IJMS, Vol. 20, Pages 3182: Renin Activity in Heart Failure with Reduced Systolic Function—New Insights International Journal of Molecular Sciences doi: 10.3390/ijms20133182 Authors: Ryan D. Sullivan Radhika M. Mehta Ranjana Tripathi Guy L. Reed Inna P. Gladysheva Regardless of the cause, symptomatic heart failure (HF) with reduced ejection fraction (rEF) is characterized by pathological activation of the renin–angiotensin–aldosterone system (RAAS) with...
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IJMS, Vol. 20, Pages 3181: Importance of the Choice of a Recombinant System to Produce Large Amounts of Functional Membrane Protein hERG International Journal of Molecular Sciences doi: 10.3390/ijms20133181 Authors: Vasseur Cens Wagner Saint Kugler Chavanieu Ouvry Dupré Ferry Boutin Human ether-a-gogo related gene (hERG) product is the membrane potassium channel Kv11.1, which is involved in the electrical activity of the heart. As such, it is a key...
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IJMS, Vol. 20, Pages 3183: Autocrine Production of PDGF Stimulated by the Tenascin-C-Derived Peptide TNIIIA2 Induces Hyper-Proliferation in Glioblastoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms20133183 Authors: Motomichi Fujita Tetsuya Yamamoto Takuya Iyoda Tatsuya Fujisawa Reo Nagai Chikako Kudo Manabu Sasada Hiroaki Kodama Fumio Fukai Expression level of tenascin-C is closely correlated to poor prognosis in glioblastoma patients, while...
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IJMS, Vol. 20, Pages 3179: Integrated Computational Analysis Highlights unique miRNA Signatures in the Subventricular Zone and Striatum of GM2 Gangliosidosis Animal Models International Journal of Molecular Sciences doi: 10.3390/ijms20133179 Authors: Francesco Morena Vasileios Oikonomou Chiara Argentati Martina Bazzucchi Carla Emiliani Angela Gritti Sabata Martino This work explores for the first time the potential contribution of microRNAs (miRNAs) to the pathophysiology...
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IJMS, Vol. 20, Pages 3180: Genome-Wide Identification and Expression Profiling of the Polygalacturonase (PG) and Pectin Methylesterase (PME) Genes in Grapevine (Vitis vinifera L.) International Journal of Molecular Sciences doi: 10.3390/ijms20133180 Authors: Nadeem Khan Fizza Fatima Muhammad Salman Haider Hamna Shazadee Zhongjie Liu Ting Zheng Jinggui Fang In pectin regulation, polygalacturonases (PGs) and pectin methylesterases (PMEs) are critical components in the...
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IJMS, Vol. 20, Pages 3177: The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism International Journal of Molecular Sciences doi: 10.3390/ijms20133177 Authors: Marjorie Reyes-Farias Catalina Carrasco-Pozo Cancer is a problem with worldwide importance and is the second leading cause of death globally. Cancer cells reprogram their metabolism to support their uncontrolled expansion by increasing biomass (anabolic metabolism—glycolysis) at the expense...
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IJMS, Vol. 20, Pages 3176: Reduced Diet-induced Thermogenesis in Apolipoprotein A-IV Deficient Mice International Journal of Molecular Sciences doi: 10.3390/ijms20133176 Authors: Sydney Pence Qi Zhu Erin Binne Min Liu Haifei Shi Chunmin C. Lo In the presence of dietary lipids, both apolipoprotein A-IV (ApoA-IV) production and brown adipose tissue (BAT) thermogenesis are increased. The effect of dietary lipid-induced AproA-IV on BAT thermogenesis and energy expenditure...
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IJMS, Vol. 20, Pages 3175: Sex- and Age-Related Estrogen Signaling Alteration in Inflammatory Bowel Diseases: Modulatory Role of Estrogen Receptors International Journal of Molecular Sciences doi: 10.3390/ijms20133175 Authors: Damian Jacenik Adam I. Cygankiewicz Anna Mokrowiecka Ewa Małecka-Panas Jakub Fichna Wanda M. Krajewska The pathogenesis of inflammatory bowel diseases (IBD) seems to be associated with alterations of immunoregulation. Several lines of evidence suggest...
