Publication date: Available online 13 November 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): A.G. Miller
Wed Nov 13, 2019 18:57
Publication date: Available online 13 November 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): J.N. Khanna, Radhika RamaswamiAbstractAnkylosis of the temporomandibular joint (TMJ) is a severely deforming, disabling condition as a result of craniomandibular fusion caused mainly by condylar fractures with displacement of the meniscus. Ankylosis may be fibrous, fibro-osseous, or bony, and unilateral or bilateral. The severity of the deformity is based on the onset, duration,...
Wed Nov 13, 2019 18:57
Publication date: Available online 12 November 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): V. Pandey, P. Tiwari, S.P. Sharma, R. Kumar, P. Panigrahi, O.P. Singh, S. PatneAbstractLymphangioma of the tongue is a rare lymphatic malformation, and various authors have reported the successful use of sirolimus for its treatment. However, the safety of sirolimus in children needs further evaluation so that those who do not respond are not necessarily exposed to its potential adverse...
Tue Nov 12, 2019 12:07
Publication date: Available online 11 November 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): R.J.J. Pilkington, N.R. Aculate, D. Gahir, M. Isles
Tue Nov 12, 2019 12:07
Publication date: Available online 11 November 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): L. Shah, S. Fogden, A. MajumdarAbstractOral biopsies are common diagnostic and therapeutic procedures in oral and maxillofacial surgical (OMFS) outpatient departments. The chalazion clamp is similar to a pair of forceps. One extension has a flat, solid, oval plate, the other, a ring-like structure that is used to clamp and retract soft tissues. We highlight the benefits of using...
Tue Nov 12, 2019 12:07
Publication date: Available online 11 November 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): S. Kita, K. Fujita, H. Imai, M. Aoyagi, K. Shimazaki, I. Yonemitsu, S. Omura, T. OnoAbstractWe aimed to compare the postoperative stability of conventional bimaxillary surgery (with bilateral sagittal split osteotomy) with that of maxillary impaction surgery (with mandibular autorotation without bilateral sagittal split osteotomy) in patients with skeletal class II retrognathia....
Tue Nov 12, 2019 12:07
Publication date: Available online 11 November 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): L.M. Lee, Y.Q. Deng, P.K.-T. Chen, Y.M. Zhu, X. LiangAbstractIdiopathic hemipalatal hypoplasia is rare and leads to speech problems and the regurgitation of fluids, and the reconstruction of asymmetrical velopharyngeal incompetence is a challenge to the cleft surgeon. We present a case in a 5-year-old boy, and introduce the one-stage surgical technique that we used to resolve it.
Tue Nov 12, 2019 12:07
Publication date: Available online 11 November 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): H.-q. Zhang, Q.-x. Li, Y.-y. Wang, Z.-s. Wang, Z.-y. Lin, L.-j. Sha, D.-m. Zhang, J. Liu, J.-j. Wang, J.-s. Li, S. FanAbstractBiomechanics are crucial for bony regeneration and survival of implants in functional maxillary and mandibular reconstructions. However, we know of no study that has included an analysis of biomechanics to guide the optimal position of a fibular graft in virtual...
Tue Nov 12, 2019 12:07
Publication date: Available online 11 November 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): E.Z. Goh, N.H.W. Loh, J.S.P. LohAbstractSubmental intubation is a low-risk alternative to tracheostomy when nasotracheal or orotracheal intubation is not appropriate. To improve the selection of patients and clinical outcomes we have explored published papers on submental intubation in oral and maxillofacial surgery, and included a proposal for a decision pathway. Systematic searches...
Tue Nov 12, 2019 12:07
Background: Gastric cancer (GC) is one of the most common malignant tumors. It is likely to occur in lymph nodes and is prone to distant metastasis in its early stages, which portends a poor prognosis. Previous studies have shown that miRNA-21 was abnormally highly expressed and associated with early metastasis in GC, but the mechanism by which it regulates the invasion and metastasis of GC has not been elucidated. Methods: Epithelial-mesenchymal transition (EMT) is an important pathologic basis...
Wed Nov 13, 2019 18:05
We present a microinjectrode system designed for electrophysiology and assisted delivery of experimental probes (i.e., nanosensors, microelectrodes), with optional drug infusion. Widely available microfluidic components are coupled to a cannula containing the probe. A step-by-step protocol for microinjectrode construction is included, with results during muscimol infusion in macaque cortex.
Wed Nov 13, 2019 18:00
This protocol provides an open source, compiled MATLAB program that generates multitaper spectrograms for electroencephalographic data.
