Related ArticlesBrainstem-cortical functional connectivity for speech is differentially challenged by noise and reverberation. Hear Res. 2018 09;367:149-160 Authors: Bidelman GM, Davis MK, Pridgen MH Abstract Everyday speech perception is challenged by external acoustic interferences that hinder verbal communication. Here, we directly compared how different levels of the auditory system (brainstem vs. cortex) code speech and how their neural representations...
Tue Sep 17, 2019 13:05
Related ArticlesDecline of auditory-motor speech processing in older adults with hearing loss. Neurobiol Aging. 2018 12;72:89-97 Authors: Panouillères MTN, Möttönen R Abstract Older adults often experience difficulties in understanding speech, partly because of age-related hearing loss (HL). In young adults, activity of the left articulatory motor cortex is enhanced and it interacts with the auditory cortex via the left-hemispheric dorsal stream during...
Tue Sep 17, 2019 13:05
Related ArticlesOutcomes of Onabotulinum Toxin A Treatment for Adductor Spasmodic Dysphonia and Laryngeal Tremor. JAMA Otolaryngol Head Neck Surg. 2018 04 01;144(4):293-299 Authors: Patel PN, Kabagambe EK, Starkweather JC, Keller M, Gamsarian V, Lee J, Kulkarni V, Garrett CG, Francis DO Abstract Importance: The relative outcomes of onabotulinum toxin A injections for treatment of adductor spasmodic dysphonia (ADSD), ADSD with lateral laryngeal tremor...
Tue Sep 17, 2019 13:05
Related ArticlesCompensatory increases in tear volume and mucin levels associated with meibomian gland dysfunction caused by stearoyl-CoA desaturase-1 deficiency. Sci Rep. 2018 02 20;8(1):3358 Authors: Inaba T, Tanaka Y, Tamaki S, Ito T, Ntambi JM, Tsubota K Abstract The stearoyl-CoA desaturase (SCD) family of enzymes catalyzes monounsaturated fatty acid synthesis by inserting a cis double bond at the Δ9 position of saturated fatty acids. Disruption...
Tue Sep 17, 2019 13:05
Related ArticlesInjectable Soft-Tissue Augmentation for the Treatment of Tracheoesophageal Puncture Enlargement. JAMA Otolaryngol Head Neck Surg. 2018 Apr 01;144(4):383-384 Authors: Tjoa T, Bunting G, Deschler DG PMID: 29543950 [PubMed - indexed for MEDLINE]
Tue Sep 17, 2019 13:05
Related ArticlesIdentification of the External Branch of the Superior Laryngeal Nerve during Thyroid Surgery. Folia Med (Plovdiv). 2018 Mar 01;60(1):154-157 Authors: Aleksova L, Ali MM, Chakarov DI, Yozgyur ZM Abstract AIM: To compare the level of intra-operative identification of external branch of the superior laryngeal nerve (EBSLN) through classical conventional clinical methods of prevention against those applying intraoperative neuromonitoring...
Tue Sep 17, 2019 13:05
Related ArticlesA Bowel of Flowers. Int J Surg Pathol. 2019 Apr;27(2):192 Authors: Kakagia DD, Tsaroucha A, Lambropoulou M PMID: 29785868 [PubMed - indexed for MEDLINE]
Tue Sep 17, 2019 13:05
Related ArticlesA bispecific antibody strategy to target multiple type 2 cytokines in asthma. J Allergy Clin Immunol. 2018 10;142(4):1185-1193.e4 Authors: Godar M, Deswarte K, Vergote K, Saunders M, de Haard H, Hammad H, Blanchetot C, Lambrecht BN Abstract BACKGROUND: Asthma is a chronic inflammatory airway disease in which innate and adaptive immune cells act together to cause eosinophilic inflammation, goblet cell metaplasia (GCM), and bronchial hyperreactivity...
