Abstract Purpose The definition of growth response in growth hormone (GH)-treated children is controversial. This study aims at: (1) evaluating short-term and long-term efficacy of GH treatment in a cohort of short children with GH deficiency (GHD); (2) assessing and compare various poor response criteria; (3) identifying predictive factors of growth response. Methods ...
Abstract Purpose Treatment of space-occupying lesions (SOLs) in the sellar region is a clinical challenge, especially in pregnant women because many treatment decisions are restrained due to pregnancy. We attempt to discuss the surgical indications and timing for pregnant patients and highlight the importance of multidisciplinary team (MDT) treatment. Methods ...
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Publication date: December 2019Source: Current Opinion in Neurobiology, Volume 59Author(s): Daniel R Connolly, Zhaolan ZhouMethyl-CpG binding protein 2 (MeCP2) plays fundamental roles in the nervous system, as both gain-of-function and loss-of-function of MECP2 are associated with severe neurological conditions. Understanding the molecular function of MeCP2 will not only provide insights into the pathogenesis of MeCP2-related disorders, but will also shed light on the epigenetic regulation of neuronal...
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Publication date: Available online 17 August 2019Source: NeuroImageAuthor(s): Matthew T. Cherukara, Alan J. Stone, Michael A. Chappell, Nicholas P. BlockleyAbstractStreamlined Quantitative BOLD (sqBOLD) is an MR technique that can non-invasively measure physiological parameters including Oxygen Extraction Fraction (OEF) and deoxygenated blood volume (DBV) in the brain. Current sqBOLD methodology rely on fitting a linear model to log-transformed data acquired using an Asymmetric Spin Echo (ASE) pulse...
Publication date: Available online 17 August 2019Source: NeuroImageAuthor(s): Dorelle C. Hinton, Alexander Thiel, Jean-Paul Soucy, Laurent Bouyer, Caroline PaquetteAbstractWhen walking on a split-belt treadmill, where each leg is driven at a different speed, a temporary change is made to the typical steady-state walking pattern. The exact ways in which the brain controls these temporary changes to walking are still unknown. Ten young adults (23±3y) walked on a split-belt treadmill for 30 min on 2...
Publication date: Available online 16 August 2019Source: NeuroImageAuthor(s): Joe Steinman, Lindsay S. Cahill, Margaret M. Koletar, Bojana Stefanovic, John G. SledAbstractThe 3D organization of cerebral blood vessels determines the overall capacity of the cerebral circulation to meet the metabolic requirements of the brain. Imaging methodologies which combine 3D microvascular structural imaging with blood flow quantification can shed light on the relationship between vascular structure and function,...
Publication date: Available online 16 August 2019Source: NeuroImageAuthor(s): Rinaldo Livio Perri, Francesco Rossani, Francesco Di RussoAbstractA large literature indicated hypnosis as a useful tool to reduce pain perception, especially in high susceptible individuals. However, due to different methodological aspects, it was still not clear whether hypnosis modulates the early sensory processing of the stimuli or if it affects only the later stages of affective processing. In the present study, we...
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Publication date: Available online 17 August 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Anastasios Raptis, Michalis Xenos, Konstantinos Spanos, George Kouvelos, Athanasios Giannoukas, Miltiadis MatsagkasObjectivesThe implication of haemodynamics in the occurrence of complications after endovascular aneurysm repair (EVAR) has been raised in the literature. Different aortic stent graft configurations may lead to different haemodynamic properties. The current study deals...
Publication date: Available online 16 August 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Victoria N. Tedjawirja, Vivian de Waard
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Cancers, Vol. 11, Pages 1202: Soluble HLA in the Aqueous Humour of Uveal Melanoma Is Associated with Unfavourable Tumour Characteristics Cancers doi: 10.3390/cancers11081202 Authors: Annemijn P. A. Wierenga Gülçin Gezgin Els van Beelen Michael Eikmans Marijke Spruyt-Gerritse Niels J. Brouwer Mieke Versluis Robert M. Verdijk Sjoerd G. van Duinen Marina Marinkovic Gregorius P. M. Luyten Martine J. Jager A high HLA expression in uveal melanoma (UM) is part...
