelial colonies that are often considered uniform entities. To test this uniformity, we analyzed pie-slice sections of a colony grown on spatially separated substrates (glucose, wheat bran, sugar beet pulp) us

  New GEO Series

  2h
• GSE126819 Transcriptional logic of cell fate specification and axon guidance in early born retinal neurons revealed by single-cell mRNA profiling [C1]

  Contributors : Quentin L Lo Giudice ; Marion L Leuleu ; Gioele L La Manno ; Pierre F FabreSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusApplication of single-cell sequencing C1 to obtain neural retinal transcriptomes.

  New GEO Series

  2h
• GSE85965 Transcriptome effects mediated by forced overexpression of BACE1-AS in HAOEC cells

  Contributors : Simona Greco ; Christine Voellenkle ; J M Garcia-Manteiga ; Fabio MartelliSeries Type : Expression profiling by arrayOrganism : Homo sapiensRecently, high-throughput studies identified tens of thousands of sites transcribed to produce transcripts with little protein-coding potential. The function of these transcripts remains largely obscure and their relevance to cardiovascular disease is mostly undefined. Many non-protein-codin

  New GEO Series

  2h
• A Multicenter Case-Historical Control Study on Short-Term Outcomes of Tele-Intensive Care Unit

  Telemedicine and e-Health, Ahead of Print.

  Telemedicine and e-Health - Table of Contents

  2h
• Effect of 'lifestyle stigma on public support for NHS-provisioned pre-exposure prophylaxis (PrEP) and preventative interventions for HPV and type 2 diabetes: a nationwide UK survey

  ObjectivesThis study examines how the perceived role of poor lifestyle and irresponsible behaviour in contracting HIV, human papilloma virus (HPV) and diabetes affects public support for government-provisioned prevention efforts in Britain. It assesses whether public attitudes on healthcare spending are broadly sensitive to ‘lifestyle stigmas’. MethodsWe conducted an online survey of 738 respondents in Britain and embedded three separate survey

  BMJ Open recent issues

  2h
• Clinical and cost-effectiveness of teen online problem-solving for adolescents who have survived an acquired brain injury in the UK: protocol for a randomised, controlled feasibility study (TOPS-UK)

  IntroductionPaediatric acquired brain injury is a leading cause of mortality in children in the UK. Improved treatment during the acute phase has led to increased survival rates, although with life-long morbidity in terms of social and emotional functioning. This is the protocol for a feasibility randomised controlled trial with an embedded qualitative study and feasibility economic evaluation. If feasible, a later definitive trial will test the

  BMJ Open recent issues

  2h
• Pulmonary rehabilitation for pneumoconiosis: protocol for a systematic review and meta-analysis

  IntroductionPneumoconiosis is characterised by diffuse fibrosis in lung tissue, and its incidence is on the rise. At present, there are limited therapeutic options for pneumoconiosis. Pulmonary rehabilitation (PR) has been widely used to treat pneumoconiosis，however, there is limited evidence concerning its efficacy. Therefore, we plan to conduct a systematic review to investigate the efficacy and safety of PR for pneumoconiosis. Methods and ana

  BMJ Open recent issues

  2h
• Phenylketonuria incidence in China between 2013 and 2017 based on data from the Chinese newborn screening information system: a descriptive study

  ObjectiveThis study examines the incidence and spatial clustering of phenylketonuria (PKU) in China between 2013 and 2017. MethodsData from the Chinese Newborn Screening Information System were analysed to assess PKU incidence with 95% CIs by province, region and disease severity. Spatial clustering of PKU cases was analysed using global and local spatial autocorrelation analysis in the geographic information system. ResultsThe database contain

  BMJ Open recent issues

  2h
• Outcomes associated with peripherally inserted central catheters in hospitalised children: a retrospective 7-year single-centre experience

  ObjectivesThe use of peripherally inserted central catheters (PICCs) are an integral part of caring for hospitalised children. We sought to estimate the incidence of and identify the risk factors for complications associated with PICCs in an advanced registered nurse practitioners (ARNP)-driven programme. DesignRetrospective cohort study. SettingSingle-centre, large quaternary children's hospital. ParticipantsHospitalised children who had PICC