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IJMS, Vol. 20, Pages 3178: ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1 International Journal of Molecular Sciences doi: 10.3390/ijms20133178 Authors: Yu Ran Lee Hee Kyoung Joo Eun Ok Lee Hyun Sil Cho Sunga Choi Cuk-Seong Kim Byeong Hwa Jeon Acetylation of nuclear apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is associated with its extracellular secretion, despite the lack of an N-terminal protein...
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IJMS, Vol. 20, Pages 3174: 3D-PP: A Tool for Discovering Conserved Three-Dimensional Protein Patterns International Journal of Molecular Sciences doi: 10.3390/ijms20133174 Authors: Alejandro Valdés-Jiménez Josep-L. Larriba-Pey Gabriel Núñez-Vivanco Miguel Reyes-Parada Discovering conserved three-dimensional (3D) patterns among protein structures may provide valuable insights into protein classification, functional annotations or the rational design of multi-target drugs. Thus,...
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IJMS, Vol. 20, Pages 3172: Physiologically Relevant Alternative Carbon Sources Modulate Biofilm Formation, Cell Wall Architecture, and the Stress and Antifungal Resistance of Candida glabrata International Journal of Molecular Sciences doi: 10.3390/ijms20133172 Authors: Shu Yih Chew Kok Lian Ho Yoke Kqueen Cheah Doblin Sandai Alistair J.P. Brown Leslie Thian Lung Than Flexibility in carbon metabolism is pivotal for the survival and propagation of many human fungal pathogens...
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IJMS, Vol. 20, Pages 3171: A Novel HIF Inhibitor Halofuginone Prevents Neurodegeneration in a Murine Model of Retinal Ischemia-Reperfusion International Journal of Molecular Sciences doi: 10.3390/ijms20133171 Authors: Hiromitsu Kunimi Yukihiro Miwa Hiroyoshi Inoue Kazuo Tsubota Toshihide Kurihara Neurodegeneration caused with retinal ischemia or high intraocular pressure is irreversible in general. We have focused on the role of hypoxia-inducible factor (HIF) in retinal homeostasis...
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IJMS, Vol. 20, Pages 3170: In Silico Prediction of PAMPA Effective Permeability Using a Two-QSAR Approach International Journal of Molecular Sciences doi: 10.3390/ijms20133170 Authors: Cheng-Ting Chi Ming-Han Lee Ching-Feng Weng Max K. Leong Oral administration is the preferred and predominant route of choice for medication. As such, drug absorption is one of critical drug metabolism and pharmacokinetics (DM/PK) parameters that should be taken into consideration in the process...
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IJMS, Vol. 20, Pages 3169: The Role of Soil Fungi in K+ Plant Nutrition International Journal of Molecular Sciences doi: 10.3390/ijms20133169 Authors: Rosario Haro Begoña Benito K+ is an essential cation and the most abundant in plant cells. After N, its corresponding element, K, is the nutrient required in the largest amounts by plants. Despite the numerous roles of K in crop production, improvements in the uptake and efficiency of use of K have not been major focuses in conventional...
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IJMS, Vol. 20, Pages 3168: Reversible Regulation of Polyubiquitin Gene UBC via Modified Inducible CRISPR/Cas9 System International Journal of Molecular Sciences doi: 10.3390/ijms20133168 Authors: Seung-Woo Han Byung-Kwon Jung So-Hyun Park Kwon-Yul Ryu Ubiquitin is required under both normal and stress conditions. Under stress conditions, upregulation of the polyubiquitin gene UBC is essential to meet the requirement of increased ubiquitin levels to confer stress resistance....
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IJMS, Vol. 20, Pages 3173: Meta-Analysis of Microarray Expression Studies on Metformin in Cancer Cell Lines International Journal of Molecular Sciences doi: 10.3390/ijms20133173 Authors: Hans-Juergen Schulten Sherin Bakhashab Several studies have demonstrated that metformin (MTF) acts with variable efficiency as an anticancer agent. The pleiotropic anticancer effects of MTF on cancer cells have not been fully explored yet. By interrogating the Gene Expression Omnibus (GEO) for microarray...