Cancers, Vol. 11, Pages 1201: Progesterone Receptor B signaling Reduces Breast Cancer Cell Aggressiveness: Role of Cyclin-D1/Cdk4 Mediating Paxillin Phosphorylation Cancers doi: 10.3390/cancers11081201 Authors: Francesca Ida Montalto Francesca Giordano Chiara Chiodo Stefania Marsico Loredana Mauro Diego Sisci Saveria Aquila Marilena Lanzino Maria Luisa Panno Sebastiano Andò Francesca De Amicis Progesterone-Receptor (PR) positivity is related with an enhanced...
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MRI SCREENING OF WHOLE SPINE, SI AND HIP JOINTMultiple vertebrae show subchondral collapse in dorso lumbar region. Hip screening show avascular necrosis involving bilateral capital femoral epiphysis..Ill-defined heterogeneous marrow oedema involving Acetabular fossa, Femoral head neck on either side, mild joint effusion.Suggested detailed haematological / bone marrow evaluation.Further evaluation turned out sickle cell anaemia.
MRI study of brain reveals:Diffuse cerebral cortical atrophy.Enlarged Peri vascular spaces involving bilateral Cingulate gyri, corpus callosum.Diffuse thickening of bony calvarium.J shaped Sella.MRI study of Spine reveals:Bullet-shaped vertebra at multiple levels.Dorsal dermal sinus in sacral region extending towards S4 without fusion or segmentation anomaly. No obvious cord tethering.Spleen 10 cm, moderate splenomegaly.Liver 12 cmM mild to moderate hepatomegaly.Possibility of Mucopolysaccharidosis...
Clinical Details : 45 yo male, from last five months has been having slowly progressive right distal arm, hand and recently right leg weakness which seems to be progressive. There is no sensory symptoms. No bowel bladder disturbance. Recently has also noted some slurrring of speech and tremulousness of both hands. Clinical examination shows poly myoclonus. Hyper reflexia, right plantar is extensor. Mild right facial weakness, eye movements are normal. Sensations are normal.MRI Findings:Contiguous...
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Neurobiology of resilience in depression: immune and vascular insights from human and animal studies
Abstract Major depressive disorder (MDD) is a chronic and recurrent psychiatric condition characterized by depressed mood, social isolation and anhedonia. It will affect 20% of individuals with considerable economic impacts. Unfortunately, 30‐50% of depressed individuals are resistant to current antidepressant treatments. MDD is twice as prevalent in women and associated symptoms are different. Depression's main environmental risk factor is chronic stress and women report higher levels of stress...
Abstract Gilles de la Tourette Syndrome (GTS) is a neurological condition characterized by motor and vocal tics. Previous studies suggested that this syndrome is associated with abnormal sensorimotor cortex activity at rest, as well as during the execution of voluntary movements. It has been hypothesized that this abnormality might be interpreted as a form of increased tonic inhibition, probably to suppress tics; however, this hypothesis has not been tested so far. The present study was designed...
Abstract Inhibitory GABAergic interneurons create different brain activity patterns that correlate with behavioral states. In this characterizing study, we used single‐cell RNAseq to analyze anatomically‐ and electrophysiologically‐identified hippocampal oriens‐lacunosum moleculare (OLM) interneurons. OLMs express somatostatin (Sst), generate feedback inhibition, and play important roles in theta oscillations and fear encoding. Although an anatomically‐ and biophysically‐homogenous population, OLMs...
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Journal of Cutaneous Medicine and Surgery, Ahead of Print. Background:Presurgical curettage before nonmelanoma skin cancer surgery may help delineate tumor subclinical extensions.Objective:To determine histologically whether presurgical curettage appropriately or inappropriately changes excision specimen size.Materials and Methods:One hundred fifty consecutive nonmelanoma skin cancers treated with Mohs micrographic surgery. The clinical margin (CM) was marked. Presurgical curettage was then performed...
