Sporadic fatal adverse events have been reported during treatment of multiple sclerosis with alemtuzumab. To provide a systematic overview, we searched the centralized European Medicines Agency database of sus...
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Background:Some reports suggest that body mass index (BMI) is not strongly associated with mortality in Hispanic populations.Objective:To assess the causal relevance of adiposity to mortality in Mexican adults, avoiding reverse causality biases.Design:Prospective study.Setting:2 Mexico City districts.Participants:159 755 adults aged 35 years and older at recruitment, followed for up to 14 years. Participants with a hemoglobin A1c level of 7% or greater, diabetes, or other chronic diseases were excluded.Measurements:BMI,...
Both the United States and New Zealand have experienced tragic mass shootings. This commentary contrasts the responses to these tragedies in the 2 countries in the context of how they each view and regulate firearms.
Description:The American Diabetes Association (ADA) annually updates its Standards of Medical Care in Diabetes to provide clinicians, patients, researchers, payers, and other interested parties with evidence-based recommendations for the diagnosis and management of patients with diabetes.Methods:The ADA Professional Practice Committee comprises physicians, adult and pediatric endocrinologists, diabetes educators, registered dietitians, epidemiologists, pharmacists, and public health experts. To develop...
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Nature, Published online: 12 August 2019; doi:10.1038/d41586-019-02439-1Changes to the United States' landmark conservation law make it easier to strip threatened species of the strongest protections.
Nature, Published online: 12 August 2019; doi:10.1038/d41586-019-02421-xFor a small carbon footprint, a bicycle might be a better choice than one of the battery-powered scooters littering many cities.
Nature, Published online: 12 August 2019; doi:10.1038/d41586-019-02442-6People who receive either therapy soon after infection have a 90% survival rate, according to data from a clinical trial in the Democratic Republic of the Congo.
Nature, Published online: 12 August 2019; doi:10.1038/s41586-019-1477-8Investigation of a free-standing graphene monolayer using a technique based on transmission electron microscopy allows identification of atomic vibrations characteristic of the bulk or the edge of the sample.
Nature, Published online: 12 August 2019; doi:10.1038/d41586-019-02432-8Archaeologists have turned up inscribed bones from a site in northern China previously linked to the ancient hominins.
Nature, Published online: 12 August 2019; doi:10.1038/d41586-019-02407-9Teach people to think critically about claims and comparisons using these concepts, urge Andrew D. Oxman and an alliance of 24 researchers — they will make better decisions.
Nature, Published online: 12 August 2019; doi:10.1038/d41586-019-02372-3Scientists can improve how they inform politicians and other policymakers on how to make decisions, say Hannah Safford and Austin Brown.
Nature, Published online: 12 August 2019; doi:10.1038/d41586-019-02391-0Cubes made from colourful ‘hydrogels’ are joined together to make a miniature model of the classic puzzle.
Nature, Published online: 12 August 2019; doi:10.1038/d41586-019-02424-8A telescope in Arizona will conduct the largest spectroscopic survey of galaxies.
Nature, Published online: 12 August 2019; doi:10.1038/d41586-019-02418-6Karen Masterson appraises the disease vector’s role in scientific and military history.
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Analytical ChemistryDOI: 10.1021/acs.analchem.9b01015
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02363
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02881
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02102
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02231
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02971
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01701
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Representative experimental procedures for the addition of amine nucleophiles to tricarbonyl(tropone)iron and subsequent demetallation of the resulting complexes are presented in detail.
Reciprocal hemizygosity via sequencing (RH-seq) is a powerful new method to map the genetic basis of a trait difference between species. Pools of hemizygotes are generated by transposon mutagenesis and their fitness is tracked through competitive growth using high-throughout sequencing. Analysis of the resulting data pinpoints genes underlying the trait.
In this article, we present and discuss new developments in the synthesis and applications of nucleic acid microarrays fabricated in situ. Specifically, we show how the protocols for DNA synthesis can be extended to RNA and how microarrays can be used to create retrievable nucleic acid libraries.
Here we present a protocol to quantify the chemotactic activity of blood monocytes in mouse models, to assess the effects of nutritional, pharmacological and genetic interventions on blood monocyte and to characterize the blood monocytes derived macrophages in mouse models using monocyte-chemoattractant protein-1 (MCP-1)-loaded basement membrane-derived gel plugs.