Wed Nov 13, 2019 17:00
This work presents a protocol to yield homogeneous cell cultures of primary oculomotor, trochlear, and spinal motor neurons. These cultures can be used for comparative analyses of the morphological, cellular, molecular, and electrophysiological characteristics of ocular and spinal motor neurons.
Tue Nov 12, 2019 19:00
This protocol demonstrates how to use an electrophysiological system for closed-loop stimulation triggered by neuronal activity patterns. Sample Matlab code that can be easily modified for different stimulation devices is also provided.
Tue Nov 12, 2019 18:00
We describe a quantitative real-time in vitro cytolysis assay system to evaluate the potency of chimeric antigen receptor T cells targeting liquid and solid tumor cells. This protocol can be extended to assess other immune effector cells, as well as combination treatments.
Tue Nov 12, 2019 17:00
The aim of our study was to assess the effects of mitochondrial coenzyme Q (MitoQ) on sepsis-induced acute lung injury (ALI) and investigate its possible mechanisms. The cecal ligation and puncture (CLP) method was used to establish a septic ALI model. Rats were randomly divided into Con group, CLP group, MitoQ group, and MitoQ + LY294002 group. The survival rate of the rats was recorded, and the survival rate curve was plotted. Moreover, the ratio of wet/dry weight (W/D) in lung tissue was measured....
Wed Nov 13, 2019 17:05
Background. Several studies found that physicians develop a negative attitude toward biochemistry and genetics disciplines. Many medical schools adopt an integrated system-based curriculum supplemented with clinical correlations. Medical schools in Jordan switched to the integrated curriculum; however, studies that evaluate the attitude of physicians toward biochemistry and genetics are lacking. Objectives. This study aimed to evaluate the attitude of physicians toward biochemistry and genetics including...
Wed Nov 13, 2019 16:15
Background. Spinal cord injury (SCI) is often associated with long-term impairments related to functional limitations in the sensorimotor system. The use of virtual reality (VR) technology may lead to increased motivation and engagement, besides allowing a wide range of possible tasks/exercises to be implemented in rehabilitation programs. The present review aims to investigate the possible benefits and efficacy of VR-based rehabilitation in individuals with SCI. Methods. An electronically systematic...
Wed Nov 13, 2019 15:05
A- and D-ring-modified luotonin-inspired heterocycles have been synthesized and were evaluated for their activity against the viability of four cancer cell lines in vitro, namely, MCF7, HCT116, JURKAT, and NCI-H460. The analysis of results indicated that two of the synthesized derivatives displayed good inhibition against the growth of the human colon cancer HCT116 cell line, with potencies lower than but in the same order of magnitude as camptothecin (CPT). These two luotonin analogues also showed...
Wed Nov 13, 2019 15:05
Background and Objectives. Alternative splicing is increasingly associated with cancers. HnRNP L is a splicing factor that promotes carcinogenesis in head and neck squamous cell carcinoma (HNSCC) and other cancers. Alternative exon 7 of hnRNP L contains an in-frame stop codon. Exon 7-included transcripts can be degraded via nonsense-mediated decay or encode a truncated hnRNP L protein. Exon 7-excluded transcripts can encode full-length functional hnRNP L protein. HnRNP L has an autoregulation mechanism...
Wed Nov 13, 2019 13:05
Background. Sepsis-associated encephalopathy (SAE) is a transient and reversible brain dysfunction, that occurs when the source of sepsis is located outside of the central nervous system; SAE affects nearly 30% of septic patients at admission and is a risk factor for mortality. In our study, we sought to determine whether metabolite changes in plasma could be a potential biomarker for the early diagnosis and/or the prediction of the prognosis of sepsis. Method. A total of 31 SAE patients and 28 healthy...
Tue Nov 12, 2019 13:05
The body’s autoimmune process is involved in the development of Graves’ disease (GD), which is manifested by an overactive thyroid gland. In some patients, autoreactive inflammatory reactions contribute to the development of symptoms such as thyroid ophthalmopathy, and the subsequent signs and symptoms are derived from the expansion of orbital adipose tissue and edema of extraocular muscles within the orbit. The autoimmune process, production of antibodies against self-antigens such as TSH receptor...
Tue Nov 12, 2019 11:05
Surveillance studies have shown that OXA-48-like carbapenemases are the most common carbapenemases in Enterobacterales in certain regions of the world and are being introduced on a regular basis into regions of nonendemicity, where they are responsible for nosocomial outbreaks. OXA-48, OXA-181, OXA-232, OXA-204, OXA-162, and OXA-244, in that order, are the most common enzymes identified among the OXA-48-like carbapenemase group. OXA-48 is associated with different Tn1999 variants on IncL plasmids...
