A 56-year-old woman presented to the emergency department with a 1-month history of epigastric and left-upper-quadrant abdominal pain. Her medical history included polysubstance use disorder (including cocaine and heroin use) and hepatitis C virus infection, as well as rheumatoid arthritis, for…
A 35-year-old man presented to the emergency department with a 3-week history of fatigue and painful distention of the left side of his abdomen. He had a history of hepatosplenic T-cell lymphoma and had completed treatment 9 months earlier. Physical examination revealed massive enlargement of the…
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Background: The prevalence of obstructive sleep apnea (OSA) is very high in stroke patients, whereas the acceptance of positive airway pressure (PAP) therapy is low. Although telemedicine offers new options to increase acceptance, effective concepts and patient groups are not yet known. Objective: The aim of this study was to investigate the effect of a telemedicine concept consisting of telemonitoring and support when usage time drops. Methods: PAP naive stroke patients with apnea-hypopnea index...
Background: When introducing new equipment or reference equations into the lung function laboratory, systematic z-score deviations could arise due to local differences in population or equipment. Objective: To propose a workable method for aligning reference equations with lung function equipment. Method: Using two cases of equipment transition in our laboratory as a test case, we first performed lung function testing after the transition, on a control group of 40 normal young adults (20 male/20...
Acute pulmonary embolism (PE) impairs hemodynamics, gas exchange, and lung mechanical capacity. Considering PE pathophysiology, most attention has been paid to hemodynamic impairment. However, the most prevalent symptoms in PE patients come from gas exchange alterations, which have not been in the spotlight for many years. Pulmonary physiology and consequent gas exchange impairment play a pivotal role in the high risk of death from PE. In this review, we will look at the pathophysiology of PE, from...
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Publication date: October 2019Source: Magnetic Resonance Imaging, Volume 62Author(s):
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Publication date: Available online 6 August 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Scott Rooney, Leslie Wood, Fiona Moffat, Lorna PaulAbstractObjectiveTo determine the relationship between self-reported fatigue and aerobic capacity and muscle strength in people with Multiple Sclerosis (MS).Data sourcesFour databases (CINAHL, MEDLINE, ProQuest, and Web of Science Core Collections) were searched up to October 2018.Study selectionCross-sectional or longitudinal studies...
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Publication date: Available online 6 August 2019Source: CortexAuthor(s): Giovanni Anobile, David C. Burr, Filippo Gasperini, Guido Marco CicchiniAbstractDyscalculia is often associated with poor numerosity sensitivity. However, it is not known whether the perceptual systems of dyscalculics have implicit access to the sensory noise of numerosity judgments, and whether their perceptual systems take the noise levels into account in optimizing their perception. We tackled this question by measuring central...
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Publication date: Available online 6 August 2019Source: Behavioural Brain ResearchAuthor(s): Antonio Luque-Casado, Noa Fogelson, Eliseo Iglesias-Soler, Miguel Fernandez-del-OlmoAbstractBackgroundThe interest in the use of anodal transcranial direct current stimulation (tDCS) for the enhancement of cognitive functioning has increased significantly in recent years. However, the efficacy of this technique remains to be established.ObjectiveThe current study explored the effects of anodal vs. sham tDCS...
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Publication date: Available online 7 August 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): George A. Antoniou, Stavros A. Antoniou
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Researchers have investigated the evolution of the two most prevalent orchid viruses using information representing their global distribution. The study revealed that considerable international trade of cultivated orchids has effectively 'homogenized' the genetic diversity of the viruses. In other words, the two viruses have displayed few genetic differences since their first emergence, across countries and host plants.
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“If you want to beat me for my heartfelt birthday poem, come and find me at my home. Ask the bodabodamen [male commercial motorcycle drivers] to direct you to Mama Stella’s house with a red gate,” anthropologist Stella Nyanzi wrote at the end of a Facebook post last September. Nyanzi had dedicated the poem to Ugandan President Yoweri Museveni, who has been in office since 1986. On November 2, 2018, the government arrested Nyanzi, charging her with “cyber harassment” and “offensive communication.”...
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Nature Communications, Published online: 07 August 2019; doi:10.1038/s41467-019-11392-6Chiral 1,1-diaryl alkanes are important targets in pharmaceutical industry. Here, the authors report report a redox-neutral enantioselective benzylic C−H bond arylation via photoredox/nickel dual catalysis accessing chiral 1,1-diarylalkane compounds under mild conditions.
