GastrointestDisord, Vol. 1, Pages 290-300: Immunomodulatory Effects of TGF-β Family Signaling within Intestinal Epithelial Cells and Carcinomas Gastrointestinal Disorders doi: 10.3390/gidisord1020024 Authors: Paula Marincola Smith Anna Means R. Beauchamp TGF-β superfamily signaling is responsible for many critical cellular functions including control of cell growth, cell proliferation, cell differentiation, and apoptosis. TGF-β appears to be critical in gastrulation, embryonic...
Tue Jun 25, 2019 03:00
GastrointestDisord, Vol. 1, Pages 273-289: Diabetes Mellitus and Colon Carcinogenesis: Expectation for Inhibition of Colon Carcinogenesis by Oral Hypoglycemic Drugs Gastrointestinal Disorders doi: 10.3390/gidisord1020023 Authors: Junichi Kato Yohei Shirakami Masahito Shimizu The global deaths due to colorectal cancer and diabetes mellitus have increased by 57% and 90%, respectively. The relationship between various cancers and diabetes mellitus has been shown in multiple epidemiological...
Wed Jun 12, 2019 03:00
GastrointestDisord, Vol. 1, Pages 266-272: Bifidobacteria and Mucosal-Associated Invariant T (MAIT) Cells: A New Approach to Colorectal Cancer Prevention? Gastrointestinal Disorders doi: 10.3390/gidisord1020022 Authors: Hüseyin Bozkurt Eamonn Quigley Colorectal cancer is the most preventable form of cancer worldwide. The pathogenesis of colorectal cancer includes gut inflammation, genetic and microbial composition factors. İmpairment of the gut microbiota has been associated with...
Fri May 31, 2019 03:00
GastrointestDisord, Vol. 1, Pages 261-265: Asymptomatic Inflammatory Bowel Disease and Colorectal Cancer Screening Programs: How Common Is It and What Should be Done About It? Gastrointestinal Disorders doi: 10.3390/gidisord1020021 Authors: Affifa Farrukh John F. Mayberry The growing international popularity of screening programs for the early detection of pre-cancerous changes or early cancer in the colon has brought to the fore the issue of people with asymptomatic inflammatory...
Fri May 17, 2019 03:00
GastrointestDisord, Vol. 1, Pages 253-260: Evidence of Differences and Discrimination in the Delivery of Care: Colorectal Screening in Healthy People and in the Care and Surveillance of Patients with Inflammatory Bowel Disease Gastrointestinal Disorders doi: 10.3390/gidisord1020020 Authors: Afffa Farrukh John Mayberry Objectives: In this review the management of colorectal disease will be investigated as an exemplar of common practice in the UK in an attempt to identify factors responsible...
Mon Apr 08, 2019 03:00
GastrointestDisord, Vol. 1, Pages 241-252: Correlation between Helicobacter pylori Infection and Gastric Atrophy Examined in the Sera of Mongolian People Gastrointestinal Disorders doi: 10.3390/gidisord1020019 Authors: Avarzed Amgalanbaatar Hirofumi Shimomura Kentaro Sugano Tsatsralt-Od Bira Hiroaki Okamoto Yoshikazu Hirai Serum specimens obtained from 680 individuals were examined to measure the amounts of pepsinogens 1 and 2, anti-CagA antibodies, and anti-Helicobacter...
Wed Apr 03, 2019 03:00
GastrointestDisord, Vol. 1, Pages 231-240: The Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Disease Gastrointestinal Disorders doi: 10.3390/gidisord1010018 Authors: Stefano Nobile Michela A. Tenace Helen M. Pappa Vitamin D has a complex role in the pathogenesis of inflammatory bowel disease (IBD), which is still under investigation. We conducted a literature search using PubMed through December 2018 through the use of relevant search terms. We found an abundance...
Tue Mar 05, 2019 02:00
GastrointestDisord, Vol. 1, Pages 220-230: The Predictive Factors of Responsiveness to Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis Gastrointestinal Disorders doi: 10.3390/gidisord1010017 Authors: Atsushi Hashimoto Takashi Sugawa Narika Iwakura Risa Uemura Akinari Sawada Koji Otani Koichi Taira Shuhei Hosomi Yasuaki Nagami Fumio Tanaka Noriko Kamata Hirokazu Yamagami Tetsuya Tanigawa Toshio Watanabe Yasuhiro Fujiwara Approximately...
