Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01430F, PaperZimeng Liu, Haiyan WangWe report here a highly sensitive sandwich type electrochemical aptasensor for lysozyme (lys) detection by integration of antifouling interface with HRP-based signal amplification. The biosensing interface with antifouling ability is...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01087D, PaperChetan Shende, Carl Brouillette, Stuart FarquharsonA simple-to-use device to measure drugs in saliva, blood plasma, and whole blood for point-of-care analysis and treatment of overdose patients has been investigated. A rudimentary flow strip has been...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN00746F, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Milagros Montemurro, Andreas Schwaighofer, Anatol Schmidt, Maria J Culzoni, H. K. Mayer, Bernhard LendlAnalysis of bovine milk proteins is crucial in many food and non-food industrial applications, nevertheless labour-intensive wet-chemical, low-throughput methods are still routinely used. In this work, external cavity-quantum...
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Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01205B, CommunicationClaudia C Rullich, Johannes KieferIn-line determination of the enantiomeric ratio is still a challenge in process analytical technology (PAT). This study combines enantioselective Raman (esR) spectroscopy with partial least-squares regression (PLSR) to determine the...The content of this RSS Feed (c) The Royal Society of Chemistry
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Cancers, Vol. 11, Pages 1158: A Tyrosine Kinase Expression Signature Predicts the Post-Operative Clinical Outcome in Triple Negative Breast Cancers Cancers doi: 10.3390/cancers11081158 Authors: Alexandre de Nonneville Pascal Finetti José Adelaide Éric Lambaudie Patrice Viens Anthony Gonçalves Daniel Birnbaum Emilie Mamessier François Bertucci Triple negative breast cancer (TNBC) represent 15% of breast cancers. Histoclinical features and marketed prognostic gene...
Cancers, Vol. 11, Pages 1157: A Novel Type of Blood Biomarker: Distinct Changes of Cytokine-Induced STAT Phosphorylation in Blood T Cells Between Colorectal Cancer Patients and Healthy Individuals Cancers doi: 10.3390/cancers11081157 Authors: Yun Lee Kim Chun Engleman Kim Kang Background: Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Although early diagnosis and treatment is the most successful strategy for improving...
Cancers, Vol. 11, Pages 1156: Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma Cancers doi: 10.3390/cancers11081156 Authors: Lehang Lin De-Chen Lin Esophageal squamous cell carcinoma (ESCC) is a common and aggressive malignancy, with hitherto dismal clinical outcome. Genomic analyses of patient samples reveal a complex heterogeneous landscape for ESCC, which presents in both intertumor and intratumor forms, manifests at both genomic and epigenomic...
Cancers, Vol. 11, Pages 1155: Hepatic Resection Following Selective Internal Radiation Therapy for Colorectal Cancer Metastases in the FOXFIRE Clinical Trial: Clinical Outcomes and Distribution of Microspheres Cancers doi: 10.3390/cancers11081155 Authors: Helen Winter Joseph Rassam Pradeep S. Virdee Rob Goldin Priyankaa Pitcheshwar Klara Weaver John Primrose David P. Berry Harpreet S. Wasan Ricky A. Sharma The FOXFIRE (5-Fluorouracil, OXaliplatin and Folinic...
Cancers, Vol. 11, Pages 1154: Association between Circulating Fibroblast Growth Factor 21 and Aggressiveness in Thyroid Cancer Cancers doi: 10.3390/cancers11081154 Authors: Yea Eun Kang Jung Tae Kim Mi Ae Lim Chan Oh Lihua Liu Seung-Nam Jung Ho-Ryun Won Kyungmin Lee Jae Won Chang Hyon-Seung Yi Hyun Jin Kim Bon Jeong Ku Minho Shong Bon Seok Koo Fibroblast growth factor 21 (FGF21) plays important roles in regulating glucose, lipid, and energy metabolism;...