  BMJ Open recent issues

  2h
• Choosing Healthy Eating for Infant Health (CHErIsH) study: protocol for a feasibility study

  IntroductionChildhood obesity is a public health challenge. There is evidence for associations between parents’ feeding behaviours and childhood obesity risk. Primary care provides a unique opportunity for delivery of infant feeding interventions for childhood obesity prevention. Implementation strategies are needed to support infant feeding intervention delivery. The Choosing Healthy Eating for Infant Health (CHErIsH) intervention is a complex i

  BMJ Open recent issues

  2h
• Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium

  ObjectiveTo study the association of educational level and risk of death from all causes, cardiovascular disease (CVD) and cancer among Asian populations. DesignA pooled analysis of 15 population-based cohort studies. Setting and participants694 434 Asian individuals from 15 prospective cohorts within the Asia Cohort Consortium. InterventionsNone. Main outcome measuresHRs and 95% CIs for all-cause mortality, as well as for CVD-specific mortal

  BMJ Open recent issues

  2h
• Learning types and learning success in a structured diabetes education programme for patients with type 2 diabetes: study protocol of a prospective, longitudinal study

  IntroductionDiabetes mellitus (DM) has had a wide-ranging impact on healthcare politics. Secondary diseases and complications caused by diabetes are relevant cost and utilisation factors in the healthcare system. For decades, diabetes self-management education (DSME) has played a major role in the treatment of patients with type 2 DM (T2DM). The aim of this training is to empower patients to actively influence their diabetes process by gaining kn

  BMJ Open recent issues

  2h
• Efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a protocol for systematic review and individual patient data (IPD) meta-analysis

  IntroductionPregnant women are more vulnerable to malaria leading to adverse impact on both mothers and fetuses. However, knowledge on the efficacy and safety of antimalarials in pregnancy is limited by the paucity of randomised control trials and the lack of standardised protocols in this special subpopulation. Pooling individual patient data (IPD) for meta-analysis could address in part these limitations to summarise accurately the currently av

  BMJ Open recent issues

  2h
• The joint effect of insomnia symptoms and lifestyle factors on risk of self-reported fibromyalgia in women: longitudinal data from the HUNT Study

  ObjectivesTo investigate the association between insomnia symptoms and risk of self-reported fibromyalgia in women, and to explore whether leisure time physical activity and body mass index (BMI) modify this association. DesignProspective cohort study. SettingWe used longitudinal data from the Norwegian Nord-Trøndelag Health Study collected in 1995–1997 (baseline) and 2006–2008 (follow-up). ParticipantsA total of 14 172 women who reported to b

  BMJ Open recent issues

  2h
• PCASTt/SPCG-17--a randomised trial of active surveillance in prostate cancer: rationale and design

  IntroductionOvertreatment of localised prostate cancer is substantial despite increased use of active surveillance. No randomised trials help define how to monitor patients or when to initiate treatment with curative intent. Methods and analysisA randomised, multicentre, intervention trial designed to evaluate the safety of an MRI-based active surveillance protocol, with standardised triggers for repeated biopsies and radical treatment. The aim

  BMJ Open recent issues

  2h
• Optimising neonatal service provision for preterm babies born between 27 and 31 weeks gestation in England (OPTI-PREM), using national data, qualitative research and economic analysis: a study protocol

  IntroductionIn England, for babies born at 23–26 weeks gestation, care in a neonatal intensive care unit (NICU) as opposed to a local neonatal unit (LNU) improves survival to discharge. This evidence is shaping neonatal health services. In contrast, there is no evidence to guide location of care for the next most vulnerable group (born at 27–31 weeks gestation) whose care is currently spread between 45 NICU and 84 LNU in England. This group repre

  BMJ Open recent issues

  2h
• Physical activity, sedentary time and their associations with clustered metabolic risk among people with type 2 diabetes in Jiangsu province: a cross-sectional study

