Zusammenfassung Hintergrund Die Studienlage zu Kautabak und Zigarettenrauch ist eindeutig und zeigt karzinogenes Potenzial. Über Schnupftabak ist hingegen wenig bekannt, v. a. auf zellulärer Ebene gibt es keine ausreichenden wissenschaftlichen Publikationen. Somit lässt sich die eventuell mutagene Wirkung von Schnupftabak nur schwer einschätzen. In Konsequenz stützt sich die WHO in ihrer Einstufung des Schnupftabaks als nicht karzinogen...
Wed Sep 11, 2019 03:00
Zusammenfassung Abweichungen der Tonhörschwellen können mit einer bestimmten Wahrscheinlichkeit zufällig oder aufgrund systematischer Änderungen des Gehörs, des Testsystems oder der Testmethodik auftreten. Deshalb ist für diagnostische und gutachterliche Aussagen eine Signifikanzanalyse unverzichtbar. Mit den hier veröffentlichten Tabellen zur Zufallswahrscheinlichkeit können in einfacher Weise beliebige signifikante Hörschwellenveränderungen mit einer Irrtumswahrscheinlichkeit...
Tue Sep 10, 2019 03:00
Abstract We describe a 2-year-old girl with bow hunter syndrome complicated by vertebral artery dissection and multiple ischemic infarcts. Pediatric bow hunter syndrome is a rare and likely under-recognized disorder. Interestingly, our patient had atlanto-occipital ligament calcification on CT scan, an imaging finding that has not been reported in association with bow hunter syndrome and one that might help increase recognition of this dynamic disorder of the posterior circulation.
Wed Sep 11, 2019 03:00
Related ArticlesmiR-9-5p attenuates ischemic stroke through targeting ERMP1-mediated endoplasmic reticulum stress. Acta Histochem. 2019 Sep 06;:151438 Authors: Chi L, Jiao D, Nan G, Yuan H, Shen J, Gao Y Abstract Ischemic stroke (IS) is a cerebrovascular disease with serious neurological function impairment, which may activate endoplasmic reticulum (ER) stress. However, the underlying regulatory mechanism of ER stress under IS remains unclear. miR-9-5p...
Wed Sep 11, 2019 18:19
Related ArticlesImmunohistochemical localization of afatinib in male rat intestines and skin after its oral administration. Acta Histochem. 2019 Sep 06;:151439 Authors: Yamamoto Y, Saita T, Yamamoto Y, Sogawa R, Kimura S, Narisawa Y, Kimura S, Shin M Abstract Afatinib, a second-generation tyrosine kinase inhibitor, was designed to bind covalently to and irreversibly inhibit active ErbB family receptors. The major metabolites of afatinib in human plasma...
Wed Sep 11, 2019 18:19
Abstract Medial arterial calcification (MAC) is a major complication of chronic kidney disease (CKD) and an indicator of poor prognosis. Aortic overexpression of tissue‐nonspecific alkaline phosphatase (TNAP) accelerates MAC formation. The present study aimed to assess whether a TNAP inhibitor, SBI‐425, protects against MAC and improves survival probability in a CKD‐ mineral and bone disorder (MBD) mouse model. CKD‐MBD mice were divided in three groups: vehicle, SBI‐10, and SBI‐30. They were fed...
