Related ArticlesImaging-guided precision medicine in glioblastoma patients treated with immune checkpoint modulators: research trend and future directions in the field of imaging biomarkers and artificial intelligence. EJNMMI Res. 2019 Aug 20;9(1):78 Authors: Sinigaglia M, Assi T, Besson FL, Ammari S, Edjlali M, Feltus W, Rozenblum-Beddok L, Zhao B, Schwartz LH, Mokrane FZ, Dercle L Abstract Immunotherapies that employ immune checkpoint modulators (ICMs)...
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Related ArticlesHaploidentical hematopoietic stem cell transplantation with αβTCR+/CD19+ depletion in pediatric patients with malignant and non-malignant disorders. Bone Marrow Transplant. 2019 Aug;54(Suppl 2):694-697 Authors: Bielorai B, Jacoby E, Varda-Bloom N, Hutt D, Churi C, Vernitsky H, Toren A Abstract Haploidntical hematopoietic stem cell transplantation has been increasingly used in recent years for patients without a matched donor. The αβTCR+/CD19+...
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Related ArticlesHaploidentical stem cell transplantation (HaploSCT) for patients with acute leukemia-an update on behalf of the ALWP of the EBMT. Bone Marrow Transplant. 2019 Aug;54(Suppl 2):713-718 Authors: Nagler A, Ruggeri A Abstract Allogeneic stem cell transplantations (alloSCT) from haploidentical (>2 HLA mismatch) donors (HaploSCT) are constantly increasing in Europe. From 2005 to 2015 numbers of HaploSCT increased by close to 300%. In parallel,...
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Related ArticlesPseudoprogression after radiation therapies for low grade glioma in children and adults: A systematic review and meta-analysis. Radiother Oncol. 2019 Aug 17;: Authors: Lu VM, Welby JP, Laack NN, Mahajan A, Daniels DJ Abstract BACKGROUND: Pseudoprogression (PsP) following radiation therapy (RT) for low grade glioma (LGG, WHO grade I and II), including both photon-based intensity-modulated RT (IMRT) and proton beam therapy (PBT), has been...
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Related ArticlesAchieving margin negative resection-doing less is justified: oncological outcomes of wedge excision of liver in gallbladder cancer (GBC) surgery. Chin Clin Oncol. 2019 Aug 07;: Authors: Patkar S, Patil V, Acharya MR, Kurunkar S, Goel M Abstract BACKGROUND: The extent of liver resection for gallbladder cancer (GBC) is still debated. We evaluated the post-operative and oncological outcomes of patients with GBC who underwent liver wedge...
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Related ArticlesMultiple bone metastases: what the palliative care specialist should know about the potential, limitations and practical aspects of radiation therapy. Ann Palliat Med. 2019 Aug 08;: Authors: Tsao MN, Barnes EA, Chow E Abstract Bone metastases represent a significant health care problem in the cancer population. The most common symptom for bone metastases is pain. Bone metastases may also cause pathologic fracture, spinal cord compression,...
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Related ArticlesLong Noncoding RNA: Function and Mechanism on Differentiation of Mesenchymal Stem Cells and Embryonic Stem Cells. Curr Stem Cell Res Ther. 2019;14(3):259-267 Authors: Zhu J, Wang Y, Yu W, Xia K, Huang Y, Wang J, Liu B, Tao H, Liang C, Li F Abstract BACKGROUND: Long suspected as transcriptional noise, recently recognized, long non-coding RNAs (lncRNAs) are emerging as an indicator, biomarker and therapy target in the physiologic and...
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Related ArticlesRandomised phase II trial to investigate catumaxomab (anti-EpCAM × anti-CD3) for treatment of peritoneal carcinomatosis in patients with gastric cancer. Br J Cancer. 2018 08;119(3):296-302 Authors: Knödler M, Körfer J, Kunzmann V, Trojan J, Daum S, Schenk M, Kullmann F, Schroll S, Behringer D, Stahl M, Al-Batran SE, Hacker U, Ibach S, Lindhofer H, Lordick F Abstract BACKGROUND: Peritoneal carcinomatosis (PC) represents an unfavourable...
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Related ArticlesClinical Indications for Carbon Ion Radiotherapy. Clin Oncol (R Coll Radiol). 2018 05;30(5):317-329 Authors: Mohamad O, Yamada S, Durante M Abstract Compared with photon and proton therapy, carbon ion radiotherapy (CIRT) offers potentially superior dose distributions, which may permit dose escalation with the potential for improved sparing of adjacent normal tissues. CIRT has increased biological effectiveness leading to increased tumour...
