Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) is a causative agent of severe-to-fatal pneumonia especially in patients with pre-existing conditions, such as smoking and chronic obstructive pulmonary disease (COPD). MERS-CoV transmission continues to be reported in the Saudi Arabian Peninsula since its discovery in 2012. However, it has rarely been epidemic outside the area except one large outbreak in South Korea in May 2015. The genome of the epidemic MERS-CoV...
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Abstract The phytopathogenic Burkholderia species B. glumae and B. plantarii are the causal agents of bacterial wilt, grain rot, and seedling blight, which threaten the rice industry globally. Toxoflavin and tropolone are produced by these phytopathogens and are considered the most hostile biohazards with a broad spectrum of target organisms. However, despite their nonspecific toxicity, the effects of toxoflavin and tropolone on bacteria remain unknown. RNA-seq based transcriptome...
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Abstract A Gram-stain-positive, oxidase- and catalase-positive motile, aerobic, and rod-shaped bacterial strain, designated as DCT-5T, was isolated from a native plant belonging to the genus Campanula at Dokdo island, Republic of Korea. Growth of the strain DCT-5T was observed at 15–37°C (optimum 30°C) on R2A broth, pH 6.0–8.0 (optimum 7.0), and 0–5% (w/v) NaCl concentration (optimum 0%). The 16S rRNA gene sequence analysis revealed that strain DCT-5T was most closely related...
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Abstract Salterns are hypersaline extreme environments with unique physicochemical properties such as a salinity gradient. Although the investigation of microbiota in salterns has focused on archaea and bacteria, diverse fungi also thrive in the brine and soil of salterns. Fungi isolated from salterns are represented by black yeasts (Hortaea werneckii, Phaeotheca triangularis, Aureobasidium pullulans, and Trimmatostroma salinum), Cladosporium, Aspergillus, and Penicillium species....
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Abstract A Gram-staining-positive, motile and short-rod-shaped actinobacterium designated 9W16Y-2T was isolated from surface-sterilized leaves of reed (Phragmites australis) collected from Taklamakan Desert in Xinjiang Uygur Autonomous Region, China. Colonies were pale greenish yellow, circular, smooth, and convex. The 16S rRNA gene sequence of strain 9W16Y-2T exhibited highest sequence similarities with Aeromicrobium camelliae CGMCC 1.12942T (99.0%) and Aeromicrobium erythreum...
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Abstract Most commercialized virus-like particle (VLP) vaccines use aluminum salt as adjuvant, even though VLPs provoke adequate antibody responses without adjuvant. We do not have detailed knowledge of how adjuvant affects the profile of anti-VLP antibodies. Meanwhile, there is evidence that differences between vaccination protocols influence the glycosylation of antibodies, which may alter their effector functions. In the present study a murine model was used to investigate...
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This study described voice use and lifestyle information about student actors and assessed whether different information is reported at study intake compared to data extracted from a 3-week voice Log.
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Current guidelines on suicide prevention from the Department of Veterans Affairs are "as good as one will now find," but "unlikely to dramatically reduce the...
5h
Check out the latest from NEJM Group: NEJM Primary Care/Hospitalist Page: Case record: A 27-year-old homeless woman was evaluated because of a...
5h
Greater consumption of plant-based proteins — like those found in cereals and legumes — is associated with lower mortality risk, according to an observational study in...
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The CDC has published its recommendations for influenza vaccination for the 2019–2020 season in MMWR. Among the changes for this year: The Afluria Quadrivalent...
5h
Non-melanoma skin cancer (NMSC) is the most common cancer in the United States with over 5 million new cases each year; however detailed molecular mechanisms governing the development of NMSC are lacking. The protein function for autoimmune regulator (Aire) was originally characterized in the thymus, where Aire controls the expression of tissue-restricted antigens to develop T-cell tolerance and thus prevent autoimmunity. We recently identified Aire to be expressed in tumor-prone skin in mice and...
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Traditionally, the lymphoma progression was viewed with a shift to Th1 to Th2 immune response along with an increase in the number of T regulatory cells (Treg) resulting in dampening cytotoxic immune responses. However, at present, the cytokine milieu expands beyond Th1/Th2 dichotomy. Here, we evaluate the expression of 64 biomarkers including cytokine of Th1, Th2, Th9, Th17, Treg as well growth factor, eotaxin MiG, RANTES21, IP-10, MCP, PDGF, MMP-1, MMP-7, MMP-8 from the serum of 186 healthy individuals...