We describe a novel gait analysis system, Paw-Print Analysis of Contrast-Enhanced Recordings (PrAnCER), an open-access automated system for the quantification of gait characteristics in rats that utilizes a novel semitransparent floor to automatically quantify gait. This system was validated using the haloperidol model of Parkinson’s Disease.
This article provides an overview of a multi-modal brain mapping program designed to identify regions of the brain that support critical cognitive functions in individual neurosurgery patients.
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Gonioscopy-assisted transluminal trabeculectomy is a novel and useful technique for ab interno trabeculotomy. However, gonioscopy-assisted transluminal trabeculectomy is difficult to perform in patients with c...
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Abstract Background National guidelines recommend maximal safe resection of low-grade and high-grade oligodendrogliomas. However, there is no level 1 evidence to support these guidelines, and recent retrospective studies on the topic have yielded mixed results. Objective To assess the association between extent of resection (EOR) and survival for oligodendrogliomas...
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A new medical device is showing that it may be possible to improve and even reverse cognitive decline in those with Alzheimer’s disease, all without drugs and with little noticeable side effects. The MemorEM system from NeuroEM Therapeutics, a company based in Phoenix, Arizona, delivers transcranial electromagnetic treatment, or TEMT, to the brains of patients in two one-hour sessions each day for two months. This involves propagating electromagnetic waves toward β-amyloid aggregates...
ExThera, a company based outside of Oakland, California, won European regulatory approval for its Seraph 100 Microbind Affinity Blood Filter. The device removes a variety of pathogens in patients with bloodstream infections thanks to its “sorbent-type” filter. It can remove not only molecular compounds, such as cytokines and endotoxin, but also infectious pathogens such as bacteria, viruses, and fungi directly from whole blood. The device can help to reduce the load of drug...
As many medical technologies continue to miniaturize, the task of accurately measuring blood pressure still requires a cumbersome upper-arm cuff. Scientists at the University of Toronto and Hangzhou Normal University in China have now shown that it may be possible to use existing smartphones to measure blood pressure. Their approach relies on noticing slight changes in the optical characteristics of the skin from a few seconds of a video of the face. Called transdermal optical imaging,...
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Background The neutrophil serine proteases neutrophil elastase (NE), cathepsin G (CG), and proteinase 3 (PR3) are implicated in the regulation of inflammatory conditions. Pseudomonas aeruginosa elastase (PE), also a serine protease, has been found to behave similarly to NE and has been proposed to assist the pathogen in evading the host immune response. The effect of serine proteases on human nasal epithelial barrier function requires further investigation to better understand the pathophysiology...
Background Spontaneous skull base defects can result in life‐threatening intracranial complications (ICCs), including meningitis and pneumocephalus. Endoscopic skull base reconstruction (ESBR) has traditionally been the treatment of choice, but its impact upon ICCs is not known. In this study, we aimed to describe the incidence rate of preoperative ICCs in patients with spontaneous skull base defects, risk factors associated with ICC development, and the impact of surgical repair on the incidence...
Background This study aimed to analyze the prognostic factors and survival outcomes of squamous cell carcinoma (SCC) originating from sinonasal inverted papillomas (IPs), based on data from a single institution. Methods The data from 120 patients treated at the affiliated Beijing Tongren Hospital, Capital Medical University, for SCC originating from sinonasal IPs between 2005 and 2018 were retrospectively reviewed. Data related to demographic features, tumor characteristics, treatment modality,...
Background Interleukin (IL)‐17A is involved in the pathogenesis of allergic rhinitis (AR). Increased expression of IL‐17A is correlated with disease severity and nasal eosinophilia. However, the molecular mechanisms by which IL‐17A contributes to T‐helper 2 cytokine IL‐13‒driven pathology in AR remain unclear. We sought to obtain mechanistic insight into how IL‐17A and IL‐13 regulate the epithelial production of eotaxin‐3 representing eosinophilic inflammation in AR. Methods Human nasal epithelial...