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IJMS, Vol. 20, Pages 3166: Phase I Clinical Trial Using Autologous Ex Vivo Expanded NK Cells and Cytotoxic T Lymphocytes for Cancer Treatment in Vietnam International Journal of Molecular Sciences doi: 10.3390/ijms20133166 Authors: Nguyen Thanh Liem Nguyen Van Phong Nguyen Trung Kien Bui Viet Anh Truong Linh Huyen Chu Thi Thao Nguyen Dac Tu Doan Trung Hiep Do Thi Hoai Thu Hoang Thi My Nhung (1) Background: Immune cell therapy recently attracted enormous attention...
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IJMS, Vol. 20, Pages 3165: Cellular Metabolomics Reveal the Mechanism Underlying the Anti-Atherosclerotic Effects of Aspirin Eugenol Ester on Vascular Endothelial Dysfunction International Journal of Molecular Sciences doi: 10.3390/ijms20133165 Authors: Mei-Zhou Huang Xiao-Rong Lu Ya-Jun Yang Xi-Wang Liu Zhe Qin Jian-Yong Li Aspirin eugenol ester (AEE) possesses anti-thrombotic, anti-atherosclerotic and anti-oxidative effects. The study aims to clarify the mechanism underlying...
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IJMS, Vol. 20, Pages 3164: Photosensitive Melanopsin-Containing Retinal Ganglion Cells in Health and Disease: Implications for Circadian Rhythms International Journal of Molecular Sciences doi: 10.3390/ijms20133164 Authors: Pedro Lax Isabel Ortuño-Lizarán Victoria Maneu Manuel Vidal-Sanz Nicolás Cuenca Melanopsin-containing retinal ganglion cells (mRGCs) represent a third class of retinal photoreceptors involved in regulating the pupillary light reflex and circadian photoentrainment,...
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IJMS, Vol. 20, Pages 3167: Salinity Effects on Sugar Homeostasis and Vascular Anatomy in the Stem of the Arabidopsis Thaliana Inflorescence International Journal of Molecular Sciences doi: 10.3390/ijms20133167 Authors: Sahar Sellami Rozenn Le Hir Michael R. Thorpe Françoise Vilaine Nelly Wolff Faiçal Brini Sylvie Dinant The regulation of sugar metabolism and partitioning plays an essential role for a plant’s acclimation to its environment, with specific responses...
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IJMS, Vol. 20, Pages 3162: Aristolochic Acid and Immunotherapy for Urothelial Carcinoma: Directions for unmet Needs International Journal of Molecular Sciences doi: 10.3390/ijms20133162 Authors: Huang-Yu Yang Chih-Chao Yang Chao-Yi Wu Li-Jen Wang Kun-Lin Lu Urothelial carcinoma of the bladder (UCB) and upper tracts (UTUC) used to share management with similar principles. However, their genetic and epigenetic differences along with different responses to immunotherapy were...
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IJMS, Vol. 20, Pages 3163: mRNA Engineering for the Efficient Chaperone-Mediated Co-Translational Folding of Recombinant Proteins in Escherichia coli International Journal of Molecular Sciences doi: 10.3390/ijms20133163 Authors: Le Minh Bui Almando Geraldi Thi Thuy Nguyen Jun Hyoung Lee Ju Young Lee Byung-Kwan Cho Sun Chang Kim The production of soluble, functional recombinant proteins by engineered bacterial hosts is challenging. Natural molecular chaperone systems...
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IJMS, Vol. 20, Pages 3161: Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders International Journal of Molecular Sciences doi: 10.3390/ijms20133161 Authors: Eryn L. Werry Fiona M. Bright Olivier Piguet Lars M. Ittner Glenda M. Halliday John R. Hodges Matthew C. Kiernan Clement T. Loy Jillian J. Kril Michael Kassiou Neuroinflammation is an inflammatory response in the brain and spinal cord, which can involve...
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IJMS, Vol. 20, Pages 3160: Chlorogenic Acid Alleviates Thiram-Induced Tibial Dyschondroplasia by Modulating Caspases, BECN1 Expression and ECM Degradation International Journal of Molecular Sciences doi: 10.3390/ijms20133160 Authors: Jialu Zhang Shucheng Huang Xiaole Tong Lihong Zhang Xiong Jiang Hui Zhang Khalid Mehmood Jiakui Li Chlorogenic acid (CGA) is a widely applied traditional Chinese medicine ingredient which can be used for the treatment of osteoporosis....