Cancers, Vol. 11, Pages 1153: Main Inflammatory Cells and Potentials of Anti-Inflammatory Agents in Prostate Cancer Cancers doi: 10.3390/cancers11081153 Authors: Takuji Hayashi Kazutoshi Fujita Makoto Matsushita Norio Nonomura Prostate cancer is the most common type of cancer and the leading cause of cancer deaths among men in many countries. Preventing progression is a major concern for prostate cancer patients on active surveillance, patients with recurrence after radical...
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This document summarizes consensus reached by the International Anorectal Physiology Working Group (IAPWG) for the performance of anorectal function testing and introduces a consensus classification for disorders of anorectal function based on objective, physiological measurement. Abstract Background This manuscript summarizes consensus reached by the International Anorectal Physiology Working Group (IAPWG) for the performance, terminology used, and interpretation of anorectal function testing...
In some patients lettuce produces abdominal distension, which is not related to gas, but rather to an uncontrolled reaction of the abdominal muscles and the diaphragm. Hence, learning to control the abdominal muscles may prevent distension with no need of dietary restrictions. Abstract Background Some patients complain that eating lettuce, gives them gas and abdominal distention. Our aim was to determine to what extent the patients' assertion is sustained by evidence. Methods An in vitro...
This study shows a strong therapeutic effect of a gum‐based thickener on safety of swallow in post‐stroke dysphagia that depends on shear viscosity levels, and a therapeutic range of 150‐800 mPa s. Increasing viscosity shortened time to laryngeal vestibule closure at all viscosities and reduced bolus velocity at ≥450 mPa s. Abstract Background Increasing viscosity with thickening agents is a valid therapeutic strategy for oropharyngeal dysphagia (OD). To assess the therapeutic effect of a xanthan...
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Stem Cells and Development, Ahead of Print.
Stem Cells and Development, Ahead of Print.
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Future Oncology, Ahead of Print.
Future Oncology, Ahead of Print.
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Oncogenesis, Published online: 12 August 2019; doi:10.1038/s41389-019-0150-2The epigenetic factor BORIS (CTCFL) controls the androgen receptor regulatory network in ovarian cancer
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Abstract Purpose To assess if CT texture analysis (TA) can serve as a biomarker of liver toxicity in patients with colorectal cancer treated with 5-fluorouracil (5-FU)-based chemotherapy. Methods In this IRB-approved, HIPAA-compliant retrospective study, patients with colorectal cancer treated with 5-FU-based regimens during 2008–2010 were identified...
Abstract Purpose To determine if texture analysis can differentiate placenta accreta spectrum (PAS) from normal placenta on MRI. Methods We performed retrospective image analysis of 80 patients, comprised of 46 patients with PAS and 34 patients without PAS. Histopathology was used as the reference standard. Sagittal single shot fast spin echo...
Abstract Purpose To determine the imaging features that help differentiate hypervascular primary hepatic tumors showing hepatobiliary hypointensity on gadoxetic acid MRI. Methods This study comprised 148 patients with pathologically proven hypervascular hepatic tumors who underwent gadoxetic acid MRI. Tumors included 23 atypical focal nodular...
Abstract Objective The purpose of this article is to describe and illustrate uncommon imaging evolutions of benign (i.e., cyst, hemangioma, focal nodular hyperplasia-like nodules, and hepatic angiomyolipoma) and malignant (i.e., HCC and non HCC malignancies) lesions in a cirrhotic liver. The content highlights relevant pathogenesis and imaging clues for proper differential diagnosis. Revision of prior imaging and knowledge of these...
Abstract Purpose The purpose of this study was to retrospectively evaluate the efficacy and safety of side-hole catheter technique for transarterial chemoembolization (TACE) via transradial artery access (TRA) in patients with hepatocellular carcinoma. Materials and methods From November 2015 to August 2017, a total of 1040 TACE procedures were...
