Abstract Background Limb girdle muscular dystrophy type R1/2A (LGMDR1/LGMD2A) is a progressive myopathy caused by deficiency of calpain 3, a calcium-dependent cysteine protease of skeletal muscle, and it represents the most frequent type of LGMD worldwide. In the last few years, muscle magnetic resonance imaging (MRI) has been proposed as a tool for identifying patterns of muscular involvement in genetic disorders and as a biomarker of...
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Abstract Background The epidemiology of paraneoplastic neurological syndromes (PNS) remains to be defined. We present here the first population-based incidence study and report the clinical spectrum and antibody profile of PNS in a large area in Northeastern Italy. Methods We performed a 9-year (2009–2017) population-based epidemiological study of PNS in...
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Abstract Objective To determine the diagnostic and monitoring value of serum neurofilament light chain (NfL) in spinal muscular atrophy (SMA). Methods We measured serum NfL in 46 SMA patients at baseline and over 14 months of treatment with the antisense-oligonucleotide (ASO) nusinersen using the ultrasensitive single molecule array (Simoa) technology. Serum...
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La espalda de las chicas sufre más por el peso de las mochilas que la de los chicos
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Los veteranos con problemas de salud mental tienen un mayor riesgo de enfermedad cardíaca, accidente cerebrovascular
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Modificaciones simples del estilo de vida clave para prevenir un gran porcentaje de casos
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Abstract We demonstrate how to use numerical simulation models directly on micro-CT images to understand the impact of several enhanced oil recovery (EOR) methods on microscopic displacement efficiency. To describe the physics with high-fidelity, we calibrate the model to match a water-flooding experiment conducted on the same rock sample (Akai et al. in Transp Porous Media 127(2):393–414, 2019. https://doi.org/10.1007/s11242-018-1198-8). First we show comparisons of water-flooding...
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Journal of Medicinal Food, Ahead of Print.
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Journal of Medicinal Food, Ahead of Print.
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Microorganisms, Vol. 7, Pages 391: Predictive Values of Serum Chlamydia trachomatis TroA and HtrA IgG Antibodies as Markers of Persistent Infection in the Detection of Pelvic Adhesions and Tubal Occlusion Microorganisms doi: 10.3390/microorganisms7100391 Authors: Tiina Rantsi Jolande A. Land Päivi Joki-Korpela Sander Ouburg Kati Hokynar Jorma Paavonen Aila Tiitinen Mirja Puolakkainen Chlamydia trachomatis IgG antibody testing (CAT) has been used as a screening test...
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Microorganisms, Vol. 7, Pages 390: Genetic Modification of mfsT Gene Stimulating the Putative Penicillin Production in Monascus ruber M7 and Exhibiting the Sensitivity towards Precursor Amino Acids of Penicillin Pathway Microorganisms doi: 10.3390/microorganisms7100390 Authors: Ramzan Safiullah Virk Muhammad Ahmed Yuan Chen : The biosynthesis of penicillin G (PG) is compartmentalized, which forces penicillin and its intermediates to cross the membrane barriers. Although...
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Microorganisms, Vol. 7, Pages 389: Molecular Epidemiological Characterization of Staphylococcus argenteus Clinical Isolates in Japan: Identification of Three Clones (ST1223, ST2198, and ST2550) and a Novel Staphylocoagulase Genotype XV Microorganisms doi: 10.3390/microorganisms7100389 Authors: Aung Urushibara Kawaguchiya Sumi Takahashi Ike Ito Habadera Kobayashi Staphylococcus argenteus, a novel emerging species within Staphylococcus aureus complex (SAC),...
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Microorganisms, Vol. 7, Pages 386: Lefamulin. Comment on: “Novel Antibiotics for Multidrug-Resistant Gram-Positive Microorganisms. Microorganisms, 2019, 7, 270” Microorganisms doi: 10.3390/microorganisms7100386 Authors: Despoina Koulenti Elena Xu Isaac Yin Sum Mok Andrew Song Drosos E. Karageorgopoulos Apostolos Armaganidis Jeffrey Lipman Sotirios Tsiodras On 18 August 2019, an article was published in Microorganisms presenting novel, approved anti-Gram-positive...
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Microorganisms, Vol. 7, Pages 388: Optimizing a Whole-Genome Sequencing Data Processing Pipeline for Precision Surveillance of Health Care-Associated Infections Microorganisms doi: 10.3390/microorganisms7100388 Authors: Weihua Huang Guiqing Wang Changhong Yin Donald Chen Abhay Dhand Melissa Chanza Nevenka Dimitrova John T. Fallon The surveillance of health care-associated infection (HAI) is an essential element of the infection control program. While whole-genome...
