Related ArticlesHydroxytyrosol promotes autophagy by regulating SIRT1 against advanced oxidation protein product‑induced NADPH oxidase and inflammatory response. Int J Mol Med. 2019 Aug 05;: Authors: Sun T, Chen Q, Zhu SY, Wu Q, Liao CR, Wang Z, Wu XH, Wu HT, Chen JT Abstract Advanced oxidation protein products (AOPPs) can trigger NADPH oxidase (NOX) and lead to the production of reactive oxygen species (ROS) in the pathophysiology of rheumatoid arthritis...
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Related ArticlesAutophagy in breast cancer metastatic dormancy: Tumor suppressing or tumor promoting functions? J Cancer Metastasis Treat. 2019;5: Authors: Flynn AB, Schiemann WP Abstract Breast cancer is the second leading cause of cancer-associated death in women in the United States, with more than 90% of those deaths attributed to metastasis. Breast cancer metastasis is incurable and possesses few treatment options and a poor overall prognosis due...
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Related ArticlesMicrogravity inhibits decidualization via decreasing Akt activity and FOXO3a expression in human endometrial stromal cells. Sci Rep. 2019 Aug 20;9(1):12094 Authors: Cho HJ, Baek MO, Khaliq SA, Chon SJ, Son KH, Lee SH, Yoon MS Abstract Decidualization is characterized by the differentiation of endometrial stromal cells (eSCs), which is critical for embryo implantation and maintenance of pregnancy. In the present study, we investigated...
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Related ArticlesRetromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling. J Cell Biol. 2019 Aug 20;: Authors: Kvainickas A, Nägele H, Qi W, Dokládal L, Jimenez-Orgaz A, Stehl L, Gangurde D, Zhao Q, Hu Z, Dengjel J, De Virgilio C, Baumeister R, Steinberg F Abstract Retromer is an evolutionarily conserved multiprotein complex that orchestrates the endocytic recycling of integral membrane proteins. Here, we...
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Related ArticlesNeuroprotective effects of memantine via enhancement of autophagy. Biochem Biophys Res Commun. 2019 Aug 17;: Authors: Hirano K, Fujimaki M, Sasazawa Y, Yamaguchi A, Ishikawa KI, Miyamoto K, Souma S, Furuya N, Imamichi Y, Yamada D, Saya H, Akamatsu W, Saiki S, Hattori N Abstract INTRODUCTION: Chemical intervention of autophagy has been investigated in clinical trials for various age-related conditions such as sarcopenia and neurodegeneration....
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Related ArticlesSusceptibility of microtubule-associated protein 1 light chain 3β (MAP1LC3B/ LC3B) knockout mice to lung injury and fibrosis. FASEB J. 2019 Aug 20;:fj201900854R Authors: Kesireddy VS, Chillappagari S, Ahuja S, Knudsen L, Henneke I, Graumann J, Meiners S, Ochs M, Ruppert C, Korfei M, Seeger W, Mahavadi P Abstract Insufficient autophagy has been reported in idiopathic pulmonary fibrosis (IPF) lungs. Specific roles of autophagy-related proteins...
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Related ArticlesRole of Autophagy in Zinc Oxide Nanoparticles-Induced Apoptosis of Mouse LEYDIG Cells. Int J Mol Sci. 2019 Aug 19;20(16): Authors: Shen J, Yang D, Zhou X, Wang Y, Tang S, Yin H, Wang J, Chen R, Chen J Abstract Zinc oxide nanoparticles (ZnO NPs) have shown adverse health impact on the human male reproductive system, with evidence of inducing apoptosis. However, whether or not ZnO NPs could promote autophagy, and the possible role of autophagy...