Wed Sep 11, 2019 18:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN00798A, Critical ReviewSubham Adak, Laxmi Narayan TripathiTerahertz time-domain spectroscopy (THz-TDS) is a non-invasive, non-contact and label-free technique for biological and chemical sensing as THz-spectra is less energetic and lies in the characteristic vibration frequency regime of...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Sep 11, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01216H, PaperValentina D'Atri, Valerie GabelicaMaintenance of the telomeres is key to chromosome integrity and cell proliferation. The G-quadruplex structures formed by telomeric DNA and RNA (TTAGGG and UUAGGG repeats, respectively) are key to this...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Sep 11, 2019 02:00
Analyst, 2019, Advance ArticleDOI: 10.1039/C9AN90087J, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ting-Hang Liu, Shu-Shen Cheng, Huey-Ling You, Mel S. Lee, Gwo-Bin LeeTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Sep 11, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01558B, PaperFeifei Sun, Xiaomei Sun, Yijing Jia, Zhian Hu, shenghao xu, Lin Li, Na Na, Jin OuyangWith the increment of the cancer risk, early immunodiagnosis is of great significance for timely therapy. In this work, a DNA-mediated immunosensor for highly sensitive detection of prostate specific antigen...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Sep 11, 2019 02:00
Cancers, Vol. 11, Pages 1340: Multigene Panel Testing Increases the Number of Loci Associated with Gastric Cancer Predisposition Cancers doi: 10.3390/cancers11091340 Authors: Gianluca Tedaldi Francesca Pirini Michela Tebaldi Valentina Zampiga Ilaria Cangini Rita Danesi Valentina Arcangeli Mila Ravegnani Raefa Abou Khouzam Chiara Molinari Carla Oliveira Paolo Morgagni Luca Saragoni Maria Bencivenga Paola Ulivi Dino Amadori Giovanni Martinelli...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1341: Local Treatment of Breast Cancer Liver Metastasis Cancers doi: 10.3390/cancers11091341 Authors: Reto Bale Daniel Putzer Peter Schullian Breast cancer represents a leading cause of death worldwide. Despite the advances in systemic therapies, the prognosis for patients with breast cancer liver metastasis (BCLM) remains poor. Especially in case of failure or cessation of systemic treatments, surgical resection for BCLMs has been considered as the treatment...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1344: The Potential Use of Electrochemotherapy in the Treatment of Uveal Melanoma: In Vitro Results in 3D Tumor Cultures and In Vivo Results in a Chick Embryo Model Cancers doi: 10.3390/cancers11091344 Authors: Miltiadis Fiorentzis Arne Viestenz Udo Siebolts Berthold Seitz Sarah E. Coupland Joana Heinzelmann Uveal melanoma (UM) is the most common primary intraocular tumor that arises from neoplastic melanocytes in the choroid, iris, and ciliary...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1343: Epigenetic Regulation of p21cip1/waf1 in Human Cancer Cancers doi: 10.3390/cancers11091343 Authors: Matthias Ocker Samar Al Bitar Ana Carolina Monteiro Hala Gali-Muhtasib Regine Schneider-Stock p21cip1/waf1 is a central regulator of cell cycle control and survival. While mutations are rare, it is commonly dysregulated in several human cancers due to epigenetic mechanisms influencing its transcriptional control. These mechanisms include promoter...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1342: Significance of BRAF Kinase Inhibitors for Melanoma Treatment: From Bench to Bedside Cancers doi: 10.3390/cancers11091342 Authors: Taku Fujimura Yasuhiro Fujisawa Yumi Kambayashi Setsuya Aiba According to clinical trials, BRAF kinase inhibitors in combination with MEK kinase inhibitors are among the most promising chemotherapy regimens for the treatment of advanced BRAF-mutant melanoma, though the rate of BRAF mutation gene-bearing cutaneous melanoma...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1348: 18F-Facbc in Prostate Cancer: A Systematic Review and Meta-Analysis Cancers doi: 10.3390/cancers11091348 Authors: Laudicella Albano Alongi Argiroffi Bauckneht Baldari Bertagna Boero Vincentis Sole Rubini Fantechi Frantellizzi Ganduscio Guglielmo Nappi Evangelista on the behalf of Young AIMN Working Group Trans-1-amino-3-18F-fluorocyclobutanecarboxylic-acid (anti-[18F]-FACBC) has been approved...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1345: Targeting Autophagy by MPT0L145, a Highly Potent PIK3C3 Inhibitor, Provides Synergistic Interaction to Targeted or Chemotherapeutic Agents in Cancer Cells Cancers doi: 10.3390/cancers11091345 Authors: Chun-Han Chen Tsung-Han Hsieh Yu-Chen Lin Yun-Ru Liu Jing-Ping Liou Yun Yen Anticancer therapies reportedly promote pro-survival autophagy in cancer cells that confers drug resistance, rationalizing the concept to combine autophagy inhibitors...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1346: Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story Cancers doi: 10.3390/cancers11091346 Authors: Naffouje Grover Yu Sendilnathan Wolfe Majd Smith Takeuchi Senda Kofuji Sasaki The purine nucleotides ATP and GTP are essential precursors to DNA and RNA synthesis and fundamental for energy metabolism. Although de novo purine nucleotide biosynthesis is increased in highly proliferating cells, such...
