Audience: Consumer, Health Professional, Pharmacy September 23, 2019 -- Sandoz Inc. is voluntarily recalling all quantities and lots within expiry of Ranitidine Hydrochloride Capsules in the US to the consumer level because of confirmed...
1h
Audience: Consumer, Health Professional, Pharmacy September 23, 2019 -- Sandoz Inc. is voluntarily recalling all quantities and lots within expiry of Ranitidine Hydrochloride Capsules in the US to the consumer level because of confirmed...
3h
Pediatric specialists are often unavailable in low- and middle-income countries. As part of multiple professional associations' efforts to improve access to endocrine expertise globally, a pediatric endocrine teleconsultation network was established on a store-and-forward teleconsultation platform to facilitate focused, language-appropriate advice that can be kept for future reference while bypassing real-time video-conferencing, and obviating the need for a scheduled appointment. User information...
1h
Enterococci are fecal indicator bacteria (FIB) used for monitoring the microbial quality of bathing water. However, the reliability of health protection by monitoring FIB is questioned. This study evaluated the decay pattern of Enterococcus faecalis in beach environment and compared it with decay patterns of the pathogen Vibrio cholerae and the virus indicator MS2 coliphage. Tests were done in an experimental mesocosm simulating natural Nordic summer daylight conditions with and without the aquatic...
16h
1h
Contributors : Doowon Huh ; Sohail F TavazoieSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensWe report the changes in tRNA fragment abundance as measured by small RNA sequencing after cells have been exposed to oxidative stress by H2O2.
1h
Series Type : OtherOrganism : Drosophila melanogasterThis SuperSeries is composed of the SubSeries listed below.
1h
Series Type : Expression profiling by high throughput sequencing ; Genome variation profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
1h
Contributors : Stephen S Gisselbrecht ; Alexandre Palagi ; Jesse V Kurland ; Julia M Rogers ; Hakan Ozadam ; Ye Zhan ; Job Dekker ; Martha L BulykSeries Type : OtherOrganism : Drosophila melanogasterWe generated HiC data from sorted mesodermal and non-mesodermal cells from stage 11-12 Drosophila embryos to explore the distribution of genomic contacts of silencers and non-silencers (identified elsewhere in the manuscript).
1h
Contributors : Edwin A Rosado-Oliveri ; Idil I Aigha ; Jennifer H Kenty ; Dani Swain ; José Rivera-Feliciano ; Douglas A MeltonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe beta (β) cell mass formed during embryogenesis is amplified by cell replication that occurs primarily during fetal and early postnatal development. Thereafter, β cells become functionally mature and their mass is maintained by a very low rate of replication. For those few β cells...
1h
Contributors : Souhila Medjkane ; Roberta CodatoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMembers of the SMYD family of Histone Lysine Methyltransferases, including SMYD3, were shown to be involved in both cardiac and skeletal myogenesis. Currently, very little is known about their mechanisms of action and their potential target genes. To study the cellular and molecular function of SMYD3 in skeletal muscle differentiation, we used loss and gain of function...
1h
Contributors : Xuefei Zhang ; Frederick W AltSeries Type : Genome variation profiling by high throughput sequencingOrganism : Mus musculusIn a B lymphocyte immunoglobulin heavy chain locus (IgH), a developmentally assembled V(D)J exon encoding an antibody variable region lies upstream of exons encoding a m constant region (Cm), allowing generation of mIgH chain transcripts and IgM-class antibodies1. Mouse IgH class switch recombination (CSR) replaces Cmwith one of 6 sets of constant region exons...
1h
Contributors : Yuji Otsuki ; Juntaro Yamasaki ; Kentaro Suina ; Shogo Okazaki ; Naoyoshi Koike ; Hideyuki Saya ; Osamu NaganoSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe major antioxidant glutathione (GSH) protects cancer cells from oxidative damage leading to ferroptosis, an iron-dependent cell death. Therapy-resistant cancer cells often manifest high expression of the cystine-glutamate antiporter subunit xCT which enhances cystine uptake leading to GSH synthesis...