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Related ArticlesA Spectrum of Clinical Findings from ALPS to CVID: Several Novel LRBA Defects. J Clin Immunol. 2019 Aug 20;: Authors: Cagdas D, Halaçlı SO, Tan Ç, Lo B, Çetinkaya PG, Esenboğa S, Karaatmaca B, Matthews H, Balcı-Hayta B, Arıkoğlu T, Ezgü F, Aladağ E, Saltık-Temizel İN, Demir H, Kuşkonmaz B, Okur V, Gümrük F, Göker H, Çetinkaya D, Boztuğ K, Lenardo M, Sanal Ö, Tezcan İ Abstract INTRODUCTION: Autosomal recessively inherited lipopolysaccharide-responsive...
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Related Articles[A case of secondary central nervous system lymphoma presenting marked hypoglycorrhachia]. Rinsho Shinkeigaku. 2019 Jun 22;59(6):365-370 Authors: Yamashita A, Tokuda M, Matsuo M, Irie J, Tateishi Y, Mutsukura K Abstract A 67-year-old male was transferred to our hospital with diplopia, decreased deep tendon reflex and ataxia. He had been suspected Fisher syndrome because of previous upper respiratory tract infection. A cerebrospinal fluid...
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Related ArticlesMultiple myeloma immunophenotyping: method validation. Ann Biol Clin (Paris). 2019 Apr 01;77(2):197-217 Authors: Vergnolle I, Rieu JB, Avet-Loiseau H, Corre J, Vergez F Abstract Flow cytometric immunophenotyping has become essential for management of multiple myeloma (assessment of clonality, prognostic information on the risk of progression in gammopathy of undetermined significance, minimal residual disease monitoring). Immunophenotyping...
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Related ArticlesB-cell non-Hodgkin lymphoma discovery after observation of a platelet satellitism around atypical lymphocytes. Ann Biol Clin (Paris). 2019 Apr 01;77(2):191-195 Authors: Gatignol A, Amirault M, Legac É, Decker J Abstract We report the case of an 83-year-old woman admitted to the accident and emergency unit for pneumopathy. The blood cell count on the DXH automaton (Coulter® ™ UniCel® DxH) found a normochromic and normocytic anemia, anormal...
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Related ArticlesTwo novel alleles, HLA-A*32:01:01:09 and 32:01:01:10, identified by Pacific Bioscience's SMRT sequencing. HLA. 2018 12;92(6):409-411 Authors: Cambridge CA, Turner TR, Georgiou X, Marsh SGE, Mayor NP Abstract Pacific Bioscience's SMRT DNA sequencing was used to identify two novel intronic variants of HLA-A*32:01:01:01.PMID: 30311452 [PubMed - indexed for MEDLINE]
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Related ArticlesClinicopathologic and molecular features in hairy cell leukemia-variant: single institutional experience. Mod Pathol. 2018 11;31(11):1717-1732 Authors: Angelova EA, Medeiros LJ, Wang W, Muzzafar T, Lu X, Khoury JD, Ravandi F, Patel KP, Hu Z, Kanagal-Shamanna R Abstract Hairy cell leukemia-variant is rare. Only a small number of cases have been reported in the literature with little cytogenetic or molecular data available. In this study,...
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Related ArticlesChimeric antigen receptor T cell therapy for non-Hodgkin lymphoma. Curr Res Transl Med. 2018 05;66(2):43-49 Authors: Ghobadi A Abstract Non-Hodgkin Lymphoma (NHL) is the most common hematologic malignancy. More than 20,000 people in United States, more than 37,000 people in Europe and more than 199,000 people worldwide die of NHL every year. Recent advances in immunotherapeutic approaches for cancer have resulted in development of new...
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Related ArticlesQuantitative Evaluation of Different Protein Fractions of Cerebrospinal Fluid Using 18O Labeling. Methods Mol Biol. 2019;2044:119-128 Authors: Birke R, Krause E, Schümann M, Blasig IE, Haseloff RF Abstract Molecular analysis of cerebrospinal fluid (CSF) provides comprehensive information on physiological and pathological processes related to the brain. In particular, proteomic studies give insights into the pathogenesis of many brain...