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Related ArticlesTowards personalized, tumour-specific, therapeutic vaccines for cancer. Nat Rev Immunol. 2018 03;18(3):168-182 Authors: Hu Z, Ott PA, Wu CJ Abstract Cancer vaccines, which are designed to amplify tumour-specific T cell responses through active immunization, have long been envisioned as a key tool of effective cancer immunotherapy. Despite a clear rationale for such vaccines, extensive past efforts were unsuccessful in mediating clinically...
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207 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: health technology These pubmed results were generated on 2019/08/22PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Related ArticlesNovel variant p.E269K confirms causative role of PLS1 mutations in autosomal dominant hearing loss. Clin Genet. 2019 Aug 21;: Authors: Diaz-Horta O, Bademci G, Tokgoz-Yilmaz S, Guo S, Zafeer F, Sineni CJ, Duman D, Farooq A, Tekin M Abstract Auditory reception relies on the perception of mechanical stimuli by stereocilia and its conversion to electrochemical signal. Mechanosensory stereocilia are abundant in actin, which provides them...
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Related ArticlesAxonal sprouting in the dorsal cochlear nucleus affects gap‑prepulse inhibition following noise exposure. Int J Mol Med. 2019 Aug 19;: Authors: Han KH, Mun SK, Sohn S, Piao XY, Park I, Chang M Abstract One of the primary theories of the pathogenesis of tinnitus involves maladaptive auditory‑somatosensory plasticity in the dorsal cochlear nucleus (DCN), which is assumed to be due to axonal sprouting. Although a disrupted balance between...
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Related ArticlesDexamethasone-loaded chitosan-based genipin-cross-linked hydrogel for prevention of cisplatin induced ototoxicity in Guinea pig model. Int J Pediatr Otorhinolaryngol. 2019 Jul;122:60-69 Authors: Yüksel Aslıer NG, Tağaç AA, Durankaya SM, Çalışır M, Ersoy N, Kırkım G, Yurdakoç K, Bağrıyanık HA, Yılmaz O, Sütay S, Güneri EA Abstract OBJECTIVES: The aim of this study was to investigate the protective effects of a sustained release form of...
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Related ArticlesModulation of radiation sensitivity and antitumor immunity by viral pathogenic factors: Implications for radio-immunotherapy. Biochim Biophys Acta Rev Cancer. 2019 01;1871(1):126-137 Authors: Rödel F, Martin D, Balermpas P, Wieland U, Winkelmann R, Riekmann T, Falk S, Rödel C, Fokas E Abstract Several DNA viruses including Human Papillomavirus (HPV), Epstein-Barr virus (EBV), and Human cytomegalovirus (HCMV) are mechanistically associated...
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Related ArticlesComparison of anal cancer screening strategies including standard anoscopy, anal cytology, and HPV genotyping in HIV-positive men who have sex with men. Br J Cancer. 2018 08;119(3):381-386 Authors: Pernot S, Boucheron P, Péré H, Lucas ML, Veyer D, Fathallah N, de Parades V, Pavie J, Netter J, Collias L, Taieb J, Grabar S, Weiss L Abstract BACKGROUND: There is no consensus on screening strategy of high-grade intraepithelial neoplasia...
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HPV Self-Sampling for Primary Cervical Cancer Screening: A Review of Diagnostic Test Accuracy and Clinical Evidence – An Update Book. 2019 05 30Authors: Chao YS, McCormack S Abstract The introduction of cervical cancer screening and timely intervention is associated with the recent decrease in cervical cancer incidence.1 There are several options to screen cervical cancer. Two of the methods commonly used in Canada are cytology and human papillomavirus (HPV) tests.2 Cytology...
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Mechanisms Associated with the Adverse Vascular Consequences of Rapid Posthypothermic Rewarming and Their Therapeutic Modulation in Rats. Ther Hypothermia Temp Manag. 2019 Aug 21;: Authors: Ueda Y, Oda Y, Povlishock JT, Wei EP Abstract We previously demonstrated that rapid posthypothermic rewarming in noninjured animals was capable of damaging cerebral arterioles both at endothelial and smooth muscle levels. Such adverse consequences could be prevented...
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Hypothermia post-cardiopulmonary resuscitation with low inputs: an experience report. Rev Bras Enferm. 2019 Aug 19;72(4):1114-1118 Authors: Lazzarini MTB, Bonjorno Junior JC, Fernandes MP, Sant Anna ALGG, Machado RC Abstract OBJECTIVE: to report the experience of conducting directed temperature control of a post-cardiopulmonary resuscitation patient, with reduced and basic inputs available at the institution. METHOD: an experience report of...