6h
Despite the number of drugs and formulations designed for treating inflammatory skin conditions such as psoriasis and atopic dermatitis, the available tools for precisely studying their performance in situ have been limited. For this reason, there is a major need for techniques that can enable the direct visualization and quantification of small molecule Pharmacokinetics and Pharmacodynamics (PK/PD). We have developed a quantitative imaging toolkit that utilizes Stimulated Raman Scattering (SRS)...
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Objective: Investigate susceptibility and acquired resistance of Cutibacterium acnes to FMX101 4% topical minocycline foam and comparator antibiotics. Methods: Conducted studies to determine 1) minimal inhibitory concentration (MIC) range of FMX101 4% against Bacteroides fragilis (0.016 – 0.063 μg/mL); 2) susceptibility of C. acnes to FMX101 4%, minocycline, and foam vehicle by broth and agar dilution; 3) MIC90 activity of FMX101 4% and comparators vs 102 C. acnes isolates and identify clonal type...
6h
Background: Effective delivery of active ingredients into the pilosebaceous follicle is necessary for efficacy of topical acne treatments. To achieve follicular delivery, the active molecule must penetrate the sebum-filled pilosebaceous duct. FMX101 4% is a non-aqueous, oil-based topical foam formulation of minocycline developed to be miscible with sebum, thus facilitating penetration of minocycline into the pilosebaceous duct. Objective: Compare the impact of 2 formulations, FMX101 4% and an oil-in-water...
6h
Liangxue Jiedu Formula is a Chinese medicine formula prepared from medicinal herbs and used in China for the treatment of psoriasis. In order to quickly define the chemical profiles and control the quality of Liangxue Jiedu Formula preparations, a Thermo Q Exactive™ Plus Orbitrap™ mass spectrometer was applied for simultaneous identification of multiple constituents. The sample was filtered through a 0.22μm syringe filter, and 10μl was injected into the LC instrument for LC-MS analysis. In addition,...
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A tumour-targeted CRISPR gene editing system, encapsulated in a nanogel and injected into the body, could effectively and safely halt the growth of triple-negative breast cancer, report researchers at Boston Children's Hospital. Their proof-of-principle...
7h
A cancer therapy invented at Rice University has crossed a milestone in clinical trials, a major development in a decades long quest to develop a treatment that destroys tumours without the debilitating side effects of chemotherapy, invasive surgery and...
9h
Role of Transesophageal Echocardiography - In the surgical correction of Post Pneumonectomy Syndrome
Post-pneumonectomy syndrome (PPS) is an extremely rare, late complication after pneumonectomy, occurring in 0.16% to 2% of cases.1 It is characterized by excessive shift and rotation of the mediastinum into a vacated pleural space, typically leading to compression of mainstem bronchi against the aorta or vertebral bodies.1,2 We present a case of PPS caused by left lower pulmonary vein (LLPV) obstruction, after a completion right pneumonectomy and its surgical correction, wherein intraoperative transesophageal...
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Background: Evidence about whether neutrophil counts, neutrophil ratio linked with clinical outcome in patients with minor stroke after thrombolysis is scarce. The purpose of this study is to explore the association of neutrophil counts, neutrophil ratio with the 90-day clinical outcome in patients with minor stroke treated with intravenous thrombolysis. Materials and methods: A total of 163 patients with minor stroke treated with thrombolysis within window time were recruited from 2013 to 2017.
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Abstract Introduction Mapping protein synthesis and turnover during development will provide insight into functional tissue assembly; however, quantitative in vivo characterization has been hindered by a lack of tools. To address this gap, we previously demonstrated murine embryos can be labeled with the non-canonical amino acid azidohomoalanine (Aha), which enables the enrichment and identification of newly synthesized proteins. Using...
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Abstract Introduction Mesenchymal stem cells (MSCs) represent a very important cell source in the field of regenerative medicine and for bone and cartilage tissue engineering applications. Three-dimensional (3D) bioprinting has the potential to improve the classical tissue engineering concept as this technique allows the printing of cells with high spatial control of cell allocation within a 3D construct. In this study, we systematically...
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Neurological illnesses are often viewed as having a unique impact on a patient’s recoverability and quality of life, leading to a centuries-old perception that such conditions are hopeless and have no cure [1]. This perception persists even in the face of medical advancements in the treatment of neurologic conditions. The concept of therapeutic nihilism, or skepticism regarding the worth of therapeutic agents especially in a particular disease, as defined by Merriam-Webster, may lead to early withdrawal...
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Absence seizures are common in children and adolescents, characterized by brief, sudden, automatic movements and frequent periods of unconsciousness [1,2]. Absence seizures have a significant impact on social function and quality of life. On the EEG, Absence seizures have a typical wave pattern and spike. Absence seizures are different from complex partial seizures by their lack of a postictal phase and abrupt ending. About 10% of seizures with epilepsy in children and adolescent are typical absence...