Nature Communications, Published online: 07 August 2019; doi:10.1038/s41467-019-11498-xInsulin replacement is a valuable therapy for insulin deficiency, however, other therapies are being investigated to restore metabolic homeostasis. Here, the authors identify S100A9 as a leptin induced circulating cue that improves glucose and lipid homeostasis and extends survival in insulin deficient mice.
Nature Communications, Published online: 07 August 2019; doi:10.1038/s41467-019-11514-0Single-particle tracking PALM (sptPALM) provides quantitative information in vivo if the protein of interest remains in a single diffusional state during track acquisition. Here the authors develop a custom-built sptPALM microscope and a Monte-Carlo based diffusion distribution analysis to study dynamic DNA-dCas9 interactions in live bacteria.
Nature Communications, Published online: 07 August 2019; doi:10.1038/s41467-019-11544-8To fulfill the great promise of Li-O2 batteries, the high charge overpotential is a major challenge that has to be addressed. Here the authors introduce triethylsulfonium iodide as a redox mediator as well as an enabler of a protective layer on Li anode, leading to notable electrochemical performance.
Nature Communications, Published online: 07 August 2019; doi:10.1038/s41467-019-11403-6PIK3CA mutations and ARID1A loss co-exist in endometrial neoplasms. Here, the authors show that these co-mutations drive gene expression profiles correlated with differential chromatin accessibility and ARID1A binding in the endometrial epithelium, resulting in partial EMT and myometrial invasion.
Nature Communications, Published online: 07 August 2019; doi:10.1038/s41467-019-11500-6Vascular remodelling contributes to the development of pulmonary hypertension (PH). Here Luo and colleagues find that increases in CD146 levels drive vascular remodelling in PH through a cross-talk with hypoxia inducible factor (HIF) signalling, and show that inhibition of CD146 can attenuate disease progression.
Nature Communications, Published online: 07 August 2019; doi:10.1038/s41467-019-11578-yMetasurfaces can be programmed for a spatial transformation of the wavefront, allowing on-chip optical signal processing. Here, the authors demonstrate a one-dimensional high-contrast transmitarray metasurface-based lens on SOI substrate and demonstrate functionalities of Fourier transformation and differentiation.
Nature Communications, Published online: 07 August 2019; doi:10.1038/s41467-019-11531-zDigital proximity ligation assay (dPLA) can measure proteins and mRNAs in single cells, but is not compatible with cell imaging and cannot quantify rare proteins due to a high dilution factor. Here the authors present an automated microfluidic device that combines live-cell imaging, chemical stimulation, and dPLA in a smaller reaction volume.
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Publication date: Available online 6 August 2019Source: Journal of VoiceAuthor(s): Elizabeth Johnson Knight, Stephen F. AustinSummaryA study was undertaken to identify the effect of head flexion/extension on singing voice quality. The amplitude of the fundamental frequency (F0) and the singing power ratio (SPR), an indirect measure of Singer's Formant activity, were measured. F0 and SPR scores at four experimental head positions were compared with the subjects’ scores at their habitual positions....
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Publication date: Available online 7 August 2019Source: American Journal of Infection ControlAuthor(s): Kelly A. Reagan, David M. Chan, Ginger Vanhoozer, Michael P. Stevens, Michelle Doll, Emily J. Godbout, Kaila Cooper, Rachel J. Pryor, Robin R. Hemphill, Gonzalo BearmanBackgroundMultiple studies have shown that bathing with chlorhexidine gluconate (CHG) wipes reduces hospital-acquired infections (HAIs). We employed a mathematical model to assess the impact of CHG patient bathing on central line–associated...
Publication date: Available online 7 August 2019Source: American Journal of Infection ControlAuthor(s): Iara Rossi, Sabrina Royer, Melina Lorraine Ferreira, Paola Amaral Campos, Bruna Fuga, Gabriel Nogueira Melo, Luiz Gustavo Machado, Daiane Silva Resende, Deivid Batistão, Jane Eire Urzedo, Paulo P. Gontijo-Filho, Rosineide Marques RibasBackgroundCarbapenem-resistant Acinetobacter baumannii (CR-Ab) has become a worrying health care problem, mainly in developing countries, such as Brazil. The objective...
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