Background Frontal sinus trephination is traditionally performed through a small cutaneous incision and osteotomy, allowing irrigation of the frontal sinus. Utilizing the trephination osteotomy for endoscopic visualization and surgical manipulation requires a larger opening. This “mega‐trephination” is thought to carry an increased risk of cosmetic deformity given the increased bony removal at the anterior table. The purpose of our study was to clarify the risks of frontal sinus mega‐trephination...
Background The pathogenic roles of fungus and bacteria in chronic rhinosinusitis (CRS) remain unclear. Recently, we described the bacterial ball, which is distinct from the fungus ball, as an unusual phenotype of bacterial infection. In this study, we investigated the clinical, histopathologic, and immunologic characteristics of sinonasal microorganic materials, including fungus ball and bacterial ball. Methods In this study, we enrolled 80 CRS patients with sinonasal microorganic materials...
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Abstract Purpose The 7th Heidelberg Myeloma Workshop was held on April 5th and 6th, 2019 at the University Hospital Heidelberg. Methods and results Main topics of the meeting were (1) diagnostics and prognostic factors, (2) role of immunotherapy in multiple myeloma (MM), (3) current therapy of MM, (4) biology and genomics of MM as well as (5) novel treatment...
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Zusammenfassung Hintergrund Die chronische Rhinosinusitis (CRS) gehört zu den häufigsten chronischen Erkrankungen überhaupt. Die Prävalenz von Immundefekten ist bei diesen Patienten höher als in der Normalbevölkerung. Methodik Es wurden eine selektive Literaturrecherche in Pubmed und Medline für den Zeitraum 2008 bis 2018 durchgeführt und zusätzlich die aktuellen...
Zusammenfassung Die im Rahmen der transnasalen funktionellen Endoskopie erhobenen Befunde „Insuffizienz des oberen ösophagealen Sphinkters“, „Kardiainsuffizienz“, „Ösophagitis“, „gastrale Heterotopie“, „axiale Gleithernie“ und „sichtbare Aerosole“ werden in Beziehung zur pharyngealen Säureexposition durch Messung des pH-Werts im Oropharynx gesetzt. Signifikant erhöhte pharyngeale Säurebelastungen zeigten sich bei den Merkmalen gastrale Heterotopie und axiale Gleithernie. Für alle...
Zusammenfassung Als Folge der aktuellen demographischen Entwicklungen rücken vermehrt auch rechtliche Fragen im Zusammenhang mit der Behandlung älterer Menschen in den Fokus. Auch wenn Patienten im fortgeschrittenen Lebensalter natürlich erst einmal ganz normale Patienten sind, benötigen sie oftmals besondere ärztliche und pflegerische Begleitung. Dies schlägt sich nicht zuletzt auch in erhöhten Sorgfaltsanforderungen nieder, die ärztlicherseits zu beachten sind. Besondere rechtliche...
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ObjectivesNight shift work has been suggested as a possible risk factor for multiple sclerosis (MS). The objective of the present analysis was to prospectively evaluate the association of rotating night shift work history and MS risk in two female cohorts, the Nurses’ Health Study (NHS) and NHSII.MethodsA total of 83 992 (NHS) and 114 427 (NHSII) women were included in this analysis. We documented 579 (109 in NHS and 470 in NHSII) incident physician-confirmed MS cases (moderate and definite diagnosis),...
BackgroundAlthough several studies highlighted an association between occupational exposure and Dupuytren’s contracture (DC), they were often limited by the highly selected population. We aimed to study this association using a job-exposure matrix (JEM) and self-reported exposure in a large cohort.MethodsFrom CONSTANCES, a French population-based prospective cohort, we retrieved sex, age, social position, alcohol/tobacco intake and diabetes. Lifetime exposures were assessed by two different methods:...
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Abstract Curcumin is well known for possessing anti-inflammatory properties and for its beneficial effects in the treatment of asthma. Current study investigates the immunomodulatory and anti-inflammatory effects of curcumin using mouse model of ovalbumin-induced allergic asthma. BALB/c mice were immunized with ovalbumin on day 0 and 14 to induce allergic asthma. Animals were treated with two different doses of curcumin (20 mg/kg and 100 mg/kg)...
