Abstract Objective To assess whether systemic sclerosis (SSc) is associated with total knee arthroplasty (TKA) outcomes. Methods We used the 1998–2014 US National Inpatient Sample. We conducted multivariable-adjusted logistic regression analyses to examine the association of a diagnosis of SSc with post-TKA in-hospital complications (implant infection, revision,...
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Abstract Introduction Kimura disease (KD) is a rare idiopathic inflammatory disorder of unknown etiology. Unusual presentations of KD might cause diagnostic difficulty or be misdiagnosed as malignancy if clinical suspicion is insufficiently high. Here, we aimed to determine the clinicopathological features of Chinese KD patients to reveal further insights into the natural history and treatment of this disease. ...
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Abstract Introduction/objectives The aim of our study was to investigate possible differences in nailfold videocapillaroscopy (NVC) features between patients with dermatomyositis (DM), overlap myositis (OM), antisynthetase syndrome (ASS), and immune-mediated necrotizing myopathy (IMNM). Methods We performed a cross-sectional monocentric study. All patients...
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Abstract To systematically review the role of ultrasound (US) in the assessment of the joint-enthesial-nail apparatus in patients with psoriatic arthritis (PsA) or psoriasis (PSO) in terms of prevalence, diagnosis, prognosis, monitoring and treatment. A systematic literature review was conducted through medical databases (PubMed, Embase) and the grey literature up to February 2018. The main areas of application of nail US were first identified, allowing the development of research...
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In recent years, nanoparticles (NPs) have repetitively been reported to play a significant role in modern medicine. They have been analyzed for different clinical applications, such as drug carriers, gene delivery to tumors, and contrast agents in imaging.In this review, we discuss the role of NPs in treating cancer among different drug delivery methods for cancer therapy. Abstract Rapid growth in nanotechnology toward the development of nanomedicine agents holds massive promise to improve therapeutic...
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Background In recent years, insulinoma‐associated protein 1 (INSM1) has been shown to be a key regulator of neuroendocrine development, and it has been evaluated for diagnostic use in some organs. Methods To evaluate the relationship between INSM1 and synaptophysin, and to confirm the cutoff value using receiver operating characteristic curve (ROC) analysis, the authors performed INSM1 immunocytochemistry using cell block (CB) samples from 53 cases of bronchial brushings and 32 cases of pleural...
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Summary Background Tegoprazan (CJ‐12420) is a potassium‐competitive acid blocker (P‐CAB) with therapeutic potential for gastro‐oesophageal reflux disease (GERD) by reversibly suppressing gastric H+/K+‐ATPase. Aims To investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of tegoprazan Methods A phase I, randomised, double‐blind and placebo‐controlled clinical trial was conducted in 56 healthy male subjects without Helicobacter pylori infection. In the single ascending...
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In this review, we focus on how the presence and/or abundance of interacting species (i.e., the community context) influences evolutionary effects of human‐caused global changes because (1) the global change alters the strength of species interactions and the strength of selection imposed by species interactions, or reciprocally (2) species interactions alter the strength of selection imposed directly by global change. Abstract Evolution in nature occurs in the proverbial tangled bank. The...
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This paper aimed to identify novel interacting partners of adhesion G protein–coupled receptors (ADGRs) through affinity proteomics utilizing tandem affinity purifications combined with mass spectrometry. The data suggest that ADGRs not only have functional roles at synapses but also at intracellular membranes. Furthermore, nuclear localization of ADGR domains together with their physical interaction with several transcription factors suggest a role of ADGRs in gene regulation. Abstract Adhesion...
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Key points Obstructive sleep apnoea (OSA) is characterized by intermittent hypoxia, which causes oxidative stress and inflammation and increases the risk of cardiovascular disease. OSA during pregnancy causes adverse maternal and fetal outcomes. The effects of pre‐existing OSA in pregnant women on cardiometabolic outcomes in the offspring are unknown. We evaluated basic metabolic parameters, as well as aortic vascular and perivascular adipose tissue (PVAT) function in response to adiponectin,...