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Related ArticlesHospital survey showed wide variations in therapeutic hypothermia for neonates in Germany. Acta Paediatr. 2019 Aug 20;: Authors: Giannakis S, Ruhfus M, Rüdiger M, Sabir H, German Neonatal Hypothermia Network Abstract Perinatal asphyxia is a major contributor to neonatal death in term born infants. Hypoxic-ischaemic encephalopathy (HIE) is the most important asphyxia-related complication affecting the newborn brain and causes 23% of neonatal...
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Related ArticlesDo parents have knowledge of first aid management of burns in their children? A hospital based survey. J Pak Med Assoc. 2019 Aug;69(8):1142-1145 Authors: Naumeri F, Ahmad HM, Yousaf MS, Waheed K, Farooq MS Abstract OBJECTIVE: To ascertain knowledge of first aid among parents of children suffering from burns. METHODS: The cross-sectional study was conducted at Mayo Hospital, Lahore, Pakistan, from July 2017 to January 2018, and...
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Related ArticlesNeuroprotection for ischemic stroke in the endovascular era: A brief report on the future of intra-arterial therapy. J Clin Neurosci. 2019 Aug 17;: Authors: Griauzde J, Ravindra VM, Chaudhary N, Gemmete JJ, Pandey AS Abstract Mechanical thrombectomy is now at the forefront of the treatment of large vessel acute ischemic stroke (AIS). Selective intra-arterial (IA) access has opened a new avenue for neuroprotection in AIS that has the potential...
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The relationship between hearing loss and insomnia for patients with tinnitus. Int J Audiol. 2019 Aug 21;:1-5 Authors: Aazh H, Heinonen-Guzejev M, Moore BCJ Abstract Objective: It is possible that tinnitus, hearing loss and insomnia are all linked to oxidative stress. If so, there should be a relationship between insomnia and hearing loss among patients with tinnitus. The aim of this study was to assess the relationship between insomnia and hearing thresholds...
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Clinicians' views of using cortical auditory evoked potentials (CAEP) in the permanent childhood hearing impairment patient pathway. Int J Audiol. 2019 Aug 21;:1-9 Authors: Mehta K, Mahon M, Van Dun B, Marriage J, Vickers D Abstract Objective: To obtain clinicians' views on the use of cortical auditory evoked potentials (CAEP) in the clinical pathway. Design: A questionnaire aimed at clinicians who use the HEARLab system with the Aided Cortical Assessment...
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40 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: macrophage These pubmed results were generated on 2019/08/22PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming. Cell Rep. 2019 Aug 20;28(8):1971-1980.e8 Authors: Buj R, Chen CW, Dahl ES, Leon KE, Kuskovsky R, Maglakelidze N, Navaratnarajah M, Zhang G, Doan MT, Jiang H, Zaleski M, Kutzler L, Lacko H, Lu Y, Mills GB, Gowda R, Robertson GP, Warrick JI, Herlyn M, Imamura Y, Kimball SR, DeGraff DJ, Snyder NW, Aird KM Abstract Reprogrammed metabolism and cell cycle dysregulation are two cancer...
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Neutral iridium(iii) complexes bearing BODIPY-substituted N-heterocyclic carbene (NHC) ligands: synthesis, photophysics, in vitro theranostic photodynamic therapy, and antimicrobial activity. Photochem Photobiol Sci. 2019 Aug 21;: Authors: Liu B, Monro S, Jabed MA, Cameron CG, Colón KL, Xu W, Kilina S, McFarland SA, Sun W Abstract The synthesis, photophysics, and photobiological activities of a series of novel neutral heteroleptic cyclometalated iridium(iii)...
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Related ArticlesQuinalizarin induces cycle arrest and apoptosis via reactive oxygen species-mediated signaling pathways in human melanoma A375 cells. Drug Dev Res. 2019 Aug 20;: Authors: Luo YH, Li JQ, Zhang Y, Wang JR, Xu WT, Zhang Y, Feng YC, Li SZ, Jin CH Abstract Quinalizarin, a bioactive and highly selective compound, is known to promote apoptosis in colon and lung cancer cells. However, studies evaluating quinalizarin-induced apoptosis in melanoma...
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Related ArticlesMcl-1 Inhibitor Induces Cells Death in BRAF-Mutant Amelanotic Melanoma Trough GSH Depletion, DNA Damage and Cell Cycle Changes. Pathol Oncol Res. 2019 Aug 20;: Authors: Respondek M, Beberok A, Rzepka Z, Rok J, Wrześniok D Abstract Mcl-1 is a potent antiapoptotic protein and amplifies frequently in many human cancer. Currently, it is considered that the extensively expressed of Mcl-1 protein in melanoma cells is associated with rapid tumor...