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Publication date: Available online 11 August 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Anand Dharia, John Vincent Lacci, Nikhil Gupte, Ali SeifiAbstractObjectiveThe management of patients suffering traumatic brain injury (TBI) in the context of multiple significant trauma represents one of the most challenging scenarios in trauma critical care. The identification of risk factors, utilizing large national databases, may help in developing medical strategies and health care policies...
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Abstract Purpose Age at diagnosis of type 1 diabetes (DM1) has been implied as an important factor associated with the development of the microvascular complications. Our aim was to identify factors associated with prevalent diabetic retinopathy (DR) and proliferative diabetic retinopathy (PDR) in DM1 people with early and late-onset. Methods We reviewed...
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Publication date: Available online 12 August 2019Source: Autoimmunity ReviewsAuthor(s): Pamela Munguia-Realpozo, Claudia Mendoza-Pinto, Cristina Sierra Benito, Ricardo O. Escarcega, Mario Garcia-Carrasco, Socorro Mendez Martinez, Ivet Etchegaray Morales, Jose Luis Galvez Romero, Alejandro Ruiz-Arguelles, Ricard CerveraAbstractSystemic lupus erythematosus (SLE) is associated with a high burden of cardiovascular disease (CVD), which is in part imputed to classical vascular risk factors such as hypertension....
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Abstract Background Physician practice patterns regarding diagnosis and management of malnutrition in the head and neck cancer patient population are not well studied. Methods A 17‐question survey was distributed to 1392 members of the American Head and Neck Society (AHNS). The impact of hospital type, fellowship training, experience, and specialty was assessed. Results Among AHNS members, there were 124 total respondents (9% response rate), including both otolaryngologists and radiation...
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Nature Chemistry, Published online: 12 August 2019; doi:10.1038/s41557-019-0303-0During the synthesis of inorganic materials nickel oxysulfide and nickel–cobalt hydroxide, clusters with well-defined structures—such as polyoxometalates—can co-assemble with nuclei to produce uniform binary assemblies. The resulting materials can, in turn, incorporate a third, and fourth, type of nanocluster deposited on their surface to form ternary and quaternary assemblies, respectively.
Nature Chemistry, Published online: 12 August 2019; doi:10.1038/s41557-019-0297-7Although they are synthetically tunable, organic molecules that undergo singlet fission (the generation of two excitons from one photon) have not demonstrated the excited-state properties necessary to improve optoelectronic devices. Now, a general ‘energy cleft’ molecular design scheme has been demonstrated that enables rapid generation and long lifetimes of multiple triplet excitons that are for device applications.
Nature Chemistry, Published online: 12 August 2019; doi:10.1038/s41557-019-0318-6Proteins are biosynthesized from α-amino acids using hefty biological machinery, but the origin of this process on the early Earth is unclear. Now, a bottom-up approach for forming peptides, taking place under mild, prebiotically-plausible conditions, has been developed. This strategy uses α-aminonitrile precursors, bypassing α-amino acids entirely.
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Objectives To evaluate the safety/efficacy of performing open bedside tracheotomy (OBT) in intensive care unit (ICU) patients and identify predictive factors for outcomes. Methods This is a retrospective cohort study. We identified 1000 consecutive patients undergoing OBT at a single university hospital starting from August 1, 2007. Complication rate, 30‐day mortality, decannulation rate, time to surgery (TTS) from initial consult, and ICU length of stay were analyzed. Multivariate analysis...
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Publication date: Available online 12 August 2019Source: Medical HypothesesAuthor(s): Dumitru Zdrenghea, Gabriel Guşetu, Mihnea Zdrenghea, Gabriel Cismaru, Bogdan Caloian, Georgeta Vaidean, Dana PopAbstractBackground and aimsNowadays it is recommended to use risk scores to evaluate the magnitude of cardiovascular risk in healthy people,most popular being SCORE (Europe) and Framingham and ASCVD (US). Unfortunately, they are not enough motivating in young and old population, don’t consider protective...
Publication date: Available online 12 August 2019Source: Medical HypothesesAuthor(s): A. Moodley, K Van Der MeydenAbstractOpen-angle glaucoma, idiopathic intracranial hypertension, and Meniere’s disease are disorders managed by different specialties in medicine viz. ophthalmology, neurology, and otorhinolaryngology respectively. By working in silos, the similarity of these disorders is overlooked. Close inspection of these disorders reveals the presence of signs and symptoms triggered by fluid under...
