Translate

Κυριακή 18 Αυγούστου 2019


Analysis of contemporary tools for the measurement of enophthalmos: a PRISMA-driven systematic review
Enophthalmos has many causes, and serious post-traumatic cases indicate the need for operation. Such diagnoses should be made objectively, and a robust method for quantifying the degree to which the globe has been displaced is key. Current methods of measurement, however, have long been considered unreliable and inconsistent, in particular with regard to interobserver variability. The aim of this paper therefore was to review all these methods systematically, to analyse their reliability, and to...
Oral and Maxillofacial Surgery
13h
First clinical real-time motion-including tumor dose reconstruction during radiotherapy delivery
The utility of stereotactic body radiotherapy (SBRT) is clearly increasing [1]. High accuracy at each individual fraction is essential, but also challenged by intrafraction motion and anatomical changes [2–5]. For liver SBRT, studies on dose reconstruction has demonstrated that motion can substantially deteriorate the tumor dose [6–8]. These motion-including dose calculations were performed post-treatment with no possibility to intervene in case of unacceptable dose errors. Real-time motion-including...
Radiotherapy and Oncology
13h
Predicting the tumor response to chemoradiotherapy for rectal cancer: Model development and external validation using MRI radiomics
The current standard treatment for patients with locally advanced rectal cancer (LARC) is total mesorectal excision (TME) after neoadjuvant chemoradiation (CRT) [1,2]. Despite this homogeneous treatment schedule, the response of these tumors is very heterogeneous and approximately 20% of patients will achieve a pathological complete response (pCR) defined as no residual tumor and complete nodal response as reported at histology after a standard resection [3]. Given the good oncological outcome of...
Radiotherapy and Oncology
13h
Pseudoprogression after radiation therapies for low grade glioma in children and adults: A systematic review and meta-analysis
Low grade gliomas (LGG; World Health Organization (WHO) grade I and II) include astrocytomas and oligodendrogliomas, and collectively prognosticate a relatively favorable outcome with surgery, chemotherapy and radiation therapy (RT) compared to high grade gliomas (HGG; WHO grade III and IV) [1–4]. The age-adjusted annual incidence of LGG is approximately 1.0–1.7 cases per 100,000 person-years worldwide, with 10-year survival greater than 80% in pediatric subjects, and greater than 60% in adult subjects...
Radiotherapy and Oncology
13h
Cost-effectiveness analysis of neoadjuvant chemoradiotherapy followed by surgery versus surgery alone for locally advanced esophageal squamous cell carcinoma based on the NEOCRTEC5010 trial
Esophageal cancer is a highly lethal disease, especially in developing countries. China has been a high-incidence area of esophageal cancer for many years and accounts for over 50% of the global morbidity and mortality [1]. The two major histological types of esophageal cancer are squamous cell carcinoma (ESCC) and adenocarcinoma, and there is a striking geographical variation in the incidence of the esophageal cancer subtypes. In China, approximately 90% of patients with esophageal cancer are diagnosed...
Radiotherapy and Oncology
13h
Deep learning-assisted literature mining for in vitro radiosensitivity data
Radiation therapy is one of the main pillars of cancer treatment. As precision medicine is adopted more widely, individualization of radiation therapy based on patients’ biological information is becoming more important [1]. However, the biological profiles associated with cancer cell radiosensitivity have not yet been fully elucidated [1]. Clonogenic assays are the gold standard for determining reproductive cell death induced by ionizing radiation [2]. Past studies have shown that ex vivo SF2 (clonogenic...
Radiotherapy and Oncology
13h
Safety and efficacy of reduced dose and margins to involved lymph node metastases in locally advanced NSCLC patients
Concurrent chemoradiotherapy (cCRT) for locally advanced non-small cell lung cancer (LA-NSCLC) results in a 5-year overall survival (OS) of 32% [1,2]. Local and regional failures as well as severe acute and late toxicities adversely affect OS [1,3,4]. Determining the balance between optimal treatment outcomes and low toxicity rates is challenging.