1h
Series Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
1h
Contributors : Stephen S Gisselbrecht ; Alexandre Palagi ; Jesse V Kurland ; Julia M Rogers ; Hakan Ozadam ; Ye Zhan ; Job Dekker ; Martha L BulykSeries Type : OtherOrganism : Drosophila melanogasterSilencers active in the Drosophila embryonic mesoderm were identified by reporter assays in dissociated embryonic cells. We find that, despite the presence of ChIP peaks for known transcriptional corepressors and marks of repressed chromatin, the only significantly enriched source of mesodermal silencers...
1h
Contributors : Lisa M McEwen ; Kieran J O’Donnell ; Megan G McGill ; Rachel D Edgar ; Meaghan J Jones ; Julia L MacIsaac ; David T Lin ; Katia Ramadori ; Alexander Morin ; Nicole Gladish ; Elika Garg ; Eva Unternaehrer ; Irina Pokhvisneva ; Neerja Karnani ; Michelle Z Kee ; Torsten Klengel ; Nancy E Adler ; Ronald G Barr ; Nicole Letourneau ; Gerald F Giesbrecht ; James N Reynolds ; Darina Czamara ; Jeffrey M Armstrong ; Marilyn J Essex ; Carolina de Weerth ; Roseriet Beijers ; Marieke...
1h
Contributors : Ronak Lakhia ; Vishal PatelSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: Determine the differential gene expression pattern between wildtype, Pkd2-KO and Pkd2-miR-214 KO miceMethods: kidney mRNA profiles of Pkd2-KO and Pkd2-mir-214-KO mice was sequenced with N of 3 in each groupResults: 972 differentially expressed transcripts were identified between Pkd2-KO kidneys and Pkd2-miR-214-KO kidneysConclusion: Deletion of miR-214 promotes...
1h
Contributors : Xuefei Zhang ; Frederick W AltSeries Type : Genome variation profiling by high throughput sequencingOrganism : Mus musculusIn a B lymphocyte immunoglobulin heavy chain locus (IgH), a developmentally assembled V(D)J exon encoding an antibody variable region lies upstream of exons encoding a constant region (C), allowing generation of IgH chain transcripts and IgM-class antibodies1. Mouse IgH class switch recombination (CSR) replaces Cwith one of 6 sets of constant region exons...
1h
Contributors : Bingjie Wang ; Zehui SunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose:The primary cilia play central roles in transducing or regulating various signaling pathways during brain development. However, the function of primary cilia in mature nerve system is currently largely unknown.We aimed to identify transcriptional changes resulting from depletion of ciliary GPCR 5-HT6R.Methods: We performed RNA sequencing in the hippocampal tissues...
1h
Contributors : Doowon Huh ; Sohail F TavazoieSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe report the CLIP binding interactions from the RNA binding protein SSB
1h
Contributors : Guanglong Hu ; Weitao MaoSeries Type : Expression profiling by high throughput sequencingOrganism : Castanea mollissimaChinese Chestnut (Castanea mollissima BL.) has high nutritional and ecological value, so it is widely planted.However, the number of male flowers far exceeds the number of female flowers is an important factor limiting the yield of Chinese chestnut.A naturally occurring mutation in male catkin has been found on a Chinese chestnut tree in the mountains of Beijing,...