Tue Sep 17, 2019 13:05
Related ArticlesDer Stimmlippenpolyp. Laryngorhinootologie. 2018 Dec;97(12):836-837 Authors: Nawka T PMID: 30536281 [PubMed - indexed for MEDLINE]
Tue Sep 17, 2019 17:15
Related Articles[Ultrasound assessment of vocal cords function after thyroid surgery]. Khirurgiia (Mosk). 2019;(7):24-28 Authors: Shulutko AM, Semikov VI, Gorbacheva AV, Patalova AR, Boblak YA, Kulikov IO, Osmanov EG, Mansurova GT Abstract OBJECTIVE: To analyze vocal cords function after thyroid surgery by using of ultrasound examination. MATERIAL AND METHODS: Assessment of voice quality according to GRBAS scale, ultrasound examination of vocal...
Tue Sep 17, 2019 13:05
Related ArticlesAtypical Laryngeal Infections: Localized Lesions from Unusual Organisms May Simulate Malignancy. Ann Otol Rhinol Laryngol. 2019 Sep 14;:3489419875755 Authors: Yan K, Taxy JB, Paintal A, Friedman AD Abstract OBJECTIVE: The identification of rare sources of laryngeal infection in immunocompetent patients. Recovered organisms were Mycobacterium tuberculosis (laryngeal tuberculosis [LTB]), Mycobacterium fortuitum (laryngeal Mycobacterium...
Tue Sep 17, 2019 13:05
Related ArticlesOncologic and functional outcomes of transoral CO2 laser cordectomy for early glottic cancer. Auris Nasus Larynx. 2019 Sep 12;: Authors: Del Mundo DAA, Morimoto K, Masuda K, Iwaki S, Furukawa T, Teshima M, Shinomiya H, Miyawaki D, Otsuki N, Sasaki R, Nibu KI Abstract OBJECTIVE: To investigate the oncological and functional outcomes of the patients treated with transoral CO2 laser cordectomy for early glottic cancer. PATIENTS...
Tue Sep 17, 2019 13:05
Related ArticlesEffect of adjuvant radioactive iodine therapy on survival in rare oxyphilic subtype of thyroid cancer (Hürthle cell carcinoma). PeerJ. 2019;7:e7458 Authors: Yang Q, Zhao Z, Zhong G, Jin A, Yu K Abstract Purpose: Radioactive iodine (RAI) is widely used for adjuvant therapy after thyroidectomy, while its value for thyroid cancer has been controversial recently. The primary objectives of this study were to clarify the influence of Radioactive...
Tue Sep 17, 2019 13:08
Related ArticlesEndobronchial Ultrasound-Guided Iodine-125 Radioactive Seed Implantation as a Novel Therapy for Mediastinal Tumors. Cancer Biother Radiopharm. 2019 Sep 18;: Authors: Xu T, Peng WD, Gu X, Yu WJ Abstract Objective: This study aims to test the treatment effect of endobronchial ultrasound (EBUS)-guided interstitial iodine-125 (125I) seed implantation for mediastinal lymph node metastasis or advanced mediastinal lung cancer. Materials and...
Tue Sep 17, 2019 16:59
Related ArticlesSelective Internal Radiation Therapy for Liver Metastasis of Papillary Thyroid Carcinoma. Clin Nucl Med. 2019 Sep 12;: Authors: Kesim S, Ones T, Ozguven S, Dulundu E, Baltacioglu F Abstract Papillary carcinoma of thyroid (PTC) is the most common neoplasm of the thyroid gland that usually invades lymphatics rather than blood vessels. Hematogenous metastasis of PTC is rare, and distant metastasis to the liver is even rarer. Selective internal...
Tue Sep 17, 2019 16:59
Related ArticlesPresence of synchrony-generating hubs in the human epileptic neocortex. J Physiol. 2019 Sep 15;: Authors: Kandrács Á, Hofer KT, Tóth K, Tóth EZ, Entz L, Bagó AG, Erőss L, Jordán Z, Nagy G, Fabó D, Ulbert I, Wittner L Abstract KEY POINTS: Initiation of pathological synchronous events such as epileptic spikes and seizures is linked to the hyperexcitability of the neuronal network both in humans and animals. Here we show that epileptiform...
