Related ArticlesMargin Analysis in Head and Neck Cancer: State of the Art and Future Directions. Ann Surg Oncol. 2019 Aug 05;: Authors: Li MM, Puram SV, Silverman DA, Old MO, Rocco JW, Kang SY Abstract BACKGROUND: The status of surgical margins is the most important prognosticator for patients undergoing surgical resection of head and neck squamous cell carcinoma (HNSCC). Despite this, analysis of surgical margins is fraught with inconsistencies, including...
Related ArticlesInhibition of ZIP4 reverses epithelial-to-mesenchymal transition and enhances the radiosensitivity in human nasopharyngeal carcinoma cells. Cell Death Dis. 2019 Aug 05;10(8):588 Authors: Zeng Q, Liu YM, Liu J, Han J, Guo JX, Lu S, Huang XM, Yi P, Lang JY, Zhang P, Wang CT Abstract ZIP4 is a zinc transporter involved in epithelial cell morphology and migration in various cancers. In the epithelial-to-mesenchymal transition (EMT), epithelial...
Related ArticlesChange in prevalence and molecular characteristics of isoniazid-resistant tuberculosis over a 10-year period in China. BMC Infect Dis. 2019 Aug 05;19(1):689 Authors: Huo F, Lu J, Zong Z, Jing W, Shi J, Ma Y, Dong L, Zhao L, Wang Y, Huang H, Pang Y Abstract BACKGROUND: Isoniazid (INH) represents the cornerstone for the treatment of cases infected with Mycobacterium tuberculosis (MTB) strains. Several molecular mechanisms have been shown...
Related ArticlesTherapeutic Effect of Ecdysterone Combine Paeonol Oral Cavity Direct Administered on Radiation-Induced Oral Mucositis in Rats. Int J Mol Sci. 2019 Aug 03;20(15): Authors: Yang L, Pan J Abstract Radiation-induced oral mucositis represents an influential factor in cancer patients' accepted radiation therapy, especially in head and neck cancer. This research investigates the treatment effect of Ecdysterone (a steroid derived from the dry...
Related ArticlesPerineurioma of the colon: an uncommon tumor with an unusual location. Report of a case and review of the literature. Pathologica. 2018 Sep;110(2):111-115 Authors: Motta F, Spadola S, Bosco A, Aprile G, Piombino E, Magro G Abstract Perineurioma is a relatively rare benign peripheral nerve sheath tumor composed of cells resembling to normal perineurium. Although this tumor may arise in the context of a nerve (intraneural perineurioma),...
Related ArticlesNumerical simulation of thermal water delivery in the human nasal cavity. Comput Biol Med. 2018 09 01;100:62-73 Authors: Covello V, Pipolo C, Saibene A, Felisati G, Quadrio M Abstract This work describes an extensive numerical investigation of thermal water delivery for the treatment of inflammatory disorders in the human nasal cavity. The numerical simulation of the multiphase air-droplets flow is based upon the Large Eddy Simulation...
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Publication date: Available online 6 August 2019Source: Clinics in Plastic SurgeryAuthor(s): Mario Pelle-Ceravolo, Matteo Angelini
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Publication date: 1 January 2020Source: Talanta, Volume 206Author(s): Hongyi Zhang, Zhen Qiao, Ningning Wei, Yanru Zhang, KeWei WangAbstractNitroxyl (HNO), generated from nitric oxide (NO) in biological system, plays distinct biological roles in physiological process, but the role of endogenous HNO in biosystems still remains unclear, because of lacking of specific and sensitive detector to monitor HNO in real time. The conventional methods indicate the level of HNO through detecting the ultimate...
Publication date: 1 January 2020Source: Talanta, Volume 206Author(s): Yuanyuan Li, Qianqian Du, Xiaodan Zhang, Yuming HuangAbstractTetracycline (TC), a widely-used antibiotic to treat bacterial infections, combines with Eu3+ to form a stable EuTC complex that has a low fluorescence (FL) yield because of Eu3+ coordination with water molecules. We report a simple, label-free ratiometric fluorescent platform for sensitively and selectively sensing of TC, using L-histidine caped gold nanoclusters (His-AuNCs)...