1h
Contributors : Masafumi Horie ; Fan Li ; Beiyun Zhou ; Zea BorokSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculussingle cell RNA-sequencing of alveolar type 1 cells
1h
Contributors : Sinisa Vidovic ; Juan E AbrahanteSeries Type : Expression profiling by high throughput sequencingOrganism : Salmonella enterica subsp. enterica serovar EnteritidisWe report our results of RNA-seq analysis on the wild type Salmonella Enteritidis and its yccT (i.e., yccT encodes STY1099 protein) mutant with and without H2O2 treatment
1h
Contributors : Keisuke Tamari ; Hideshi IshiiSeries Type : Expression profiling by arrayOrganism : Homo sapiensmiRNA and mRNA expression of HeLa cancer stem cells and non-cancer stem cells
1h
Contributors : Sinisa Vidovic ; Juan E AbrahanteSeries Type : Expression profiling by high throughput sequencingOrganism : Salmonella enterica subsp. enterica serovar EnteritidisWe report our results of RNA-seq analysis on Salmonella Enteritidis biofilms and planktonic cells of the wild type and its cpxR mutant
1h
Contributors : Hao Pan ; Yuhong Wang ; Zhangui TangSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; synthetic constructOral squamous cell carcinoma (OSCC) accounts for the high mortality rate and morbidity in head and neck cancer. Data for analysis were obtained from the microarray data of 6 OSCC tissues, tissues adjacent to cancer, and contralateral normal tissues.We used the affy package under the R environment to preprocess and normalize the original gene chip data.
1h
Contributors : Hirzahida Mohd Padil ; Kok-Gan Chan ; Mohd-Firdaus Mohd-Raih ; Sheila NathanSeries Type : Methylation profiling by high throughput sequencingOrganism : Burkholderia pseudomalleiWe report the methylome sequencing and annotation of Burkholderia pseudomallei D286 based on high-throughput profiling using PacBio SMRT technology
1h
Contributors : Lixin Xia ; Zhihui ZhaoSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Bos taurusFor RNA-seq, the sequencing library of each RNA sample was prepared by using Ion Total RNA-Seq Kit v2. For Solexa suquencing, we download the data obtained by a previous study in our laboratory. Genes and miRNAs were considered differentially expressed according to log2FC >1 or log2FC
1h
Contributor : Jin M KimSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed RNA-seq for profiling genetic changes in mouse embryonic submandibular glands upon blebbistatin treatment.
1h
Contributors : Xuefei Zhang ; Frederick W AltSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusIn a B lymphocyte immunoglobulin heavy chain locus (IgH), a developmentally assembled V(D)J exon encoding an antibody variable region lies upstream of exons encoding a m constant region (Cm), allowing generation of mIgH chain transcripts and IgM-class antibodies1. Mouse IgH class switch recombination (CSR) replaces Cmwith one of 6 sets of constant region...
1h
Contributors : Byunghyun Kang ; Luigi J Alvarado ; Andre Larochelle ; Brian KelsallSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTissue macrophages (MPs) develop distinctive functions due to unique transcriptional programs driven by local environmental ques. In the intestine, it is known that MPs are heterogeneous cells that differentiate from blood monocytes and embryonic precursors, and are essential for homeostasis with the vast microbiome through their...
1h
Contributors : Xuefei Zhang ; Frederick W AltSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusIn a B lymphocyte immunoglobulin heavy chain locus (IgH), a developmentally assembled V(D)J exon encoding an antibody variable region lies upstream of exons encoding a constant region (C), allowing generation of IgH chain transcripts and IgM-class antibodies1. Mouse IgH class switch recombination (CSR) replaces Cwith one of 6 sets of constant region...
1h
Contributors : J E Davis ; K D Insigne ; E M Jones ; Q B Hastings ; W B Boldridge ; S KosuriSeries Type : OtherOrganism : Escherichia coli ; Homo sapiensWe designed and assayed 24,531 synthetic regulatory elements varying c-amp response element number, affinity, distance to the promoter, spacing between multiple CREs, and surrounding sequence content. Using 5 massively-parallel reporter assays, we measure the expression driven by these sequences when placed upstream of a minimal promoter using next-generation...
1h
Series Type : Non-coding RNA profiling by high throughput sequencing ; Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
1h
Contributors : Vanessa Merino ; Soonweng ChoSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo study the function of CRYBB2, we overexpressed CRYBB2 in breast cancer cell lines using lentiviral vectors and investigated transcriptomic changes using Agilent 4x44K microarrays.