Tue Sep 17, 2019 13:09
Related ArticlesAbsence of hyperexcitability of spinal motoneurons in patients with ALS. J Physiol. 2019 Sep 15;: Authors: Marchand-Pauvert V, Peyre I, Lackmy-Vallee A, Querin G, Bede P, Lacomblez L, Debs R, Pradat PF Abstract KEY POINTS: ALS motoneurons become hypoexcitable with disease progression in experimental models, raising questions about the neural hyperexcitability supported by clinical observations. A variant of the ∆F method, based on motor...
Tue Sep 17, 2019 13:09
Related ArticlesProtective effect of bioaccessible fractions of citrus fruit pulps against H2O2-induced oxidative stress in Caco-2 cells. Food Res Int. 2018 01;103:335-344 Authors: Cilla A, Rodrigo MJ, Zacarías L, De Ancos B, Sánchez-Moreno C, Barberá R, Alegría A Abstract Fruit pulps from Navel (N) and Cara Cara (CC) oranges, and Clementine mandarin freshly harvested (M) and refrigerated stored (M12) were used to evaluate the cytoprotective effect...
Tue Sep 17, 2019 13:09
Related ArticlesDeletion of the formin Diaph1 protects from structural and functional abnormalities in the murine diabetic kidney. Am J Physiol Renal Physiol. 2018 12 01;315(6):F1601-F1612 Authors: Manigrasso MB, Friedman RA, Ramasamy R, D'Agati V, Schmidt AM Abstract Diaphanous 1 (DIAPH1), a member of the formin family, binds to the cytoplasmic domain of the receptor for advanced glycation end products (RAGE) and is required for RAGE signal transduction....
Tue Sep 17, 2019 13:09
Related ArticlesPharmacological inhibition of autophagy by 3-MA attenuates hyperuricemic nephropathy. Clin Sci (Lond). 2018 11 15;132(21):2299-2322 Authors: Bao J, Shi Y, Tao M, Liu N, Zhuang S, Yuan W Abstract Autophagy has been identified as a cellular process of bulk degradation of cytoplasmic components and its persistent activation is critically involved in the renal damage induced by ureteral obstruction. However, the role and underlying mechanisms...
Tue Sep 17, 2019 13:09
Related ArticlesSelective Degradation of Polo-like Kinase 1 by a Hydrophobically Tagged Inhibitor of the Polo-Box Domain. Angew Chem Int Ed Engl. 2018 12 21;57(52):17043-17047 Authors: Rubner S, Scharow A, Schubert S, Berg T Abstract Hydrophobic tagging (HT) of bioactive compounds can induce target degradation via the proteasomal pathway. The first application of hydrophobic tagging to an existing inhibitor of protein-protein interactions is now presented....
Tue Sep 17, 2019 13:09
Related ArticlesProtective effects of 18β-glycyrrhetinic acid on pulmonary arterial hypertension via regulation of Rho A/Rho kinsase pathway. Chem Biol Interact. 2019 Sep 25;311:108749 Authors: Zhang M, Chang Z, Zhang P, Jing Z, Yan L, Feng J, Hu Z, Xu Q, Zhou W, Ma P, Hao Y, Zhou R Abstract PURPOSE: Excessive proliferation, migration and anti-apoptosis of pulmonary artery smooth muscle cells (PASMCs) are the basis for the development of pulmonary vascular...