Radiotherapy and Oncology
13h
Predicting and implications of target volume changes of brain metastases during fractionated stereotactic radiosurgery
Stereotactic radiosurgery (SRS) is one of the mainstay treatment modalities for brain metastases (BM) [1]. Two recent trials showed a beneficial effect of adjuvant SRS to the surgical cavity for resected brain metastases [2,3]. The decision whether SRS is delivered in a single fraction or in multiple fractions depends mainly on the target size and the location [4–6].
Radiotherapy and Oncology
13h
A mid-treatment break and reassessment maintains tumor control and reduces toxicity in patients with hepatocellular carcinoma treated with stereotactic body radiation therapy
Stereotactic body radiation therapy (SBRT) is an effective treatment option for hepatocellular carcinoma (HCC) [1] with increasing utilization [2]. However, broad adoption has been limited over concerns regarding radiation induced liver toxicity [3,4], as many patients with HCC have underlying liver dysfunction secondary to cirrhosis and/or a history of prior liver directed therapies. While clinical features can aid in identifying patients at risk for toxicity [3], there remains significant variability...
Radiotherapy and Oncology
13h
[68Ga-]PSMA-11 PET/CT and multiparametric MRI for gross tumor volume delineation in a slice by slice analysis with whole mount histopathology as a reference standard – Implications for focal radiotherapy planning in primary prostate cancer
Conventionally the whole prostate is irradiated with a homogeneous dose to the entire gland in patients with primary prostate cancer (PCa) [1]. Even though an escalation of radiation dose is known to benefit tumor response, escalation to the whole prostate is not feasible due to toxicity [2,3]. This can lead to pivotal lesions lacking a proper dose and response [4]. For this reason local recurrences often arise at the primary location of malignant lesions [4,5]. The concept of focal therapies in...
Radiotherapy and Oncology
13h
International comparison of cosmetic outcomes of breast conserving surgery and radiation therapy for women with ductal carcinoma in situ of the breast
Breast conserving surgery (BCS) followed by radiation therapy (RT) is the primary management for many women with early-stage, invasive breast cancer and ductal carcinoma in situ (DCIS) [1–4]. Most women achieve good to excellent cosmesis after BCS and RT but some experience cosmetic failure, defined as fair or poor cosmetic outcomes [5–17]. However, comparisons of cosmetic outcomes across international jurisdictions using contemporary surgical and RT techniques for DCIS are lacking.
Radiotherapy and Oncology
13h
SBRT combined with concurrent chemoradiation in stage III NSCLC: Feasibility study of the phase I Hybrid trial
Stereotactic body radiotherapy (SBRT) results in excellent local control (LC) in early stage non-small cell lung cancer (NSCLC) with 3 year LC rates of >90% and is standard of care in inoperable NSCLC [1,2]. Unfortunately, one third of patients with NSCLC present with locally advanced (LA) disease and are not considered for SBRT, but receive concurrent chemoradiation (CCRT) if they have a good performance status [3]. Even with modern treatment planning and delivery, two-year local failure rates...
Radiotherapy and Oncology
13h
A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN)
Mepitel® Film (MEP) and standard care (STD) were compared for radiation dermatitis in SCCHN patients. This trial was stopped prematurely since13/28 patients did not tolerate MEP. Grade ≥2 dermatitis: 34.8% (MEP) vs. 35.7% (STD) at 50 Gy, 65.2% vs. 59.3% at 60 Gy. MEP was unsatisfactorily tolerated and appeared not superior (NCT03047174).
Radiotherapy and Oncology
13h
Xerostomia-related quality of life for patients with oropharyngeal carcinoma treated with proton therapy
Proton therapy has an important role in the management of head and neck cancer, where the dosimetric characteristics of proton particles are advantageous for treating tumors in complex anatomic areas. In addition to highly targeted dose depositions owing to the Bragg peak and superior lateral dose distribution of proton therapy, the introduction of spot-scanning techniques that allow intensity-modulated proton therapy (IMPT) further improve dose distributions and normal-tissue sparing relative to...