Abstract Purpose The aim of this study was to build an appropriate diagnostic model for predicting pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC), by combining magnetic resonance imaging (MRI) parameters with clinical factors. Methods Eighty-four patients...
Abstract Objective To investigate the imaging findings and hepatic artery variations encountered in patients with aberrant left gastric vein (ALGV). Methods A retrospective database search between January 2014 and November 2018 was carried for ALGV. The course and types (1–3) of ALGV, the presence of associated liver lesions, and coexistence...
Abstract Purpose To formulate consensus recommendations for CT angiography technical parameters used to evaluate overt gastrointestinal (GI) bleeding. Methods An electronic questionnaire consisting of 17 questions was sent to a panel of 16 radiologists with expertise on the imaging of GI bleeding from the Society of Abdominal Radiology GI Bleeding...
Abstract At times, technologies fail for reasons other than an inability to deliver on their promises. The iconic Blackberry, for example, was once coined “Research in Motion”, sold tens of millions of units, and then “disappeared” from the market because it did not accompany the new trends in design. Promising technologies may also “disappear” in the medical field. What follows is the tale of the rise and fall of proton magnetic resonance spectroscopic imaging (1H MRSI) of the...
Abstract Unlike nodal lymphoma, primary lymphomas of the intraabdominal organs are uncommon neoplasms whose diagnosis may be challenging in certain clinical circumstances. Despite this difficulty for imaging diagnosis, there are several imaging features on ultrasonography, computed tomography, magnetic resonance imaging, and positron emission tomography that may suggest the correct diagnosis. The scope of this review is to describe and illustrate the imaging features of primary...
Abstract Objectives To determine the proportion of diagnostic computed tomography colonography (CTC) Reporting and Data System (C-RADS) categories in a non-screening population, and which patient factors are associated with a positive CTC (C2–4), a non-diagnostic CTC (C0), and potentially relevant extracolonic findings (ECF, E3–4). Methods Diagnostic...
Abstract Purpose To compare qualitative results obtained from computer-aided dual-ratio analysis on T1-weighted two-point Dixon, with T2*-corrected multi-echo Dixon and T2-corrected multi-echo single-voxel MR spectroscopy sequence (MRS) for evaluation of liver fat and iron at 3T. Methods and materials This retrospective, HIPAA-compliant, IRB-approved...
Abstract Objective The aim of this article is to focus on etiology, risk factors, clinical presentation and classification systems of acute and chronic PVT as well as focusing on current diagnostic and therapeutic options for the management of acute and chronic PVT. Results PVT represents a serious clinical concern in cirrhotic patients and in those with...
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Modern SNP genotyping technologies allow measurement of the relative abundance of different alleles for a given locus and consequently estimation of their allele dosage, opening a new road for genetic studies in autopolyploids. Despite advances in genetic linkage analysis in autotetraploids, there is a lack of statistical models to perform linkage analysis in organisms with higher ploidy levels. In this paper, we present a statistical method to estimate recombination fractions and infer linkage phases...
Egg diapause in Locusta migratoria L. (Orthoptera: Acridoidea) is believed to be influenced by maternal photoperiod. However, the molecular mechanism regulating the phenomenon of maternal diapause induction is unclear. Here we performed transcriptomic analyses from the central nervous system (CNS) of migratory locusts under long and short photoperiods to identify differentially expressed genes (DEGs) related to diapause induction. There were total of 165750 unigenes from 569491 transcripts, and 610...
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Abstract Some of the most important natural pigments have been produced from fungi and used for coloring in food, cosmetics, textiles, and pharmaceutical products. Forty-seven isolates of endophytic fungi were isolated from Cinnamomum zeylanicum in northern Thailand. Only one isolate, CMU-ZY2045, produced an extracellularly red pigment. This isolate was identified as Nigrospora aurantiaca based on morphological characteristics and the molecular phylogenetic analysis of a combined...