Wed Sep 11, 2019 03:00
Cancers, Vol. 11, Pages 1347: The miR-205-5p/BRCA1/RAD17 Axis Promotes Genomic Instability in Head and Neck Squamous Cell Carcinomas Cancers doi: 10.3390/cancers11091347 Authors: Valenti Sacconi Ganci Grasso Strano Blandino Agostino Defective DNA damage response (DDR) is frequently associated with tumorigenesis. Abrogation of DDR leads to genomic instability, which is one of the most common characteristics of human cancers. TP53 mutations with gain-of-function...
Wed Sep 11, 2019 03:00
Abstract Kinematic and spatiotemporal gait parameters are known to scale with gait speed, though inter-joint coordination during swing remains consistent, at least across comfortable speeds. The purpose of this study was to determine whether coordination patterns serving limb clearance and shortening change across a range of gait speeds. We assessed 17 healthy adults walking overground at their self-selected speed and multiple, progressively slower speeds. We collected lower extremity...
Wed Sep 11, 2019 03:00
We describe the a priori computational prediction and realization of multi‐component cage pots, starting with molecular predictions based on candidate precursors through to crystal structure prediction and synthesis using robotic screening. The molecules were formed by the social self‐sorting of a tri‐topic aldehyde with both a tri‐topic amine and di‐topic amine, without using orthogonal reactivity or precursors of the same topicity. Crystal structure prediction suggested a rich polymorphic landscape,...
Tue Sep 10, 2019 21:09
Numerous applications of metal ion‐mediated base pairs (metallo‐base pairs) to nucleic acid‐based nanodevices and genetic code expansion have extensively been studied. Many of these metallo‐base pairs are formed in DNA and RNA duplexes containing Watson‐Crick base pairs. Recently, a crystal structure of a metal‐DNA nanowires with uninterrupted one‐dimensional silver array has been reported. Herein, we have determined a crystal structure of a novel DNA helical wire containing Hg(II)‐mediated T:T and...
Tue Sep 10, 2019 21:09
A new strategy is demonstrated for the synthesis of warped, negatively curved, all‐sp²‐carbon π‐scaffolds. Multifold C−C coupling reactions are used to transform a polyaromatic borinic acid into a saddle‐shaped polyaromatic hydrocarbon (2) bearing two heptagonal rings. Notably, this Schwarzite substructure is synthesized in only two steps from an unfunctionalized alkene. A highly warped structure of 2 was revealed by X‐ray crystallographic studies and pronounced flexibility of this π‐scaffold was...
Tue Sep 10, 2019 21:10
The functionalization of aryl and heteroaryls using α‐carbonyl sulfoxonium ylides without the help of a directing group has remained so far a neglected area, despite the advantageous safety profile of sulfoxonium ylides. Described herein are the cyclizations of α‐carbonyl sulfoxonium ylides onto benzenes, benzofurans and N‐p‐toluenesulfonyl indoles in the presence of a base in HFIP, whereas pyrroles and N‐methyl indoles undergo cyclization in the presence of an iridium catalyst. Significantly, these...
Tue Sep 10, 2019 21:10
Waterproof metal‐organic frameworks (MOFs) may take up the challenges of demands for practical applications in industry fields. In this work, we demonstrate an unprecedented synthetic mechanism to tune hydrophilic UiO‐67 MOF into hydrophobic UiO‐67‐Rs (Rs = ethyl, n‐butyl, n‐hexyl or n‐octyl) by introducing alkyl‐chains into organic‐linkers, which are firstly discovered not only to protect hydrophilic Zr₆O₈‐clusters to endow MOF interspace with superoleophilicity, but also to modulate the crystal...
Tue Sep 10, 2019 21:10
Advanced materials for high‐efficiency photocatalytic CO2 reduction are desirable for solar‐to‐carbon fuel conversion. Herein, highly dispersed nickel cobalt oxyphosphide nanoparticles (NiCoOP NPs) have been confined in multichannel hollow carbon fibers (MHCFs) to construct the NiCoOP NPs@MHCFs catalysts for efficient CO2 photoreduction. The synthetic strategy involves a multistep process (i.e., electrospinning, phosphidation and carbonization) and permits facile tuning of chemical composition. In...
Tue Sep 10, 2019 21:10
Stable organic nitroxyl radicals are an important class of catalysts for oxidation reactions, but their wide applications are hindered by their steric hinderance, high cost, complex operation and separation procedures. Herein, we reported for the first time that NO2 in DMSO could effectively catalyze the aerobic oxidative cleavage of C(OH)−C bonds to form carboxylic group, and NO2 was in‐situ generated by decomposition of nitrates. A diverse range of secondary alcohols were selectively converted...