Radiotherapy and Oncology
13h
Incidence and patterns of retropharyngeal lymph node involvement in oropharyngeal carcinoma
Data regarding the incidence of retropharyngeal lymph node (RP LN) metastases in oropharyngeal cancer are limited due to the difficulty of surgical access [1] with pathological data based upon small series [2,3]. Imaging studies report a variable incidence (2–21%) of RP LN metastases [4–11]. MRI is superior to CT for the detection of RP LNs [1,12,13]. 2-[Fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography-computed tomography (PET-CT) is considered the most sensitive imaging modality...
Radiotherapy and Oncology
13h
Estimation of the α/β ratio of non-small cell lung cancer treated with stereotactic body radiotherapy
The radiobiological principles of stereotactic body radiation therapy (SBRT) are currently vividly discussed [1–3]. Compared to conventional fractionation, SBRT may exhibit some unique biological features including beneficial effects such as enhancement of systemic anti-tumor immunity [4] and a better ability to kill cancer stem cells [5], but also a difficulty to overcome tumor hypoxia with one or only a few fractions due to limited reoxygenation [2,3]. More specifically, when cells in vitro are...
Radiotherapy and Oncology
13h
Single fraction urethra-sparing prostate cancer SBRT: Phase I results of the ONE SHOT trial
The ONE SHOT trial is the first phase I/II prospective, multicenter, single-arm study assessing the efficacy and safety of a single-dose SBRT for men with localized prostate cancer. Aim of this paper is to present the phase I results of a 19 Gy single fraction urethra-sparing SBRT with real-time electromagnetic tracking.
Radiotherapy and Oncology
13h
Diffusion-weighted MRI with ADC mapping for response prediction and assessment of oesophageal cancer: A systematic review
Oesophageal cancer is a malignancy with a poor prognosis, as reflected by an average overall 5-year survival of only 18% [1]. Locally advanced oesophageal cancer patients are generally treated by chemo- and/or radiotherapy, either as definite treatment or as neoadjuvant treatment prior to surgery [2–4]. However, not all patients benefit equally. In 23% of adenocarcinomas (AC) and 49% of squamous cell carcinomas (SCC) a pathological complete response (pCR, tumour regression grade (TRG) 1) is determined...
Radiotherapy and Oncology
13h
Radiosensitization of high-grade gliomas through induced hyperthermia: Review of clinical experience and the potential role of MR-guided focused ultrasound
Gliomas comprise approximately 30% of all primary brain tumors (BTs). Glioblastoma multiforme (GBM) accounts for more than half of all gliomas and is a highly malignant form of brain cancer with a 5-year survival rate of <10% [1,2]. The addition of radiation therapy (RT) to the GBM treatment paradigm has proven to prolong survival from 6 to 12 months compared to surgery alone [1,3]. The addition of the DNA-alkylating agent temozolomide (TMZ) to RT has been found to further improve the median survival...
Radiotherapy and Oncology
13h
Re: Differential impact of FLASH versus conventional dose rate irradiation: Spitz et al.,
The article by Spitz and colleagues describes an integrated physico-chemical approach to understanding the relative protection of normal tissue versus tumor tissue after ionizing radiation (IR) by the use of FLASH (>40 Gy/s) versus conventional (∼0.05 Gy/s) dose-rates [1]. Due to the potential importance of FLASH radiotherapy [2,3], and inspired by the Spitz analysis, this letter suggests specific criteria and investigations that may improve future assessment. https://doi.org/10.1016/j.radonc.2019.03.028
Radiotherapy and Oncology
13h
Validation of different PSMA-PET/CT-based contouring techniques for intraprostatic tumor definition using histopathology as standard of reference
The identification and accurate contouring of the intraprostatic tumor volume is a crucial step for diagnostic and therapeutic approaches in patients with primary prostate cancer (PCa). In the last decade the concept of focal radiation therapy (RT) has gained interest for patients with PCa and boosting the RT dose to the visible tumor areas within the prostate may improve treatment outcome [1,2]. Moreover, recurrent PCa after conventional RT often occurs at the site of the primary tumor [3,4]. Currently,...