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Microorganisms, Vol. 7, Pages 387: Vibrio Proteases for Biomedical Applications: Modulating the Proteolytic Secretome of V. alginolyticus and V. parahaemolyticus for Improved Enzymes Production Microorganisms doi: 10.3390/microorganisms7100387 Authors: Monica Salamone Aldo Nicosia Giulio Ghersi Marcello Tagliavia Proteolytic enzymes are of great interest for biotechnological purposes, and their large-scale production, as well as the discovery of strains producing new molecules,...
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Microorganisms, Vol. 7, Pages 385: Effects of Vertical Water Mass Segregation on Bacterial Community Structure in the Beaufort Sea Microorganisms doi: 10.3390/microorganisms7100385 Authors: Yunyun Fu Richard B. Rivkin Andrew S. Lang The Arctic Ocean is one of the least well-studied marine microbial ecosystems. Its low-temperature and low-salinity conditions are expected to result in distinct bacterial communities, in comparison to lower latitude oceans. However, this is an ocean...
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Microorganisms, Vol. 7, Pages 384: Root Bacteria Recruited by Phragmites australis in Constructed Wetlands Have the Potential to Enhance Azo-Dye Phytodepuration Microorganisms doi: 10.3390/microorganisms7100384 Authors: Valentina Riva Francesca Mapelli Evdokia Syranidou Elena Crotti Redouane Choukrallah Nicolas Kalogerakis Sara Borin The microbiome associated with plants used in phytodepuration systems can boost plant growth and services, especially in ecosystems dealing...
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There is a pressing need for nucleic acid-based assays that are capable of rapidly and reliably detecting pathogenic organisms. Many of the techniques available for the detection of pathogenic RNA possess one or more limiting factors that make the detection of low-copy RNA challenging. While RT-PCR is the most commonly used method for detecting pathogen-related RNA, it requires expensive thermocycling equipment and is comparatively slow. Isothermal methods promise procedural simplicity, but have...
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NEAT1 is one of the most studied lncRNAs, in part because its silencing in mice causes defects in mammary gland development and corpus luteum formation, and protects them from skin cancer development. Moreover, depleting NEAT1 in established cancer cell lines reduces growth and sensitizes cells to DNA damaging agents. However, NEAT1 produces two isoforms and because the short isoform, NEAT1_1, completely overlaps the 5' part of the long NEAT1_2 isoform, the respective contributions of each of the...
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Artificial intelligence (AI)—also known as deep learning—might be able to detect diseases from medical imaging with similar levels of accuracy as doctors, according to a review of current...
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Artificial intelligence (AI)—also known as deep learning—might be able to detect diseases from medical imaging with similar levels of accuracy as doctors, according to a review of current...
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While revising this Analysis article (BMJ 2019;366:l4137, doi:10.1136/bmj.l4137) the authors mistakenly included a section on the reanalysis of the Minnesota Coronary Experiment. The authors had...
11h
Private health screening companies should be held accountable for the follow-up care of the patients they see and not expect the NHS to pick up the bill, the Royal College for General Practitioners...
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Mathew’s welcome comment on empathy in medicine rightly notes that patients put high value on our capacity to “identify with and transiently experience” their emotional states.1 She does not say how...
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GPs delivering weight management programmes should have regular supervision sessions with psychologists to increase their awareness of how mental health can contribute to obesity, a report has...
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bmj;366/sep24_11/l5704/FAF1faWiktor Szymanowicz/Getty ImagesThousands of demonstrators took part in a global climate strike on 20 September in London and other towns and cities across the UK to draw...
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The European Medicines Agency (EMA) has approved the first cannabis based medicine to treat two rare and severe forms of childhood onset epilepsy, although hurdles remain before the drug becomes...
11h
While revising this Analysis article (BMJ 2019;366:l4137, doi:10.1136/bmj.l4137) the authors mistakenly included a section on the reanalysis of the Minnesota Coronary Experiment. The authors had...
14h
Private health screening companies should be held accountable for the follow-up care of the patients they see and not expect the NHS to pick up the bill, the Royal College for General Practitioners...
14h
Mathew’s welcome comment on empathy in medicine rightly notes that patients put high value on our capacity to “identify with and transiently experience” their emotional states.1 She does not say how...
15h
GPs delivering weight management programmes should have regular supervision sessions with psychologists to increase their awareness of how mental health can contribute to obesity, a report has...
15h
bmj;366/sep24_11/l5704/FAF1faWiktor Szymanowicz/Getty ImagesThousands of demonstrators took part in a global climate strike on 20 September in London and other towns and cities across the UK to draw...