1h
Contributors : Doowon Huh ; Sohail F TavazoieSeries Type : OtherOrganism : Homo sapiensWe report the changes in ribosome protected fragments as measured by ribosome profiling in cells with or without depletion of tRNA-Tyr-GUA
1h
Contributors : Tyler S Alioto ; Fernando Cruz ; Jèssica Gómez-Garrido ; Miriam Triyatni ; Marta Gut ; Leonor Frias ; Anna Esteve-Codina ; Stephan Menne ; Anna Kiialainen ; Nadine Kumpesa ; Fabian Birzele ; Roland Schmucki ; Ivo G Gut ; Olivia SpleissSeries Type : Expression profiling by high throughput sequencingOrganism : Marmota monaxGene expression profiling by RNAseq of lung, thymus, heart, pancreas, kidney, spleen and liver tissues from woodchuck as a preclinical animal model for...
1h
Contributors : Doowon Huh ; Sohail F TavazoieSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensWe report the changes in tRNA abundance as measured by tRNA profiling after cells have been exposed to oxidative stress by H2O2.
1h
Contributors : Lisa M McEwen ; Kieran J O’Donnell ; Megan G McGill ; Rachel D Edgar ; Meaghan J Jones ; Julia L MacIsaac ; David T Lin ; Katia Ramadori ; Alexander Morin ; Nicole Gladish ; Elika Garg ; Eva Unternaehrer ; Irina Pokhvisneva ; Neerja Karnani ; Michelle Z Kee ; Torsten Klengel ; Nancy E Adler ; Ronald G Barr ; Nicole Letourneau ; Gerald F Giesbrecht ; James N Reynolds ; Darina Czamara ; Jeffrey M Armstrong ; Marilyn J Essex ; Carolina de Weerth ; Roseriet Beijers ; Marieke...
1h
Contributors : Chiaki Ishida ; Markus SiegelinSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe performed microarray analysis in order to evaluate the combination effect of the mitochondrial matrix chaperone inhibitor gamitrinib-triphenylphosphonium (G-TPP) and Liver X receptor agonist LXR623 on gene expression in stem cell like glioma cells (NCH644).
1h
Contributors : Lisa M McEwen ; Kieran J O’Donnell ; Megan G McGill ; Rachel D Edgar ; Meaghan J Jones ; Julia L MacIsaac ; David T Lin ; Katia Ramadori ; Alexander Morin ; Nicole Gladish ; Elika Garg ; Eva Unternaehrer ; Irina Pokhvisneva ; Neerja Karnani ; Michelle Z Kee ; Torsten Klengel ; Nancy E Adler ; Ronald G Barr ; Nicole Letourneau ; Gerald F Giesbrecht ; James N Reynolds ; Darina Czamara ; Jeffrey M Armstrong ; Marilyn J Essex ; Carolina de Weerth ; Roseriet Beijers ; Marieke...
1h
Contributors : Keisuke Tamari ; Hideshi IshiiSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensmiRNA and mRNA expression of HeLa cancer stem cells and non-cancer stem cells
1h
GSE137884 The PedBE clock estimates DNA methylation age in pediatric buccal cells [dataset 2, C3ARE]
Contributors : Lisa M McEwen ; Kieran J O’Donnell ; Megan G McGill ; Rachel D Edgar ; Meaghan J Jones ; Julia L MacIsaac ; David T Lin ; Katia Ramadori ; Alexander Morin ; Nicole Gladish ; Elika Garg ; Eva Unternaehrer ; Irina Pokhvisneva ; Neerja Karnani ; Michelle Z Kee ; Torsten Klengel ; Nancy E Adler ; Ronald G Barr ; Nicole Letourneau ; Gerald F Giesbrecht ; James N Reynolds ; Darina Czamara ; Jeffrey M Armstrong ; Marilyn J Essex ; Carolina de Weerth ; Roseriet Beijers ; Marieke...
1h
Contributors : Jaana Rysä ; Markku Pasanen ; Pasi HuuskonenSeries Type : Expression profiling by arrayOrganism : Homo sapiensEffects of pioglitazone and beta-naphtoflavone treatmend for 72 hours on human primary trophoblasts were investigated. 0.25% DMSO was a control.
