Abstract Background The robot-assisted laparoscopic management of post-chemotherapy retroperitoneal metastasis and inferior vena cava tumor thrombus secondary to testicular cancer is a challenging task for urologists. Case presentation A pathological examination of a 36-year-old Caucasian man who had undergone a right radical orchiectomy showed...
3h
Lipopolysaccharide (LPS) is normally considered to be essential for viability in Gram-negative bacteria but can be removed in A. baumannii. Mutant cells lacking this component of the outer membrane show growth and morphological defects. Here we report that growth rates equivalent to the wild type can be achieved simply by propagation in minimal medium. The loss of LPS requires that cells rely on phospholipids for both leaflets of the outer membrane. We show that growth rate in the absence of LPS...
3h
Staphylococcus aureus competes for myriad essential nutrients during host infection. One of these nutrients is the organosulfur compound lipoic acid – a cofactor required for the activity of several metabolic enzyme complexes. In S. aureus, these include the E2 subunits of three α-ketoacid dehydrogenases and two H proteins – GcvH of the glycine cleavage system and its paralog, GcvH-L. We previously determined that the S. aureus amidotransferase, LipL, is required for lipoylation of the E2 subunits...
3h
Iron is essential for most lifeforms. Under iron-limiting conditions, many bacteria produce and release siderophores, molecules with high affinity for iron, which are then transported into the cell in their iron-bound form, allowing incorporation of the metal into a wide range of cellular processes. However, free iron can also be a source of reactive oxygen species that cause DNA, protein and lipid damage. Not surprisingly, iron capture is finely regulated, and linked to oxidative stress responses....
3h
We investigate the effect of bacteriophage infection and antibiotic treatment on the coordination of swarming, a collective form of flagellum- and pilus-mediated motility in bacteria. We show that phage infection of the opportunistic bacterial pathogen Pseudomonas aeruginosa abolishes swarming motility in the infected sub-population and induces the release of the Pseudomonas quinolone signaling molecule PQS, which repulses uninfected sub-populations from approaching the infected area. These mechanisms...
3h
Coxiella burnetii is an obligate intracellular gammaproteobacterium and zoonotic agent of Q fever. We previously identified 15 small non-coding RNAs (sRNAs) of C. burnetii. One of them, CbsR12 (Coxiella b urnetii small RNA 12), is highly transcribed during axenic growth and becomes more prominent during infection of cultured mammalian cells. Secondary structure predictions of CbsR12 revealed four putative CsrA-binding sites in stem loops with consensus AGGA/ANGGA motifs. We subsequently determined...
3h
Staphylococcus aureus is a widespread opportunistic pathogen to humans and ani-mals. 20-25% of its genome is variable between strains and consists of phages, path-ogenicity islands, transposons, and genomic islands. S. aureus harbors up to three genomic islands: vSaα, vSaβ, and vSa. The vSaβ region of S. aureus can encode a number of virulence-associated factors such as serine proteases, leukocidines, enter-otoxins, bacteriocins, or a hyaluronate lyase. In this study, the vSaβ regions of 103 clinically...
3h
Utilization of robotic-assistance for esophagectomy is increasing. The differences in outcomes between robotic-assisted minimally-invasive esophagectomy (RAMIE) and non-robotic minimally-invasive esophagectomy (MIE) for esophageal cancer are unknown. The purpose of this study was to compare 30-day postoperative outcomes between RAMIE and MIE.
3h
This study described voice use and lifestyle information about student actors and assessed whether different information is reported at study intake compared to data extracted from a 3-week voice Log.
3h
PHILADELPHIA, PA – In a move that will most certainly not be received well by the medical community, the American Board of Internal Medicine (ABIM) will now require that physicians undergo daily recertification in their respective fields of practice. “A career in medicine should be a lifelong practice of education and reeducation,” explained President of the ABIM Chaz Moneybags. “Take Internal Medicine, for example. Isn’t it a little too long: 10 years between the traditional exam or 2...
3h
Emphysematous aortitis is a rare but lethal form of infectious vasculitis. This condition was found incidentally on computed tomography of the chest during the evaluation of a patient presenting with pneumonia coincident with adynamic ileus. The patient did not have a history of malignancy. While colon cancer could not be ruled out, it is possible that ileus may have contributed to or resulted in bacterial translocation in this case. Appropriate investigations and empirical therapy against Clostridium...
