In terms of pediatric healthcare-associated infections (HAI), neonatal intensive care units (NICU) constitute the greatest risk. Contacting a health care personnel, either directly or indirectly, elevates NICU...
Wed Nov 13, 2019 02:00
During organ culture of intact vessels, endothelin receptors (ETRs) were upregulated in vascular smooth muscle cells (VSMCs) by various stimuli, but whether inflammation alters ETR expression in vivo remains unclear. We aimed to explore the effects of lipopolysaccharide (LPS) challenge on ETR expression in the VSMC in vivo. Male Sprague-Dawley rats received a single intraperitoneal injection of LPS (5 mg/kg body weight) or normal saline (NS) for 6 hrs. The function and expression of ETR type A (ETA)...
07:05
Mechanical ventilation (MV) is a major life support technique for the management of trauma-associated hemorrhagic shock (HS). Ventilator-induced diaphragm dysfunction (VIDD), one of the most common complications of MV, has been well demonstrated in animal and human studies. However, few data are available concerning the effects of MV on diaphragm function in HS victims. In the present study, we found diaphragm muscle atrophy and weakness in HS but not in healthy animals after 4 hours of MV. The inhibition...
07:05
Anemia is one of the most common complications in patients with inflammatory bowel disease (IBD). Hepcidin as a key regulator of iron metabolism is pivotal in mediating the occurrence of anemia of chronic disease. Herein, we analyzed the levels of hepcidin in sera from IBD patients by enzyme-linked immunosorbent assay and investigated its potential role in regulating the anemia in IBD. We observed that the levels of serum hepcidin were increased in active IBD patients compared with those in remitted...
Wed Nov 13, 2019 10:05
The most common postoperative complication after reconstructive surgery is flap necrosis. Adipose-derived stem cells (ADSCs) and their secretomes are reported to mediate skin repair. This study was designed to investigate whether conditioned media from ADSCs (ADSC-CM) protects ischemia/reperfusion- (I/R-) induced injury in skin flaps by promoting cell proliferation and increasing the number of hair follicles. The mouse flap model of ischemia was ligating the long thoracic vessels for 3 h, followed...
Wed Nov 13, 2019 06:05
Osteoporosis is a civilization disease which is still challenging for contemporary medicine in terms of treatment and prophylaxis. It results from excessive activation of the osteoclastic cell line and immune cells like macrophages and lymphocytes. Cell-to-cell inflammatory information transfer occurs via factors including cytokines which form a complex network of cell humoral correlation, called cytokine network. Recently conducted studies revealed the participation of CX3CL1 chemokine in the pathogenesis...
Tue Nov 12, 2019 10:05
Leptin resistance is either a condition induced by human obesity or a natural phenomenon associated with seasonality in ruminants. In the cardiovascular system, the leptin resistance state presence is a complex issue. Moreover, the perivascular adipose tissue (PVAT) appears to be crucial as a source of proinflammatory cytokines and as a site of interaction for leptin contributing to endothelium dysfunction and atherosclerosis progression. So the aim of this study was to examine the influence of the...
Tue Nov 12, 2019 10:05
The literature shows that phenolic compounds possess important antioxidant and anti-inflammatory activities; however, the mechanism underlying these effects is not elucidated yet. The genus Calea is used in folk medicine to treat rheumatism, respiratory diseases, and digestive problems. In this context, some phenolic compounds were isolated with high purity from Calea uniflora Less. and identified as noreugenin (NRG) and α-hydroxy-butein (AH-BU). The aim of this study was to analyze the effect of...
Tue Nov 12, 2019 09:05
Signia (a brand of WS Audiology A/S) announced the general availability of its latest hearing aid innovation, the Pure® Charge&Go X. Built upon the recently launched Signia Xperience platform, the new devices provide wearers with superior hearing even when in motion – all in a sleek, rechargeable hearing aid.Pure Charge&Go X is a receiver-in-canal (RIC) device that includes the world's first acoustic-motion sensors. Since a hearing aid wearer's sound environment can change suddenly, this...
Wed Nov 13, 2019 11:04
Signia (a brand of WS Audiology A/S) announced the general availability of its latest hearing aid innovation, the Pure® Charge&Go X. Built upon the recently launched Signia Xperience platform, the new devices provide wearers with superior hearing even when in motion – all in a sleek, rechargeable hearing aid.Pure Charge&Go X is a receiver-in-canal (RIC) device that includes the world's first acoustic-motion sensors. Since a hearing aid wearer's sound environment can change suddenly, this...
Wed Nov 13, 2019 11:04
The Consumer Electronics Association (CES) has named Oticon Xceed and Oticon RemoteCare as honorees in the CES 2020 Innovations Awards. The leading international awards program annually selects the best of the best in consumer electronics. Oticon Xceed was recognized in the highly competitive Health & Wellness category, while Oticon RemoteCare, a new e-health solution that will enable hearing care professionals to provide convenient aftercare service to their patients (to be released in 2020),...
