Publication date: Available online 26 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Kenneth A. Michelson, Timothy E. Dribin, David Vyles, Mark I. Neuman
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Authors: Garcia-Marcos L PMID: 31401986 [PubMed - in process] (Source: Allergologia et Immunopathologia)
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Publication date: Available online 23 August 2019Source: Allergology InternationalAuthor(s): Mari Tanaka, Yukinobu Nakagawa, Misa Hayashi, Yorihisa Kotobuki, Ichiro Katayama, Manabu Fujimoto
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Abstract Background Food allergy is associated with a high personal health and economic burden. For immunomodulation towards tolerance, food compounds could be chemically modified, e.g. by posttranslational protein nitration, which also occurs via diet‐derived nitrating agents in the gastrointestinal tract. Objective We sought to analyze the effect of pre‐treatment with nitrated food proteins on the immune response in a mouse food allergy model and on human monocyte‐derived dendritic cells...
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Abstract Despite being one of the most frequent chronic diseases, asthma patients live in times of hope. The introduction of regular treatment with inhaled corticosteroids (ICS) was crucial, impacting and changing the lives of several hundred million asthmatics. Advances with new molecules, whether alone or in combination, coupled with developments in inhaler technology and the advent of biologics raise the aspiration of achieving control and normalising (as opposed to optimizing) lung function,...
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Abstract For many years treatment for immune‐mediated and or autoimmune diseases focused on improving suppression of pro‐inflammatory processes. Products of T‐helper 1 (Th1) cells such as TNF‐α were the first to be targeted. In accordance with this approach, anti‐IL‐17 was also added to this arsenal of suppressive anti‐inflammatory therapies intended to treat psoriasis and psoriatic arthritis.
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Abstract Allergies are typically endemic, complex and heterogeneous diseases with a high impact at quality of life. Mechanistically, type 2 immune responses involving eosinophil and basophil granulocytes, mast cells and humoral factors such as IgE are key drivers of allergic diseases. Fighting allergic diseases knows three strategies: prevention, symptomatic and causative therapy. While remarkable progress was made in understanding molecular events in allergies as a prerequisite for effective prevention...
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Dermatological illness can affect the quality of life and may coexist with psychiatric disorders.
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Publication date: Available online 23 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Joan H. Dunlop, Corinne A. Keet
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Publication date: Available online 23 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Jae Woong Hwang, Ki Jeong Lee, In Hak Choi, Hye Min Han, Tae Hoon Kim, Sang Hag LeeAbstractBackgroundLittle is known about the antiviral responses in the sinonasal mucosa of patients with chronic rhinosinusitis (CRS).Objectivewe investigated the presence of virus, the expression of TLR3 and TLR7, and interferon (IFN) and IFN-stimulated genes (ISGs) in healthy mucosa of control and inflammatory...
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Publication date: Available online 23 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Jonathan I. Silverberg, Andreas Pinter, Grazyna Pulka, Yves Poulin, Jean-David Bouaziz, Andreas Wollenberg, Dédée F. Murrell, Andrew Alexis, Lisa Lindsey, Faiz Ahmad, Christophe Piketty, Alan ClucasAbstractBackgroundNemolizumab targets the interleukin 31 receptor alpha subunit (IL-31RA) involved in atopic dermatitis (AD) pathogenesis.ObjectiveTo evaluate a new dosing strategy of nemolizumab...
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Publication date: Available online 22 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Noora Ottman, Nanna Fyhrquist
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Publication date: Available online 22 August 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Wen-Hui Jiang, Yi-Dan Qiao, Ting Liu, Jie Chen, Gen Lu
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Publication date: Available online 23 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Sneha Suresh, Harjit Dadi, Brenda Reid, Linda Vong, Dennis E. Bulman, Chaim M. Roifman
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Publication date: Available online 23 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Satvinder Singh Bakshi
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Asthma is often accompanied by peripheral eosinophilia and eosinophilic airway inflammation. This article explores the relationship between asthma and short-term pulmonary infiltrate with eosinophilia, which r...
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The lymphohematopoietic cells originating from feto-maternal trafficking during pregnancy may cause microchimerism and lead to materno-fetal graft versus host disease (GVHD) in severe combined immunodeficiency...
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Chronic urticaria (CU) is a common, heterogeneous and debilitating disease. Antihistamines and omalizumab are the mainstay therapies of CU. Additional treatment options are needed. Here, we review the off and beyond label use of licensed drugs, novel treatments that are currently under development, and promising new targets.
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A significant proportion of primary immunodeficiency (PID) diseases include humoral deficiency. Humoral deficiencies range in severity from complete deficiencies observed in diseases such as X-linked or autosomal recessive agammaglobulinemias and certain severe combined immune deficiencies (SCID), to milder specific antibody deficiencies. According to a recent update from the Jeffrey Modell Centers Network, disorders classified as primarily humoral deficiencies accounted for 45% of survey center...
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Abstract Background There is growing evidence that environmental peanut exposure through non‐oral routes, including the skin and respiratory tract, can result in peanut sensitization. Environmental adjuvants in indoor dust can promote sensitization to inhaled antigens, but whether they contribute to peanut allergy development is unclear. Objective We investigated whether indoor dust promotes airway sensitization to peanut and peanut allergy development in mice. Methods Female and...
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Abstract Background Allergic diseases (eczema, wheeze and rhinitis) in children often present as heterogeneous phenotypes. Understanding genetic associations of specific patterns of symptoms might facilitate understanding of the underlying biological mechanisms. Objective To examine associations between allergic disease‐related variants identified in a recent genome‐wide association study and latent classes of allergic diseases (LCADs) in two population‐based birth cohorts. Methods...