Abstract Betulinic acid (BA) and its derivatives possess potent pharmacological activity against cancer and HIV. As with many phytochemicals, access to BA is limited by the requirement for laborious extraction from plant biomass where it is found in low amounts. This might be alleviated by metabolically engineering production of BA into an industrially relevant microbe such as Saccharomyces cerevisiae (yeast), which requires complete elucidation of the corresponding biosynthetic...
Abstract The increasing demand for biopharmaceuticals produced in mammalian cells has driven the industry to enhance the productivity of bioprocesses through intensification of culture process. Fed-batch and perfusion culturing strategies are considered the most attractive choices, but the application of these processes requires the availability of reliable online measuring systems for the estimation of cell density and metabolic activity. This manuscript reviews the methods...
Abstract Protein display approaches have been useful to endow the cell surface of yeasts with new catalytic activities so that they can act as enhanced whole-cell biocatalysts. Despite their biotechnological potential, protein display technologies remain poorly developed for filamentous fungi. The lignocellulolytic character of some of them coupled to the cell surface biosynthesis of valuable molecules by a single or a cascade of several displayed enzymes is an appealing prospect....
Abstract Sulfur minerals originating from coal mining represent an important environmental problem. Turning these wastes into value-added by-products can be an interesting alternative. Biotransformation of coal tailings into iron-containing nanoparticles using Rhodococcus erythropolis ATCC 4277 free cells was studied. The influence of culture conditions (stirring rate, biomass concentration, and coal tailings ratio) in the particle size was investigated using a 23 full factorial...
Abstract 10-hydroxy-cis-12 octadecenoic acid (10-HOE) is a type of octadecenoic acid with a hydroxyl on the C10 carbon. It is generated from linoleic acid (LA) catalyzed by linoleate hydratase in lactobacilli, which was initially named as myosin-cross-reactive antigen (MCRA). In lactobacilli, 10-HOE is the first intermediate in the production of conjugated LA (CLA). Although MCRA from bifidobacteria can generate 10-HOE, the precise role of 10-HOE in CLA production in bifidobacteria...
Abstract Use of recombinant glycosidases is a promising approach for the production of minor ginsenosides, e.g., Compound K (CK) and F1, which have potential applications in the food industry. However, application of these recombinant enzymes for food-grade preparation of minor ginsenosides are limited by the lack of suitable expression hosts and low productivity. In this study, Corynebacterium glutamicum ATCC13032, a GRAS strain that has been used extensively for the industrial-grade...
Abstract Filamentous fungi play an important role in human health and industrial/agricultural production. With the increasing number of full genomes available for fungal species, the study of filamentous fungi has brought about a wider range of genetic manipulation opportunities. However, the utilization of traditional methods to study fungi is time consuming and laborious. Recent rapid progress and wide application of a versatile genome editing technology, i.e., the CRISPR (clustered...
Abstract The selective marker in the plasmid-based expression system is usually a gene that encodes an antibiotic-resistant protein; therefore, the antibiotic has to add to maintain the plasmid when growing the bacteria. This antibiotic addition would lead to increase of production cost and the environment contamination. In this study, a novel Escherichia coli expression system, the lpxA deletion mutant harboring an lpxA-carrying vector, was developed. To develop this system,...
Abstract The explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a contaminant at many military sites. RDX bioremediation as a clean-up approach has been gaining popularity because of cost benefits compared to other methods. RDX biodegradation has primarily been linked to six functional genes (diaA, nfsI, pnrB, xenA, xenB, xplA). However, current methods for gene quantification have the risk of false negative results because of low theoretical primer coverage. To address...
Abstract Since polycyclic aromatic hydrocarbons (PAHs) are mutagenic, teratogenic, and carcinogenic, they are of considerable environmental concern. A biotechnological approach to remove such compounds from polluted ecosystems could be based on the use of white-rot fungi (WRF). The potential of well-adapted indigenous Ganoderma strains to degrade PAHs remains underexplored. Seven native Ganoderma sp. strains with capacity to produce high levels of laccase enzymes and to degrade...