Wed Nov 13, 2019 15:30
Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological niche, the fungus has learned how to adapt and proliferate in hostile environments. This capacity has helped the fungus to resist and survive against human host defenses and, further, to be responsible for one of the most devastating lung infections in terms of morbidity and mortality. In this review, we will provide (i) a description of the biological cycle of A. fumigatus; (ii) a historical perspective...
Wed Nov 13, 2019 15:30
The clinical presentation of brucellosis in humans is variable and unspecific, and thus, laboratory corroboration of the diagnosis is essential for the patient’s proper treatment. The diagnosis of brucellar infections can be made by culture, serological tests, and nucleic acid amplification assays. Modern automated blood culture systems enable detection of acute cases of brucellosis within the routine 5- to 7-day incubation protocol employed in clinical microbiology laboratories, although a longer...
Wed Nov 13, 2019 15:30
Publication date: Available online 12 November 2019Source: Journal of ProteomicsAuthor(s): Gergo Peter Szekeres, Nerea Fernandez-Iglesias, Janina Kneipp, Maria Montes-Bayón, Jörg BettmerAbstractThe diagnostic and therapeutic application of nanoparticles requires comprehensive knowledge of their interaction with the biomolecular surroundings. The formation of the protein corona on nanoparticles that were internalized by living cells is yet to be understood. In this study, we present a robust approach...
Wed Nov 13, 2019 17:40
Publication date: Available online 12 November 2019Source: Journal of ProteomicsAuthor(s): María del Pilar Chantada-Vázquez, Antonio Castro López, María García Vence, Sergio Vázquez-Estévez, Benigno Acea-Nebril, David G. Calatayud, Teresa Jardiel, Susana B. Bravo, Cristina NúñezAbstractNowadays, there are no targeted therapeutic modalities for triple negative breast cancer (TNBC). This disease is associated with poor prognosis and worst clinical outcome because of the aggressive nature of the tumor,...
Wed Nov 13, 2019 17:40
Publication date: Available online 12 November 2019Source: Journal of ProteomicsAuthor(s): Graphical abstract
Tue Nov 12, 2019 17:26
Key‐points •Fractalkine receptor antagonist inhibited neutrophil recruitment to masseter muscles and exacerbated fatigability during masticatory activity. •Fractalkine‐mediated neutrophil recruitment is required for both upregulation of myokines (CXCL1, IL‐6) and enhanced GLUT4 translocation in response to masticatory activity. •Fractalkine and ICAM‐1 expressions in endothelial cells increased in response to masticatory activity. •In vitro experiments demonstrated contracting myotubes to lack...
Wed Nov 13, 2019 13:36
Key points ‐We determined if bed rest increased mitochondrial derived reactive oxygen species and cellular redox stress, contributing to the induction insulin resistance ‐Bed rest decreased maximal and submaximal ADP‐stimulated mitochondrial respiration ‐Bed rest did not alter mitochondrial H2O2 emission in the presence of ADP concentrations indicative of resting muscle, the ratio of H2O2 emission to JO2 consumption, or markers of oxidative stress ‐The present data strongly suggests that mitochondrial...
Tue Nov 12, 2019 20:39
Key points Respiratory sinus arrhythmia is physiological pacing of the heart that disappears in cardiovascular disease and is associated with poor cardiac prognosis In heart failure, cardiac pacing has little if any variation in rate at rest We proposed that reinstatement of respiratory sinus arrhythmia would improve cardiac function in rats with heart failure Heart failure rats were paced daily for 2 weeks with either respiratory sinus arrhythmia or paced monotonically at a matched heart rate;...
Tue Nov 12, 2019 15:18
Key points •To explore the capability of cathodal tDCS to induce late‐phase LTD via repeated stimulation •Conventional (1mA for 15min) and intensified (3mA for 20min) protocols with short (20min) and long (24 h) intervals were tested •Late‐phase plasticity was not induced by a single repetition of stimulation •Repetition reduced the efficacy of stimulation protocols with higher intensities Abstract Transcranial direct current stimulation (tDCS) has promising results in pilot studies...
Tue Nov 12, 2019 11:33
Key points •Mutations in the SCN8A gene cause early infantile epileptic encephalopathy. •We characterize a new epilepsy‐related SCN8A mutation, R850Q, in the human SCN8A channel and present gain‐of‐function properties of the mutant channel. •Systematic comparison of R850Q with three other SCN8A epilepsy mutations, T761I, R1617Q, R1872Q, identifies one common dysfunction in resurgent current, although these mutations alter distinct properties of the channel. •Computational simulations in two...
Tue Nov 12, 2019 11:09
Abstract Background and objectives Orlistat which is taken by obese patients may present some therapeutic assistance through its inhibition of lipase activity. Otherwise, a natural lipase inhibitor as cinnamon is widely used traditional medicine to decrease cholesterol and body weight. The current study aimed to investigate the weight management of orlistat in comparison with cinnamon through different obesity related targets. ...