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Understanding the genomic signatures, genes, and traits underlying local adaptation of organisms to heterogeneous environments is of central importance to the field evolutionary biology. Mixed linear models that identify allele associations to environment, while controlling for genome-wide variation at other loci, have emerged as the method of choice when studying local adaptation. Despite their importance, it is unclear whether this approach performs better than identifying environmentally-associated...
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MicroRNAs (miRNAs) play crucial roles in tumor initiation and development. Previously, we indicated that miR-504 is downregulated and suppresses tumor proliferation in glioblastoma (GBM). However, the regulati...
A major limitation in the treatment for malignant mesothelioma is related to serious side effects caused by chemotherapeutics and to the development of cancer-resistance. Advances in cancer therapies have been...
Triple Negative Breast cancer (TNBC) is incurable cancer with higher rates of relapse and shorter overall survival compared with other subtypes of breast cancer. Cellular retinoic acid binding protein 2 (CRABP...
Epidemiological observations have demonstrated that ambient fine particulate matter with dp
In the original publication of this article [1], there is a mistake in Fig. 4E.
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Journal Name: Biological ChemistryIssue: Ahead of print
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Chronic kidney disease (CKD) causes several systemic changes, including muscular homeostasis, and eventually results in muscle atrophy. CKD-induced muscle atrophy is highly prevalent, and exercise is well known to enhance muscle function in these cases, although the exact mechanism remains unclear. Here, we aim to assess whether the protective effect of aerobic exercise in 5/6 nephrectomized (CKD) mice is associated with mitochondrial dysfunction, autophagy, or inflammation. C57BL/6J mice were randomly...
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Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07729
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b03770
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The objective of this study was to investigate if there are differences in acoustic parameters between diabetic patients and normal controls.
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Objective: Delayed facial palsy has been reported following various types of otologic surgery. However, the exact characteristics of this disease have not been fully elucidated because of its low incidence. This study analyzed case series studies on delayed facial palsy to increase the sample size and outline credible disease characteristics. Data Sources: PubMed, Embase, and Cochrane Library databases were searched on October 10, 2018. Study Selection: Delayed facial palsy case series...
Objective(s): To investigate the differences in percutaneous versus passive transcutaneous bone-conduction stimulation in individuals with single-sided deafness. Study Design: Prospective, single-subject. Setting: Tertiary academic referral center. Patients: Adult bone-anchored implant listeners with single-sided deafness using a percutaneous implant system. Interventions: Experienced percutaneous bone anchored implant recipients were tested in the percutaneous and transcutaneous...
The Influence of Metabolic Syndrome on the Prognosis of Idiopathic Sudden Sensorineural Hearing Loss
Objectives: We aimed to verify the hypothesis that metabolic syndrome (MetS) and its components affect the prognosis of idiopathic sudden sensorineural hearing loss (ISNNHL). Study Design: A retrospective cohort study. Setting: Tertiary otology referral center. Patients: We divided patients who were diagnosed with ISSNHL between January 2015 and January 2018 into a MetS group and a Non-MetS group according to the diagnostic criteria of MetS. Interventions: We diagnosed ISSNHL...
Objective: This meta-analysis compares the efficacy and safety of endoscopic and microscopic approaches to tympanoplasty and stapes surgery, two common middle ear procedures. Data Sources: A comprehensive electronic search of PubMed/MEDLINE, Scopus, Web of Science, and Cochrane Library was conducted for studies published from the year 1960 through June 2018. Article selection and screening proceeded according to the strategies outlined in the standard Preferred Reporting Items for Systematic...
Objectives: To evaluate the long-term outcomes of three different types of bone conduction hearing implants (BCHI)—BAHA, Ponto, and Bonebridge—in Mandarin-speaking patients with bilateral microtia-atresia. Methods: This cohort study enrolled 59 patients affected by bilateral microtia-atresia, with an upper bone conduction threshold limit of 30 dB HL at frequencies of 0.5 to 4 kHz. All subjects underwent unilateral BCHI surgery, including 26 (18 males, 8 females, of mean age 8.7 ± 1.9 yr)...