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IJMS, Vol. 20, Pages 3157: Carbon Monoxide Releasing Molecule-2-Upregulated ROS-Dependent Heme Oxygenase-1 Axis Suppresses Lipopolysaccharide-Induced Airway Inflammation International Journal of Molecular Sciences doi: 10.3390/ijms20133157 Authors: Chih-Chung Lin Li-Der Hsiao Rou-Ling Cho Chuen-Mao Yang The up-regulation of heme oxygenase-1 (HO-1) is mediated through nicotinamaide adenine dinucleotide phosphate (NADPH) oxidases (Nox) and reactive oxygen species (ROS) generation,...
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IJMS, Vol. 20, Pages 3159: Testis-Specific Isoform of Na/K-ATPase (ATP1A4) Interactome in Raft and Non-Raft Membrane Fractions from Capacitated Bovine Sperm International Journal of Molecular Sciences doi: 10.3390/ijms20133159 Authors: Gayathri D. Rajamanickam John P. Kastelic Jacob C. Thundathil The plasma membrane of sperm contains highly dynamic lipid microdomains (rafts), which house signaling proteins with a role in regulating capacitation. We reported that ATP1A4, the testis-specific...
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IJMS, Vol. 20, Pages 3158: Immunization of Rabbits with Recombinant Human Cytomegalovirus Trimeric versus Monomeric gH/gL Protein Elicits Markedly Higher Titers of Antibody and Neutralization Activity International Journal of Molecular Sciences doi: 10.3390/ijms20133158 Authors: Xinle Cui Zhouhong Cao Shuishu Wang Michael Flora Stuart P. Adler Michael A. McVoy Clifford M. Snapper Congenital human cytomegalovirus (HCMV) infection and HCMV infection of immunosuppressed...
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IJMS, Vol. 20, Pages 3156: Real Microgravity Influences the Cytoskeleton and Focal Adhesions in Human Breast Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms20133156 Authors: Mohamed Zakaria Nassef Sascha Kopp Markus Wehland Daniela Melnik Jayashree Sahana Marcus Krüger Thomas J. Corydon Hergen Oltmann Burkhard Schmitz Andreas Schütte Thomas J. Bauer Manfred Infanger Daniela Grimm With the increasing number of spaceflights,...
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IJMS, Vol. 20, Pages 3152: Management of Diabetes Mellitus in Normal Renal Function, Renal Dysfunction and Renal Transplant Recipients, Focusing on Glucagon-Like Peptide-1 Agonist: A Review Based upon Current Evidence International Journal of Molecular Sciences doi: 10.3390/ijms20133152 Authors: Shang-Feng Tsai Cheng-Hsu Chen Diabetes Mellitus (DM) is a leading cause of both Cardiovascular Disease (CVD) and End-stage Renal Disease (ESRD). After 2008, there has been much evidence presented,...
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IJMS, Vol. 20, Pages 3155: GPathFinder: Identification of Ligand-Binding Pathways by a Multi-Objective Genetic Algorithm International Journal of Molecular Sciences doi: 10.3390/ijms20133155 Authors: José-Emilio Sánchez-Aparicio Giuseppe Sciortino Daniel Viladrich Herrmannsdoerfer Pablo Orenes Chueca Jaime Rodríguez-Guerra Pedregal Jean-Didier Maréchal Protein–ligand docking is a widely used method to generate solutions for the binding of a small molecule with...
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IJMS, Vol. 20, Pages 3154: Evaluation of Disease Severity and Global Transcriptome Response Induced by Citrus bark cracking viroid, Hop latent viroid, and Their Co-Infection in Hop (Humulus lupulus L.) International Journal of Molecular Sciences doi: 10.3390/ijms20133154 Authors: Nataša Štajner Sebastjan Radišek Ajay Kumar Mishra Vishnu Sukumari Nath Jaroslav Matoušek Jernej Jakše Viroids are small non-capsidated, single-stranded, covalently-closed circular noncoding RNA...