Wed Nov 13, 2019 02:00
Abstract Purpose To comprehensively investigate the associations of subclinical thyroid dysfunction with BMD and fractures at various sites. Methods Comprehensive electronic and manual searches of databases were systematically conducted to identify prospective cohort studies from the inception of the databases to May 2019. The summary results for fractures...
Wed Nov 13, 2019 02:00
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Wed Nov 13, 2019 02:00
Publication date: Available online 12 November 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Lisa Q. Rong, Jonathan W. Weinsaft
Wed Nov 13, 2019 16:28
Publication date: Available online 12 November 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Mark J. Portou, Rebekah Yu, Daryll Baker, Shiwen Xu, David Abraham, Janice TsuiObjectiveDiabetes mellitus has reached epidemic proportions. Foot ulceration is a multifactorial complication of diabetes associated with marked morbidity and mortality. Innate immune Toll-like receptor 4 (TLR4) mediated inflammation has been implicated in the systemic pathogenesis of diabetes and...
Wed Nov 13, 2019 16:28
Publication date: Available online 12 November 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Anne-Florence Rouby, Salomé Kuntz, Charline Delay, Fabien Thaveau, Yannick Georg, Anne Lejay, Nabil ChakfeObjectiveThe aim of this study was to assess the post-operative volumetric evolution of common iliac arteries (CIA) ≥ 17 mm diameter with respect to the type of endovascular technique performed and to assess type 1b endoleak risk factors.MethodsAll consecutive patients presenting...
Wed Nov 13, 2019 16:28
Publication date: Available online 11 November 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Leonie Henstra, Ozan Yazar, Arne de Niet, Ignace F.J. Tielliu, Geert W.H. Schurink, Clark J. ZeebregtsObjectiveAn ageing population leads to more age related diseases, such as complex abdominal aortic aneurysms (AAA). Patients with complex AAAs and multiple comorbidities benefit from fenestrated endovascular aneurysm repair (FEVAR), but for the elderly this benefit is not completely...
Tue Nov 12, 2019 12:37
Publication date: Available online 11 November 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Emiel M.J. van Disseldorp, Julia J. van Dronkelaar, Josien P.W. Pluim, Frans N. van de Vosse, Marc R.H.M. van Sambeek, Richard G.P. LopataBackgroundCurrent clinical guidelines for surgical repair of abdominal aortic aneurysms (AAAs) are primarily based on maximum diameter assessment. From a biomechanical point of view, not only the diameter but also peak wall stresses will play...
Tue Nov 12, 2019 12:37
Zusammenfassung Das Ideal eines Instituts für Pathologie bestand aus dem großen Sektionsbereich und einer breiten Präparatesammlung für die Ausbildung von Studenten und klinisch tätigen Ärzten. Zusätzliche Abteilungen, die den Sektionsbereich unterstützten, waren ein chemisches und bakteriologisches Labor. In weiteren Abteilungen waren experimentelle Labors für Biologie, Immunologie, Zellforschung und Tierställe angesiedelt. Ein Hauptpfeiler des Medizinstudiums...
Wed Nov 13, 2019 02:00
Zusammenfassung Hyperosmolares Mikromilieu wurde sowohl unter physiologischen (Nierenmark, lymphatisches Gewebe) als auch pathologischen (Allorejektion, solide Tumoren) Bedingungen beobachtet. Hyperosmolarität kann die Genexpression modulieren und das stimulierende Profil von Makrophagen und dendritischen Zellen verändern. Wir haben berichtet, dass dendritische Zellen nach der Exposition gegenüber den hypertonischen Reizen ihr Profil in Richtung eines Makrophagen-M2-ähnlichen Phänotyps...
Wed Nov 13, 2019 02:00
Wed Nov 13, 2019 02:00
Zusammenfassung Hintergrund Auf Basis rezenter historischer Forschungen kann gezeigt werden, dass der mentalitätsgeschichtliche Kontext für die Medizin- und Pathologiegeschichte im Nationalsozialismus eine entscheidende Rolle spielt. Fragestellung Welche Auswirkung hatte das „Zeitalter der Gewalt“, die Zeit zwischen 1914 und 1945, auf den Betrieb der Pathologie...
Tue Nov 12, 2019 02:00
Zusammenfassung Hintergrund Um Patienten die optimale Therapie anbieten zu können, sind heutzutage immer präzisere Diagnosen notwendig. Daher wird das oft nur in geringen Mengen vorliegende Probenmaterial mit immer aufwendigeren, insbesondere genomischen Methoden untersucht. Da die Genomik aber nur eine unvollständige Abbildung der Dynamik des menschlichen Organismus bietet, liegt eine Lösung in der Verwendung proteomischer Methoden, d. h....