3h
In this study, we aimed to test the hypothesis whether ASICs might be involved in modifying the excitability of stellate cells in the cochlear nucleus (CN). We determined gene expressions of ASIC1, ASIC2 and ASIC3 in the CN of BALB/mice. ASIC currents in stellate cells were characterized by using whole-cell patch-clamp technique. In the voltage-clamp experiments, inward currents were recorded upon application of 2-[N-Morpholino ethanesulfonic acid]-normal artificial cerebrospinal fluid (MES –aCSF),...
3h
. (Source: Cochlear Implants International)
3h
Abstract Radiology reports often contain follow-up imaging recommendations. Failure to comply with these recommendations in a timely manner can lead to delayed treatment, poor patient outcomes, complications, unnecessary testing, lost revenue, and legal liability. The objective of this study was to develop a scalable approach to automatically identify the completion of a follow-up imaging study recommended by a radiologist in a preceding report. We selected imaging-reports containing...
3h
Abstract Whole-heart coronary magnetic resonance angiography (WHCMRA) permits the noninvasive assessment of coronary artery disease without radiation exposure. However, the image resolution of WHCMRA is limited. Recently, convolutional neural networks (CNNs) have obtained increased interest as a method for improving the resolution of medical images. The purpose of this study is to improve the resolution of WHCMRA images using a CNN. Free-breathing WHCMRA images with 512 × 512 pixels...
3h
CDK4/6 inhibitors are used in the treatment of advanced estrogen receptor (ER)(+) breast cancer (BC). Their efficacy in ER(-) and early stage BC is currently under investigation. Here, we show that palbociclib, a CDK4/6 inhibitor, can inhibit both progression of ductal carcinoma in situ (DCIS) and growth of invasive disease in both an ER(-) basal BC model (MCFDCIS) and an ER(+) luminal model (MCF7 intraductal injection). In MCFDCIS cells palbociclib repressed cell cycle gene expression, inhibited...
3h
An emerging approach for cancer treatment employs the use of extracellular vesicles (EVs), specifically exosomes and microvesicles, as delivery vehicles. We previously demonstrated that microvesicles can functionally deliver plasmid DNA to cells and showed that plasmid size and sequence, in part, determine the delivery efficiency. In this study, delivery vehicles comprised of microvesicles loaded with engineered minicircle (MC) DNA that encodes prodrug converting enzymes were developed as a cancer...
3h
Sentinel lymph node biopsy (SLNB) is an accurate staging procedure for malignant melanoma but its use in patients with melanoma of the head and neck has been questioned in the past because of a perceived record of poor safety and accuracy. Technical improvements have sought to redress this.Vital structures and variable lymphatic pathways can make its use in the head and neck challenging. In our study we have examined the data and the experiences of clinicians from University Hospital Southampton...
3h
The aims of this study were to compare preoperative and postoperative quality of life (QoL) in 24 patients with fibrous dysplasia of the mandible, and evaluate the effects of two surgical techniques on their postoperative QoL. Their QoL was assessed using the University of Washington Quality of Life (UW-QoL) questionnaire. The patients was divided into two groups according to the two different surgical techniques used. The first group (n=11) were managed with focal bone modification, and their results...
3h
We investigated the effects of hydrogen-rich saline solution (HRSS) on intestinal anastomosis performed after intestinal ischemia reperfusion injury (IRI).
3h
Acute kidney injury (AKI) may contribute to high mortality rates after liver transplantation. Few studies have investigated AKI in pediatric liver transplantation. This retrospective study was conducted to investigate the risk factors for and associated outcomes of AKI in pediatric liver transplant recipients.
3h
Abstract Background Allergic reactions to tattoos are amongst the most common side effects occurring with this permanent deposition of pigments into the dermal skin layer. The characterization of such pigments and their distribution has been investigated in recent decades. The health impact of tattoo equipment on the extensive number of people with inked skin has been the focus of neither research nor medical diagnostics. Although...