Publication date: 1 January 2020Source: Talanta, Volume 206Author(s): Yihui Liu, Yuhui Wang, Kai Jiang, Shan Sun, Sihua Qian, Qiaoping Wu, Hengwei LinAbstractHemoglobin (Hb) plays an important role in oxygen carriage for mammals, which is also a typical biomarker for certain diseases. Although numerous methods had been developed for the detection of Hb in red blood cells, analytical technology for the monitoring of low-abundance Hb in serum or plasma is still a challenge. Herein, persistent luminescence...
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Abstract Primary melanocytes isolated from skin and expanded in culture have been widely used for laboratory research and clinical applications. The conventional method to isolate primary melanocytes from skin usually requires about 3 to 4 weeks of culture for melanocytes to grow sufficiently to passage. Considering that melanocytes comprise only 3‐7% of epidermal cells in normal human skin, it would be extremely helpful to increase the isolation efficiency and shorten the initial culture time to...
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Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Agro‐Kanesho submitted a request to the competent national authority in Germany to modify the existing maximum residue level (MRLs) for the active substance acequinocyl in citrus fruits. The data submitted in support of the request were found to be sufficient to derive MRL proposals for grapefruits, oranges, lemons, limes and mandarins. Adequate analytical methods for enforcement are available to control the residues...
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ABSTRACT Optical projection tomography (OPT) is a 3D mesoscopic imaging modality that can utilize absorption or fluorescence contrast. 3D images can be rapidly reconstructed from tomographic data sets sampled with sufficient numbers of projection angles using the Radon transform, as is typically implemented with optically cleared samples of the mm‐to‐cm scale. For in vivo imaging, considerations of phototoxicity and the need to maintain animals under anesthesia typically preclude the acquisition...
ABSTRACT An optical forward‐scatter model was generalized to encompass the diverse nature of bacterial colony morphologies and the spectral information. According to the model, the colony shape and the wavelength of incident light significantly affect the characteristics of a forward elastic‐light‐scattering pattern. To study the relationship between the colony morphology and the scattering pattern, 3‐dimensional colony models were generated in various morphologies. The propagation of light passing...
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Oncogenesis, Published online: 06 August 2019; doi:10.1038/s41389-019-0149-8Hydrogen peroxide inducible clone-5 sustains NADPH oxidase-dependent reactive oxygen species-c-jun N-terminal kinase signaling in hepatocellular carcinoma
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Abstract Place and Duration Initial Audit of CT PS performed at Royal Sussex County Hospital over a three month period from 1st December 2016 to 1st March 2017. Following focused clinician education and the introduction of a CT paranasal sinus protocol a second audit cycle was performed from 1st June 2017 to 1st August 2017. Methods All patients who had CT paranasal sinuses requested by the ENT department within the audit cycle periods were included. Retrospective electronic case nose review...
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Sibling competition shapes survival and reproductive outcomes in captive callitrichine monkeys. Abstract In many birds and mammals, the size and sex composition of litters can have important downstream effects for individual offspring. Primates are model organisms for questions of cooperation and conflict, but the factors shaping interactions among same‐age siblings have been less‐studied in primates because most species bear single young. However, callitrichines (marmosets, tamarins, and lion...
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Multiple sclerosis (MS) has classically been described as a disease of the young Caucasian female. While the prevalence may seem to be higher in Caucasians (CAs), recent studies suggest that the real incidence of MS may actually be higher in African Americans (AAs). Here, we discuss a nonclassical case of MS in an older African American male, prognostic factors, disease patterns in African Americans, and how a delay in diagnosis and socioeconomic factors can lead to worse outcomes. In patients that...
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A phosphite mediated [2,3]‐aza‐Wittig rearrangement has been developed for the regio‐ and enantioselective allylic alkylation of six‐membered hetero‐aromatic compounds (azaarenes). The nucleophilic phosphite adduct of N‐allyl salts undergoes a stereoselective base mediated aza‐Wittig rearrangement and dissociation of the chiral phosphite for overall C–H functionalization of azaarenes. This method provides efficient access to tertiary and quaternary chiral centers in isoquinoline, quinoline,...
Dihydroartemisinin (DHA) has attracted increasing attention as an innovative anticancer agent. However, using DHA to treat cancer usually depends on the synergistic effect of exogenous components and the unexpected release of DHA during delivery greatly reduces the effectiveness of cancer therapy. Herein, we reported a programmed release nanoplatform of DHA to synergistically treat cancer with CaCO3 mineralized Fe‐TCPP NMOF, which could avoid DHA leakage during transport in bloodstream. When the...