Radiotherapy and Oncology
13h
Evofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity
Esophageal cancer incidence in the Western world has risen over the past decades, with adenocarcinomas now being more prevalent than squamous cell carcinomas [1]. Alcohol intake, tobacco smoking and overweight are key risk factors, especially for adenocarcinomas. The disease is rarely curable with a 5-year overall survival of approximately 20% [2,3]. Standard treatment consists of neoadjuvant chemoradiotherapy followed by surgery [4].
Radiotherapy and Oncology
13h
The 2017 Assisi Think Tank Meeting on rectal cancer: A positioning paper
To describe current practice in the management of rectal cancer, to identify uncertainties that usually arise in the multidisciplinary team (MDT)’s discussions (‘grey zones’) and propose next generation studies which may provide answers to them.
Radiotherapy and Oncology
13h
Differences between planned and delivered dose for head and neck cancer, and their consequences for normal tissue complication probability and treatment adaptation
Head and neck image-guided radiotherapy studies have demonstrated considerable geometric uncertainties, such as setup errors, posture changes, weight-loss and tumor shrinkage during fractionated radiotherapy [1,2]. These geometrical changes impact the dose distribution such that the actual delivered dose is different from the planned dose [3,4], impacting organs-at-risk (OAR) dose(s) to clinically meaningful degrees.
Radiotherapy and Oncology
13h
High efficacy of hypofractionated proton therapy with 4 fractions of 5 Gy as a boost to 50 Gy photon therapy for localized prostate cancer
Technical advances have made it possible to create highly conformal dose distributions using photon-based radiotherapy, prompting interest in hypofractionated radiotherapy. Prostate cancer shows higher fractionation sensitivity and a lower α/β ratio than healthy tissue; thus, the rationale is to use higher doses per fraction compared with conventional fractionation [1–3]. Randomized studies have shown that moderate hypofractionation was not inferior to conventional fractions [4–6], but they have...
Radiotherapy and Oncology
13h
Proton vs photon: A model-based approach to patient selection for reduction of cardiac toxicity in locally advanced lung cancer
Outcome of patients with locally advanced non-small cell lung cancer (NSCLC) (stage III) is poor. In RTOG 0617, a median survival of less than 28 months is reported following radical chemoradiotherapy [1]. Efforts to improve survival through dose escalation have been unsuccessful and in fact appeared to be detrimental. Increased cardiac dose was implicated as one of the reasons for this. Since RTOG-0617 was reported, growing evidence shows that cardiac morbidity and mortality secondary to radiotherapy...
Radiotherapy and Oncology
13h
Revascularization of the necrotic femoral head after traumatic open anterior hip dislocation in a child: a case report
Avascular necrosis of the femoral capital epiphysis is the most serious complication after traumatic dislocation of the hip in children. This case report discusses the localization and revascularization of the...
Journal of Medical Case Reports - Latest Articles
13h
The Helitron family classification using SVM based on Fourier transform features applied on an unbalanced dataset
Abstract Helitrons are mobile sequences which belong to the class 2 of eukaryotic transposons. Their specificity resides in their mechanism of transposition: the rolling circle mechanism. They play an important role in remodeling proteomes due to their ability to modify existing genes and introducing new ones. A major difficulty in identifying and classifying Helitron families comes from the complex structure, the unspecified length, and the unbalanced appearance number of each...
Latest Results for Medical
15h
Animal ICU… Why not also use the existing veterinary ICUs?
Annals of Intensive Care - Latest Articles
15h
Clinical application of presepsin as diagnostic biomarker of infection: overview and updates
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Clinical Chemistry and Laboratory Medicine (CCLM)
15h
Hearing Loss Linked to Higher Risk of Dementia among Middle-Aged Adults
​Hearing loss is positively associated with a risk of dementia, especially among adults 45 to 64 years old, according to a new study (JAMA Netw Open. 2019;2[7]:e198112). Researchers in Taiwan analyzed data of 16,270 patients from 2000 to 2013 from the National Health Insurance Research Database of Taiwan, comparing the incidence of dementia of those with and without hearing loss. Of the 16,270 patients included, 1868 developed dementia, and the dementia incidence rate in the hearing loss group was...