Importance: Benign paroxysmal positional vertigo (BPPV) is a common cause of acute dizziness. Strong evidence exists for diagnosing BPPV using the Dix-Hallpike Test (DHT) and treating it with the canalith repositioning maneuver (CRM). Despite this, both are infrequently used in the emergency department (ED). Objective: As an early method to evaluate a BPPV-focused educational intervention, we evaluated whether an educational intervention improved ED provider performance on hypothetical stroke...
Objective: The objective of this study is to determine the reliability of a new tablet-based software that utilizes postoperative computed tomography to determine angular insertion depth (AID), cochlear duct length (CDL), and the cochlear place frequency of individual electrodes in cochlear implant recipients. Patients: Twenty adult cochlear implant recipients with lateral-wall electrode arrays of varying lengths were included in the study. Intervention: Cochlear and electrode array...
No abstract available
Objective: Evaluation of the accuracy and clinical applicability of a single measure cochlear implant angular insertion depth prediction method. Background: Cochlear implantation outcomes still vary extensively between patients. One of the possible reasons could be variability in intracochlear electrode array placement. For this reason, single measure methods were suggested to preoperatively predict angular insertion depths. Based on a previously performed accuracy study in human temporal...
Objective: To review a single institution experience with pediatric stapedotomy for juvenile otosclerosis (JO), congenital stapes footplate fixation (CSFF), or tympanosclerosis. Study Design: Retrospective chart review. Setting: Tertiary referral center. Patients: Pediatric patients undergoing surgery for stapes fixation from 2001 to 2017. Main Outcome Measures: Hearing result based on preoperative, first postoperative, and final postoperative pure-tone average air-bone gap...
Objective: To evaluate speech perception following the first (CI-1) and second (CI-2) cochlear implantation (CI) in children with sequential bilateral CI. Study Design: Retrospective. Patients: Seventy children with follow-up for 60 months post CI-1 and 36 months post CI-2. Main Outcome Measures: Word recognition score (WRS) was the main outcome. WRSs were compared by age at CI operation (group A ≤ 3.5 yr, B 3.6–8.6, for CI-1; group I ≤ 3.5 yr, II 3.6–7.0, III 7.1–13, IV > 13,...
Objective: To analyze and compare experiences of anxiety and discomfort caused by the Epley maneuver and the willingness for a potential retreatment between younger (≤70 yr) and older (>70 yr) patients. Study Design: Prospective, observational cohort study. Setting: Tertiary referral center. Methods: Dutch adults, diagnosed with posterior canal benign paroxysmal positional vertigo, were included. Patients with dementia or subjected to an Epley maneuver ≤4 months before the hospital...
Objective: Examine postoperative speech perception outcomes in a large vestibular aqueduct syndrome (LVAS) patients at a major cochlear implantation center. Study Design: Retrospective analysis of the Sydney Cochlear Implant Centre (SCIC) database and medical records from January 1994 to December 2015 was performed. Setting: Tertiary referral center. Patients: Patients with a diagnosis of LVAS who received a cochlear implant (CI). Only those with speech perception outcomes recorded...
Objective: To examine quality of life changes for patients with vestibular schwannoma (VS) undergoing observation or stereotactic radiosurgery (SRS). Study Design: Retrospective review. Setting: Academic medical center. Patients: Patients with VS who underwent observation or SRS and had at least two audiograms and Penn Acoustic Neuroma Quality of Life (PANQOL) surveys, a quality of life survey for patients with VS. Interventions: SRS or observation. Main Outcome Measures:...
Hypothesis: Cochlear implantation may result in an increase in the density of macrophages in vestibular endorgans in the human. Background: Vestibular symptoms are a common complication of cochlear implantation. In a previous study, we demonstrated histological evidence of a foreign-body response caused by silicon and platinum in the human cochlea following cochlear implantation. The objective of the current study was to seek evidence of a possible immune response in vestibular endorgans...