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Zusammenfassung Die Therapie möglicher ursächlicher, prozedurenspezifischer und/oder -begleitender Akutschmerzen ist ein essenzielles Qualitätsmerkmal in jedem chirurgischen Fachgebiet. Ziele einer interdisziplinären und interprofessionellen Schmerztherapie sind unmittelbar eine Verbesserung der Lebensqualität durch Schmerzfreiheit, mittelfristig eine Reduktion des postoperativen Morbiditäts- und Mortalitätsrisikos, langfristig eine Verhinderung der Chronifizierung von Schmerzen...
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IJMS, Vol. 20, Pages 4113: Emerging Role of Genetic Alterations Affecting Exosome Biology in Neurodegenerative Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20174113 Authors: Paola Riva Cristina Battaglia Marco Venturin The abnormal deposition of proteins in brain tissue is a common feature of neurodegenerative diseases (NDs) often accompanied by the spread of mutated proteins, causing neuronal toxicity. Exosomes play a fundamental role on their releasing...
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IJMS, Vol. 20, Pages 4109: Induction of Necrosis in Human Macrophage Cell Lines by Corynebacterium diphtheriae and Corynebacterium ulcerans Strains Isolated from Fatal Cases of Systemic Infections International Journal of Molecular Sciences doi: 10.3390/ijms20174109 Authors: Dulanthi Weerasekera Jonas Hahn Martin Herrmann Andreas Burkovski When infecting a human host, Corynebacterium diphtheriae and Corynebacterium ulcerans are able to impair macrophage maturation and induce...
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IJMS, Vol. 20, Pages 4110: Neuroprotective and Anti-Inflammatory Effects of a Hydrophilic Saffron Extract in a Model of Glaucoma International Journal of Molecular Sciences doi: 10.3390/ijms20174110 Authors: Jose A. Fernández-Albarral Ana I. Ramírez Rosa de Hoz Nerea López-Villarín Elena Salobrar-García Inés López-Cuenca Ester Licastro Antonio M. Inarejos-García Paula Almodóvar Maria D. Pinazo-Durán José M. Ramírez Juan J. Salazar Glaucoma is a neurodegenerative...
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IJMS, Vol. 20, Pages 4106: In Silico Prediction of Drug-Induced Liver Injury Based on Ensemble Classifier Method International Journal of Molecular Sciences doi: 10.3390/ijms20174106 Authors: Wang Xiao Chen Wang Drug-induced liver injury (DILI) is a major factor in the development of drugs and the safety of drugs. If the DILI cannot be effectively predicted during the development of the drug, it will cause the drug to be withdrawn from markets. Therefore, DILI is crucial...
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IJMS, Vol. 20, Pages 4108: Perineuronal Nets and Their Role in Synaptic Homeostasis International Journal of Molecular Sciences doi: 10.3390/ijms20174108 Authors: Mateusz Bosiacki Magdalena Gąssowska-Dobrowolska Klaudyna Kojder Marta Fabiańska Dariusz Jeżewski Izabela Gutowska Anna Lubkowska Extracellular matrix (ECM) molecules that are released by neurons and glial cells form perineuronal nets (PNNs) and modulate many neuronal and glial functions. PNNs, whose structure...
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IJMS, Vol. 20, Pages 4107: Plastid Genomes of Carnivorous Plants Drosera rotundifolia and Nepenthes × ventrata Reveal Evolutionary Patterns Resembling Those Observed in Parasitic Plants International Journal of Molecular Sciences doi: 10.3390/ijms20174107 Authors: Eugeny V. Gruzdev Vitaly V. Kadnikov Alexey V. Beletsky Elena Z. Kochieva Andrey V. Mardanov Konstantin G. Skryabin Nikolai V. Ravin Carnivorous plants have the ability to capture and digest small animals...
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IJMS, Vol. 20, Pages 4105: The Hen or the Egg: Impaired Alveolar Oxygen Diffusion and Acute High-altitude Illness? International Journal of Molecular Sciences doi: 10.3390/ijms20174105 Authors: Heimo Mairbäurl Christoph Dehnert Franziska Macholz Daniel Dankl Mahdi Sareban Marc M. Berger Individuals ascending rapidly to altitudes >2500 m may develop symptoms of acute mountain sickness (AMS) within a few hours of arrival and/or high-altitude pulmonary edema (HAPE),...