Mon Feb 25, 2019 02:00
GastrointestDisord, Vol. 1, Pages 210-219: Determination of Tumor Location in Rectosigmoid Carcinomas: Difficulties in Preoperative Diagnostics Gastrointestinal Disorders doi: 10.3390/gidisord1010016 Authors: Els Moltzer Bo Jan Noordman Nomdo S. Renken Daphne Roos Differentiation between rectal and sigmoid carcinomas is a diagnostic challenge with important implications for further treatment. Depending on the tumor stage, treatment for rectal carcinoma consists of preoperative...
Tue Feb 19, 2019 02:00
GastrointestDisord, Vol. 1, Pages 201-209: Sarcopenia Is Associated with Postoperative Outcome in Patients with Crohn’s Disease Undergoing Bowel Resection Gastrointestinal Disorders doi: 10.3390/gidisord1010015 Authors: Diogo Carvalho Charlene Viana Isabel Marques Catarina Costa Sandra F. Martins Sarcopenia is as an important prognostic factor in inflammatory bowel disease. In patients with Crohn’s disease (CD), sarcopenia has impact on morbidity after surgical...
Mon Feb 18, 2019 02:00
GastrointestDisord, Vol. 1, Pages 191-200: Inhibition of Stearoyl-CoA Desaturase-1 Activity Suppressed SREBP Signaling in Colon Cancer Cells and Their Spheroid Growth Gastrointestinal Disorders doi: 10.3390/gidisord1010014 Authors: Xian-Yang Qin Soichi Kojima Unsaturated fatty acids are critical in promoting colon tumorigenesis and its stemness. Stearoyl-CoA desaturase-1 (SCD1) is a rate-limiting lipid desaturase associated with colon cancer cell proliferation and metastasis control....
Sat Jan 26, 2019 02:00
GastrointestDisord, Vol. 1, Pages 176-190: The Evolving Role of Mucosal Histology in the Evaluation of Pediatric Functional Dyspepsia: A Review Gastrointestinal Disorders doi: 10.3390/gidisord1010013 Authors: Craig A. Friesen Jennifer M. Colombo Jennifer V. Schurman Although not required to establish the diagnosis, endoscopy with mucosal biopsy is commonly performed in the evaluation of children with dyspepsia. Traditionally, esophagogastroduodenoscopy (EGD) has been performed...
Wed Jan 09, 2019 02:00
GastrointestDisord, Vol. 1, Pages 164-175: Endoscopic Botulinum Toxin for Gastroparesis: Results of a Retrospective Series Gastrointestinal Disorders doi: 10.3390/gidisord1010012 Authors: Fabiënne G. M. Smeets Denise Strijbos Daniel Keszthelyi Chantal V. Hoge Joanna W. Kruimel José M. Conchillo Ad A.M. Masclee Beneficial effects of pyloric botulinum toxin injection have been described in a subgroup of gastroparesis patients. Our aim is to evaluate whether clinical,...
Fri Dec 14, 2018 02:00
GastrointestDisord, Vol. 1, Pages 147-163: Histopathology of Barrett’s Esophagus and Early-Stage Esophageal Adenocarcinoma: An Updated Review Gastrointestinal Disorders doi: 10.3390/gidisord1010011 Authors: Feng Yin David Hernandez Gonzalo Jinping Lai Xiuli Liu Esophageal adenocarcinoma carries a very poor prognosis. For this reason, it is critical to have cost-effective surveillance and prevention strategies and early and accurate diagnosis, as well as evidence-based treatment...
Tue Nov 27, 2018 02:00
GastrointestDisord, Vol. 1, Pages 129-146: Pathogenesis of Inflammatory Bowel Disease: Basic Science in the Light of Real-World Epidemiology Gastrointestinal Disorders doi: 10.3390/gidisord1010010 Authors: Davide Giuseppe Ribaldone Rinaldo Pellicano Giovanni C. Actis Major advances in the last few decades have favored the view of inflammatory bowel disease (IBD) as a disease of hyper- or, more often, paradoxical hyporesponsiveness of the gut-associated immune system. The relevant...
Mon Nov 12, 2018 02:00
GastrointestDisord, Vol. 1, Pages 120-128: Paradigm Shift of Healthcare Cost for Patients with Inflammatory Bowel Diseases: A Claims Data-Based Analysis in Japan Gastrointestinal Disorders doi: 10.3390/gidisord1010009 Authors: Shota Saito Kyoko Nakazawa Kenji Suzuki Takashi Ishikawa Kouhei Akazawa Anti-tumor necrosis factor-α (anti-TNFα) agents are used for induction and maintenance of remission in patients with inflammatory bowel diseases (IBD). However,...