1h
Contributors : Yuichi Mitobe ; Kazuhiro Ikeda ; Kuniko Horie-Inoue ; Satoshi InoueSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo examine the role of long non-coding RNA TMPO-AS1 in breast cancer, MCF-7 cells were treated with siRNAs targeting TMPO-AS1 (siTMPO-AS1) or control siRNA (siControl). TMPO-AS1 was shown to closely associate with estrogen signaling pathway.
2h
Contributors : Minjae Kim ; Yixiang Zhong ; Kyoung H Jung ; Young G ChaiSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicuspXEN cells have intrinsic property for vacuolation generally and in proper condition, vacuolated cells contribute to cavitation, so call vesiculation, via merge together. So, we want to find meaning of morphogenesis and connection with in vivo gastrulation stage.
5h
Contributors : Michalina Janiszewska ; Doris P Tabassum ; Zafira Castrano ; Simona Cristea ; Kimiyo N Yamamoto ; Natalie L Kingston ; Katherine C Murphy ; Shaokun Shu ; Nicholas W Harper ; Carlos Gil Del Alcazar ; Maša Alečković ; Muhammad Ekram ; Ofir Cohen ; Minsuk Kwak ; Yuanbo Qin ; Tyler Laszewski ; Adrienne Luoma ; Andriy Marusyk ; Kai W Wucherpfennig ; Nikhil Wagle ; Rong Fan ; Franziska Michor ; Sandra McAllister ; Kornelia PolyakSeries Type : Expression profiling by high...
6h
Contributors : Zhijuan Wu ; Wenjing ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCopper (Cu) regulates hypoxia-inducible factor-1 (HIF-1) transcription activity by affecting the selectivity of HIF-1α targeting to the promoters of the affected genes. Here, we made an effort to provide a comprehensive understanding of Cu regulation of the selectivity of HIF-1α targeting across genome. We used tetraethylenepentamine (TEPA), a Cu selective...
6h
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
6h
Contributors : Zhijuan Wu ; Wenjing ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCopper (Cu) regulates hypoxia-inducible factor-1 (HIF-1) transcription activity by affecting the selectivity of HIF-1α targeting to the promoters of the affected genes. Here, we made an effort to provide a comprehensive understanding of Cu regulation of the selectivity of HIF-1α targeting across genome. We used tetraethylenepentamine (TEPA), a Cu selective chelator, to...
6h
Contributors : Rick B Vega ; Michelle B Trevino ; Xiaolei Zhang ; Robert A Standley ; Bret H Goodpaster ; Daniel P Kelly ; Paul M CoenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOlder individuals were subjected to complete bed rest for 10 days. Muscle biopsies from the vastus lateralis were obtained immediately prior and at the conclusion of the bed rest. RNA-sequencing was performed to determine the gene expression changes associated with bed rest. Marked...
9h
Contributors : Alistair Harrison ; Rachael L Hardison ; Rachel M Wallace ; James Fitch ; Derek R Heimlich ; Megan O'Bryan ; Robert P Sebra ; Laura Dubois ; Lisa St. John-Williams ; Peter White ; M. Arthur Mosely ; J. Will Thompson ; Sheryl S Justice ; Kevin M MasonSeries Type : Expression profiling by high throughput sequencingOrganism : Haemophilus influenzaeWe used an in vitro evolved strain of nontypeable Haemophilus influenzae (NTHI) to examine the metabolic contributions to persistence...
10h
Contributors : Julie Lorent ; Eric Kusnadi ; Vincent van Hoef ; Richard J Rebello ; Matthew Leibovitch ; Johannes Ristau ; Shan Chen ; Mitchell G Lawrence ; Krzysztof J Szkop ; Baila Samreen ; Preetika Balanathan ; Francesca Rapino ; Pierre Close ; Patricia Bukczynska ; Karin Scharmann ; Itsuhiro Takizawa ; Gail P Risbridger ; Luke A Selth ; Sebastian A Leidel ; Qishan Lin ; Ivan Topisirovic ; Ola Larsson ; Luc FuricSeries Type : Expression profiling by high throughput sequencing...