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IJMS, Vol. 20, Pages 4111: The Ability to Regulate Transmembrane Potassium Transport in Root Is Critical for Drought Tolerance in Barley International Journal of Molecular Sciences doi: 10.3390/ijms20174111 Authors: Kangfeng Cai Huaizhou Gao Xiaojian Wu Shuo Zhang Zhigang Han Xiaohui Chen Guoping Zhang Fanrong Zeng In this work, the effect of drought on K+ uptake in root and its translocation from root to shoot was investigated using six barley genotypes contrasting...
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IJMS, Vol. 20, Pages 4104: VceC Mediated IRE1 Pathway and Inhibited CHOP-induced Apoptosis to Support Brucella Replication in Goat Trophoblast Cells International Journal of Molecular Sciences doi: 10.3390/ijms20174104 Authors: Feijie Zhi Dong Zhou Furong Bai Junmei Li Caixia Xiang Guangdong Zhang Yaping Jin Aihua Wang The effectors of the type IV secretion system (T4SS) of bacteria play important roles in mediating bacterial intracellular proliferation and manipulating...
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IJMS, Vol. 20, Pages 4103: Systematic Analysis of Differentially Expressed Maize ZmbZIP Genes between Drought and Rewatering Transcriptome Reveals bZIP Family Members Involved in Abiotic Stress Responses International Journal of Molecular Sciences doi: 10.3390/ijms20174103 Authors: Liru Cao Xiaomin Lu Pengyu Zhang Guorui Wang Li Wei Tongchao Wang The basic leucine zipper (bZIP) family of transcription factors (TFs) regulate diverse phenomena during plant growth and development...
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IJMS, Vol. 20, Pages 4102: Prediction of Potential Drug–Disease Associations through Deep Integration of Diversity and Projections of Various Drug Features International Journal of Molecular Sciences doi: 10.3390/ijms20174102 Authors: Ping Xuan Yingying Song Tiangang Zhang Lan Jia Identifying new indications for existing drugs may reduce costs and expedites drug development. Drug-related disease predictions typically combined heterogeneous drug-related and disease-related data...
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IJMS, Vol. 20, Pages 4100: The GATA-Type Transcriptional Factor Are1 Modulates the Expression of Extracellular Proteases and Cellulases in Trichoderma reesei International Journal of Molecular Sciences doi: 10.3390/ijms20174100 Authors: Yuanchao Qian Yu Sun Lixia Zhong Ningning Sun Yifan Sheng Yinbo Qu Yaohua Zhong Trichoderma reesei is a biotechnologically important filamentous fungus with the remarkable ability to secrete large amounts of enzymes, whose production...
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IJMS, Vol. 20, Pages 4101: An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20174101 Authors: Nand Kishor Roy Dey Parama Kishore Banik Devivasha Bordoloi Amrita Khwairakpam Devi Krishan Kumar Thakur Ganesan Padmavathi Mehdi Shakibaei Lu Fan Gautam Sethi Ajaikumar B. Kunnumakkara Natural compounds, in recent years, have attracted significant attention for their...
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IJMS, Vol. 20, Pages 4099: Transcriptome Profiling of Placenta through Pregnancy Reveals Dysregulation of Bile Acids Transport and Detoxification Function International Journal of Molecular Sciences doi: 10.3390/ijms20174099 Authors: Peng Wang Yumo Song Heju Zhong Sen Lin Xiaoling Zhang Jian Li Lianqiang Che Bin Feng Yan Lin Shengyu Xu Yong Zhuo De Wu Douglas G. Burrin Zhengfeng Fang Placenta performs the function of several adult organs for the...
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IJMS, Vol. 20, Pages 4097: Alcohol-Induced Mesenteric Lymphatic Permeability: Link to Immunometabolic Modulation of Perilymphatic Adipose Tissue International Journal of Molecular Sciences doi: 10.3390/ijms20174097 Authors: Flavia M. Souza-Smith Liz Simon Robert Siggins Patricia E. Molina Alcohol exerts significant immunomodulatory effects on innate and adaptive immune responses, impairing host defense against infections. Gut-mucosa-derived dendritic cells (DCs) traffic to mesenteric...
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IJMS, Vol. 20, Pages 4094: Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological Sequelae International Journal of Molecular Sciences doi: 10.3390/ijms20174094 Authors: Eliah G. Overbey Amber M. Paul Willian A. da Silveira Candice G.T. Tahimic Sigrid S. Reinsch Nathaniel Szewczyk Seta Stanbouly Charles Wang Jonathan M. Galazka Xiao Wen Mao Spaceflight poses many challenges for humans. Ground-based analogs...