Audiology
15h
Bose Called Out for Inaccurate Clinical Trials on Self-Fit Hearing Aids
The Hearing Industries Association (HIA) argued against the Food and Drug Administration's (FDA) marketing authorization of Bose's self-fitting hearing aids. According to the HIA, the authorization relied on a flawed Phase II clinical study design that the HIA stated "does not provide enough evidence of effectiveness of the self-fitting method given the study's initial reliance on professionals for fitting." The FDA originally granted the self-fitting hear aid a 'De Novo' in 2018 based on clinical...
Audiology
15h
New Drug Could Prevent Hearing Loss
Medicine to treat age-related hearing loss could potentially receive FDA approval through a study being conducted at the University of South Florida (USF). Chair of the USF Medical Engineering Department and Director of the USF Global Center for Hearing and Speech Research Robert Frisina, PhD, and his team were awarded a U.S. patent for his theory on managing hearing loss. He and his team believe that you can slow hearing loss by combining supplements for the hormone aldosterone with anti-inflammatory...
Audiology
15h
The use of Rituximab as adjuvant in the treatment of oral pemphigus vulgaris
Abstract Background Pemphigus vulgaris patients with exclusive oral involvement (OPV) treated with conventional immunosuppressive therapy may be non‐responders or experience severe side effects and/or relapses. In such cases, Rituximab could be used as adjuvant in recalcitrant OPV patients Methods A retrospective single‐centre study on patients with oral pemphigus vulgaris treated with RTX at the dosage of 375mg/m2 was performed, evaluating the complete clinical and immunological remission,...
Oral Pathology & Medicine
15h
JUP, a potential prognostic marker of oral squamous cell carcinoma, promotes proliferation, migration and invasion
Abstract Background Junction plakoglobin (JUP) is an important cell‐cell junction protein. Recently, its deregulation has been correlated with the initiation and progression of various malignancies. Our aim was to investigate the expression of JUP in oral squamous cell carcinoma (OSCC) and its correlation with prognosis and to further study the effects of JUP on the proliferation, apoptosis, migration and invasion of OSCC cells. Methods We detected JUP expression in 273 OSCC specimens using...
Oral Pathology & Medicine
15h
A Semi-High-Throughput Adaptation of the NADH-Coupled ATPase Assay for Screening Small Molecule Inhibitors
A nicotinamide adenine dinucleotide (NADH)-coupled ATPase assay has been adapted to semihigh throughput screening of small molecule myosin inhibitors. This kinetic assay is run in a 384-well microplate format with total reaction volumes of only 20 µL per well. The platform should be applicable to virtually any ADP producing enzyme.
JoVE: Journal of Visualized Experiments
16h
Tuning the Acidity of Pt/ CNTs Catalysts for Hydrodeoxygenation of Diphenyl Ether
A protocol for the synthesis of HNbWO6, HNbMoO6, HTaWO6 solid acid nanosheet modified Pt/CNTs is presented.
JoVE: Journal of Visualized Experiments
17h
Consistent within‐individual plasticity is sufficient to explain temperature responses in red deer reproductive traits
Abstract Warming global temperatures are affecting a range of aspects of wild populations, but the exact mechanisms driving associations between temperature and phenotypic traits may be difficult to identify. Here, we use a 36‐year data‐set on a wild population of red deer to investigate the causes of associations between temperature and two important components of female reproduction: timing of breeding and offspring size. By separating within‐ versus between‐individual associations with temperature...
Journal of Evolutionary Biology
17h
Response to letter regarding <strong>“</strong>An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses<strong>”</strong>
Publication date: Available online 16 August 2019Source: Radiotherapy and OncologyAuthor(s): Douglas R. Spitz, Garry R. Buettner, Charles L. Limoli
Radiotherapy and Oncology
17h

Induction chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: long-term results of a phase III multicentre randomised controlled trial
Publication date: September 2019Source: European Journal of Cancer, Volume 119Author(s): Qi Yang, Su-Mei Cao, Ling Guo, Yi-Jun Hua, Pei-Yu Huang, Xiao-Long Zhang, Mei Lin, Rui You, Xiong Zou, You-Ping Liu, Yu-Long Xie, Zhi-Qiang Wang, Hai-Qiang Mai, Qiu-Yan Chen, Lin-Quan Tang, Hao-Yuan Mo, Ka-Jia Cao, Chao-Nan Qian, Chong Zhao, Yan-Qun XiangAbstractBackgroundInitial 3-year results from our clinical trial in locoregionally advanced nasopharyngeal carcinoma (NPC) patients showed that induction chemotherapy...