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Abstract Background Chlorine is widely used in daily life as disinfectant. However, chronic exposure to chlorine products aggravates allergic TH2 inflammation and airway hyperresponsiveness (AHR). Innate lymphoid cells (ILCs) in airways contribute to the inception of asthma in association with virus infection, pollution, and excess of nutrient but it is not known whether chronic chlorine exposure can activate innate immune cells. The aim of this study is to evaluate the impact of chlorine inhalation...
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AbstractThe clinical presentation of a sphenoid fungal ball (FB) is often non-specific and tends to be overlooked, particularly in hosts with an intact immune status. Rarely, potentially life-threatening complications may arise, owning its anatomical characteristics with contiguous structures. Herein, we present an unusual case of sphenoid FB complicated with orbital apex syndrome in an immunocompetent patient. The diagnosis dilemma and subsequent management are further discussed.
ABSTRACTGastrobronchial fistulae (GBF) following minimally invasive oesophagectomy (MIO) is a rare entity, with an estimated incidence of 0.3–1.5% according to the published literature. It could present with persistent cough (Ohno’s sign), chest pain, haemoptysis and recurrent pneumonia. Barium swallow examination remains the most sensitive investigation in 78% of the cases; the main stay of management is surgical and in some cases endoscopic (stent insertion). We report a rare case of a GBF 1 month...
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Η συντηρητική αγωγή με φάκελο/νάρθηκα ακινητοποίησης του ώμου σε περίπτωση κατάγματος μπορεί να αντικαταστήσει την χειρουργική επέμβαση στον ώμο σε περίπτωση κατάγματος υποστηρίζουν Δανοί ερευνητές από το Πανεπιστήμιο του Aarhus. Η τοποθέτηση του ώμου σε έναν ειδικό φάκελο υποστήριξης θεραπεύει το τραύμα εξίσου καλά με μια επέμβαση με βίδες και λούπες όπως αποκαλύπτει μια ενδελεχής έρευνα από το Πανεπιστήμιο του Aarhus που αποτελεί μέρος της Νορβηγικής Ερευνητικής Σύμπραξης. Δεν υπάρχει κάποιο...
14h
Το έντονο φως φαίνεται ότι ενισχύει ένα συγκεκριμένο γονίδιο που δρα υποστηρικτικά στα αιμοφόρα αγγεία και προστατεύει από το έμφραγμα. Αυτό το συμπέρασμα εξήγαγαν ερευνητές από την Ιατρική Σχολή του Πανεπιστημίου Anschutz του Κολοράντο σε νέα μελέτη που δημοσιεύθηκε στο Cell Reports. «Γνωρίζαμε ήδη ότι το έντονο φως μπορεί να προστατεύσει από το έμφραγμα αλλά τώρα έχουμε βρει τον υποκείμενο μηχανισμό», δήλωσε ο πρώτος συγγραφέας της μελέτης Δρ. Tobias Eckle, καθηγητής Αναισθησιολογίας στην Ιατρική...
17h
Μία ιατρική παρέμβαση που στοχεύει στο να καθυστερήσει την εμμηνόπαυση μέχρι και 20 χρόνια άρχισε να εφαρμόζεται στη Βρετανία. Πρόκειται για την αφαίρεση και κατάψυξη ωοθηκικού ιστού που χρησιμοποιείται για την διατήρηση γονιμότητας σε νέες γυναίκες, οι οποίες πρόκειται να κάνουν θεραπεία για καρκίνο και η οποία άρχισε να εφαρμόζεται και σε υγιείς γυναίκες με σκοπό να καθυστερήσει η εμμηνόπαυση. Η τεχνική αυτή μπορεί να είναι επωφελής για χιλιάδες γυναίκες, οι οποίες έχουν σοβαρά προβλήματα υγείας...