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Rhythmic Training Improves Temporal Anticipation and Adaptation Abilities in Children With Hearing Loss During Verbal Interaction. J Speech Lang Hear Res. 2019 Aug 21;:1-14 Authors: Hidalgo C, Pesnot-Lerousseau J, Marquis P, Roman S, Schön D Abstract Purpose In this study, we investigate temporal adaptation capacities of children with normal hearing and children with cochlear implants and/or hearing aids during verbal exchange. We also address the question...
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[Dimensions of the human temporal bone that are relevant to cochlear implantation surgery in infants and toddlers. A clinical-radiological study]. Orv Hetil. 2019 Jun;160(24):936-943 Authors: Perényi Á, Jóri J, Csanády M, Rovó L Abstract Introduction: Early cochlear implantation enables prelingual deaf individuals to become full members of the hearing society. Although early diagnostics are widely accessible and enable early rehabilitation, implant surgery...
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Glendonald Auditory Screening Procedure (GASP): clinical markers of the development of auditory recognition and comprehension abilities in children using cochlear implants. Codas. 2019 Aug 15;31(4):e20180142 Authors: Silva BCS, Moret ALM, Silva LTDN, Costa OAD, Alvarenga KF, Silva-Comerlatto MPD Abstract PURPOSE: To verify the influence of the age of implantation in the development of closed-set auditory recognition and auditory comprehension abilities...
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Understanding the therapeutic alliance in stroke rehabilitation. Disabil Rehabil. 2019 Aug 21;:1-10 Authors: Bishop M, Kayes N, McPherson K Abstract Purpose: The quality of the therapeutic alliance between a client and their clinician is thought to play an important role in healthcare but there is limited research about this concept in stroke rehabilitation. This study explored the core components of a therapeutic alliance and the factors perceived to...
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Performance of school-aged children with cerebral palsy at GMFCS levels I and II on high-level, sports-focussed gross motor assessments. Disabil Rehabil. 2019 Aug 21;:1-9 Authors: Clutterbuck GL, Auld ML, Johnston LM Abstract Purpose: To investigate performance of children with cerebral palsy (CP) at GMFCS Levels I-II on sports-focussed gross motor assessments; and concurrent validity of mainstream and CP-specific high-level assessment batteries and...
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Related ArticlesComparative study of PROMISⓇ self-efficacy for managing chronic conditions across chronic neurologic disorders. Qual Life Res. 2019 Jul;28(7):1893-1901 Authors: Shulman LM, Velozo C, Romero S, Gruber-Baldini AL Abstract PURPOSE: Self-efficacy (SE) for managing chronic conditions is the belief that one can carry out behaviors to reach health goals. The study objective is to investigate (1) SE for managing chronic conditions across diverse...
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NTCP model validation method for DAHANCA patient selection of protons versus photons in head and neck cancer radiotherapy. Acta Oncol. 2019 Aug 21;:1-6 Authors: Hansen CR, Friborg J, Jensen K, Samsøe E, Johnsen L, Zukauskaite R, Grau C, Maare C, Johansen J, Primdahl H, Bratland Å, Kristensen CA, Andersen M, Eriksen JG, Overgaard J Abstract Introduction: Prediction models using logistic regression may perform poorly in external patient cohorts. However,...
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Related ArticlesThe impact of 0.2% chlorhexidine gel on oral health and the incidence of pneumonia amongst adults with profound complex neurodisability. Spec Care Dentist. 2019 Aug 20;: Authors: Prasad R, Daly B, Manley G Abstract AIMS: Investigate the effect of toothbrushing with 0.2% chlorhexidine gel on oral health and pneumonia amongst patients with a neurodisability who are fed via percutaneous endoscopic gastrostomy. METHOD: Forty-nine...
