Cerebrospinal fluid physiology. Curr Opin Otolaryngol Head Neck Surg. 2019 Aug 19;: Authors: Samy RN PMID: 31433333 [PubMed - as supplied by publisher]
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Physiology of cerebrospinal fluid circulation. Curr Opin Otolaryngol Head Neck Surg. 2019 Aug 19;: Authors: Shapey J, Toma A, Saeed SR Abstract PURPOSE OF REVIEW: This article describes the physiology of cerebrospinal fluid (CSF). We review current evidence and new concepts relating to CSF physiology with respect to CSF secretion, circulation and resorption and we highlight key pathophysiological associations including the relationship between CSF and...
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Referral pathways and outcome of patients with colorectal peritoneal metastasis (CRPM). Eur J Surg Oncol. 2019 Jul 04;: Authors: Larentzakis A, O'Dwyer ST, Becker J, Shuweihdi F, Aziz O, Selvasekar CR, Fulford P, Renehan AG, Wilson M Abstract INTRODUCTION: Traditionally patients with colorectal peritoneal metastases (CRPM) were offered palliative chemotherapy and best supportive care. With the introduction of cytoreductive surgery (CRS) and hyperthermic...
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Related ArticlesOptimal thresholds of risk parameters for gastrointestinal stromal tumors. Eur J Surg Oncol. 2019 Aug 12;: Authors: Sander B, Cameron S, Gunawan B, Füzesi L Abstract BACKGROUND: Gastrointestinal stromal tumors (GIST) are the most frequent mesenchymal neoplasms of the gastrointestinal tract with highly variable potential for relapse. Tumor size and mitotic index (MI) are major risk factors that predict the outcome of GIST patients. Recent...
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Related ArticlesCirculating cell-free long DNA fragments predict post-hepatectomy recurrence of colorectal liver metastases. Eur J Surg Oncol. 2019 Aug 12;: Authors: Iwai T, Yamada T, Takahashi G, Takeda K, Koizumi M, Shinji S, Matsuda A, Yokoyama Y, Hara K, Ueda K, Ohta R, Taniai N, Yoshida H Abstract INTRODUCTION: Most patients with colorectal liver metastases, who undergo hepatectomy, experience recurrence. Although the prognosis is poorer for patients...
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Related ArticlesThe prevalence and incidence of thyroid dysfunction in patients with diabetes - a longitudinal follow-up study. Ir J Med Sci. 2019 Aug 20;: Authors: Tudor RM, Garrahy A, Woods CP, Crowley RK, Tormey WT, Smith D, Hatunic M, Thompson CJ Abstract BACKGROUND: Thyroid dysfunction (TD) occurs in 13.4% of diabetic patients, which has prompted recommendations for annual thyroid screening in patients with diabetes. However, recommendations for...
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Related ArticlesmiR‑378a‑3p inhibits cellular proliferation and migration in glioblastoma multiforme by targeting tetraspanin 17. Oncol Rep. 2019 Aug 20;: Authors: Guo XB, Zhang XC, Chen P, Ma LM, Shen ZQ Abstract Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor and patients with this disease tend to have poor clinical outcome. MicroRNAs (miRs) are important regulators of a number of key pathways implicated in tumor pathogenesis....
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Related ArticlesExpression of LXR‑β, ABCA1 and ABCG1 in human triple‑negative breast cancer tissues. Oncol Rep. 2019 Aug 14;: Authors: Pan H, Zheng Y, Pan Q, Chen H, Chen F, Wu J, Di D Abstract Previous studies have reported that liver X receptor (LXR), ATP‑binding cassette sub‑family G number 1 (ABCG1) and ATP‑binding cassette transporter number 1 (ABCA1), which are associated with cholesterol metabolism, may be associated with the development and progression...
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Related ArticlesDisrupting myddosome assembly in diffuse large B‑cell lymphoma cells using the MYD88 dimerization inhibitor ST2825. Oncol Rep. 2019 Aug 19;: Authors: Wang X, Tan Y, Huang Z, Huang N, Gao M, Zhou F, Hu J, Feng W Abstract Diffuse large B‑cell lymphoma (DLBCL), the most common type of non‑Hodgkin's lymphoma, is classified into germinal center and activated B cell (ABC) subtypes. The myeloid differentiation primary response gene 88 (MYD88)...