Wed Sep 11, 2019 11:34
A chiral Brønsted base‐catalyzed asymmetric annulation of ortho‐alkynylanilines has been developed to access axially chiral naphthyl‐C2‐indoles through vinylidene ortho‐quinone methides (VQMs) intermediates. This strategy provides a unique organocatalytic atroposelective route to axially chiral aryl‐C2‐indole skeletons with excellent enantioselectivity and functional group tolerance. This transformation was applicable to the deca‐gram preparation (50.0 g) with perfect enantioselectivity through simple...
Wed Sep 11, 2019 12:03
All‐inorganic CsPbBr3 perovskite solar cell (PSC) is a promising solution to balance the high efficiency and poor stability of state‐of‐the‐art organic‐inorganic PSCs. Through setting inorganic hole‐transporting layers at perovskite/electrode interface undoubtedly reduces charge carrier recombination without sacrificing superiority in ambient air atmosphere. Herein, M‐substituted, p‐type inorganic Cu(Cr,M)O2 (M = Ba2+, Ca2+ or Ni2+) nanocrystals with enhanced hole‐transporting characteristics by...
Wed Sep 11, 2019 12:11
A metal‐free convergent paired electrolysis strategy to synthesize benzylic amines via a direct arylation of tertiary amines and benzonitrile derivatives has been developed at room temperature. This catalytic TEMPO‐mediated electrolysis takes full use of both anodic oxidation and cathodic reduction without metals or stoichiometric oxidants, showing the great potential and advantages in practical synthesis. This convergent paired electrolysis method represents a straightforward and powerful access...
Wed Sep 11, 2019 12:33
Wed Sep 11, 2019 15:43
Catalyst co‐op: A phosphine‐catalyzed atroposelective (4+2) annulation of δ‐acetoxy allenoates and 2‐hydroxyquinone derivatives provides expedient access to aryl‐naphthaquinone atropisomers by the de novo construction of a benzene ring. The two functionalities of the catalyst, a tertiary phosphine (Lewis base) and a tertiary amine (Brønsted base), cooperatively enable this process with high regio‐ and enantioselectivities. Abstract Although asymmetric phosphine catalysis is a powerful tool...
Wed Sep 11, 2019 15:43
The right alignment: Polymer macro‐nanodiscs are used as a novel alignment medium for the measurement of residual dipolar couplings using high‐resolution NMR spectroscopy. Their easy preparation, high stability against pH changes and the presence of divalent metal ions, and high homogeneity make them an efficient tool for the investigation of a wide range of molecular systems including natural products, proteins, and RNA. Abstract Experimentally measured residual dipolar couplings (RDCs) are...
Wed Sep 11, 2019 15:43
Adamantane‐type organotin chalcogenide clusters of the general composition [(RT) 4 S 6 ] (R = aromatic substituent, T = Si, Ge, Sn) have recently been proven to be a new class of materials with extreme non‐linear optical properties that generate highly directional white‐light upon irradiation with an inexpensive infrared laser diode. However, the mechanism behind this type of supercontinuum generation is not yet understood. As it has been suggested that the nature of the organic substituents...
Wed Sep 11, 2019 15:51
Oriented and penetrating molecular sieving membranes are helpful to enhance their separation performances. Through a simple flat‐scraping of polyimide (PI) solution containing highly dispersed ZIF‐7(Ш) sheets in CHCl3, we have developed a novel oriented and penetrating ZIF‐7@PI mixed matrix membrane (MMM) with 50 wt.% ZIF‐7 loading. Because the height of the ZIF‐7 sheets (5 µm) is higher than the film thickness after drying, every ZIF‐7 sheet penetrates both surfaces of the polyimide film. Since...
Wed Sep 11, 2019 15:51
The unsaturated bicyclic acetal levoglucosenyl methyl ether is readily obtained from sustainable feedstock (cellulose) and polymerized by cationic ring‐opening polymerization to produce a semi‐crystalline thermoplastic, unsaturated polyacetal with relatively high apparent molar mass (up to ~36 kg mol ‐1 ) and decent dispersity (~1.4). The double bonds along the chain are prone to hydrogenation and thiol‐ene chemistry as well as to crosslinking, making this polyacetal potentially interesting as...