3h
MONDAY, Aug. 26, 2019 -- Men should be included in clinical trials of new breast cancer treatments, the U.S. Food and Drug Administration says. "Less than 1 percent of all breast cancer cases occur in men, but men are more likely to be diagnosed at...
3h
MONDAY, Aug. 26, 2019 -- An Oklahoma judge on Monday ruled against one of America's biggest companies, Johnson & Johnson -- fining it $572 million as part of the first trial of an opioid maker sued by a state for the human and financial costs of...
3h
MONDAY, Aug. 26, 2019 -- People who were at Disneyland and other Southern California tourist attractions earlier this month may have been exposed to measles by a tourist from New Zealand, say health officials from Los Angeles and Orange...
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MONDAY, Aug. 26, 2019 -- In clinical guidelines published online Aug. 27 in the Annals of Internal Medicine, recommendations are presented related to screening, treatment, and management strategies for reducing suicide among veterans. Kristen E....
3h
MONDAY, Aug. 26, 2019 -- Greater acceptance of organs from deceased donors who were older and had comorbidities could provide survival benefits among individuals awaiting kidney transplant in the United States, according to a study published online...
3h
MONDAY, Aug. 26, 2019 -- Nearly three-quarters of all adolescent cannabis users report use of cannabis concentrates, which are plant extracts that contain high concentrations of Δ-9-tetrahydrocannbinol (THC), according to a study published online...
11h
MONDAY, Aug. 26, 2019 -- The recommendations of the Advisory Committee on Immunization Practices (ACIP) relating to the use of seasonal influenza vaccines in the United States have been updated for 2019 to 2020; the updated recommendations have been...
11h
MONDAY, Aug. 26, 2019 -- There was an increase in provision of palliative care for patients hospitalized between 2006 and 2014 with end-stage kidney disease (ESKD) requiring dialysis, but rates were lower for black and Hispanic patients, according...
11h
MONDAY, Aug. 26, 2019 -- Recall of electronic nicotine delivery systems (ENDS) marketing at retail stores is associated with increased subsequent ENDS initiation among youth and young adults, according to a study published online Aug. 26 in...
11h
MONDAY, Aug. 26, 2019 -- Pregnancy alters the shape of the rectus abdominis muscle, which may in turn affect abdominoplasty outcomes, according to a study published in the August issue of Plastic and Reconstructive Surgery. Lindsay E. Janes, M.D.,...
11h
MONDAY, Aug. 26, 2019 -- Survivors of childhood cancer have an increased risk for all subtypes of cardiovascular disease (CVD), according to a research letter published online Aug. 26 in Circulation. Ashna Khanna, from the University of Toronto, and...
11h
MONDAY, Aug. 26, 2019 -- There is an increased risk for gallbladder- or biliary tract-related events among patients with type 2 diabetes taking liraglutide versus placebo, according to a study published online Aug. 9 in Diabetes Care. Michael A....
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MONDAY, Aug. 26, 2019 -- Postprescription audit and review (PPR) is a feasible and effective strategy for antimicrobial stewardship in community hospitals, according to a study published online Aug. 16 in JAMA Network Open. Deverick J. Anderson,...
11h
MONDAY, Aug. 26, 2019 -- Group-based aerobic exercise programs, like cardiac rehabilitation, provide benefits to stroke survivors, according to a review published online Aug. 14 in the Journal of the American Heart Association. Elizabeth W. Regan,...
11h
MONDAY, Aug. 26, 2019 -- Individuals with restless legs syndrome (RLS) have an increased risk for suicide and self-harm, according to a study published online Aug. 23 in JAMA Network Open. Sheng Zhuang, M.D., from The Second Affiliated Hospital of...
11h
The prevalence of diabetes mellitus (DM) has been increasing dramatically worldwide, but the pathogenesis is still unknown. A growing amount of evidence suggests that an abnormal developmental environment in early life increases the risk of developing metabolic diseases in adult life, which is referred to as the “metabolic memory” and the Developmental Origins of Health and Disease (DOHaD) hypothesis. The mechanism of “metabolic memory” has become a hot topic in the field of DM worldwide and could...