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Purpose of review The recent developments in the manufacturing and quality assessment of allergenic extracts in Europe are summarized. Recent findings Quality assessment has always been a fundamental part of allergen product evaluation. New analytical methods have been reported that fill currently existing gaps in the characterization of commonly used allergen products. New types of products require innovative considerations and concepts for their assessment. Advanced standardization efforts...
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Historically, pediatric allergic diseases have been understudied, and their treatments were missing their mark. For example, not very many decades ago “parentectomy” was a viable therapeutic option when treating severe pediatric asthma. Subsequently, the concept of asthma as an inflammatory disease emerged, and we began using inhaled corticosteroids (ICS) with the thought that using them regularly would interrupt disease progression and even r everse underlying asthma. To prove this, in the early...
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Out of all type-2 immune cells, only ILC2s withstand corticosteroid treatment due to a reduced pro-apoptotic machinery. The findings may advance the understanding on the mechanism in steroid-resistant diseases and facilitate the development of improved therapies. (Source: Journal of Allergy and Clinical Immunology)
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IFN and ISGs ubiquitously expressed in normal sinus mucosa are downregulated in inflammatory mucosa. These abnormal innate immune may increase the susceptibility to viral infection in patients with CRS. (Source: Journal of Allergy and Clinical Immunology)
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This study evaluated nemolizumab plus topical corticosteroids in patients with AD and severe pruritus and found a significant effect on cutaneous signs of AD (by EASI and IGA), plus a rapid reduction of pruritus. (Source: Journal of Allergy and Clinical Immunology)
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In analyses adjusted for immigration, Asian-American children demonstrate high risk of food allergy, eczema, and asthma, with Filipino-American children exhibiting particularly high risk. (Source: Journal of Allergy and Clinical Immunology)
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(Source: Journal of Allergy and Clinical Immunology)
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Capsule Summary: Endotoxin and plasma from IgA-deficient common variable immunodeficiency subjects with autoimmune cytopenias promote enlarged and altered T follicular helper cell populations. (Source: Journal of Allergy and Clinical Immunology)
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Food allergies are a significant public health issue and the only effective management option currently available is strict avoidance of all foods containing the allergen. In view of the practical impossibility to limit risks to zero, quantitative allergen risk assessment and management strategies are needed. (Source: Journal of Allergy and Clinical Immunology)
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Effector CD4 T cells signal to myeloid cells via IL-10 to restrict pathogenic IFN- γ-dependent immunity in the context of type 2-low allergic airway disease in mice (Source: Journal of Allergy and Clinical Immunology)
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Moderate-to-severe atopic dermatitis (AD) has been associated with significant disease burden and systemic abnormalities and often requires systemic treatments. Currently, safe and effective oral systemic treatments for moderate-to-severe AD are not yet available. ASN002 is an oral inhibitor of the Janus kinase/spleen tyrosine kinase signaling pathways, targeting several cytokine axes (TH2/TH22/TH17/TH1) and epidermal differentiation. (Source: Journal of Allergy and Clinical Immunology)
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IFN and ISGs ubiquitously expressed in normal sinus mucosa are downregulated in inflammatory mucosa. These abnormal innate immune may increase the susceptibility to viral infection in patients with CRS.
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In analyses adjusted for immigration, Asian-American children demonstrate high risk of food allergy, eczema, and asthma, with Filipino-American children exhibiting particularly high risk.
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This study evaluated nemolizumab plus topical corticosteroids in patients with AD and severe pruritus and found a significant effect on cutaneous signs of AD (by EASI and IGA), plus a rapid reduction of pruritus.
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Abstract Background Asthma is often accompanied by peripheral eosinophilia and eosinophilic airway inflammation. This article explores the relationship between asthma and short-term pulmonary infiltrate with eosinophilia, which results from irregular asthma treatment. Case presentation We report five unique cases of asthma-induced short-term...
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Abstract Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease associated with major obstetrical complications such as gestational loss, preterm delivery, fetal growth restriction (FGR) and preeclampsia. Published literature is not consensual regarding the main risk factors for each of these outcomes. Our goal with this study was to determine the most important predictors for each of the main adverse pregnancy outcomes in this population. We conducted a retrospective...
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PPIs are approved for use in pediatric patients, but these drugs have been associated with some potentially serious adverse effects. Find out what there is to know.Pediatric Pharmacotherapy (Source: Medscape Allergy Headlines)
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Publication date: Available online 23 August 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Pavel Kolkhir, Sabine Altrichter, Melba Munoz, Tomasz Hawro, Marcus MaurerAbstractObjectiveChronic urticaria (CU) is a common, heterogeneous and debilitating disease. Antihistamines and omalizumab are the mainstay therapies of CU. Additional treatment options are needed. Here, we review the off and beyond label use of licensed drugs, novel treatments that are currently under development,...
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Publication date: Available online 23 August 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Rebecca A. Marsh, Jordan S. Orange
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Publication date: Available online 22 August 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Emily H. Liang, Cy Y. Kim, Javed Sheikh, Shefali A. Samant
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Publication date: Available online 22 August 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Miles Weinberger
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Related ArticlesWestern oropharyngeal and gut microbial profiles are associated with allergic conditions in Chinese immigrant children. World Allergy Organ J. 2019 Aug;12(8):100051 Authors: Guo J, Lv Q, Ariff A, Zhang X, Peacock CS, Song Y, Wen X, Saiganesh A, Melton PE, Dykes GA, Moses EK, LE Souëf PN, Lu F, Zhang G Abstract Background: The allergy epidemic resulting from western environment/lifestyles is potentially due to modifications of the human...
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