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Related ArticlesHow I Approach Dysphagia. Curr Gastroenterol Rep. 2019 Aug 20;21(10):49 Authors: Kim JP, Kahrilas PJ Abstract PURPOSE OF REVIEW: This review presents an overview of the diagnostic approach to esophageal dysphagia and summarizes recent epidemiological trends and technical advancements. RECENT FINDINGS: The evaluation of dysphagia begins with a detailed history followed by endoscopy to evaluate for any structural abnormalities...
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Related ArticlesCervical Deformity Patients Have Baseline Swallowing Dysfunction but Surgery Does Not Increase Dysphagia at 3 Months: Results From a Prospective Cohort Study. Global Spine J. 2019 Aug;9(5):532-539 Authors: Iyer S, Kim HJ, Bao H, Smith JS, Protopsaltis TS, Mundis GM, Passias P, Neuman BJ, Klineberg EO, Lafage V, Ames CP, International Spine Study Group (ISSG) Abstract Study Design: Prospective cohort study. Objectives: Most studies...
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Related ArticlesOutcomes of Halo Immobilization for Cervical Spine Fractures. Global Spine J. 2019 Aug;9(5):521-526 Authors: Isidro S, Molinari R, Ikpeze T, Hernandez C, Mahmoudi MS, Mesfin A Abstract Study Design: Retrospective. Objectives: To evaluate complications and outcomes of halo immobilization in patients with cervical spine fractures treated at a level I trauma center. Methods: A retrospective evaluation of patients treated...
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Related ArticlesSafety and efficacy of reduced dose and margins to involved lymph node metastases in locally advanced NSCLC patients. Radiother Oncol. 2019 Aug 17;: Authors: van Diessen JNA, Kwint M, Sonke JJ, Walraven I, Stam B, de Langen AJ, Knegjens J, Belderbos JSA Abstract BACKGROUND AND PURPOSE: (Chemo)Radiotherapy for locally advanced non-small lung cancer (LA-NSCLC) causes severe dysphagia due to the radiation dose to the mediastinal lymphadenopathy....
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Related ArticlesDifferences between planned and delivered dose for head and neck cancer, and their consequences for normal tissue complication probability and treatment adaptation. Radiother Oncol. 2019 Aug 17;: Authors: Heukelom J, Kantor ME, Mohamed ASR, Elhalawani H, Kocak-Uzel E, Lin T, Yang J, Aristophanous M, Rasch CR, Fuller CD, Sonke JJ Abstract BACKGROUND AND PURPOSE: Anatomical changes induce differences between planned and delivered dose....
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Related ArticlesLaparoscopic Hiatal Hernia Repair Followed by Transoral Incisionless Fundoplication With EsophyX Device (HH + TIF): Efficacy and Safety in Two Community Hospitals. Surg Innov. 2019 Aug 20;:1553350619869449 Authors: Janu P, Shughoury AB, Venkat K, Hurwich D, Galouzis T, Siatras J, Streeter D, Korman K, Mavrelis G, Mavrelis P Abstract The TIF (transoral incisionless fundoplication) 2.0 procedure is indicated for patients with a hiatal hernia...
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Related Articles[Umbilical moxibustion for patients with idiopathic pulmonary fibrosis complicated with gastroesophageal reflux of lung-spleen qi deficiency]. Zhongguo Zhen Jiu. 2019 Mar 12;39(3):241-5 Authors: Li B, Zhang Y, Yang QM Abstract OBJECTIVE: To evaluate the clinical efficacy of umbilical moxibustion in the treatment of patients with idiopathic pulmonary interstitial fibrosis complicated with gastroesophageal reflux of lung-spleen qi deficiency....
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Related ArticlesGastroesophageal Reflux Disease (GERD). Mo Med. 2018 May-Jun;115(3):214-218 Authors: Clarrett DM, Hachem C Abstract Gastroesophageal reflux disease (GERD) is a common clinical problem, affecting millions of people worldwide. Patients are recognized by both classic and atypical symptoms. Acid suppressive therapy provides symptomatic relief and prevents complications in many individuals with GERD. Advances in diagnostic and therapeutic...