Mon Nov 11, 2019 15:40
The Consumer Electronics Association (CES) has named Oticon Xceed and Oticon RemoteCare as honorees in the CES 2020 Innovations Awards. The leading international awards program annually selects the best of the best in consumer electronics. Oticon Xceed was recognized in the highly competitive Health & Wellness category, while Oticon RemoteCare, a new e-health solution that will enable hearing care professionals to provide convenient aftercare service to their patients (to be released in 2020),...
Mon Nov 11, 2019 15:40
Tissue Engineering Part A, Ahead of Print.
Tue Nov 12, 2019 10:00
The ladybird beetle Serangium japonicum is an important predator of whiteflies. Investigations of the molecular mechanisms of this predatory beetle have been hindered by the scarcity of gene sequence data. To obtain gene sequences for the ladybird beetle and determine differences in gene expression between the summer and winter seasons, paired-end sequencing was performed. Real-time PCR was used to validate differences in Krueppel homolog 1 gene (Kr-h1) mRNA expression in summer versus winter samples....
00:31
From yeast to humans, the cell cycle is tightly controlled by regulatory networks that regulate cell proliferation and can be monitored by dynamic visual markers in living cells. We have observed S phase progression by monitoring nuclear accumulation of the FHA-containing DNA binding protein Tos4, which is expressed in the G1/S phase transition. We use Tos4 localization to distinguish three classes of DNA replication mutants: those that arrest with an apparent 1C DNA content and accumulate Tos4 at...
Tue Nov 12, 2019 22:18
Mycobacterium abscessus is a fast growing mycobacterium species mainly causing skin and respiratory infections in human. M. abscessus is resistant to numerous drugs, which is a major challenge for the treatment. In this study, we have sequenced the genomes of two clinical M. abscessus strains having rough and smooth morphology, using the single molecule real-time and Illumina HiSeq sequencing technology. In addition, we reported the first comparative methylome profiles of a rough and a smooth M....
Tue Nov 12, 2019 22:18
Hereditary angioedema with normal C1 inhibitor (HAE-nC1 INH) is a rare, underappreciated condition characterized by recurrent subcutaneous angioedema. The underlying pathophysiology and diagnostic criteria con...
Tue Nov 12, 2019 02:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03958
Wed Nov 13, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04286
Wed Nov 13, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03629
Wed Nov 13, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03035
Wed Nov 13, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04429
Wed Nov 13, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03960
Wed Nov 13, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03305
Wed Nov 13, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03263
Wed Nov 13, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04028
Wed Nov 13, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03596
Wed Nov 13, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04444
Wed Nov 13, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03091
Wed Nov 13, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04481
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04000
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04068
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03846
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03780
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03487
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04859
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04868
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04711
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04126
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04112
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03923
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03412
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04036
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04257
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01847
Tue Nov 12, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03772
Tue Nov 12, 2019 07:00
Current guidelines have unsatisfied performance in predicting severe outcomes after Clostridium difficile infection (CDI). Our objectives were to develop a risk prediction model for 30-day mortality and to examin...
Tue Nov 12, 2019 02:00
The Asia Pacific Society of Infection Control (APSIC) launched the APSIC Guidelines for the Prevention of Surgical Site Infections in 2018. This document describes the guidelines and recommendations for the se...
Tue Nov 12, 2019 02:00
Much effort has been made over the last two decades to educate and train healthcare professionals working on antimicrobial resistance in French hospitals. However, little has been done in France to assess perc...
Tue Nov 12, 2019 02:00
Vascular lesions mainly affect soft tissues, and less than 1% affect bone. In 1982, they were categorised by Mulliken and Glowacki as haemangiomas or vascular malformations, and an updated classification was subsequently published by the International Society for the Study of Vascular Anomalies. These lesions, however, continue to be termed haemangiomas and there is little attempt to differentiate between them. We report eight cases of intraosseous venous malformation that were inappropriately labelled...
Wed Nov 13, 2019 02:00
Laurence was the consultant who developed Oral & Maxillofacial Surgery services in Somerset. A gifted postgraduate educator, he passed away on 2nd October 2019.
Wed Nov 13, 2019 02:00
Ankylosis of the temporomandibular joint (TMJ) is a severely deforming, disabling condition as a result of craniomandibular fusion caused mainly by condylar fractures with displacement of the meniscus. Ankylosis may be fibrous, fibro-osseous, or bony, and unilateral or bilateral. The severity of the deformity is based on the onset, duration, and type of ankylosis. Various surgical techniques have been described for treatment, but no single treatment is recommended because of inconsistent results...
Wed Nov 13, 2019 02:00
Lithopedion is a word derived from the Greek words lithos, meaning stone, and paidion, meaning child, to describe a fetus that has become stony or petrified. Lithopedion is a rare complication of pregnancy which ...
Tue Nov 12, 2019 02:00
Surgeons at the Cleveland Clinic managed to implant a donor kidney into a patient using a surgical robot, and all through one small incision. The technique, in which instruments as well as the donor kidney can be passed through a four centimeter (1.6 inch) wide incision, is designed to make it easier to perform transplants on patients with difficult anatomies and to cause less collateral damage to internal and external tissues. “The aim was not only to make a smaller incision, but also to...