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IJMS, Vol. 20, Pages 4096: Chondroitin-Sulfate-A-Coated Magnetite Nanoparticles: Synthesis, Characterization and Testing to Predict Their Colloidal Behavior in Biological Milieu International Journal of Molecular Sciences doi: 10.3390/ijms20174096 Authors: Ildikó Y. Tóth Erzsébet Illés Márta Szekeres István Zupkó Rodica Turcu Etelka Tombácz Biopolymer coated magnetite nanoparticles (MNPs) are suitable to fabricate biocompatible magnetic fluid (MF). Their comprehensive...
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IJMS, Vol. 20, Pages 4098: Cardiac Pathophysiology and the Future of Cardiac Therapies in Duchenne Muscular Dystrophy International Journal of Molecular Sciences doi: 10.3390/ijms20174098 Authors: Tatyana A. Meyers DeWayne Townsend Duchenne muscular dystrophy (DMD) is a devastating disease featuring skeletal muscle wasting, respiratory insufficiency, and cardiomyopathy. Historically, respiratory failure has been the leading cause of mortality in DMD, but recent improvements in symptomatic...
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IJMS, Vol. 20, Pages 4093: Chromatin Remodeling and Epigenetic Regulation in Plant DNA Damage Repair
IJMS, Vol. 20, Pages 4093: Chromatin Remodeling and Epigenetic Regulation in Plant DNA Damage Repair International Journal of Molecular Sciences doi: 10.3390/ijms20174093 Authors: Jin-Hong Kim DNA damage response (DDR) in eukaryotic cells is initiated in the chromatin context. DNA damage and repair depend on or have influence on the chromatin dynamics associated with genome stability. Epigenetic modifiers, such as chromatin remodelers, histone modifiers, DNA (de-)methylation enzymes,...
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IJMS, Vol. 20, Pages 4095: Chk1 Inhibitor MK-8776 Restores the Sensitivity of Chemotherapeutics in P-glycoprotein Overexpressing Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms20174095 Authors: Qingbin Cui Chao-Yun Cai Jing-Quan Wang Shuang Zhang Pranav Gupta Ning Ji Yuqi Yang Xingduo Dong Dong-Hua Yang Zhe-Sheng Chen P-glycoprotein (P-gp), which is encoded by the ATP-binding cassette (ABC) transporter subfamily B member 1 (ABCB1)...
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Viruses are parasitic pathogens affecting probably all organisms on earth. Designing effective detection methods and understanding their biological cycle is crucial for their confrontment. This review summarizes techniques developed hitherto, describing their discovery, operating principle as well as advantages and disadvantage. Viruses are essentially composed of a nucleic acid (segmented or not, DNA, or RNA) and a protein coat. Despite their simplicity, these small pathogens are responsible...
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Abstract Objective Macitentan is a new choice for pulmonary hypertension treatment which is converted to active metabolite ACT132577 by human cytochrome P450 3A4. Human cytochrome P450 3A4 often occurred gene mutations. Gene polymorphism might cause a variety of changes of protein expression and thus give rise to metabolic difference. The aim of this study was to investigate the catalytic characteristics of 27 CYP3A4 protein variants on the metabolism of macitentan in vitro. Method The...
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Abstract Objectives Pharmacokinetics of vitamins is still a challenge. In this study, folic acid (FA) was used as a model drug and aimed at investigating a reliable method for its detailed pharmacokinetic evaluations. Methods An high‐performance liquid chromatography–tandem mass spectrometry method was developed and performed to determinate the FA and 5‐methyltetrahydrofolic acid (5‐methylTHF) simultaneously, which was applied to characterize the circadian rhythms as well as the pharmacokinetics...
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Abstract In the present study, we describe the proteome of porcine cauda epididymis fluid and spermatozoa by means of Multidimensional Protein Identification Technology (MudPIT). Ten sexually mature healthy boars were surgically castrated and epididymides were dissected to obtain the cauda epididymal content. Polled protein extracts of cauda epididymal fluid (CEF) and spermatozoa (CESperm) were loaded in an Agilent 1100 quaternary HPLC and peptides eluted from the microcapillary...
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