19h
Κάποια μέρα η μέτρηση της αρτηριακής πίεσης θα είναι τόσο εύκολη όσο η λήψη μιας σέλφι σύμφωνα νέα έρευνα του Πανεπιστημίου του Τορόντο στον Καναδά που δημοσιεύθηκε στο Circulation: Cardiovascular Imaging. Η διαδερμική οπτική απεικόνιση μετρά την αρτηριακή πίεση εντοπίζοντας τις αλλαγές της ροής του αίματος τραβώντας βίντεο ένα πρόσωπο με τη χρήση smartphone. Το φως του περιβάλλοντος διαπερνά την εξωτερική στρώση του δέρματος επιτρέποντας στους ψηφιακούς οπτικούς αισθητήρες των smartphones να οπτικοποιούν...
19h
Προβλήματα απώλειας παραγωγικότητας στην εργασία τους και χαμηλότερο επίπεδο ποιότητας ζωής αντιμετωπίζουν οι άνδρες με στυτική δυσλειτουργία. Σε αυτό το συμπέρασμα κατέληξε μελέτη του International Journal of Clinical Practice. Στην έρευνα συμμετείχαν 52.000 άνδρες από οκτώ χώρες (Βραζιλία, Κίνα, Γαλλία, Γερμανία, Ιταλία, Ισπανία, Ηνωμένο Βασίλειο και ΗΠΑ). Η συχνότητα στυτικής δυσλειτουργίας στο δείγμα ανερχόταν σε 49,7%. Το υψηλότερο ποσοστό αναφέρθηκε από τους Ιταλούς και ανερχόταν σε 54,7%....
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Οι νεότερης ηλικίας ασθενείς κάτω των 50 ετών φαίνεται ότι έχουν περισσότερες πιθανότητες να εμφανίσουν άτυπα συμπτώματα σχετιζόμενα με τον καρκίνο του παχέος εντέρου όπως αποκαλύπτει μελέτη σε 10.463 βρετανούς ασθενείς που διαγνώστηκαν με τη νόσο από το 2006 έως το 2013. Σύμφωνα με την ανάλυση που δημοσιεύθηκε online στο Colorectal Disease οι νέοι σε ηλικία ασθενείς ήταν πιο πιθανό να παρουσιάσουν άτυπα συμπτώματα όπως οξύ κοιλιακό πόνο και να οδηγηθούν στα επείγοντα. Παρατηρήθηκε επίσης μεγαλύτερη...
21h
Έχει παρατηρηθεί ότι οι καπνιστές έχουν λιγότερες πιθανότητες να αναπτύξουν ελκώδη κολίτιδα, μια μορφή Φλεγμονώδους Νόσου του Εντέρου, γι ‘ αυτό και οι καπνιστές μπορεί να μπουν στον πειρασμό να ξεκινήσουν τον κάπνισμα προκειμένου να ελέγξουν τα συμπτώματα της ελκώδους κολίτιδας. Οι ερευνητές ωστόσο δεν βρήκαν κάποια ευεργετική επίδραση του καπνίσματος στην αποτροπή των συμπτωμάτων ελκώδους κολίτιδας σύμφωνα με νέα έρευνα που δημοσιεύθηκε στο Alimentary Pharmacology & Therapeutics. Στα πλαίσια...
21h
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Abstract Sex dependent differences in learning and memory formation in humans have been frequently shown. The mechanisms underlying the formation and retention of memories are assumed to involve synaptic plasticity in the hippocampus. Estradiol was shown to effect synaptic plasticity in the hippocampus of rodents. The effects after exogenous application of estradiol to animals frequently produce inconsistent results, in particular if sex is not considered in the studies. Recently we provided evidence...
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AbstractSensory systems such as the olfactory system detect chemical stimuli and thereby determine the relationships between the animal and its surroundings. Olfaction is one of the most conserved and ancient sensory systems in vertebrates. The vertebrate olfactory epithelium is colonized by complex microbial communities, but microbial contribution to host olfactory gene expression remains unknown. In this study, we show that colonization of germ-free zebrafish and mice with microbiota leads to widespread...
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Publication date: October 2019Source: International Immunopharmacology, Volume 75Author(s): Qi Wang, Xinyao Xie, Feng Su, Jiaxue Wang, Shi Chen, Qian Wang, Daoli Jiang, Yitong Wang, Tan Zhang, Chang Liu, Min Han, Tao Tao, Quanrui Wu, Nana Xi, Zhanguo Li, Haifeng Song, Yi FangAbstractAimsSSS07 is a rabbit derived humanized anti-human TNF-α antibody. This study aimed to explore the pharmacokinetics, safety, and immunogenicity of SSS07 when administrated subcutaneously in healthy adults.MethodsThis...