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Related ArticlesTongue Shape Dynamics in Swallowing Using Sagittal Ultrasound. Dysphagia. 2019 02;34(1):112-118 Authors: Ohkubo M, Scobbie JM Abstract Ultrasound imaging is simple, repeatable, gives real-time feedback, and its dynamic soft tissue imaging may make it superior to other modalities for swallowing research. We tested this hypothesis and measured certain spatial and dynamic aspects of the swallowing to investigate its efficacy. Eleven healthy...
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A 17-cm endoscopic submucosal tunnel dissection for esophageal cancer and insertion of polyglycolic acid-coated stent. Endoscopy. 2019 Aug 21;: Authors: Yoo IK, Seo MK, Hong SP, Lee H, Cho JY PMID: 31434159 [PubMed - as supplied by publisher]
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Radiation dose and pathological response in oesophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by surgery: a multi-institutional analysis. Acta Oncol. 2019 Aug 21;:1-8 Authors: Thomas M, Borggreve AS, van Rossum PSN, Perneel C, Moons J, Van Daele E, van Hillegersberg R, Deng W, Pattyn P, Mook S, Boterberg T, Ruurda JP, Nafteux P, Lin SH, Haustermans K Abstract Purpose: To explore whether a higher neoadjuvant radiation dose...
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Related ArticlesEMX2 is epigenetically silenced and suppresses epithelial‑mesenchymal transition in human esophageal adenocarcinoma. Oncol Rep. 2019 Aug 20;: Authors: Wang L, Jin J, Zhou Y, Tian Z, He B, Huang Y, Ding F Abstract Esophageal adenocarcinoma (EAC) is an aggressive and challenging disease to treat, with an overall five‑year survival rate of <20%. Early malignant cell dissemination contributes to this poor prognosis. Epithelial‑mesenchymal...
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Related ArticlesSREBP2 is upregulated in esophageal squamous cell carcinoma and co‑operates with c‑Myc to regulate HMGCR expression. Mol Med Rep. 2019 Aug 09;: Authors: Zhong C, Fan L, Li Z, Yao F, Zhao H Abstract Dysregulations of the mevalonate pathway (MVA) have been previously identified. Our previous study demonstrated that 3‑hydroxy‑3‑methylglutaryl‑coenzyme A reductase (HMGCR), the rate‑limiting enzyme of the MVA pathway, was upregulated in esophageal...
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Related ArticlesEvofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity. Radiother Oncol. 2019 Aug 17;: Authors: Spiegelberg L, van Hoof SJ, Biemans R, Lieuwes NG, Marcus D, Niemans R, Theys J, Yaromina A, Lambin P, Verhaegen F, Dubois LJ Abstract BACKGROUND AND PURPOSE: Esophageal cancer incidence is increasing and is rarely curable. Hypoxic tumor areas cause resistance to conventional therapies, making them...
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Related ArticlesCost-effectiveness analysis of neoadjuvant chemoradiotherapy followed by surgery versus surgery alone for locally advanced esophageal squamous cell carcinoma based on the NEOCRTEC5010 trial. Radiother Oncol. 2019 Aug 17;: Authors: Zhan M, Zheng H, Yang Y, Xu T, Li Q Abstract BACKGROUND AND PURPOSE: The phase 3 NEOCRTEC5010 trial demonstrated that neoadjuvant chemoradiotherapy (NCRT) plus surgery for locally advanced esophageal squamous...
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Related ArticlesDiffusion-weighted MRI with ADC mapping for response prediction and assessment of oesophageal cancer: A systematic review. Radiother Oncol. 2019 Aug 17;: Authors: Vollenbrock SE, Voncken FEM, Bartels LW, Beets-Tan RGH, Bartels-Rutten A Abstract PURPOSE: The aim was to perform a systematic review on the value of diffusion-weighted MRI (DW-MRI) with apparent diffusion coefficient (ADC) mapping in the prediction and assessment of response...
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