Abstract In recent years, the accumulation of synthetic plastics has led to the development of a serious environmental problem. Nowadays, biodegradable films and coatings have been identified as a new approach to solve this problem by preparing renewable, abundant, low-cost materials. Gums are considered a large group of polysaccharides and polysaccharide derivatives that can easily form viscous solutions at low concentrations. Gums are mainly soluble in water and are composed...
Abstract Production of lactic acid bacteria starters for manufacturing food, probiotic, and chemical products requires the application of successive steps: fermentation, concentration, stabilization, and storage. Despite process optimization, losses of bacterial viability and functional activities are observed after stabilization and storage steps due to cell exposure to environmental stresses (thermal, osmotic, mechanical, and oxidative). Bacterial membrane is the primary target...
Abstract The nucleoside antibiotic toyocamycin (TM), which was produced by Streptomyces diastatochromogenes 1628, was found to be highly efficient against a broad range of plant pathogenic fungi. Despite its importance, little is known about the regulation TM biosynthesis. In this study, toyA, located in the TM biosynthetic gene cluster, was identified as a regulatory gene encoding a large ATP-binding regulator of the LuxR family (LAL-family). The role of toyA in TM biosynthesis...
Abstract Fibroblast growth factor (FGF) 13, a member of the FGF11 subfamily, is a kind of intracrine protein similar to other family members including FGF11, FGF12, and FGF14. Unlike classical FGF, FGF13 exerts its bioactivities independent of fibroblast growth factor receptors (FGFRs). However, the effect of exogenous administration of FGF13 still remains further investigated. In the present study, we established an Escherichia coli expression system for the large-scale production...
Abstract Bacteria and fungi were isolated from eight different soil samples from different regions in Kazakhstan contaminated with oil or salt or aromatic compounds. For the isolation of the organisms, we used, on the one hand, typical hydrocarbons such as the well utilizable aliphatic alkane tetradecane, the hardly degradable multiple-branched alkane pristane, and the biaromatic compound biphenyl as enrichment substrates. On the other hand, we also used oxygenated derivatives...
Abstract The role that the complex microbial communities play in human and environmental health cannot be understated. The increased information about community complexity, as well as the overuse of broad-spectrum antibiotics, suggest that new approaches to target specific organisms within a community context are essential towards new antimicrobial therapies. Here, we have assessed the activity and selectivity of two cell wall lytic enzymes, lysostaphin (Lst) and PlyPH, in the...
Abstract Biotechnologies that aim to produce renewable fuels, chemicals, and bioproducts from residual ligno(hemi)cellulosic biomass mostly rely on enzymatic depolymerization of plant cell walls (PCW). This process requires an arsenal of diverse enzymes, including xylanases, which synergistically act on the hemicellulose, reducing the long and complex xylan chains to oligomers and simple sugars. Thus, xylanases play a crucial role in PCW depolymerization. Until recently, the largest...
Abstract Antrodia camphorata, also known as A. cinnamomea, is a precious medicinal basidiomycete fungus endemic to Taiwan. This article summarizes the recent advances in research on the multifarious pharmacological effects of A. camphorata. The mushroom exhibits anticancer activity toward a large variety of cancers including breast, cervical, ovarian, prostate, bladder, colorectal, pancreatic, liver, and lung cancers; melanoma; leukemia; lymphoma; neuroblastoma; and glioblastoma....
Abstract Two sustainable and cost-effective cascade enzymatic systems were developed to regenerate uridine diphosphate (UDP)-α-d-glucose and UDP-β-l-rhamnose from sucrose. The systems were coupled with the UDP generating glycosylation reactions of UDP sugar–dependent glycosyltransferase (UGT) enzymes mediated reactions. As a result, the UDP generated as a by-product of the GT-mediated reactions was recycled. In the first system, YjiC, a UGT from Bacillus licheniformis DSM 13, was...