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Abstract Aspartate–glutamate carrier 1 (AGC1) is one of two exchangers within the malate‐aspartate shuttle. AGC1 is encoded by the SLC25A12 gene. Three patients with pathogenic variants in SLC25A12 have been reported in the literature. These patients were clinically characterized by neurodevelopmental delay, epilepsy, hypotonia, cerebral atrophy, and hypomyelination; however, there has been discussion in the literature as to whether this hypomyelination is primary or secondary to a neuronal defect....
Abstract Lenz–Majewski syndrome (LMS) is an extremely rare type of cutis laxa caused by dominant mutations in PTDSS1 gene. We report an Egyptian patient who presented with cutis laxa, brachydactyly, and progeroid features. LMS syndrome was suspected and a previously reported de novo heterozygous missense mutation (c.284G > T, p.R95L) in PTDSS1 was identified. To the best of our knowledge, nine molecularly proven patients with LMS from different ethnicities have been reported. Our patient is the...
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It is critical to identify biomarkers and functional networks associated with aggressive thyroid cancer to anticipate disease progression and facilitate personalized patient management. We performed miRNome sequencing of 46 thyroid tumors enriched with advanced disease patients with a median follow‐up of 96 months. MiRNome profiles correlated with tumor‐specific histopathological and molecular features, such as stromal cell infiltration and tumor driver mutation. Differential expression analysis...
The role of progesterone receptor (PR) status on the association between obesity and prognosis of estrogen receptor positive (ER+) breast cancer (BC) remains poorly understood. We aim to examine whether this association varies according to the tumor PR status. Data for 3747 women diagnosed with non‐metastatic ER+ invasive BC between 1995 and 2010 were analyzed. Women were classified according to their body mass index (BMI) (<18.5, 18.5‐24.9, 25.0‐29.9 or ≥30.0 kg/m2). Tumor PR status (PR–, PR+)...
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Summary Ulceration of melanoma is associated with neutrophil infiltrates and lower survival rates opposite to non‐ulcerated melanoma. Neutrophils release neutrophil extracellular traps (NETs) that are chromatin structures loaded with anti‐microbial proteins. Since NETs have been correlated with tumor progression we investigated whether NETs appear in melanoma and affect melanoma cells. Indeed, human primary melanoma biopsies revealed neutrophils releasing NETs in all of 27 ulcerated melanomas,...
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Publication date: Available online 11 August 2019Source: Critical Reviews in Oncology/HematologyAuthor(s): Ji Cheng, Ming Cai, Xiaoming Shuai, Jinbo Gao, Guobin Wang, Kaixiong TaoAbstractAlthough paclitaxel plus ramucirumab has been recommended as the preferred second-line strategy, other regimens also display potentially comparable efficacies. Record retrieval was conducted in PubMed, Web of Science, Cochrane Central Register of Controlled Trials, Embase, ASCO and ESMO meeting libraries. Randomized...
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Condition: Ovarian CancerIntervention: Other: DNA and RNA extraction from FFPE or frozen tissue sampleSponsor: Institut BergoniéNot yet recruiting
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Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Xiao-Ping Wang, Peng-Fei Wang, Ji-Qing Bai, Su Gao, Ya-Heng Wang, Li-Na Quan, Fang Wang, Xiao-Ting Wang, Jin Wang, Yun-Dong XieAbstractDanshen (salvia miltiorrhiza) and honghua(Carthamus tinctorius) were traditional herb pair with promoting blood circulation and removing blood stasis actions, in China. Both were widely used to treat cardiovascular diseases (CVD) for hundreds years, especially shown definite...
Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Hao Guo, Xinhuan Wan, Fengju Niu, Jujie Sun, Chenxiao Shi, Jessica Meng Ye, Changzheng ZhouAbstractIn this study, we aimed to evaluate the antiviral effect of total flavonoids extracted from Robinia pseudoacacia cv. idaho (RPTF) in vivo and its toxicity on rats with oral gavage. RPTF was prepared by percolation with 70% ethanol for 24 h and its antiviral effect on different kinds of viruses was evaluated...
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16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/08/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/08/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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