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Abstract Background Fine‐needle aspiration (FNA) of thyroid nodules leads to nearly 25% indeterminate nodules, while BRAFV600E mutation helps to predicting papillary thyroid carcinoma (PTC). However, the clinical validity and utility of the BRAFV600E mutation detected using preoperative FNA samples in a large cohort was rarely reported. Aim To explore the clinical significance of the BRAFV600E mutation on preoperative diagnosis and decision‐making in a large FNA cohort in China. Design...
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Abstract Background Thyroid hormone (TH) metabolism can have prognostic significance in brain tumors. We studied the association of common variations in three deiodinase gene single-nucleotide polymorphisms (SNPs) with circulating TH concentrations and prognosis of brain tumor patients. Methods Patients admitted for glioma and meningioma surgery between January,...
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Background and Aims. Owing to its unique anatomical structure and metabolism, epicardial adipose tissue (EAT) has attracted amount of attention in coronary artery disease (CAD) research. Here, we analyzed differences in proteome composition in epicardial (EAT) and subcutaneous adipose tissues (SAT) from patients with or without CAD. Methods. EAT and SAT samples were collected from 6 CAD patients and 6 non-CAD patients. Isobaric Tagging for Relative and Absolute Quantitation (iTRAQ) analysis combined...
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Abstract Parental care has a strong impact on neurodevelopment and mental health in the offspring. While a multitude of animal studies has revealed that the parental brain is a highly complex system involving many brain structures and neuroendocrine systems, human maternal parenting as a multi‐dimensional construct with cognitive, emotional, and behavioral components has not been characterized comprehensively. This unique multi‐method analysis aimed to examine patterns of self‐reported and observed...
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Publication date: Available online 22 August 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Martin A. Hanson, Ashok R. Shaha, James X. WuAbstractSurgery for substernal goiters can be technically demanding. Extensive mediastinal extension brings the thyroid gland into close quarters with vital intrathoracic structures. Proper preoperative planning is required to determine the potential need for an extracervical approach. Assessing the risk of requiring an...
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