Tue Nov 12, 2019 02:00
Abstract Purpose To evaluate the residual surface roughness of 5 common diamond-coated interproximal reduction (IPR) systems after consecutive in vitro applications in relation to system, diamond grain size, and instrument thickness. Methods IPR was performed on 80 extracted human incisors using motor-driven strips and discs under predefined conditions. The...
Wed Nov 13, 2019 02:00
Publication date: Available online 13 November 2019Source: Journal of the American College of SurgeonsAuthor(s): Marc Levy, Wilmer Alvarez, Lauren Vagelakos, Michelle Yore, Bertha Ben KhallouqBackgroundIn recent years, several states have enacted Stand Your Ground (SYG) legislation intended to deter crime. To date, the impact of these laws on justifiable homicide (JH) and homicide (HOM) is unknown. This study was designed to compare JH and HOM rates (JHR, HR) before and after enactment of SYG laws...
Wed Nov 13, 2019 15:30
Publication date: Available online 12 November 2019Source: Journal of the American College of SurgeonsAuthor(s): Joseph C. Maroon
Wed Nov 13, 2019 15:30
Publication date: Available online 11 November 2019Source: Journal of the American College of SurgeonsAuthor(s): Kathryn B. Sobba, Adolfo Z. Fernandez, Stephen S. McNatt, Myron S. Powell, Andrew M. Nunn, Amy N. Hildreth, Barbara K. Yoza, Jessica L. Gross, Preston R. Miller, Carl J. WestcottBackgroundThe technique for attaining photographic evidence of the critical view of safety (CVS) in laparoscopic cholecystectomy (LC) has previously been defined, however the consistency, accuracy and feasibility...
Tue Nov 12, 2019 12:45
Publication date: Available online 13 November 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Pavlos Bobos, Goris Nazari, Steve Lu, Joy C. MacDermidAbstractObjectiveThe aim of this study was to critically appraise, compare and summarize the quality of the measurement properties of grip strength (GS) in healthy participants and patients with musculoskeletal, neurological or systemic conditions.Data SourcesWe followed the COnsensus-based Standards for the selection of health...
Wed Nov 13, 2019 15:18
Abstract Background Acute appendicitis is a common general surgical condition where diagnosis is predominantly clinical, with the aid of adjunct investigations. This study reviews the relationship between normal and elevated biochemical inflammatory markers, duration of symptoms and proven appendicitis. Methods A multicentre prospective observational study was performed across 27 centres and included a total of 949 patients with clinical suspicion of appendicitis, who had both white cell...
Tue Nov 12, 2019 18:28
Minimally invasive major hepatectomy can be adopted safely today with a low open conversion rate. Over time with increasing experience, we performed minimally invasive major hepatectomy with increasing frequency in higher risk patients and in patients with multifocal tumors but with a decrease in median estimated blood loss. Abstract Background The role of minimally invasive major hepatectomy (MIMH) remains controversial and questions remain about its safety and reproducibility outside expert...
Tue Nov 12, 2019 18:28
Abstract Background The effectiveness of allergen immunotherapy (AIT) in seasonal and perennial allergic rhinitis (AR) depends on the definition of pollen exposure intensity or time period. We recently evaluated pollen and symptom data from Germany to examine the new definitions of the European Academy of Allergy and Clinical Immunology (EAACI) on pollen season and peak pollen period start and end. Now we aim to confirm the feasibility of these definitions to properly mirror symptom loads for...
Wed Nov 13, 2019 12:04
Abstract Allergen Immunotherapy (AIT) was introduced in clinical practice on an empirical basis more than 100 years ago. Since the first attempts, AIT was administered subcutaneously. Indeed, other routes of administration were proposed and studied, in particular to improve the safety, but only the sublingual route (SLIT) achieved a credibility based on evidence, and was then accepted as a viable “alternative” option to the subcutaneous route. SLIT was largely used in clinical trials and clinical...
Tue Nov 12, 2019 22:50
Abstract Eosinophilic esophagitis (EoE) is a chronic‐inflammatory disease of the esophagus, defined clinically by presence of symptoms of esophageal dysfunction and histologically by an eosinophil predominant infiltration in the esophageal mucosa.1 Due to its chronicity, EoE requires both short‐term and long‐term treatment.2 Therapeutic goals are: 1) to control clinical activity (resolution of symptoms); and 2) to control biological activity to avoid stricture formation and bolus impaction, a potentially...