Abstract We evaluated the toxicity of surfactants against different predatory bacteria. Tests with Bdellovibrio bacteriovorus HD100 and SDS, an anionic surfactant, showed the predator was very sensitive; 0.02% SDS completely killed the predatory population (7-log loss; < 10 PFU/ml remaining) both when free-swimming or within the bdelloplast, i.e., intraperiplasmic. Similar results were also observed with B. bacteriovorus 109J and Peredibacter starrii. In contrast, none of the...
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Heart failure (HF) remains a major source of late morbidity and mortality after myocardial infarction (MI). Temporospatial presence of the activated fibroblasts in the injured myocardium predicts the quality of cardiac remodelling post-MI. Therefore, monitoring of activated fibroblasts is of great interest for studying cardiac remodelling after MI. Fibroblast activation protein (FAP) expression is upregulated in activated fibroblasts. This study investigates the feasibility of imaging activated fibroblasts...
Radiation dose estimations are key for optimizing therapies that are given intra-compartmentally. We studied the role of 124I-Omburtamab (8H9) given intraventricularly via Ommaya catheter in assessing the distribution and radiation doses prior to 131I-Omburtamab therapy in patients with metastatic leptomeningeal disease and compared it to the estimates from cerebrospinal fluid (CSF) sampling. Methods: Patients with histologically proven malignancy and recurrent metastatic disease to the central...
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Hybridization increases genetic variation, hence hybrid species may have a strong evolutionary potential once their admixed genomes have stabilized and incompatibilities have been purged. Yet, little is known about how such hybrid lineages evolve at the genomic level following their formation, in particular the characteristics of their adaptive potential, i.e. constraints and facilitations of diversification. Here we investigate how the Italian sparrow (Passer italiae), a homoploid hybrid species,...
Selfish genetic elements that gain a transmission advantage through the destruction of sperm have grave implications for drive male fertility. In the X-linked SR meiotic drive system of a stalk-eyed fly, we found that drive males have greatly enlarged testes and maintain high fertility despite the destruction of half their sperm, even when challenged with fertilising large numbers of females. Conversely, we observed reduced allocation of resources to the accessory glands that probably explains the...
Whether adaptation is limited by the beneficial mutation supply is a long-standing question of evolutionary genetics, which is more generally related to the determination of the adaptive substitution rate and its relationship with the effective population size Ne. Empirical evidence reported so far is equivocal, with some but not all studies supporting a higher adaptive substitution rate in large-Ne than in small-Ne species. We gathered coding sequence polymorphism data and estimated the adaptive...
The transition from unicellular to multicellular organisms is one of the most significant events in the history of life. Key to this process is the emergence of Darwinian individuality at the higher level: groups must become single entities capable of reproduction for selection to shape their evolution. Evolutionary transitions in individuality are characterized by cooperation between the lower level entities and by division of labor. Theory suggests that division of labor may drive the transition...
Anatomically modern humans carry many introgressed variants from other hominins in their genomes. Some of them affect their phenotype and can thus be negatively or positively selected. Several individual genes have been proposed to be the subject of adaptive introgression, but the possibility of polygenic adaptive introgression has not been extensively investigated yet. In this study, we analyze archaic introgression maps with refined functional enrichment methods to find signals of polygenic adaptation...
In 2012, the reduction in Onchocerca volvulus infection prevalence through long-term mass ivermectin distribution in African meso- and hyperendemic areas motivated expanding control of onchocerciasis (river blindness) as a public health problem to elimination of parasite transmission. Given the large contiguous hypo-, meso- and hyperendemic areas with an estimated population of 204 million, sustainable elimination requires an understanding of the geographic, and in turn genetic, boundaries of different...