13h
Contributors : Julie Lorent ; Eric Kusnadi ; Vincent van Hoef ; Richard J Rebello ; Matthew Leibovitch ; Johannes Ristau ; Shan Chen ; Mitchell G Lawrence ; Krzysztof J Szkop ; Baila Samreen ; Preetika Balanathan ; Francesca Rapino ; Pierre Close ; Patricia Bukczynska ; Karin Scharmann ; Itsuhiro Takizawa ; Gail P Risbridger ; Luke A Selth ; Sebastian A Leidel ; Qishan Lin ; Ivan Topisirovic ; Ola Larsson ; Luc FuricSeries Type : Expression profiling by arrayOrganism : Mus musculusEstrogen...
13h
Contributors : Mohini Singh ; Chitra Venugopal ; Minomi Subapanditha ; Maleeha Qazi ; David Bakhshinyan ; Parvez Vora ; Naresh Murty ; Sheila K . Singh ; Tomas Tokar ; Igor JurisicaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe have used our established brain metastasis initiating cell (BMIC) models and gene expression analyses to characterize pre-metastasis in human lung-to-brain metastases.
13h
Contributors : Julie Lorent ; Eric Kusnadi ; Vincent van Hoef ; Richard J Rebello ; Matthew Leibovitch ; Johannes Ristau ; Shan Chen ; Mitchell G Lawrence ; Krzysztof J Szkop ; Baila Samreen ; Preetika Balanathan ; Francesca Rapino ; Pierre Close ; Patricia Bukczynska ; Karin Scharmann ; Itsuhiro Takizawa ; Gail P Risbridger ; Luke A Selth ; Sebastian A Leidel ; Qishan Lin ; Ivan Topisirovic ; Ola Larsson ; Luc FuricSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism...
13h
Contributors : Julie Lorent ; Eric Kusnadi ; Vincent van Hoef ; Richard J Rebello ; Matthew Leibovitch ; Johannes Ristau ; Shan Chen ; Mitchell G Lawrence ; Krzysztof J Szkop ; Baila Samreen ; Preetika Balanathan ; Francesca Rapino ; Pierre Close ; Patricia Bukczynska ; Karin Scharmann ; Itsuhiro Takizawa ; Gail P Risbridger ; Luke A Selth ; Sebastian A Leidel ; Qishan Lin ; Ivan Topisirovic ; Ola Larsson ; Luc FuricSeries Type : Expression profiling by high throughput sequencing...
13h
Series Type : Expression profiling by high throughput sequencing ; Other ; Non-coding RNA profiling by high throughput sequencing ; Expression profiling by arrayOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
14h
Contributors : Matthew Harper ; Lucy EvansSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: The purpose of this study was to examine the effect blast preconditioning on the structure and function of retinal ganglion cells (RGC), and to identify molecular pathways that contribute to RGC loss.Methods: To examine the effect of blast-preconditioning three groups of mice were analyzed, including those 1) subjected to sham injury followed by one single 20...
14h
Contributors : Maria Mavrikaki ; Lorena Pantano ; David Potter ; Max Rogers-Grazado ; Sami Amr ; Elena ChartoffSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Rattus norvegicusPurpose: This study assessed putative sex differences in miRNA expression in the bed nucleus of the stria terminalis (BNST)—a sexually dimorphic brain region implicated in anxiety—of adult male and female rats that had been exposed throughout adolescence to social isolation (SI) stress.Methods:...
14h
Contributors : Aaron Viny ; Vincent-Philippe Lavallée ; Ross L LevineSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranscriptional regulators, including the cohesin complex member STAG2, are recurrently mutated in cancer. The role of STAG2 in gene regulation, hematopoiesis, and tumor suppression remains unresolved. We show Stag2 deletion in hematopoietic stem/progenitor cells (HSPC) results in altered hematopoietic function, increased self-renewal, and impaired...