Tue Nov 12, 2019 22:43
Abstract Background There is mounting evidence that systemic uptake of food allergens is key to triggering anaphylaxis. However, direct proof for this theory is still lacking. The purpose of this study was to quantify the absorption and to determine the absorption kinetics of immunoreactive peanut protein in relation to the allergic response in human. Methods Quantitative protein assays including mass spectrometry, dot blots and Western blotting were developed to determine the level of...
Tue Nov 12, 2019 21:53
Tue Nov 12, 2019 19:04
Tue Nov 12, 2019 11:02
Abstract Background Chronic rhinosinusitis (CRS) epidemiology has been largely studied using symptom‐based case definitions, without assessment of objective sinus findings. Objective To describe radiologic sinus opacification and the prevalence of CRS, defined by the co‐occurrence of symptoms and sinus opacification, in a general population‐based sample. Methods We collected questionnaires and sinus CT scans from 646 participants selected from a source population of 200,769 primary...
Mon Nov 11, 2019 20:08
Publication date: Available online 12 November 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Wei Liu, Katherine Zukotynski, Louise Emmett, Hans T. Chung, Peter Chung, Robert Wolfson, Irina Rachinsky, Anil Kapoor, Ur Metser, Andrew Loblaw, Gerard Morton, Tracy Sexton, Michael Lock, Joelle Helou, Alejandro Berlin, Colm Boylan, Susan Archer, Greg Pond, Glenn BaumanAbstractPurposeRadio-recurrent prostate cancer is typically detected by a rising PSA and may reflect...
Wed Nov 13, 2019 14:55
Publication date: Available online 13 November 2019Source: Journal of Surgical EducationAuthor(s): Erin Brown, Joline Choi, Tesnim SairiBACKGROUNDAs surgical educators, we need to balance the training of our future colleagues against the best possible outcomes and expectations of our patients. Although the legal and ethical standards for disclosure regarding trainee involvement in delivery of surgical care are well established, it is unclear if patient experiences reflect current principles of medical...
Wed Nov 13, 2019 14:35
Publication date: Available online 13 November 2019Source: Clinical ImagingAuthor(s): Christopher P. Emerson, George C. Balazs, Susan C. Lee, Joshua S. Dines, Jean Jose, Harry G. GreditzerAbstractBackgroundSuperior capsular reconstruction (SCR) of the shoulder is an increasingly common procedure in the treatment of patients with massive, irreparable rotator cuff tears lacking significant osteoarthritis. Post-operatively, the appearance of failed grafts has only been described in isolated case reports...
Wed Nov 13, 2019 14:14
Publication date: Available online 12 November 2019Source: Clinical ImagingAuthor(s): Shadi Ebrahimian, Azin Shayganfar, Peyman Hashemi, Mahsa Masjedi Esfahani, Amir Mohammad Ghanei, Nooshin Afshar Moghadam, Shadi EbrahimianAbstractObjectivesThyroid imaging reporting and data system (TIRADS) is a combination of ultrasonographic features developed to help physicians in predicting the malignancy risk of thyroid nodules based on sonographic characteristics. Thyroid nodule size is another factor in determining...
Tue Nov 12, 2019 12:27
Publication date: Available online 11 November 2019Source: Clinical ImagingAuthor(s): Mahati Mokkarala, David H. Ballard, Robert Wesley, Fernando R. Gutierrez, Cylen Javidan-Nejad, Gautam K. Singh, Pamela K. Woodard, Kathryn J. LindleyAbstractThe present case illustrates cardiac magnetic resonance imaging (MRI) and three-dimensional (3D) printed anatomic model findings of a coronary-cameral fistula (CCF) and double-chambered right ventricle (DCRV). A pregnant woman presented with palpitations and...
Tue Nov 12, 2019 12:27
Publication date: Available online 11 November 2019Source: Clinical ImagingAuthor(s): Ali Kupeli, Mehmet Kocak, Mehmet Goktepeli, Erdal Karavas, Gurkan DanisanAbstractPurposeTo investigate the relationship between healthy brain aging and T1 relaxation time obtained by T1 mapping.Materials and methodsA total of 211 (102 males, 109 females; age range: 20–89 years; mean age: 54 years) healthy volunteers underwent T1 mapping between July 2018 and January 2019. Regions of interest (ROIs) were placed on...
Tue Nov 12, 2019 12:27
Publication date: Available online 11 November 2019Source: Clinical ImagingAuthor(s): Cheng Ting Lin, Linda Chi Hang Chu, Stefan Loy Zimmerman, Elliot K. FishmanAbstractObjectiveTo examine differences in image quality of the coronary arteries when performing high-pitch non-electrocardiography (ECG)-gated scans on the second-generation (2G) and third-generation (3G) dual-source CT scanners.MethodsWe retrospectively examined patients with high-pitch non-ECG-gated CT angiography (CTA) of the chest or...