Wed Sep 11, 2019 16:13
Methyl‐selective α‐oxygenation of tertiary amines is potentially a highly attractive approach for synthesizing formamides while preserving the amine substrate skeletons. Therefore, the development of efficient catalysts that can advance regioselective α‐oxygenation at the N‐methyl positions using molecular oxygen (O2) as the terminal oxidant is an important subject. In this study, we successfully developed a highly regioselective and efficient aerobic methyl‐selective α‐oxygenation of tertiary amines...
Wed Sep 11, 2019 16:14
Photoelectrochemical (PEC) cell can split water into hydrogen and oxygen with the assistance of solar illumination, which has become an efficient route to resolve the energy and environment crisis. However, its application is still limited by the excessive bulk carrier recombination and sluggish surface oxygen evolution reaction (OER) kinetics. Taking SnS2 as an example, a promising layered optoelectronic semiconductor, we propose an Ar plasma treatment strategy to introduce SnS/SnS2 P‐N heterojunction...
Wed Sep 11, 2019 18:51
High pressure is applied to investigate the optical response and structure evolution of a 2D double halide perovskite. (BA)4AgBiBr8 shows pressure‐induced emission accompanied with a crystal structure change, indicating potential applications in pressure sensing, information storage and trademark security. Abstract Two‐dimensional (2D) halide perovskites have attracted significant attention due to their compositional flexibility and electronic diversity. Understanding the structure–property...
Wed Sep 11, 2019 18:51
Double agent: An efficient visible light induced rhodium(I)‐catalyzed regioselective borylation of aromatic C−H bonds is reported. The photocatalytic system is based on a single NHC−RhI complex capable of both harvesting visible light and enabling the bond breaking/forming at room temperature. The bidentate structure of the NHC ligand was shown to be critical both for the stability and the reactivity of the RhI complex. Abstract An efficient visible light induced rhodium(I)‐catalyzed regioselective...
Wed Sep 11, 2019 18:51
Have your cake and eat it too: The inherent quantitative nature of NMR spectroscopy is typically sacrificed to achieve sensitivity. It is shown here that the analysis of mixtures by NMR spectroscopy can be both quantitative and time‐effective by using the relaxation enhancement from a paramagnetic co‐solute, in the form of a commercially available gadolinium chelate. Abstract NMR spectroscopy is an indispensable technique for the determination of the chemical identity and structure of small...
Wed Sep 11, 2019 18:51
More O2 release: Hypoxia significantly limits the outcome of cancer radiotherapy. TPAN was employed to catalyze the overexpressed endogenous H2O2 for sustainable O2 supplement. Moreover, the catalytic ability could be enhanced by plasmon resonance triggered by NIR‐II laser irradiation, so as to overcome tumor hypoxia and enhance radio sensitization. Abstract Hypoxia, as a characteristic feature of solid tumor, can significantly adversely affect the outcomes of cancer radiotherapy (RT), photodynamic...
Wed Sep 11, 2019 18:51
A general method for asymmetric synthesis of heteroaryl‐containing compounds provides different nitrogen‐containing aromatics, including pyridines quinolines, pyrimidines, various azoles and the derivatives of nucleobases with good to excellent enantioselectivity and diastereoselectivity. This new method is expected to serve as a useful tool in the discovery of new therapeutics and agrochemicals. Abstract A general method for asymmetric synthesis of heteroaryl‐containing cycles via palladium‐catalyzed...
Wed Sep 11, 2019 18:51
Morita–Baylis–Hillman carbonates from isatins and carbamate‐functionalized allylic carbonates were activated by a Lewis basic tertiary amine and chiral iridium complex. The resulting zwitterionic allylic ylides and π‐allyliridium complex‐contained 1,4‐dipoles underwent regio‐ and stereoselective [4+3] annulations. Similar π‐allyliridium complex‐containing 1,3‐dipoles from vinyl aziridines were utilized in asymmetric [3+3] annulations. Abstract Asymmetric reactions merging organocatalysis and...
Wed Sep 11, 2019 18:51
N‐doped carbon containing isolated Cu atoms proves highly selective for CO2 electroreduction to ethanol. Operando spectroscopic characterization of the catalyst establishes that the active species during electrolysis are transient small Cu nanoparticles. The restructuration of metal sites is reversible. Abstract It is generally believed that CO2 electroreduction to multi‐carbon products such as ethanol or ethylene may be catalyzed with significant yield only on metallic copper surfaces, implying...
Wed Sep 11, 2019 18:51
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