Hypothesis: The presence of bony inner ear malformations may associate with a number of anatomical abnormalities affecting the middle ear structures. Those malformations may create pitfalls and complications for cochlear implantation. Background: Inner ear malformations associate with varying degrees of hearing loss, and frequently require cochlear implantation for hearing rehabilitation. Therefore, the abnormalities affecting the middle- and inner-ear structures may increase the risk of...
Objective: To document the case of a patient with bilateral enlarged vestibular aqueducts who experienced sensorineural hearing loss in the nonimplanted ear following unilateral cochlear implantation complicated by perilymph gusher requiring lumbar drain insertion and to highlight the need to counsel regarding the risk of potential hearing loss to the contralateral ear when preparing for cochlear implants in the setting of inner ear malformations. Patients: One patient with bilateral enlarged...
No abstract available
Objective: To evaluate the hearing outcomes of cochlear implantation in different age groups by using data collected in the HEARRING registry. Methods: A multicenter study. Data of 146 patients were collected in a HEARRING registry. Patients were divided into three different age groups; ≤ 55 years old (age group 1, n = 66), 56 to 69 years old (age group 2, n = 45), and ≥ 70 years old (age group 3, n = 35). Speech in quiet (SPIQ), speech in noise (SPIN), and hearing implant sound quality index...
Objective: To review the demographics, treatment modalities, and survival of children with vestibular schwannomas. Study Design: Analysis using the Surveillance, Epidemiology, and End Results (SEER) database. Subjects and Methods: Pediatric patients from birth to 18 years in the SEER database were included from 2004 to 2014 based on a diagnosis of vestibular schwannoma using the primary site International Classification of Diseases (ICD) O-3 code of C72.4: acoustic nerve and the ICD...
Introduction: Middle ear cholesteatoma is a benign disease with invasive and destructive clinical behaviors. It increases the rate of both chronic otitis media complications and revision surgeries. The most effective treatment of middle ear cholesteatoma is surgical excision, and there is no medical treatment for this disease. Exploring new medical treatment options may help to create treatment alternatives instead of surgery. Materials and Methods: Required cholesteatoma tissues for cell...
Objective: Evaluation of the long-term safety and performance of an active middle ear implant (AMEI) in the treatment of hearing loss in children and adolescents with a primary focus on improvement in speech discrimination. Study Design: Prospective, multicentric, single-subject repeated-measures design in which each subject serves as his or her own control. Subjects: Thirty-one pediatric subjects aged 5 to 17 years. Intervention: Implantation of an active middle ear implant. Methods:...
Objective: To determine the audiologic improvement after middle cranial fossa (MCF) approach to repair spontaneous cerebrospinal fluid (sCSF) leaks. Study Design: Retrospective cohort study. Setting: Tertiary referral center. Patients: Twenty-four consecutive patients (27 ears) with temporal bone sCSF leak over a 4-year period. Patient age, sex, ethnicity, body mass index (BMI), location of CSF leak, recurrence of CSF leak, and presence of encephalocele(s) were recorded. Intervention:...
Objective: The aim of the study was to investigate the relationship between the presence of a hearing aid (HA) and the occurrence of various disorders of the external ear, using data from ear, nose, and throat (ENT) practices in Germany from a nationwide, representative practice database. Methods: In the period between 2012 and 2016, the incidences of disorders of the external ear (ICD-10 groups H60 and H61) in patients with HA prescriptions were compared retrospectively with a control group...
Background: Few studies report hearing preservation following middle cranial fossa (MCF) floor defect repair. Objective: To investigate audiological outcomes following MCF floor defect repair using a modified MCF suprapetrous approach. Study Design: Retrospective cohort. Setting: Tertiary referral center. Patients: Eleven patients, with MCF floor defects. Interventions: MCF floor defect surgical repairs with either fascia or fascia and bone graft. Main Outcome Measured:...
In addition to positional vertigo, it is quite common for patients with benign paroxysmal positional vertigo (BPPV) to present complaints associated with balance problems and a feeling of dizziness even after repositioning maneuvers. Objective: It was to evaluate the additional effects of vestibular rehabilitation exercises as a therapeutic resource in the treatment of BPPV, to improve symptoms and reduce recurrence. Study Design: This was an experimental, prospective, randomized, controlled...