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Related ArticlesClinical significance and prospective molecular mechanism of C‑C motif chemokine receptors in patients with early‑stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy. Oncol Rep. 2019 Aug 13;: Authors: Zhou X, Liao X, Wang X, Huang K, Yang C, Yu T, Liu J, Han C, Zhu G, Su H, Qin W, Han Q, Liu Z, Huang J, Gong Y, Ye X, Peng T Abstract The present study aimed to determine the clinical significance and potential molecular...
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Related ArticlesTannic acid synergistically enhances the anticancer efficacy of cisplatin on liver cancer cells through mitochondria‑mediated apoptosis. Oncol Rep. 2019 Aug 16;: Authors: Geng N, Zheng X, Wu M, Yang L, Li X, Chen J Abstract Cisplatin (cis‑dichlorodiamine platinum, CDDP) is a potent antitumor agent. However, its clinical application is limited by its side effects and the development of drug resistance. Tannic acid (TA) has previously been...
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Related ArticlesCurcumin inhibits cell proliferation and migration in NSCLC through a synergistic effect on the TLR4/MyD88 and EGFR pathways. Oncol Rep. 2019 Aug 14;: Authors: Zhang L, Tao X, Fu Q, Ge C, Li R, Li Z, Zhu Y, Tian H, Li Q, Liu M, Hu H, Zeng B, Lin Z, Li C, Luo R, Song X Abstract Despite the increasing number of available therapeutic methods, the prognosis of non‑small cell lung cancer (NSCLC) remains poor. Furthermore, side effects are...
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Related ArticlesRole of miR‑34 in gastric cancer: From bench to bedside (Review). Oncol Rep. 2019 Aug 16;: Authors: Xiong S, Hu M, Li C, Zhou X, Chen H Abstract Gastric cancer (GC) is a prevalent digestive system malignancy that is associated with a poor prognosis specifically for advanced‑stage patients. MicroRNAs (miRNAs) are small, non‑coding RNAs that have been reported to play roles as oncogenes or tumour suppressors in all types of cancer, including...
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Related ArticlesEMX2 is epigenetically silenced and suppresses epithelial‑mesenchymal transition in human esophageal adenocarcinoma. Oncol Rep. 2019 Aug 20;: Authors: Wang L, Jin J, Zhou Y, Tian Z, He B, Huang Y, Ding F Abstract Esophageal adenocarcinoma (EAC) is an aggressive and challenging disease to treat, with an overall five‑year survival rate of <20%. Early malignant cell dissemination contributes to this poor prognosis. Epithelial‑mesenchymal...
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Related ArticlesEfficient primary culture model of patient‑derived tumor cells from colorectal cancer using a Rho‑associated protein kinase inhibitor and feeder cells. Oncol Rep. 2019 Aug 20;: Authors: Hong HK, Pyo DH, Kim TW, Yun NH, Lee YS, Song SJ, Lee WY, Cho YB Abstract In vitro culture of patient‑derived tumor cells offers many advantages in the development of novel therapies for colorectal cancer. Although various culture systems have been developed,...
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Moderate hypofractionated helical tomotherapy for localized prostate cancer: preliminary report of an observational prospective study. Tumori. 2019 Aug 21;:300891619867846 Authors: Cuccia F, Mazzola R, Arcangeli S, Mortellaro G, Figlia V, Caminiti G, Di Paola G, Spera A, Iacoviello G, Alongi F, Lo Casto A, Magrini SM, Ferrera G Abstract OBJECTIVE: To report preliminary findings of a phase II study exploring the clinical outcomes of moderate hypofractionated...