European Journal of Cancer
18h
Non-small cell lung cancer harbouring non-resistant uncommon <em>EGFR</em> mutations: Mutation patterns, effectiveness of epidermal growth factor receptor-tyrosine kinase inhibitors and prognostic factors
Publication date: September 2019Source: European Journal of Cancer, Volume 119Author(s): Lih-Chyun Chang, Chor-Kuan Lim, Lih-Yu Chang, Kuan-Yu Chen, Jin-Yuan Shih, Chong-Jen YuAbstractIntroductionNon-small cell lung cancer (NSCLC) harbouring EGFR exon 19 deletions or L858R mutation usually respond to epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR-TKIs), whereas T790M mutation and exon 20 insertion are frequently resistant to EGFR-TKIs. EGFR mutations other than those above are...
European Journal of Cancer
18h
The use of buparlisib as a radiosentisiser: What about toxicity?
Publication date: Available online 16 August 2019Source: European Journal of CancerAuthor(s): Peter A. van Dam
European Journal of Cancer
18h
Reply to ‘The use of buparlisib as a radiosensitiser: What about toxicity?’
Publication date: Available online 16 August 2019Source: European Journal of CancerAuthor(s): Daniel R. McGowan, Michael Skwarski, Geoff S. Higgins
European Journal of Cancer
18h
Odds of Acute Kidney Injury in Patients Receiving Dipeptidyl Peptidase 4 Inhibitors: A National Cohort Study Within the Department of Veterans Affairs
Preclinical and clinical data of dipeptidyl peptidase 4 (DPP‐4) inhibitors have demonstrated discordant data regarding acute kidney injury (AKI). Therefore, we aimed to evaluate the association between DPP‐4 use and AKI. This cohort study utilized data from the Department of Veterans Affairs evaluating patients diagnosed with type 2 (T2) diabetes with a DPP‐4 inhibitor and compared with nondiabetic and diabetic patients. The primary end point is the development of AKI, and statistical analyses were...
Clinical and Translational Science
18h
A feasibility study of using noninvasive renal oxygenation imaging for the early assessment of ischemic acute kidney injury in an embolization model
Publication date: Available online 16 August 2019Source: Magnetic Resonance ImagingAuthor(s): Chengyan Wang, Bihui Zhang, Haochen Wang, Hanjing Kong, Fei Gao, Xiaoying Wang, Min Yang, Jue ZhangAbstractPurposeTo investigate the feasibility of using MRI based oxygenation imaging for early assessment of ischemic acute kidney injury (AKI) in an embolization model.MethodsIschemic AKI model was induced in 40 rabbits by injection of microspheres into the right renal arteries. Animals were grouped according...
Magnetic Resonance Imaging
18h
Free-breathing non-contrast-enhanced flow-independent MR angiography using magnetization-prepared 3D non-balanced dual-echo Dixon method: A feasibility study at 3 Tesla
Publication date: Available online 16 August 2019Source: Magnetic Resonance ImagingAuthor(s): Masami Yoneyama, Shuo Zhang, Houchun Harry Hu, Le Roy Chong, Dianna Bardo, Jeffrey H. Miller, Nobuyuki Toyonari, Kazuhiro Katahira, Yasutomo Katsumata, Amber Pokorney, Chian Keat Ng, Marc Kouwenhoven, Marc Van CauterenAbstractIn this work we aimed to investigate the feasibility of using a new pulse sequence called Relaxation-Enhanced Angiography without Contrast and Triggering (REACT) for free-breathing...