Fri Nov 09, 2018 02:00
GastrointestDisord, Vol. 1, Pages 106-119: Characteristics and Clinical Outcomes of Individuals at High Risk for Pancreatic Cancer: A Descriptive Analysis from a Comprehensive Cancer Center Gastrointestinal Disorders doi: 10.3390/gidisord1010008 Authors: Griffin P. J. McNamara Karla N. Ali Shraddha Vyas Tri Huynh Monica Nyland Deanna Almanza Christine Laronga Jason Klapman Jennifer B. Permuth Pancreatic cancer (PC), a leading cause of cancer-related deaths in...
Thu Nov 01, 2018 02:00
GastrointestDisord, Vol. 1, Pages 75-105: The Multifactorial Etiopathogeneses Interplay of Inflammatory Bowel Disease: An Overview Gastrointestinal Disorders doi: 10.3390/gidisord1010007 Authors: Amosy E. M’Koma The gastrointestinal system where inflammatory bowel disease occurs is central to the immune system where the innate and the adaptive/acquired immune systems are balanced in interactions with gut microbes under homeostasis conditions. This article overviews the high-throughput...
Thu Oct 18, 2018 03:00
GastrointestDisord, Vol. 1, Pages 57-74: CCR6–CCL20 Axis in IBD: What Have We Learnt in the Last 20 Years? Gastrointestinal Disorders doi: 10.3390/gidisord1010006 Authors: Ranmali Ranasinghe Rajaraman Eri CC chemokine receptor 6 (CCR6) and its specific partner CC chemokine ligand 20 (CCL20) are known to play a pivotal role in intestinal inflammation. CCR6-associated inflammatory bowel disease (IBD) is already at the forefront of experimental inflammatory disease models, being the...
Mon Oct 15, 2018 03:00
GastrointestDisord, Vol. 1, Pages 39-56: Regulation of Antimicrobial Pathways by Endogenous Heat Shock Proteins in Gastrointestinal Disorders Gastrointestinal Disorders doi: 10.3390/gidisord1010005 Authors: Emma Finlayson-Trick Jessica Connors Andrew Stadnyk Johan Van Limbergen Heat shock proteins (HSPs) are essential mediators of cellular homeostasis by maintaining protein functionality and stability, and activating appropriate immune cells. HSP activity is influenced by a...
Fri Sep 28, 2018 03:00
GastrointestDisord, Vol. 1, Pages 30-38: Assessment of the Acute Effects of Carbonated Beverage Consumption on Symptoms and Objective Markers of Gastric Reflux Gastrointestinal Disorders doi: 10.3390/gidisord1010004 Authors: Shi Lim Iain Brownlee Previous studies have suggested that carbonated beverages may cause gastro-oesophageal reflux. Pepsin (the major enzyme secreted by the stomach) has been suggested to be an objective, acute marker of a reflux event. This pilot study aimed...
Wed Sep 12, 2018 03:00
GastrointestDisord, Vol. 1, Pages 15-29: CCR6–CCL20-Mediated Immunologic Pathways in Inflammatory Bowel Disease Gastrointestinal Disorders doi: 10.3390/gidisord1010003 Authors: Ranmali Ranasinghe Rajaraman Eri Inflammatory bowel disease (IBD) has evoked significant interest in human immunobiology given its tactical immune evasion methodologies resulting in acute immune destabilization. IBD comprising Crohn’s disease and Ulcerative colitis manifests as chronic inflammation...
Tue Aug 21, 2018 03:00
GastrointestDisord, Vol. 1, Pages 3-14: Intrabolus Pressure Has Better Correlation Than Eosinophilia with Dysphagia Severity in Fibrostenotic Eosinophilic Esophagitis: A Pilot Study Gastrointestinal Disorders doi: 10.3390/gidisord1010002 Authors: Jason Colizzo Steven Clayton Ambuj Kumar Joel Richter Eosinophilic esophagitis is characterized by dysphagia with esophageal eosinophilia. We sought to determine if intrabolus pressure measurements on high-resolution manometry had any...
Mon Aug 13, 2018 03:00
GastrointestDisord, Vol. 1, Pages 1-2: Gastrointestinal Disorders—An Open Access Journal on Gastroenterology Gastrointestinal Disorders doi: 10.3390/gidisord1010001 Authors: Richard McCallum I am very excited about announcing the launch of a new Journal—Gastrointestinal Disorders.[...]
Fri May 11, 2018 03:00
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