IJMS, Vol. 20, Pages 3175: Sex- and Age-Related Estrogen Signaling Alteration in Inflammatory Bowel Diseases: Modulatory Role of Estrogen Receptors International Journal of Molecular Sciences doi: 10.3390/ijms20133175 Authors: Damian Jacenik Adam I. Cygankiewicz Anna Mokrowiecka Ewa Małecka-Panas Jakub Fichna Wanda M. Krajewska The pathogenesis of inflammatory bowel diseases (IBD) seems to be associated with alterations of immunoregulation. Several lines of evidence suggest...
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IJMS, Vol. 20, Pages 3173: Meta-Analysis of Microarray Expression Studies on Metformin in Cancer Cell Lines International Journal of Molecular Sciences doi: 10.3390/ijms20133173 Authors: Hans-Juergen Schulten Sherin Bakhashab Several studies have demonstrated that metformin (MTF) acts with variable efficiency as an anticancer agent. The pleiotropic anticancer effects of MTF on cancer cells have not been fully explored yet. By interrogating the Gene Expression Omnibus (GEO) for microarray...
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IJMS, Vol. 20, Pages 3174: 3D-PP: A Tool for Discovering Conserved Three-Dimensional Protein Patterns International Journal of Molecular Sciences doi: 10.3390/ijms20133174 Authors: Alejandro Valdés-Jiménez Josep-L. Larriba-Pey Gabriel Núñez-Vivanco Miguel Reyes-Parada Discovering conserved three-dimensional (3D) patterns among protein structures may provide valuable insights into protein classification, functional annotations or the rational design of multi-target drugs. Thus,...
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IJMS, Vol. 20, Pages 3176: Reduced Diet-induced Thermogenesis in Apolipoprotein A-IV Deficient Mice International Journal of Molecular Sciences doi: 10.3390/ijms20133176 Authors: Sydney Pence Qi Zhu Erin Binne Min Liu Haifei Shi Chunmin C. Lo In the presence of dietary lipids, both apolipoprotein A-IV (ApoA-IV) production and brown adipose tissue (BAT) thermogenesis are increased. The effect of dietary lipid-induced AproA-IV on BAT thermogenesis and energy expenditure...
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IJMS, Vol. 20, Pages 3171: A Novel HIF Inhibitor Halofuginone Prevents Neurodegeneration in a Murine Model of Retinal Ischemia-Reperfusion International Journal of Molecular Sciences doi: 10.3390/ijms20133171 Authors: Hiromitsu Kunimi Yukihiro Miwa Hiroyoshi Inoue Kazuo Tsubota Toshihide Kurihara Neurodegeneration caused with retinal ischemia or high intraocular pressure is irreversible in general. We have focused on the role of hypoxia-inducible factor (HIF) in retinal homeostasis...
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IJMS, Vol. 20, Pages 3170: In Silico Prediction of PAMPA Effective Permeability Using a Two-QSAR Approach International Journal of Molecular Sciences doi: 10.3390/ijms20133170 Authors: Cheng-Ting Chi Ming-Han Lee Ching-Feng Weng Max K. Leong Oral administration is the preferred and predominant route of choice for medication. As such, drug absorption is one of critical drug metabolism and pharmacokinetics (DM/PK) parameters that should be taken into consideration in the process...
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IJMS, Vol. 20, Pages 3169: The Role of Soil Fungi in K+ Plant Nutrition International Journal of Molecular Sciences doi: 10.3390/ijms20133169 Authors: Rosario Haro Begoña Benito K+ is an essential cation and the most abundant in plant cells. After N, its corresponding element, K, is the nutrient required in the largest amounts by plants. Despite the numerous roles of K in crop production, improvements in the uptake and efficiency of use of K have not been major focuses in conventional...
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IJMS, Vol. 20, Pages 3168: Reversible Regulation of Polyubiquitin Gene UBC via Modified Inducible CRISPR/Cas9 System International Journal of Molecular Sciences doi: 10.3390/ijms20133168 Authors: Seung-Woo Han Byung-Kwon Jung So-Hyun Park Kwon-Yul Ryu Ubiquitin is required under both normal and stress conditions. Under stress conditions, upregulation of the polyubiquitin gene UBC is essential to meet the requirement of increased ubiquitin levels to confer stress resistance....
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IJMS, Vol. 20, Pages 3172: Physiologically Relevant Alternative Carbon Sources Modulate Biofilm Formation, Cell Wall Architecture, and the Stress and Antifungal Resistance of Candida glabrata International Journal of Molecular Sciences doi: 10.3390/ijms20133172 Authors: Shu Yih Chew Kok Lian Ho Yoke Kqueen Cheah Doblin Sandai Alistair J.P. Brown Leslie Thian Lung Than Flexibility in carbon metabolism is pivotal for the survival and propagation of many human fungal pathogens...
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IJMS, Vol. 20, Pages 3166: Phase I Clinical Trial Using Autologous Ex Vivo Expanded NK Cells and Cytotoxic T Lymphocytes for Cancer Treatment in Vietnam International Journal of Molecular Sciences doi: 10.3390/ijms20133166 Authors: Nguyen Thanh Liem Nguyen Van Phong Nguyen Trung Kien Bui Viet Anh Truong Linh Huyen Chu Thi Thao Nguyen Dac Tu Doan Trung Hiep Do Thi Hoai Thu Hoang Thi My Nhung (1) Background: Immune cell therapy recently attracted enormous attention...
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IJMS, Vol. 20, Pages 3165: Cellular Metabolomics Reveal the Mechanism Underlying the Anti-Atherosclerotic Effects of Aspirin Eugenol Ester on Vascular Endothelial Dysfunction International Journal of Molecular Sciences doi: 10.3390/ijms20133165 Authors: Mei-Zhou Huang Xiao-Rong Lu Ya-Jun Yang Xi-Wang Liu Zhe Qin Jian-Yong Li Aspirin eugenol ester (AEE) possesses anti-thrombotic, anti-atherosclerotic and anti-oxidative effects. The study aims to clarify the mechanism underlying...
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IJMS, Vol. 20, Pages 3164: Photosensitive Melanopsin-Containing Retinal Ganglion Cells in Health and Disease: Implications for Circadian Rhythms International Journal of Molecular Sciences doi: 10.3390/ijms20133164 Authors: Pedro Lax Isabel Ortuño-Lizarán Victoria Maneu Manuel Vidal-Sanz Nicolás Cuenca Melanopsin-containing retinal ganglion cells (mRGCs) represent a third class of retinal photoreceptors involved in regulating the pupillary light reflex and circadian photoentrainment,...
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IJMS, Vol. 20, Pages 3167: Salinity Effects on Sugar Homeostasis and Vascular Anatomy in the Stem of the Arabidopsis Thaliana Inflorescence International Journal of Molecular Sciences doi: 10.3390/ijms20133167 Authors: Sahar Sellami Rozenn Le Hir Michael R. Thorpe Françoise Vilaine Nelly Wolff Faiçal Brini Sylvie Dinant The regulation of sugar metabolism and partitioning plays an essential role for a plant’s acclimation to its environment, with specific responses...
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