Magnetic Resonance Imaging
18h
<sup>23</sup>Na MRI of human skeletal muscle using long inversion recovery pulses
Publication date: Available online 16 August 2019Source: Magnetic Resonance ImagingAuthor(s): Tobias Wilferth, Lena V. Gast, Robert W. Stobbe, Christian Beaulieu, Bernhard Hensel, Michael Uder, Armin M. NagelAbstract23Na inversion recovery (IR) imaging allows for a weighting toward intracellular sodium in the human calf muscle and thus enables an improved analysis of pathophysiological changes of the muscular ion homeostasis. However, sodium signal-to-noise ratio (SNR) is low, especially when using...
Magnetic Resonance Imaging
18h
Parallel magnetic resonance image reconstruction from a single-element parametric amplifier
Publication date: Available online 16 August 2019Source: Magnetic Resonance ImagingAuthor(s): Roshan Timilsina, Chunqi QianAbstractIn magnetic resonance imaging (MRI), acquisition speed is always an important issue. In this paper, we propose a promising technique to achieve parallel MRI (pMRI) on a single-channel spectrometer, using a novel Wireless Amplified Nuclear MR Detector (WAND) for spatial encoding in image reconstruction. For this, a planar structure double frequency WAND is designed and...
Magnetic Resonance Imaging
18h
Comparison of machine learning classifiers for differentiation of grade 1 from higher gradings in meningioma: A multicenter radiomics study
Publication date: Available online 16 August 2019Source: Magnetic Resonance ImagingAuthor(s): Gordian Hamerla, Hans-Jonas Meyer, Stefan Schob, Daniel T. Ginat, Ashley Altman, Tchoyoson Lim, Georg Alexander Gihr, Diana Horvath-Rizea, Karl-Titus Hoffmann, Alexey SurovAbstractBackground and purposeAdvanced imaging analysis for the prediction of tumor biology and modelling of clinically relevant parameters using computed imaging features is part of the emerging field of radiomics research. Here we test...
Magnetic Resonance Imaging
18h
Susceptibility based multiparametric quantification of liver disease: Non-invasive evaluation of steatosis and iron overload
Publication date: Available online 16 August 2019Source: Magnetic Resonance ImagingAuthor(s): Monika Uhrig, Johannes Mueller, Thomas Longerich, Beate Katharina Straub, Lukas R. Buschle, Heinz-Peter Schlemmer, Sebastian Mueller, Christian ZienerAbstractPurposeTo evaluate if single-voxel MR spectroscopy (MRS) of iron and fat correlates with biopsy results of hepatic steatosis and iron overload, and to compare MR-measurements with room-temperature susceptometer (RTS), ultrasound, controlled attenuation...
Magnetic Resonance Imaging
18h
Diffusion kurtosis imaging does not improve differentiation performance of breast lesions in a short clinical protocol
Publication date: Available online 16 August 2019Source: Magnetic Resonance ImagingAuthor(s): Theresa Palm, Evelyn Wenkel, Sabine Ohlmeyer, Rolf Janka, Michael Uder, Elisabeth Weiland, Sebastian Bickelhaupt, Mark E. Ladd, Maxim Zaitsev, Bernhard Hensel, Frederik B. LaunAbstractBackgroundDiffusion weighted magnetic resonance imaging (DWI) is known to differentiate between malignant and benign lesions via the apparent diffusion coefficient (ADC). Here, the value of diffusion kurtosis imaging (DKI)...
Magnetic Resonance Imaging
18h
Identification of carotid non-hemorrhagic lipid-rich necrotic core by magnetization-prepared rapid acquisition gradient-echo imaging: Validation by contrast-enhanced T1 weighted imaging
Publication date: Available online 16 August 2019Source: Magnetic Resonance ImagingAuthor(s): Tao Wang, Huiyu Qiao, Huimin Xu, Dongxiang Xu, Gaifen Liu, Chun Yuan, Xihai Zhao
Magnetic Resonance Imaging
18h
Evaluation of TP53/PIK3CA mutations using texture and morphology analysis on breast MRI
Publication date: Available online 16 August 2019Source: Magnetic Resonance ImagingAuthor(s): Woo Kyung Moon, Hong-Hao Chen, Sung Ui Shin, Wonshik Han, Ruey-Feng ChangAbstractPurposeSomatic mutations in TP53 and PIK3CA genes, the two most frequent genetic alternations in breast cancer, are associated with prognosis and therapeutic response. This study predicted the presence of TP53 and PIK3CA mutations in breast cancer by using texture and morphology analyses on breast MRI.Materials and methodsA...