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Related ArticlesThe Analysis of Computed Tomography of Paranasal Sinuses in Nasal Septal Deviation. J Craniofac Surg. 2019 Mar/Apr;30(2):e143-e147 Authors: Yazici D Abstract OBJECTIVES: Anatomic variations of paranasal sinuses are frequent among population that should be analyzed and interpreted accurately. The purpose of this study is to analyze anatomical variants and their relationships of paranasal sinuses in patients with nasal septal deviation...
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Related ArticlesSeptoplasty Under Local Anesthesia. J Craniofac Surg. 2019 Mar/Apr;30(2):e142-e143 Authors: Obradovic B Abstract Septoplasty is usually performed under general anesthesia or local anesthesia with sedation. Nevertheless, septoplasty under pure local anesthesia is also feasible and it shows a great potential for fast-track surgery. This article presents a patient with nasal septal deviation where septoplasty was managed under local anesthesia...
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Related Articles[Pathophysiology of obstructive sleep apnea]. HNO. 2019 Aug 20;: Authors: Heiser C, Eckert D Abstract The prevalence of obstructive sleep apnea (OSA) is considered to be very high in western industrialized countries. There are conservative and surgical forms of treatment for OSA; however, the pathophysiology is largely unexplained and cannot be explained by anatomical abnormalities alone. In recent years, a number of non-anatomical factors...
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Related ArticlesFunctional role of gut microbiota and PCSK9 in the pathogenesis of diabetes mellitus and cardiovascular disease. Atherosclerosis. 2019 Jul 30;: Authors: Morelli MB, Wang X, Santulli G PMID: 31431286 [PubMed - as supplied by publisher]
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Related ArticlesPatient-derived xenograft models of non-small cell lung cancer for evaluating targeted drug sensitivity and resistance. Cancer Sci. 2019 Aug 20;: Authors: Kita K, Fukuda K, Takahashi H, Tanimoto A, Nishiyama A, Arai S, Takeuchi S, Yamashita K, Ohtsubo K, Otani S, Yanagimura N, Suzuki C, Ikeda H, Tamura M, Matsumoto I, Yano S Abstract Patient-derived xenograft (PDX) models are a useful tool in cancer biology research. However, the number...
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Related ArticlesBSP - αvβ3 integrin axis promotes breast cancer metastasis to the bone. Cancer Sci. 2019 Aug 20;: Authors: Wang L, Song L, Li J, Wang Y, Yang C, Kou X, Xiao B, Zhang W, Li L, Liu S, Wang J Abstract The underlying mechanisms of breast cancer cells metastasizing to distant sites are complex and multi-factorial. Bone sialoprotein (BSP) and αvβ3 integrin were reported to promote the metastatic progress of breast cancer cells, particularly...
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Related ArticlesImproved survival of CAR-T and tumor-specific T cells caused by anti-PD-1 scFv-producing CAR-T cells. Cancer Sci. 2019 Aug 20;: Authors: Nakajima M, Sakoda Y, Adachi K, Nagano H, Tamada K Abstract Chimeric antigen receptor-engineered T (CAR-T) cell therapy holds a significant promise for the treatment of hematological malignancies, especially for B-cell leukemia and lymphoma. However, its efficacy against non-hematological malignancies...
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Related ArticlesG9a and HDACs are crucial for Snail2-mediated E-cadherin repression and metastasis in hepatocellular carcinoma. Cancer Sci. 2019 Aug 20;: Authors: Hu Y, Zheng Y, Dai M, Wang X, Wu J, Yu B, Zhang H, Cui Y, Kong W, Wu H, Yu X Abstract Functional E-cadherin loss, a hallmark of epithelial-to-mesenchymal transition (EMT), is important for metastasis. However, the mechanism of Snail2 in hepatocellular (HCC) EMT and metastasis remains unclear....
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Related ArticlesInterleukin-17 is associated with expression of programmed cell death 1 ligand 1 in ovarian carcinoma. Cancer Sci. 2019 Aug 20;: Authors: Aotsuka A, Matsumoto Y, Arimoto T, Kawata A, Ogishima J, Taguchi A, Tanikawa M, Sone K, Mori-Uchino M, Tsuruga T, Oda K, Kawana K, Osuga Y, Fujii T Abstract The programmed cell death 1/programmed cell death 1 ligand 1 pathway was successfully targeted in cancer immunotherapy. Elevated interleukin-17,...