  ObjectiveInvestigating the association between total physical activity, physical activity in different domains and sedentary time with clustered metabolic risk in patients with type 2 diabetes from Jiangsu province, China. DesignInterview-based cross-sectional study conducted between December 2013 and January 2014. Setting44 selected townships across two cities, Changshu and Huai’an, in Jiangsu province. Participants20 340 participants selecte

  BMJ Open recent issues

  2h
• Readmission and processes of care across weekend and weekday hospitalisation for acute myocardial infarction, heart failure or stroke: an observational study of the National Readmission Database

  ObjectivesVariation in hospital resource allocations across weekdays and weekends have led to studies of the ‘weekend effect’ for ST elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI), heart failure (HF) and stroke. However, few studies have explored the ‘weekend effect’ on unplanned readmission. We aimed to investigate 30-day unplanned readmissions and processes of care across weekend and weekday hospitalisa

  BMJ Open recent issues

  2h
• Individual and environmental factors associated with death of cyclists involved in road crashes in Spain: a cohort study

  ObjectiveTo quantify the magnitude of associations between cyclist fatalities and both cyclist and environment related characteristics in Spain during the first 24 hours after a crash. DesignCohort study. SettingSpain. Participants65 977 cyclists injured in road crashes recorded between 1993 and 2013 in the Spanish Register of Road Crashes with Victims. Main outcomeDeath within the first 24 hours after the crash. MethodsA multiple imputation

  BMJ Open recent issues

  2h
• Protocol for a prospective observational diagnostic study: intraoperative simultaneous limb pressure monitoring (INSTANT) study

  IntroductionPeripheral vascular disease (PVD) is a condition caused by arterial blockages causing inadequate blood flow, resulting in pain and gangrene of the legs. Endovascular therapy, such as angioplasty, can be used to treat PVD, however, the operator feedback during surgery is primarily anatomic based on the angiogram. Because physiologic blood perfusion can be difficult to determine based on anatomic images, we propose introducing physiolog

  BMJ Open recent issues

  2h
• An exploratory spatial analysis of overweight and obesity among children and adolescents in Shandong, China

  ObjectiveIdentifying the spatial patterns of childhood overweight/obesity (OW/OB) can help to guide resource allocation for preventive intervention in China. This study aims to estimate rates of childhood OW/OB across counties within Shandong Province, using geographic techniques to identify sex-specific spatial patterns of childhood OW/OB as well as the presence of spatial clusters. DesignCross-sectional study. SettingShandong Province in Chin

  BMJ Open recent issues

  2h
• Effect of home-based high-intensity interval training and behavioural modification using information and communication technology on cardiorespiratory fitness and exercise habits among sedentary breast cancer survivors: habit-B study protocol for a randomised controlled trial

  IntroductionMaintaining high levels of physical activity helps to maintain and improve physical health and quality of life, and plays a role in reducing adverse effects due to cancer treatments. Moreover, a greater degree of cardiorespiratory fitness is associated with reduced risk of all-cause mortality. However, there are no home-based programme for improving cardiorespiratory fitness using body weight exercises for breast cancer survivors. Thi

  BMJ Open recent issues

  2h
• Enriching medical trainees learning through practice: a video reflexive ethnography study protocol

  IntroductionSupporting medical students’ and junior doctors’ development in busy clinical settings is challenging. As opportunities for developing trainees, for example, traditional bedside teaching, are decreasing, teaching outside of clinical practice is increasing. However, evidence suggests that effective learning through practice arises via an interplay between, first, what experiences are afforded by clinical settings and, second, how train

  BMJ Open recent issues

  2h
• Addressing the polypharmacy challenge in older people with multimorbidity (APOLLO-MM): study protocol for an in-depth ethnographic case study in primary care

  IntroductionPolypharmacy is on the rise. It is burdensome for patients and is a common source of error and adverse drug reactions, especially among older adults. Health policy advises clinicians to practice medicines optimisation—a person-centred approach to safe, effective medicines use. There has been little research exploring older patients’ perspectives and priorities around medicines-taking or their actual practices of fitting medicines into