The use of photodynamic therapy (PDT) to treat various types of cancer has received increasing attention over the last years. However, the clinically used photosensitisers (PSs) have some limitations that include poor aqueous solubility, hepatotoxicity, photobleaching, aggregation and slow clearance from the body, leading to photosensitivity. To circumvent these drawbacks, the design of new classes of PSs is of high interest. Herein, we present the first example of the use of bis(dipyrrinato)zinc(II)...
The targeted delivery of chemotherapeutic drugs is a major challenge in the clinical treatment of cancer. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier of a highly potent platinum‐based DNA intercalator (56MESS) in vivo. In our rational design, 56MESS was efficiently loaded into the double‐bundle DNA tetrahedron through intercalation with DNA duplex. With the integration of a nanobody that both targets and blocks epidermal growth factor receptor (EGFR) of tumor...
Activated endocytosis of extracellular macromolecules and their intracellular trafficking to lysosomes is an essential metabolic mechanism in cancer cells during the high rates proliferation. Cancer cells reuse a vast amount of GlcNAc supplied from GlcNAc salvage pathway for the accelerated synthesis of a pivotal UDP‐GlcNAc. Method to inactivate key glycosidases in lysosomes could critically contribute to the development of potent anticancer therapy. Here we demonstrate that “nanosomes” made of core...
The sun is the most sustainable light source available on our planet; therefore, the direct use of sunlight for photochemistry is extremely appealing. Here, we demonstrate for the first time that a diverse set of photon‐driven transformations can be efficiently powered by solar irradiation with the use of solvent‐resistant and cheap Luminescent Solar Concentrator‐based Photomicroreactors. Blue, green and red reactors can accommodate both homogeneous and multiphase reaction conditions, including photochemical...
New heterogeneous Brønsted acid catalysts with high activity and selectivity are critically needed to substitute precious acid‐based catalysts for the sustainable production of fine and commodity chemicals. However, the advance in synthetic methodology for the preparation of such highly desirable catalysts remains a huge scientific challenge. Herein, we report the incorporation of chiral phosphoric acids into indium‐based metal‐organic frameworks (In‐MOFs) by sterically preventing them from coordination....
Interfacial molecular interactions control many biological processes and can be mediated by diverse chemical and physical stimuli. New stimuli‐responsive strategies are desired to provide versatile systems that can regulate cell behavior. Here, we describe potential‐responsive surfaces that control cell adhesion and release as well as stem cell differentiation. Cell adhesion can be modulated dynamically by applying negative and positive potentials to surfaces functionalized with tailored monolayers....
Polystyrene‐g‐boramines random copolymers are dihydrogen reservoirs with tunable dehydrogenation temperatures, which can be adjusted by selecting the boramine content in the copolymers. They display a unique dihydrogen thermal release profile, which is a direct consequence of the insertion of the amine‐boranes in a polymeric scaffold, and not from a direct modification of the electronics or sterics of the amine‐borane function. Finally, the mixture of polystyrene‐g‐boramines with conventional NH3‐BH3...
Most structure‐based drug discovery protocols utilize crystal structures of receptor proteins. Crystal engineering, on the other hand, utilizes the wealth of chemical information inherent in small‐molecule crystal structures in the Cambridge Structural Database (CSD). Here we show that interaction surfaces and shapes of molecules in experimentally determined small‐molecule crystal structures can serve as effective tools in drug discovery. Our description of the shape and interaction propensities...
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Abstract Chronic Intestinal Pseudo‐Obstruction (CIPO) is a rare gastrointestinal disorder, which affects the smooth muscle contractions of the gastrointestinal tract. Dominant mutations in the smooth muscle actin gene, ACTG2, accounts for 44‐50% of CIPO patients. Other recessive or X‐linked genes, including MYLK, LMOD1, RAD21, MYH11, MYL9, and FLNA were reported in single cases. In this study, we used Whole‐Exome Sequencing (WES) to study 23 independent CIPO families including one extended...
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Background and Objectives Transoral laser surgery is the optimal surgical treatment modality for the early stages of glottic cancer. To allow for further treatment to be as effective and as minimal as possible, persistent or recurrent tumors should be detected very soon. The main aim is to minimize the risk of necessity of performing a total laryngectomy. Flexible videoendoscopy with narrow band imaging (NBI) was recommended by the European Laryngological Society as a diagnostic method for the follow‐up...
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