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IJMS, Vol. 20, Pages 3153: The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20133153 Authors: Débora Kristina Alves-Fernandes Miriam Galvonas Jasiulionis Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC), an NAD+-dependent enzyme deeply involved in gene regulation, genome stability maintenance, apoptosis, autophagy, senescence, proliferation, aging, and tumorigenesis. It also has a...
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IJMS, Vol. 20, Pages 3150: Marek’s Disease Virus Infection Induced Mitochondria Changes in Chickens International Journal of Molecular Sciences doi: 10.3390/ijms20133150 Authors: Qin Chu Yi Ding Wentao Cai Lei Liu Huanmin Zhang Jiuzhou Song Mitochondria are crucial cellular organelles in eukaryotes and participate in many cell processes including immune response, growth development, and tumorigenesis. Marek’s disease (MD), caused by an avian alpha-herpesvirus...
Thu Jun 27, 2019 03:00
IJMS, Vol. 20, Pages 3151: HDL Triglycerides: A New Marker of Metabolic and Cardiovascular Risk International Journal of Molecular Sciences doi: 10.3390/ijms20133151 Authors: Girona Amigó Ibarretxe Plana Rodríguez-Borjabad Heras Ferré Gil Correig Masana While cholesterol content in high-density lipoproteins (HDLs) is a well-established inverse marker of cardiovascular risk, the importance of HDL–triglyceride (HDL-TG) concentration is not...
Thu Jun 27, 2019 03:00
IJMS, Vol. 20, Pages 3148: Extracellular RNAs as Biomarkers of Sporadic Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20133148 Authors: Takashi Hosaka Takenari Yamashita Akira Tamaoka Shin Kwak Recent progress in the research for underlying mechanisms in neurodegenerative diseases, including Alzheimer disease (AD), Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS) has led to the development...
Thu Jun 27, 2019 03:00
IJMS, Vol. 20, Pages 3149: Disturbed Cardiorespiratory Adaptation in Preeclampsia: Return to Normal Stress Regulation Shortly after Delivery? International Journal of Molecular Sciences doi: 10.3390/ijms20133149 Authors: Helmut K. Lackner Ilona Papousek Karin Schmid-Zalaudek Mila Cervar-Zivkovic Vassiliki Kolovetsiou-Kreiner Olivia Nonn Miha Lucovnik Isabella Pfniß Manfred G. Moertl Women with pregnancies complicated by preeclampsia appear to be at increased risk...
Thu Jun 27, 2019 03:00
IJMS, Vol. 20, Pages 3146: Characterization of Maize miRNAs in Response to Synergistic Infection of Maize Chlorotic Mottle Virus and Sugarcane Mosaic Virus International Journal of Molecular Sciences doi: 10.3390/ijms20133146 Authors: Zihao Xia Zhenxing Zhao Xinran Gao Zhiyuan Jiao Yuanhua Wu Tao Zhou Zaifeng Fan The synergistic infection of maize chlorotic mottle virus (MCMV) and sugarcane mosaic virus (SCMV) causes maize lethal necrosis, with considerable losses to...
Thu Jun 27, 2019 03:00
IJMS, Vol. 20, Pages 3147: Bone Remodeling: Histone Modifications as Fate Determinants of Bone Cell Differentiation International Journal of Molecular Sciences doi: 10.3390/ijms20133147 Authors: Sun-Ju Yi Hyerim Lee Jisu Lee Kyubin Lee Junil Kim Yeojin Kim Jae-Il Park Kyunghwan Kim The bone tissue is a dynamic complex that constitutes of several interdependent systems and is continuously remodeled through the concerted actions of bone cells. Osteoblasts are mononucleated...
Thu Jun 27, 2019 03:00
IJMS, Vol. 20, Pages 3136: Characterization of the Copper Transporters from Lotus spp. and Their Involvement under Flooding Conditions International Journal of Molecular Sciences doi: 10.3390/ijms20133136 Authors: Francisco J. Escaray Cristian J. Antonelli Guillermo J. Copello Sergi Puig Lola Peñarrubia Oscar A. Ruiz Ana Perea-García Forage legumes are an important livestock nutritional resource, which includes essential metals, such as copper. Particularly, the high...
Thu Jun 27, 2019 03:00
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