Magnetic Resonance Imaging
18h
Masthead
The Laryngoscope
18h
A new editor‐in‐chief for the laryngoscope
The Laryngoscope
18h
Table of contents
The Laryngoscope
18h
The contribution of low‐frequency fatigue to the loss of quadriceps contractile function following repeated drop jumps
New Findings What is the central question of this study? Why do some subjects recover slowly following a bout of eccentric exercise and why is recovery faster following a repeated bout? What is the main finding and its importance? The results are consistent with two major causes of the reduction of quadriceps torque, the onset of low‐frequency fatigue which recovered relatively fast and a second, delayed, form of damage. Differences in the delayed damaging process largely accounted for the...
Experimental Physiology
18h
Long-term biochemical outcomes using cesium-131 in prostate brachytherapy
Publication date: Available online 16 August 2019Source: BrachytherapyAuthor(s): Brian J. Moran, Stephanie R. Rice, Arpit M. Chhabra, Neha Amin, Michelle Braccioforte, Manuj AgarwalAbstractPurposeLong-term outcomes reveal equivalent biochemical outcomes with low-dose-rate (LDR) brachytherapy (BT) compared with radical prostatectomy and external-beam radiotherapy for the management of prostate cancer. Iodine-125, the most commonly used isotope, may be associated with long-term urinary consequences....
Brachytherapy
19h
Generating brain matrices for zebra finch brain sectioning using three-dimensional printing technology
Publication date: Available online 16 August 2019Source: Journal of Neuroscience MethodsAuthor(s): Chun-Cheng Huang, Yi-Ying Chen, Yi-Ting Fang, Yu-Chi Chen, Chih-Ming HungAbstractBackgroundThe demand to sample brain regions in non-model species is increasing as more studies are integrating neurological data into behavioural, ecological or evolutionary analysis. However, the sampling operation is difficult for researchers without neuroscience background. It is also a challenge to collect neuroanatomical...
Journal of Neuroscience Methods
19h

Looking to the future of zebrafish as a model to understand the genetic basis of eye disease
Abstract In this brief commentary, we provide some of our thoughts and opinions on the current and future use of zebrafish to model human eye disease, dissect pathological progression and advance in our understanding of the genetic bases of microphthalmia, andophthalmia and coloboma (MAC) in humans. We provide some background on eye formation in fish and conservation and divergence across vertebrates in this process, discuss different approaches for manipulating gene function and...
Human Genetics
20h
Linking visual gamma to task‐related brain networks—a simultaneous EEG‐fMRI study
Abstract There is a growing interest in human gamma‐band oscillatory activity due to its direct link to neuronal populations, its associations with many cognitive processes, and its positive relationship with fMRI BOLD signal. Visual gamma has been successfully detected using concurrent EEG‐fMRI recordings and linked to activity in the visual cortex using voxel‐wise regression analysis. As gamma‐band oscillations reflect predominantly feedforward projections between brain regions, its inclusion...
Psychophysiology
20h
Effects of acute prolonged sitting on cerebral perfusion and executive function in young adults: A randomized cross‐over trial
Abstract Exposure to acute prolonged sitting reportedly leads to decreased cerebral blood flow. However, it is unclear whether this exposure translates to decreased cerebral perfusion and executive function or whether simple strategies to break up sitting can maintain cerebral perfusion and executive function. This study sought to answer two questions: in young, healthy adults, (a) does prolonged (3 hr) sitting lead to decreased cerebral perfusion and executive function? and (b) does breaking up...
Psychophysiology
20h

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου

Αρχειοθήκη ιστολογίου

Translate