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Related ArticlesGermline mutation in DNA-repair genes is associated with poor survival in BRCA1/2-negative breast cancer patients. Cancer Sci. 2019 Aug 20;: Authors: Fan Z, Hu L, Ouyang T, Li J, Wang T, Fan Z, Fan T, Lin B, Xu Y, Xie Y Abstract BRCA1/2 genes are the most frequently germline mutated DNA-repair genes and the survival of BRCA1/2 carriers has been extensively explored in breast cancer. However, the prevalence of germline mutations in non-BRCA1/2...
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Related ArticlesCombined administration of medium-chain fatty acids and glucose protects against cancer-associated skeletal muscle atrophy. Cancer Sci. 2019 Aug 20;: Authors: Mori T, Ohmori H, Luo Y, Mori S, Miyagawa Y, Nukaga S, Goto K, Fujiwara-Tani R, Kishi S, Sasaki T, Fujii K, Kawahara I, Kuniyasu H Abstract Skeletal muscle volume is associated with prognosis of cancer patients. Maintenance of skeletal muscle is an essential issue in cancer treatment....
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The effect of olfactory training on odor identification in patients with traumatic anosmia. Int Forum Allergy Rhinol. 2019 Aug 21;: Authors: Jiang RS, Twu CW, Liang KL Abstract BACKGROUND: This study investigates the effect of olfactory training on odor identification in patients with traumatic anosmia. METHODS: Patients with a clear history of loss of smell after head injury, and whose phenyl ethyl alcohol (PEA) odor detection thresholds remained...
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Outcomes of fertility-sparing surgery for stage II and III serous borderline ovarian tumors. J Int Med Res. 2019 Aug 21;:300060519865850 Authors: Lu Z, Li B, Gu C PMID: 31432738 [PubMed - as supplied by publisher]
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Related ArticlesSuccessful whole-blood exchange transfusion in a patient with paroxysmal nocturnal hemoglobinuria: A case report and literature review. J Int Med Res. 2019 Aug 21;:300060519861165 Authors: Zhang Z, Shen Y, Shu X, Li B, Li N PMID: 31431110 [PubMed - as supplied by publisher]
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Related ArticlesNitric oxide (NO) levels in patients with polycystic ovary syndrome (PCOS): a meta-analysis. J Int Med Res. 2019 Aug 21;:300060519864493 Authors: Meng C PMID: 31431096 [PubMed - as supplied by publisher]
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Debate Sparks Over LATE, a Recently Recognized Dementia. JAMA. 2019 Aug 21;: Authors: Abbasi J PMID: 31433447 [PubMed - as supplied by publisher]
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Type 1 Diabetes Advances Could Pave Way for Prevention. JAMA. 2019 Aug 21;: Authors: Abbasi J PMID: 31433442 [PubMed - as supplied by publisher]
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Variability in pathologic interpretation of mandibular invasion. Laryngoscope. 2019 Aug 21;: Authors: Namin AW, Zitsch RP, Layfield LJ Abstract OBJECTIVES/HYPOTHESIS: Our objective was to identify the accuracy, sensitivity, and specificity of pathological interpretation of mandibular invasion by oral cavity squamous cell carcinoma (SCC) and compare the sensitivity of detecting mandibular invasion in the erosive versus the infiltrative patterns of invasion....
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Antitumor effect of insulin-like growth factor-1 receptor inhibition in head and neck squamous cell carcinoma. Laryngoscope. 2019 Aug 21;: Authors: Lehman CE, Khalil AA, Axelrod MJ, Dougherty MI, Schoeff SS, Taniguchi LE, Mendez RE, David AP, McGarey PO, Hubbard MA, Donaldson L, Frierson HF, Stelow EB, Bekiranov S, Wulfkuhle JD, Petricoin EF, Gioeli DG, Jameson MJ Abstract OBJECTIVES: The insulin-like growth factor-1 receptor (IGF1R) has been implicated...
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