Tue Nov 12, 2019 12:27
Publication date: Available online 11 November 2019Source: Clinical ImagingAuthor(s): Micheal H. Raj, John N. Mullins, Joan M. Chi, Andy H. Choy, Gregory M. Grimaldi, Barak FriedmanAbstractPregnant women with abdominal pain can pose a diagnostic dilemma due to the nonspecific nature of symptoms and the desire to avoid radiation to the conceptus. Many algorithms will suggest ultrasound (US) or Magnetic Resonance Imaging (MRI) as the first-line imaging choice in pregnant women with abdominal pain due...
Tue Nov 12, 2019 12:27
Publication date: Available online 11 November 2019Source: Clinical ImagingAuthor(s): Sadia Choudhery, Eric Polley, Amy Lynn ConnersAbstractObjectivesThe purpose of this study is to retrospectively evaluate the presence of screening digital breast tomosynthesis (DBT) correlates for suspicious lesions detected on pre-operative staging magnetic resonance imaging (MRI) in patients with newly diagnosed breast cancer.MethodsAfter approval from the institutional review board (IRB), screening DBTs on breast...
Tue Nov 12, 2019 12:27
Treatment with oxycodone impairs colonic motility as measured with electromagnetic capsules. Co administration with naloxegol changes colonic motility towards normality. Detailed motility information may help us understand the mechanisms underlying opioid‐induced constipation. Abstract Background Opioid treatment often causes debilitating constipation. However, it is not well described how opioids affect colonic motility and whether opioid‐induced constipation is due to either a decrease of...
Tue Nov 12, 2019 16:11
Umami receptors (T1R1/T1R3) are expressed on smooth muscle cells of the stomach, and activation of these receptors induces muscle relaxation by decreasing intracellular calcium via Gαi2. Abstract Background l‐amino acids, such as monosodium glutamate (MSG), activate the umami receptor T1R1/T1R3. We previously showed increased peristalsis in response to activation of T1R1/T1R3 by MSG in mouse colon. However, the expression and function of these receptors in the different regions of the stomach...
Tue Nov 12, 2019 16:10
A high‐fat diet causes neuronal loss and intestinal dysmotility in the colon of obese Swiss mice, without changes in the major groups of colonic microbiota. These findings reinforce that the lipotoxicity of the diet has a major role in the damage to the enteric nervous system. Abstract Background Obesity has been linked to gastrointestinal disorders, and the loss of myenteric neurons in the intestine caused by high‐fat diets (HFD) has been attributed to changes in microbiota and lipotoxicity....
Tue Nov 12, 2019 16:09
We have conducted the first PET/CT study of cholinergic innervation of the gut in patients with esophagus cancer, who received radical surgical esophagectomy including vagotomy with comparison to healthy matched controls. We detected significantly decreased 11C‐donepezil PET signal in the small intestine and colon of vagotomized patients treated for esophagus cancer, suggesting that 11C‐donepezil PET can be used to assess damage to the parasympathetic nervous system in the GI‐tract. Abstract ...
Tue Nov 12, 2019 12:27
Publication date: Available online 13 November 2019Source: International Journal of PsychophysiologyAuthor(s): Benjamin James Dyson, Cecile Musgrave, Cameron Rowe, Rayman SandhurAbstractTo examine the behavioural and neural interactions between objective and subjective performance during competitive decision-making, participants completed a Matching Pennies game where win-rates were fixed within three conditions (win > lose, win = lose, win < lose) and outcomes were predicted at each trial....
Wed Nov 13, 2019 13:57
Nature Communications, Published online: 13 November 2019; doi:10.1038/s41467-019-12782-6Arabidopsis EH/Pan1 proteins are part of the TPLATE complex (TPC) that is required for endocytosis in plants. Here, the authors show AtEH/Pan1 proteins also act in actin-mediated autophagy, by interacting with VAP27-1 at ER-PM contact sites and recruiting TPLATE and AP-2 complex subunits, clathrin and ARP2/3/ proteins to autophagosomes.
Wed Nov 13, 2019 02:00
Nature Communications, Published online: 13 November 2019; doi:10.1038/s41467-019-13143-zThe build-up of iron in the body can have serious consequences; current treatment therapies suffer from adverse side effects and toxicity. Here, the authors developed renal clearable nanochelators with improved pharmacodynamics and demonstrated their efficacy and safety in iron overload animal models.