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Related ArticlesInflammasome activity in leucocytes decreases with abdominal aortic aneurysm progression. Int J Mol Med. 2019 Aug 07;: Authors: Erhart P, Cakmak S, Grond-Ginsbach C, Hakimi M, Böckler D, Dihlmann S Abstract Abdominal aortic aneurysms (AAAs) are characterized by chronic inflammatory cell infiltration. The present extended immunohistochemistry study aimed to characterize inflammation in AAA and aortic control samples. In specific, the composition...
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Related ArticlesThe inhibitory effect of silk sericin against ultraviolet-induced melanogenesis and its potential use in cosmeceutics as an anti-hyperpigmentation compound. Photochem Photobiol Sci. 2019 Aug 21;: Authors: Kumar JP, Mandal BB Abstract Ultraviolet radiation (UVR)-induced redox imbalance in melanocytes triggers the activation of tyrosinase that results in melanogenesis and its related skin disorders. Supplementation of biological reductants...
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Related ArticlesDesmoplastic Melanoma: Clinical Characteristics and Survival in the US Population. Cureus. 2019 Jun 18;11(6):e4931 Authors: Huayllani MT, Sisti A, Restrepo DJ, Boczar D, Cochuyt JJ, Spaulding AC, Bagaria SP, Rinker BD, Forte AJ Abstract Objective Desmoplastic melanoma (DM) is a rare variant of invasive malignancy of the skin pigmented cells. We present a comprehensive study reporting on US demographics, disease characteristics, and survival,...
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Related ArticlesPrevalence and Predictors of the Use of Sunscreen Amongst Medical Students: A Multi-center Cross-sectional Study. Cureus. 2019 Jun 17;11(6):e4926 Authors: Memon MM, Manzoor M, Ashrafi MM, Kumar S, Ul Haq Z, Irfan S, Navid Z, Khan MA, Shahid I, Nisar M, Shaikh S, Hassan SN, Motiani V, Khan MS Abstract Objective Sun exposure is a primary preventable risk factor for skin cancer. Sunscreen has been shown to reduce the risk of certain skin...
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Related ArticlesMitofusins modulate the increase in mitochondrial length, bioenergetics and secretory phenotype in therapy-induced senescent melanoma cells. Biochem J. 2019 Aug 20;: Authors: Martínez J, Tarallo D, Martínez-Palma L, Victoria S, Bresque M, Rodríguez-Bottero S, Marmisolle I, Escande C, Cassina P, Casanova G, Bollati-Fogolín M, Agorio C, Moreno M, Quijano C Abstract Cellular senescence is an endpoint of chemotherapy, and targeted therapies...
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Related ArticlesIdentification of recurrent activating HER2 mutations in primary canine pulmonary adenocarcinoma. Clin Cancer Res. 2019 Aug 20;: Authors: Lorch G, Sivaprakasam K, Zismann VL, Perdigones N, Contente-Cuomo T, Nazareno A, Facista SJ, Wong S, Drenner K, Liang WS, Amann JM, Sinicropi-Yao SL, Koenig MJ, LaPerle K, Whitsett TG, Murtaza M, Trent JM, Carbone DP, Hendricks WPD Abstract PURPOSE: Naturally occurring primary canine lung cancers share...
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Related ArticlesNew cytotoxic cembranolides from an Okinawan soft coral, Lobophytum sp. Fitoterapia. 2019 Jul;136:104162 Authors: Roy PK, Roy S, Ueda K Abstract Three new cembranolides (1-3) were isolated from an Okinawan soft coral, Lobophytum sp., together with the known cembranolide diterpenoids (4-9). Their structures were determined by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS), molecular modeling, and comparison with...
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Explanation for different behavior of peripheral and central giant cell granuloma by CD44 and CD34 immunostaining. J Investig Clin Dent. 2019 Aug 21;:e12451 Authors: Zargaran M, Baghaei F, Moghimbeigi A, Baghai F Abstract AIM: Despite their histopathological similarity, unlike peripheral giant cell granuloma (PGCG), central giant cell granuloma (CGCG) is an osteolytic lesion. Low motility of osteoclasts as bone-resorbing agents decreases osteolysis where...
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A simple modification in technique preserves oblique muscle fibers during peroral endoscopic myotomy. Endoscopy. 2019 Aug 21;: Authors: Nabi Z, Ramchandani M, Kotla R, Chavan R, Darisetty S, Reddy DN PMID: 31434154 [PubMed - as supplied by publisher]
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Related ArticlesSuffering-based medicine: practicing scientific medicine with a humanistic approach. Med Health Care Philos. 2019 Aug 20;: Authors: Del Giglio A Abstract Suffering, defined as a state of undergoing pain, distress or hardship, is a multidimensional concept; it can entail physical, psychological and spiritual distress that prompts the sufferer to seek medical attention. As a construct originating from and unique to each patient, no patient's...
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