15h
The European Medicines Agency (EMA) has approved the first cannabis based medicine to treat two rare and severe forms of childhood onset epilepsy, although hurdles remain before the drug becomes...
15h
Earlier this month England’s health and social care secretary, Matt Hancock, tweeted about some “terrific news”—death rates were at their lowest level since records began, which he claimed was the...
15h
When I was a newly qualified GP in search of a practice that would feel like home, one of the questions I used to ask was, “When and where do you meet for coffee breaks?” Clearly, the coffee itself...
16h
Frequently, a patient’s opening gambit in a consultation is a request for a hospital referral. More often than not this turns out to be entirely appropriate, but occasionally I recommend an...
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In searching for what it means to be a good doctor,1 we must ask and engage with those who are on the receiving end of our care.A systematic review of patients’ priorities conducted two decades ago...
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The wrong email address was included in this letter (BMJ 2019;366:l5440; doi:10.1136/bmj.l5440). The correct one is selena.yang@nhs.net. This has been updated online.
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What you need to knowEncouraging patients to write down their concerns before they meet with you can help make better use of the consultation Help the patient to identify his or her priorities and...
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“General practice in crisis” has been a familiar headline in recent years, as unprecedented demand, funding cuts, and workforce pressures prompted fears that the jewel in the NHS’s crown was losing...
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Salisbury describes how new services use clinicians “poached” from general practice.1 These services are often responses to pressure—the GP in the emergency department, an extra pair of hands in a...
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The NHS was now in a better position to treat thousands of patients with wet age-related macular degeneration “for a fraction of the cost,” Julie Wood, chief executive of NHS Clinical Commissioners,...
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Only a small number of children with solid tumour cancers are able to access targeted precision medicine that is already available for adults, a study has found.Researchers from the Institute of...
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The named GP scheme, introduced for all patients in England over 75 in 2014, did not lead to improvements in continuity of care or in rates of unplanned admissions to hospital, researchers have...
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Poecilia reticulata is one of the most popular ornamental fish species with a higher demand for males due to their large colorful fins. The objectives of this study were mapping of the sex-determining (SD) region on linkage group 12 of guppy, and identification of a sex specific marker. We generated eight polymorphic microsatellite markers distributed along the distal 5.4 Mbp sequence of the previously identified SD region on linkage group (LG) 12. The markers were tested for association with sex...
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A delicate relationship exists between reef-building corals and their photosynthetic endosymbionts. Unfortunately, this relationship can be disrupted, with corals expelling these algae when temperatures rise even marginally above the average summer maximum. Interestingly, several studies indicate that failure of corals to regulate symbiont cell divisions at high temperatures may underlie this disruption; increased proliferation of symbionts may stress host cells by over-production of reactive oxygen...
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The hypoxic tumor microenvironment accelerates the invasion and migration of colorectal cancer (CRC) cells. The aim of this study was to develop and validate a hypoxia gene signature for predicting the outcome...
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Triple negative breast cancer (TNBC) is a breast cancer (BC) subtype that is characterized by its strong invasion and a high risk of metastasis. However, the specific mechanisms underlying these phenotypes are...
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Persistent infection with high-risk human papillomavirus (hrHPV) is associated with cervical cancer development. This process involves the virus-encoded E6 and E7 oncoproteins, which are maintained and express...
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Publication date: Available online 23 September 2019Source: Arab Journal of GastroenterologyAuthor(s): Jinmiao Wang, Yunshou Lin, Tao Jiang, Chao Gao, Duowei Wang, Xiaodong Wang, Ying Wei, Tong Liu, Liwei Zhu, Pengzhi Wang, Feng QiAbstractBackground and study aimsAlthough the function of microRNA21 (miR-21) in the invasion and metastasis of colon cancer has been extensively studied, the mechanisms of invasion and migration related pathways between and its targets are still not elucidated. This study...
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Related ArticlesToo Many Avoidable Suicides Occur Worldwide in Young Patients. Rambam Maimonides Med J. 2019 Sep 18;: Authors: Rose K, Neubauer D, Grant-Kels JM Abstract United States (US) and European Union (EU) laws attempt to counterbalance the presumed discrimination of children in drug treatment and drug development. The US Food and Drug Administration (FDA)-rewarded pediatric studies with antidepressants triggered in 2004 an FDA black-box warning...
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Systemic lupus erythematosus (SLE) is an unusual risk factor for cerebral venous sinus thrombosis (CVST). As few CVST patients with SLE have been reported, little is known regarding its frequency as an underlying etiology, clinical characteristics, or long-term outcome. We evaluated a large cohort of CVST patients with SLE in a multicenter study of cerebral venous thrombosis, the VENOST study, and their clinical characteristics.
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