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Juvenile pilocytic astrocytoma (JPA) is the most common type of glioma in children. It commonly presents as a slow growing and well-circumscribed lesion. Standard therapy includes surgical resection followed by radiation, chemotherapy or observation for any residual tumor [1]. This approach has yielded a favorable prognosis [2]. It is widely accepted that greater extent of surgical resection (EOR) is associated with extended progression-free and overall survival [1,3–17]. Given the importance of...
8h
Longitudinal studies on cognitive decline in remote rural communities have been limited by several factors, including illiteracy, cross-cultural issues, restricted availability of diagnostic tools, and a lack of research funding [1]. Moreover, information is inconsistent since risk factors found to influence cognitive decline have varied across studies, most likely due to differences in the characteristics of participants or to different study designs [2–8]. The increasing burden of cognitive decline...
8h
Primary central nervous system lymphoma (PCNSL), a rare form of extranodal non-Hodgkin’s lymphoma, occurs in the brain with an annual incidence rate of 0.47 cases per 100,000 people [1]. The median age at diagnosis is 56 years, and the incidence in patients aged >60 years has been increasing in the past two decades [1]. The response rate of PCNSL to radiation therapy is high, but early recurrence is inevitable. Median survival of patients treated by 60-Gy irradiation (whole-brain 40 Gy and local...
8h
Musculoskeletal tuberculosis forms 10–25% of extrapulmonary tuberculosis which mainly involves the spine or weight-bearing joints. Tuberculous involvement of the sternum is a rare clinical entity even in count...
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Abstract Purpose The Stress-Prevention@Work implementation strategy has been demonstrated to be successful in reducing stress in employees. Now, we assess the economic return-on-investment to see if it would make for a favourable business case for employers. Methods Data were collected from 303 health-care workers assigned to either a waitlisted control condition...
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Abstract Purpose To examine if occupational lifting assessed as cumulative years as a baggage handler is associated with first-time hospital diagnosis or treatment for low back disorders. Methods This study is based on the Copenhagen Airport Cohort consisting of male baggage handlers performing heavy lifting every day and a reference group of unskilled men...
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Abstract Purpose To study respiratory effects of exposure to soft paper dust exposure, a relationship that is rarely studied. Methods Soft tissue paper mill workers at a Swedish paper mill were investigated using a questionnaire and lung function and atopy screening. Spirometry without bronchodilation was performed with a dry wedge spirometer, and forced...
16h
Abstract This retrospective study evaluated the influence of known risk factors on nonsurgical periodontal treatment (NSPT) response using a pocket depth fine-tuning multilevel linear model (MLM). Overall, 37 patients (24 males and 13 females) with moderate-to-severe chronic periodontitis underwent NSPT. Follow-up visits at 3, 6, and 12 months included measurements of several clinical periodontal parameters. Data were sourced from a previously reported database. In a total of 1416 initially affected...
8h
Abstract The present study aimed to evaluate the internal configuration of the maxillary molars of a population from the Northeast region of Brazil. Cone-beam computed tomography (CBCT) exams from 512 patients (1501 teeth) were evaluated regarding the anatomical configuration of the root canal system, according to Vertucci’s classification. The images were obtained using a Prexion 3D scanner operating at 90 kVp and 4 mA. The voxel size was 0.125 mm and the cut thickness was 1 mm. The images were...
8h
Abstract This study evaluated the influence of activation modes, on Diametral Tensile Strength (DTS) of dual cured resin cements subjected to a Mechanical Fatigue test (MF). Four dual-cured resin cements (RelyX UNICEM [U], RelyX ARC [A], ENFORCE [E] and Nexus 2 [N]) were activated by three different curing modes as follows: Self-Curing (SC), Dual Cure activation with photoactivation executed directly (DC) and Dual Cure activation with Photoactivation Through Porcelain (DCTP). After 24 hours, half...
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Abstract This study aimed to evaluate the role of photobiomodulation (PBM) in apexification and apexogenesis of necrotic rat molars with an open apex. Rat molars were exposed to the oral environment for 3 weeks. Canals were rinsed with 2.5% NaOCl and 17% EDTA, filled with antibiotic paste and sealed. After 7 days, canals were rinsed and divided into six groups (n=6): mineral trioxide aggregate (MTA); blood clot (BC); human dental pulp stem cells (hDPSC); MTA+PBM; BC+PBM; and hDPSC+PBM. In hDPSC groups,...
8h
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