Radiation therapy (RT) is a major actor in cancer management, with more than half of all cancer patients treated with RT, mostly given with curative potential. RT generally exploits the empirical observation that normal tissues can recover from the harmful effects of ionizing radiation to a higher extent than tumors. This differential effect can be exacerbated by two factors that can independently increase the normal tissue tolerance. The first factor is the fractionation of the total dose with a...
Radiation therapy is an important treatment modality for a broad range of brain tumors. However, the ability to cure tumors through dose intensity is limited by normal tissue injury, particularly when a large volume of the brain (up to the whole brain) must be included in the treatment volume as is the case for many clinical indications. In the prospective randomized trial RTOG 0614, 64.9% of patients developed a significant decrement in cognitive function by 24 weeks after whole brain radiation...
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