Hybridization increases genetic variation, hence hybrid species may have a strong evolutionary potential once their admixed genomes have stabilized and incompatibilities have been purged. Yet, little is known about how such hybrid lineages evolve at the genomic level following their formation, in particular the characteristics of their adaptive potential, i.e. constraints and facilitations of diversification. Here we investigate how the Italian sparrow (Passer italiae), a homoploid hybrid species,...
Procellariiform seabirds are known for their well-developed olfactory capabilities, reflected by their large olfactory bulb to brain ratio and olfactory-mediated behaviors. Many species in this clade use olfactory cues for foraging and navigation, and some species can recognize individual-specific odors. Their genomes and transcriptomes may yield important clues about how the olfactory receptor (OR) subgenome was shaped by natural and sexual selection. In this study, we assembled a high-quality Leach's...
Range shifts and species range limits are two fundamental, related processes in population and evolutionary genetics that have received much attention since a large impact of climate change in species distributions was predicted. In general, there is a broad consensus on the effects of abiotic interactions on range limits, but comprehensive evidence supporting/rejecting the impact of biotic interactions is lacking. Hybridization has long been recognized as a biotic interaction favoring marginal populations...
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While acute promyelocytic leukemia (APL) has a good prognosis with all-trans retinoic acid (ATRA) treatment, ATRA resistance is a major obstacle. It is now demonstrated that TRIBBLES 3 (TRIB3) stabilizes TWIST1, leading to ATRA resistance. Peptides that disrupt this interaction lead to the degradation of TWIST1 and overcome ATRA resistance.
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British Journal of Cancer, Published online: 13 August 2019; doi:10.1038/s41416-019-0548-9Signet ring cell colorectal cancer: genomic insights into a rare subpopulation of colorectal adenocarcinoma
British Journal of Cancer, Published online: 13 August 2019; doi:10.1038/s41416-019-0516-4In order for the light to shine so brightly, the darkness must be present—why do cancers fluoresce with 5-aminolaevulinic acid?
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Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07230
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05816
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06834
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05353
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The study is the first to put antibiotic biosynthesis and resistance into an evolutionary context. The findings will help to guide the future discovery of new antibiotics and antibiotic alternatives which are medicines that are vitally needed given the current global threat of antimicrobial resistance.
The gut-infecting bacterium Clostridium difficile is evolving into two separate species, with one group highly adapted to spread in hospitals, according to new research.
Biologists have sequenced and analyzed the genomes of four apple snail species in the family Ampullariidae. The researchers discovered that the apple snails have evolved to become highly sensitive to environmental stimuli, digest cellulose (a major component of the plant cell wall), form hard calcareous eggshells and pack neurotoxins in eggs. The findings could facilitate the development of effective genetic control measures for these destructive crop-eating snails.
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This study aimed to determine the reliability, validity, and the specificity and sensitivity of the Spanish version of two questionnaires, the Voice Fatigue Index (VFI) and the Voice Fatigue Handicap Questionnaire (VFHQ), in female teachers, analyze the influence of the sociodemographic factors on the questionnaires, and conduct a comparative study of the psychometric characteristics of the two questionnaires on vocal fatigue (VF).
The primary purpose of the current study was to determine the usefulness of Buteyko breathing technique (BBT) in reducing dyspnea in patients with one form of Paradoxical Vocal Fold Motion (PVFM), exertion-induced PVFM (EI-PVFM), concomitant with hyperventilation. The secondary purpose was to determine whether BBT had an effect on physiological markers of hyperventilation, as speculated by BBT theory: respiratory tidal minute volume (RTMV), end-tidal carbon dioxide (ETCO2), and resting heart rate...
The aim of this study was to determine the efficacy of a 4-week breathing exercise intervention in participants with voice symptoms.
Evaluating the relationship among teachers' voice symptoms, perceived voice control, and common mental disorders (CMDs) might contribute to the understanding of the relationship between vocal wear and the teacher well-being. The understanding of this relationship may also help in taking more informed clinical decisions in voice rehabilitation when considering possible perceived voice control difficulties and the need to develop voice self-control strategies.
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