Wed Nov 13, 2019 02:00
Nature Communications, Published online: 13 November 2019; doi:10.1038/s41467-019-12970-4LncRNA loci potentially contain multiple modes that can exert function, including DNA regulatory elements. Here, the authors generated genetic models in mice to dissect the role of the syntenically conserved lncRNA Firre in the context of hematopoiesis.
Wed Nov 13, 2019 02:00
Nature Communications, Published online: 13 November 2019; doi:10.1038/s41467-019-13058-9Our understanding of the mechanisms of drug interactions remains limited. Here the authors introduce a framework to study how complex cellular perturbations induced by different drugs affect each other in morphological feature space.
Wed Nov 13, 2019 02:00
Nature Communications, Published online: 13 November 2019; doi:10.1038/s41467-019-13129-xTypical methods for optical vector analysis have tradeoffs among resolution, dynamic range, and bandwidth. The authors use an asymmetric optical probe signal generator and receiver to perform attometer resolution measurement over a THz of bandwidth while maintaining high dynamic range, aiming to characterize emerging optical devices.
Wed Nov 13, 2019 02:00
Nature Communications, Published online: 13 November 2019; doi:10.1038/s41467-019-12650-3Using agent-based models of a problem-solving task in a network, the authors show that clustering people of similar knowledge maintains solution diversity and increases long run system collective performance. Clustering those with similar abilities, however, lowers solution diversity and performance.
Wed Nov 13, 2019 02:00
Nature Communications, Published online: 13 November 2019; doi:10.1038/s41467-019-13164-8The authors assemble and analyse previously generated mycobiome data linked to geographical locations across the world. They describe the distribution of fungal taxa and show that climate is an important driver of fungal biogeography and that fungal diversity appears to be concentrated at high latitudes.
Wed Nov 13, 2019 02:00
Nature Communications, Published online: 13 November 2019; doi:10.1038/s41467-019-13122-4Cytochrome bd oxidases couple quinol oxidation and the release of protons to the periplasmic side with proton uptake from the cytoplasmic side to reduce dioxygen to water and they are the terminal reductases in bacterial and archaeal respiratory chains. Here the authors present the cryo-EM structure of Escherichia coli bd oxidase and discuss mechanistic implications.
Wed Nov 13, 2019 02:00
Wed Nov 13, 2019 02:00
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Wed Nov 13, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-12631-6Parks have a previously unquantified economic value attributable to mental health, a health services value. Here, the authors proposed three methods to estimate this, and applied one of these methods to show that this value is at least US$6 trillion per annum worldwide.
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-12882-3Assembly-Disassembly-Organization-Reassembly (ADOR) is a valuable method to prepare zeolites of predictable topologies, but has yet to be successfully applied on open framework zeolites. Here, the authors show that non-contact vapour-phase-transport rearrangement allows access to new zeolite topologies from open framework zeolites.
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-12832-zNon-small cell lung cancer (NSCLC) is often associated with metastasis to the lungs. Here, the authors perform independent screens and identify NuRD as a co-repressor of ZEB1, and demonstrate TBC1D2b as a downstream target of ZEB1/NuRD complex regulating NSCLC metastasis.
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-13171-9Specific sequences are essential for the development of cationic polymers that can adhere to negatively charged surfaces in saline environments. Here, the authors show that copolymers with adjacent cation–aromatic sequences can be synthesized through cation–π complex-aided free-radical polymerization, which exhibit fast, strong, but reversible adhesion.
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-13152-yTranscription and translation are coupled in bacteria. Here, the authors show that the movement of a gene locus to the nucleoid periphery correlates with transcription, and the effect is potentiated by translation.
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-13146-wN1-methyladenosine (m1A) was recently reported as a new mRNA modification but its prevalence has been controversial. Here the authors showed that m1A, if present in mRNA, is at very low stoichiometry, with the notable exception of MT-ND5. Further, they show that the previously reported enrichment of m1A near the start of transcripts are false-positive identifications due to cross-reactivity of the commonly used...
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-13109-1Warmer temperatures could increase the growth and metabolic rates of microbes. Here, the authors assemble a dataset of thermal performance curves for over 400 bacteria and archaea, showing that metabolic rates are likely to increase under warming, with implications for global carbon cycling.
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-12860-9Models of mate choice have mainly focused on the implications of female mate choice for reproductive isolation. Here, Aubier et al. develop a population genetic model of coevolution between female and male mate choice, which can lead the population to oscillate between assortative and random mating.
Tue Nov 12, 2019 02:00
Nature Communications, Published online: 12 November 2019; doi:10.1038/s41467-019-12958-0Sleep duration is associated with an adverse lipid profile. Here, the authors perform genome-wide gene-by-sleep interaction analysis and find 49 previously unreported lipid loci when considering short or long total sleep time.
Tue Nov 12, 2019 02:00
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