  BMJ Open recent issues

  2h
• Exploring geographic variation in acute appendectomy in Ireland: results from a national registry study

  ObjectiveTo explore geographic variations in Irish laparoscopic and open appendectomy procedures. DesignAnalysis based on 2014–2017 administrative hospital data from public hospitals. SettingCounties of Ireland. ParticipantsIrish residents with hospital admissions for an appendectomy as the principal procedure. Main outcome measuresAge and gender standardised laparoscopic and open appendectomy rates for 26 counties. Geographic variation measu

  BMJ Open recent issues

  2h
• GSE118989 KCNH2-3.1 mediates aberrant complement activation to impair hippocampal-medial prefrontal pathway associated with schizophrenia

  Contributors : Ming Ren ; Zhonghua Hu ; Qiang Chen ; Andrew Jaffe ; Yingbo Li ; Vijay Sadashivaiah ; Shujuan Zhu ; Nina Rajpurohit ; Joo-Heon Shin ; Wei Xia ; Yankai Jia ; Jingxian Wu ; Sunny L Qin ; Xinjian Li ; Jian Zhu ; Qingjun Tian ; Daniel Parades ; Fengyu Zhang ; Kuan H Wang ; S V Mattay ; H J Callicott ; Karen F Berman ; Daniel R Weinberger ; Feng YangSeries Type : Expression profiling by high throughput sequencingOrgani

  GEO series published today

  2h
• GSE136214 Gene expression from ErbB2-driven mamamry tumors (MMTV-NIC model) with beta 1 integrin KO, beta 3 integrin KO or beta 1/beta 3 double KO

  Contributor : Tung BuiSeries Type : Expression profiling by arrayOrganism : Mus musculusIn this study, we used conditional knockout and gene expression approaches to understand global molecular and transciptional changes due to ablation of each integrin subunit.Affymetrix MoGene-2_0-st-v1 gene chip

  GEO series published today

  2h
• GSE119045 Apoptosis in the fetal testis eliminates developmentally defective germ cell clones

  Contributors : D H Nguyen ; D J LairdSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMammalian egg and sperm are produced by germ cells (GCs) that develop in the embryo long before reproductive maturity. Many GCs that begin this process do not contribute their genes to the next generation, although it remains unclear what determines GC fitness. Here, we examined how the composition of GCs in the fetal testis

  GEO series published today

  2h
• GSE136212 Paternal knockout of Slc38a4/SNAT4 causes placental hypoplasia associated with intrauterine growth restriction in mice

  Contributors : Shogo Matoba ; Shoko Nakamuta ; Kento Miura ; Michiko Hirose ; Hirosuke Shiura ; Takashi Kohda ; Nobuaki Nakamuta ; Atsuo OguraSeries Type : Expression profiling by arrayOrganism : Mus musculusThe placenta is critical for mammalian embryonic development because the embryo’s supply of nutrients, including amino acids, depends solely on mother-to-embryo transport through the placenta. However, the molecular mechanisms underly

  GEO series published today

  2h
• GSE136225 Dach1 downregulation marks a lymphoid-primed progenitor in early haematopoiesis

  Contributors : Luyi Tian ; Daniela Amann-Zalcenstein ; Jaring Schreuder ; Shalin H NaikSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA classical view of blood cell development is that multipotent haematopoietic stem and progenitor cells (HSPCs) become lineage-restricted at defined stages. The Lin–c-kit+Sca1+Flt3+ stage, termed lymphoid-primed multipotent progenitors (LMPPs), have lost megakaryocyte and

  GEO series published today

  2h
• GSE136211 Regulation of Drosophila intestinal stem cell proliferation by enterocyte mitochondrial pyruvate metabolism

  Contributors : Dona R Wisidagama ; Carl S ThummelSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterPurpose: The goals of this study was to compare differentially expressed transcripts when MPC expression is supressed in the adult intestines or enterocyte. The NCBI gene ID for dMPC1 is 42268.

  GEO series published today

  2h