3h
In the Forex market, the price of the currencies increases and decreases rapidly based on many economic and political factors such as commercial balance, the growth index, the inflation rate, and the employment indicators. Having a good strategy to buy and sell can make a profit from the above changes. A successful strategy in Forex should take into consideration the relation between benefits and risks. In this work, we propose an intraweek foreign exchange speculation strategy for currency markets...
3h
This paper examines optimal pricing in a two-tier product and service supply chain consisting of a manufacturer and a retailer in the context of vertical competition in extended warranty in two cases: one considering the retailer’s fairness concerns and one without considering the retailer’s fairness concerns. A manufacturer-dominated product and service supply chain game-theoretic model on the Stackelberg model is developed to analyse how the level of vertical competition in extended warranty service...
3h
The traditional spectral analysis method is used to study the characteristics of bearing fault signals in frequency domain, which is reasonable and effective in general cases. However, it is proved that the fault signals have heavy tails in this paper, which are stable distribution, and , and even the noises belong to stable distribution. Then the conventional spectral analysis methods degenerate and even fail under stable distribution environment. Several improved frequency spectral analysis...
3h
An Overshoot-Constrained Fast Setpoint Control for Nanopositioning Systems with Switched Controllers
Nanopositioning control as the key technology has been applied in many fields such as near-field optics, biomedical engineering, and nanomanipulation, where it is required to possess high positioning accuracy, reliability, and speed. In this paper, a switched PID controller-based fast setpoint control method is proposed for nanopositioning systems. In order to improve the setpoint speed of the nanopositioning system without a large overshoot, a switched controller consisting of the approach mode...
3h
Background. Pueraria lobata is used in traditional Asian medicine to treat cardiovascular diseases, diarrhea, diabetes mellitus, and diabetic complications such as diabetic retinopathy. Oxidative stress in retinal pigment epithelial cells is implicated in the pathogenesis of retinopathy and age-related macular degeneration (AMD). Here, we evaluated whether the P. lobata extract can prevent cell death and decrease membrane permeability in oxidative stress-induced human retinal pigment epithelial cells....
3h
In this work, zeolite (Z) and Z-Fe3O4 nanocomposite (Z-Fe3O4 NC) have been synthesized. The Fe3O4 nanoparticles were synthesized using the extract from maize leaves and ferric and ferrous chloride salts and encapsulated into the zeolite framework. The nanocomposite (Z-Fe3O4 NC) was characterized using X-ray diffractometer (XRD), Fourier-transform infrared (FT-IR) spectroscopy, energy-dispersive X-ray (EDX) spectroscopy, and scanning electron microscopy (SEM). The potential of Z-Fe3O4 NC as an adsorbent...
3h
Computational drug repositioning, designed to identify new indications for existing drugs, significantly reduced the cost and time involved in drug development. Prediction of drug-disease associations is promising for drug repositioning. Recent years have witnessed an increasing number of machine learning-based methods for calculating drug repositioning. In this paper, a novel feature learning method based on Gaussian interaction profile kernel and autoencoder (GIPAE) is proposed for drug-disease...
3h
We obtain weak convergence and optimal scaling results for the random walk Metropolis algorithm with a Gaussian proposal distribution. The sampler is applied to hierarchical target distributions, which form the building block of many Bayesian analyses. The global asymptotically optimal proposal variance derived may be computed as a function of the specific target distribution considered. We also introduce the concept of locally optimal tunings, i.e., tunings that depend on the current position of...
14h
Cooperative music making in networked environments has been subject of extensive research, scientific and artistic. Networked music performance (NMP) is attracting renewed interest thanks to the growing availability of effective technology and tools for computer-based communications, especially in the area of distance and blended learning applications. We propose a conceptual framework for NMP research and design in the context of classical chamber music practice and learning: presence-related constructs...
14h
There is a known relationship between serum alanine aminotransferase (ALT) and obesity in humans, but the mechanism(s) are not clarified. This study investigated the associations between serum ALT and body composition in an overweight and obese population. The results are based on data from a previous randomized controlled trial treating obesity with vitamin D3. A sample of 448 overweight and obese individuals underwent dual-energy X-ray absorptiometry (DEXA) and measured serum ALT along with supplementary...
15h
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