Objective: To perform comparisons and clarify differences in clinical manifestations between eosinophilic otitis media (EOM) and otitis media associated with eosinophilic granulomatosis with polyangiitis (EGPA). Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Twenty-two ears of 11 patients exhibiting EOM (EOM group) and 20 ears of 12 patients exhibiting otitis media associated with EGPA (EGPA group). Main Outcome Measures: Otological manifestations,...
Objective: To assess how pretreatment vestibular schwannoma (VS) tumor characteristics are associated with vestibular symptoms after gamma knife (GK) surgery. Study Design: Retrospective chart review of patients undergoing GK treatment for VS at our institution from 2005 to 2018. Setting: Academic tertiary referral center. Patients: Patients receiving primary GK surgery for vestibular schwannomas with at least 6 months of follow up. Patients with neurofibromatosis 2 or previous...
Introduction: Partial epithelial–mesenchymal transition (p-EMT) is a process by which epithelial cells partially lose their intercellular adhesion and change to obtain migration ability. The transcription factor p63 regulates the expression of cadherin family and induces epithelial cell proliferation. In this study, we hypothesized that p-EMT under p63 expression may be a key factor in epithelial cell growth in middle ear cholesteatoma. Methods: Specimens were surgically excised from patients...
Objectives: To compare the efficacy and safety of high-dose corticosteroids (initial prednisolone [PSL] of 100 mg or more daily) and standard-dose corticosteroids (initial PSL of 50–60 mg) in patients with Bell's palsy. Study Design: A systematic review and meta-analysis. Data Sources: Medline, Embase, Cochrane Central Register of Controlled Trials, Ichushi-Web, Web of Science, and CINAHL, combined with data from ClinicalTrials.gov. Study Selection: Published and unpublished cohort...
Objective: To present the first case of osteonecrosis of the external auditory canal associated with sorafenib treatment. Patient: 58-year-old patient with right-sided otorrhea and otalgia was treated for otitis externa for 1 month without improvement. Otoscopic examination revealed a large defect in the inferior wall of the tympanic bone filled with skin debris and bony fragments. Previous medical history included treatment with sorafenib for metastatic renal cell cancer; he had never been exposed...
Aim: To assess the efficacy of a prototype cleaning device in removing biofilm from skin-penetrating abutments. Background: Adverse skin reactions around percutaneous osseointegrated implants have been linked to poor hygiene and infection. A cleaning device made from open-cell polyfoam has been developed to facilitate manual cleaning of abutments by the patient. Methods: Serratia biofilm was grown on clean and sterile conical bone-anchored hearing system abutments including both pre-2007...
Background: Skull base osteomyelitis (SBO) is predominantly seen in immunocompromised patients, with diabetes mellitus being the most common underlying comorbidity. Microbial aetiology is commonly bacterial, although fungal SBO is encountered in a small fraction of patients. Treatment consists of prolonged antimicrobial therapy, control of underlying comorbidity, and surgical debridement in selected cases. Involvement of cranial nerves is a common complication and is considered a poor prognostic...
No abstract available
Objectives: The aim of this article was to investigate the effectiveness and underlying mechanisms of OK-432 therapy in patients with auricular hematomas. Study Design and Setting: Case series with planned data collection. Subjects and Methods: We tried this therapy in 47 patients with auricular hematoma between April 2008 and August 2018. We aspirated as much of the fluid content of each lesion as possible with a 21-gage needle. We injected OK-432 solution into the lesion with the same...
No abstract available
Objective: This study examines the incidence and management of traumatic loss or osseointegration failure of percutaneous bone conduction implants in children. Study Design: Case series. Setting: Pediatric tertiary care institution. Patients: Children who underwent percutaneous osseointegrated implant placement from 1996 to 2016. Interventions: Clinical evaluation and revision surgery after implant loss. Main Outcome Measures: This study compares the characteristics of...
No abstract available
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