Wed Nov 13, 2019 21:15
Eyevensys, a clinical-stage biotechnology company based in France, has developed a method to perform non-viral gene therapy in the eye, with the aim of treating ocular diseases. The system uses ocular electrotransfection to deliver therapeutic genes into the eye. Consisting of an ocular device and an electrical pulse generator, the system can deliver DNA plasmids into the ciliary muscle. The idea is that the transfected cells in the eye allow for sustained local production of therapeutic proteins,...
Tue Nov 12, 2019 23:38
Nevro, a firm based in Silicon Valley, won FDA approval for its Senza Omnia spinal cord neurostimulation system for chronic pain management. The device can deliver traditional spinal cord stimulation at frequencies below 1.5 kHz, along with Nevro’s proprietary HF10 stimulation that goes up to 10 kHz. Both low and high frequency therapies can even be provided at the same time. The Senza Omnia can operate at frequencies between 2 and 10,000 Hertz, a range unheard of in a spinal cord stimulator....
Tue Nov 12, 2019 19:35
Transcutaneous electrical muscle stimulation is used in a variety of clinical applications, including as a rehabilitation tool to help people with limited mobility. It is effective for maladies such as certain types of urinary incontinence, for example, but getting the muscles of the arm to move in unison and with appropriate strength via electrical stimulation through the skin is very difficult. Researchers at The Feinstein Institutes for Medical Research, a part of Northwell Health, a New...
Tue Nov 12, 2019 19:24
Researchers at the University of Wisconsin-Madison have developed an injectable flexible electrode that can aid in neuromodulation therapy, potentially replacing more rigid electrodes that do not mesh well with soft tissues. The injectable material consists of a silicone gel and small metal particles, and it forms a flexible bolus when injected around a target nerve. The nerve can then be electrically stimulated from the surface of the skin using a basic transcutaneous electrical nerve stimulation...
Tue Nov 12, 2019 17:17
Post-stroke dysphagia rehabilitation in the old and oldest old: outcome and relevance for discharge home. Int J Rehabil Res. 2019 Nov 07;: Authors: Castagna A, Ferrara L, Asnaghi E, Colombo V, Rega V, Fiorini G Abstract We assessed the outcome of dysphagia rehabilitation in all the 139 patients with post-stroke dysphagia admitted to our Neurorehabilitation Unit during 2 years (2017 and 2018), divided into two groups: old (aged 65-84 years) and oldest-old...
Wed Nov 13, 2019 20:53
Transcranial direct current stimulation improves the swallowing function in patients with cricopharyngeal muscle dysfunction following a brainstem stroke. Neurol Sci. 2019 Nov 12;: Authors: Wang ZY, Chen JM, Lin ZK, Ni GX Abstract OBJECTIVE: This study investigated the effects of transcranial direct current stimulation (tDCS) combined with conventional swallowing training on the swallowing function in brainstem stroke patients with cricopharyngeal muscle...
Wed Nov 13, 2019 20:53
We report the application of an elliptical femtosecond laser-assisted in situ keratomileusis (LASIK) flap for the management of post-arcuate keratotomy (AK) residual astigmatism. An 82-year-old male was referred to our institute for evaluation of his right eye due to residual regular astigmatism 1 year after AK. On examination, uncorrected distance visual acuity (UDVA) was 20/50 and corrected distance visual acuity was 20/25 (+3.25 –5.50 × 125). Slit-lamp examination revealed two 70-arc length peripheral...
Wed Nov 13, 2019 17:16
Background Despite the development of anterior skull base surgery, the anatomy of the nasal bone and anterior cribriform plate remains unclear. A recent study confirmed 2 distinct foramina in the anterior part of cribriform plate: the ethmoidal slit (ES) and the cribroethmoidal foramen (CF). The aim of this study was to specify their content, their anatomic relationship to the frontal sinus and skull base, and their potential value in skull base surgery. Methods Dissections were performed...
Wed Nov 13, 2019 17:55
Publication date: Available online 13 November 2019Source: Annals of Diagnostic PathologyAuthor(s): Eric Gars, Alexandra Butzmann, Robert Ohgami, Jayalakshmi P. Balakrishna, Dennis P. O'MalleyAbstractThe formation, development and dissolution of germinal centers is a major part of immune system function. It is important to differentiate neoplastic processes from follicular hyperplasia and regressive follicular changes. Better understanding of germinal center development and dissolution also provides...
Wed Nov 13, 2019 19:02
Abstract Purpose of Review The purpose of this review is to provide a summary of the perioperative studies that have examined transdermal lidocaine (lidocaine patch) as an analgesic and put the evidence in context of the likely overall benefit of transdermal lidocaine in the perioperative period. Recent Findings Several randomized controlled...
02:00
Abstract Purpose of Review Scientists have reported that pain is always created by the brain. This may not be entirely true. Pain is not only a sensory experience, but also can be associated with emotional, cognitive, and social components. The heart is considered the source of emotions, desire, and wisdom. Therefore, the aim of this article was to review the available evidence about the role of the heart in pain modulation. ...
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