15h
Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
15h
Contributors : Huiqing Zhou ; Bryan C Dickinson ; Chuan HeSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensChemical modifications on mRNA are increasingly recognized as a critical regulatory layer of the flow of genetic information, but quantitative tools to monitor RNA modifications in a whole-transcriptome and site-specific manner are lacking. Here we describe a versatile directed evolution platform that rapidly selects for reverse transcriptases...
15h
Contributor : Guangyong HuangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensWe aimed to identify aberrantly expressed microRNA and mRNA expression profiles of dilated cardiomyopathy (DCM) and explore their potential functions, 10 DCM blood samples and paired healthy control blood samples underwent RNA-sequence.
15h
Contributors : Dimitri Scherbakov ; Erik C BöttgerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnalysis of HEK293 cells lines expressing mutant ribosomal protein RPS2 (human A226Y). RPS2 A226Y mutation has been shown to cause misreading and readthrough. Results provide insight into the response to chronic mistranslation in mammalian cells.
17h
Contributors : Anu Suomalainen ; Riikka H HämäläinenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNAsequencing data from POLG D257A mutant mouse iPS (induced pluripotent stem) cells. These mice accumulate random point mutations in their mitochondrial genome and manifest progeric features. The reprogramming and phenotype of the cells is described in Hämäläinen et al. 2015, Cell reports, mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering...
17h
Contributors : Hebras Jade ; Nicolai Krogh ; Marty Virginie ; Henrik Nielsen ; Jérôme CavailléSeries Type : OtherOrganism : Mus musculusA sequencing-based profiling method (RiboMeth-seq) for ribose methylations was used to study methylation patterns in mouse adult tissues and during development. In contrast to previous reports based on studies of human cancer cell lines, almost all methylation sites were close to fully methylated in adult tissues. A subset of sites was differentially modified...
18h
Contributors : John P Thomson ; Ruchi Shukla ; Heidi Mjoseng ; Angie Fawkes ; Richard Clark ; Lee Murphy ; Richard R MeehanSeries Type : Methylation profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusWe carry out methyl DNA immunoprecipitation (meDIP), hydroxymethyl DNA immunoprecipitaion (hmeDIP) and H3K27me3 chromatin imminoprecipitation (ChIP) prior to sequencing on the Ion Proton semiconductor sequencing platform...
18h
Contributor : Natalia SoshnikovaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo follow the changes in the transcriptional programs accompanying the specification of the embryonic Lgr5+ cells we sequenced whole transcriptomes of embryonic intestinal epithelium progenitors (at E13.5 and E15.5). EpCAM positive embryonic gut epithelium was isolated from dissected small intestines using fluorescence activated cell sorting (FACS). Lgr5+ progenitors were purified...
20h
Contributors : Richly Holger ; Kaymak AysegulSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNAseq analysis upon KD of ZRF1 to prove that depletion of ZRF1 results in the acquisition of metastatic behavior and drug resistance via misregulation of cell death and cell survival related pathways in MCF7 cells.
20h
Contributors : Mingyue Guo ; Yanping Zhang ; Yixuan WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe tested the transcriptome of embryos from WT and Dux KO mice including zygotes (hCG 28h), early 2-cell (hCG 31-32h), middle 2-cell(hCG 41-42h), late 2-cell(hCG 47-48h) and, Dux mRNA injected embryos including zygote(5h after injection, hCG 28h), early 4-cell(6h after injection, hCG 54h) and late 4-cell (17h after injection, hCG 65h) using the Covaris...
22h
Contributor : Michael NodineSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Arabidopsis thalianaMicroRNAs (miRNAs) are short non-coding RNAs that mediate the repression of target transcripts in plants and animals. Although miRNAs are required throughout plant development, relatively little is known regarding their embryonic functions. To systematically characterize embryonic miRNAs in Arabidopsis thaliana, we developed...
22h
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