Tue Sep 17, 2019 13:09
Related ArticlesUnlike reactivity of mono- and binuclear imine-copper(II) complexes toward melanoma cells via a tyrosinase-dependent mechanism. Chem Biol Interact. 2019 Sep 25;311:108789 Authors: Nunes CJ, Otake AH, Bustos SO, Fazzi RB, Chammas R, Da Costa Ferreira AM Abstract The cytotoxicity of a dinuclear imine-copper (II) complex 2, and its analogous mononuclear complex 1, toward different melanoma cells, particularly human SKMEL-05 and SKMEL-147,...
Tue Sep 17, 2019 13:09
Related ArticlesThe crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network. Cell Cycle. 2019 Sep 16;:1-17 Authors: Wang B, Li D, Yao Y, Mieke H, Kovalchuk A, Ilnytskyy Y, Rodriguez-Juarez R, Bronson RT, Metz GAS, Kovalchuk O, Kovalchuk I Abstract Glioblastoma is the most aggressive brain tumor. Although miR-141 has been demonstrated to primarily function as a tumor suppressor...
Tue Sep 17, 2019 13:09
Related ArticlesTandem RNA isolation reveals functional rearrangement of RNA-binding proteins on CDKN1B/p27Kip1 3'UTRs in cisplatin treated cells. RNA Biol. 2019 Sep 16;:1-14 Authors: Iadevaia V, Wouters MD, Kanitz A, Matia-González AM, Laing EE, Gerber AP Abstract Post-transcriptional control of gene expression is mediated via RNA-binding proteins (RBPs) that interact with mRNAs in a combinatorial fashion. While recent global RNA interactome capture...
Tue Sep 17, 2019 13:09
Related ArticlesRibosomal Protein L15 is involved in Colon Carcinogenesis. Int J Med Sci. 2019;16(8):1132-1141 Authors: Dong Z, Jiang H, Liang S, Wang Y, Jiang W, Zhu C Abstract Ribosomal biogenesis is responsible for protein synthesis in all eukaryotic cells. Perturbation of ribosomal biogenesis processes can cause dysfunctions of protein synthesis and varieties of human diseases. In this study, we examine the role of RPL15, a large ribosomal subunit...
Tue Sep 17, 2019 13:09
Related Articlesp53 Mutant p53N236S Induces Neural Tube Defects in Female Embryos. Int J Biol Sci. 2019;15(9):2006-2015 Authors: Zhao J, Tian Y, Zhang H, Qu L, Chen Y, Liu Q, Luo Y, Wu X Abstract The p53 is one of the most important tumor suppressors through surveillance of DNA damages and abnormal proliferation signals, and activation the cell cycle arrest and apoptosis in response to stress. However, the mutation of p53 is known to be oncogenic by...
Tue Sep 17, 2019 13:09
Related ArticlesSLC1A3 contributes to L-asparaginase resistance in solid tumors. EMBO J. 2019 Sep 16;:e102147 Authors: Sun J, Nagel R, Zaal EA, Ugalde AP, Han R, Proost N, Song JY, Pataskar A, Burylo A, Fu H, Poelarends GJ, van de Ven M, van Tellingen O, Berkers CR, Agami R Abstract L-asparaginase (ASNase) serves as an effective drug for adolescent acute lymphoblastic leukemia. However, many clinical trials indicated severe ASNase toxicity in patients...
Tue Sep 17, 2019 13:09
Related ArticlesAlantolactone enhances gemcitabine sensitivity of lung cancer cells through the reactive oxygen species-mediated endoplasmic reticulum stress and Akt/GSK3β pathway. Int J Mol Med. 2019 Jul 08;: Authors: Wang J, Zhang Y, Liu X, Wang J, Li B, Liu Y, Wang J Abstract Lung cancer is one of the leading causes of cancer‑associated mortality in China and globally. Gemcitabine (GEM), as a first‑line therapeutic drug, has been used to treat lung...
Tue Sep 17, 2019 16:12
Related ArticlesMonoclonal anti‑MUC1 antibody with novel octahydropyrazino[2,1‑a:5,4‑a']diisoquinoline derivative as a potential multi‑targeted strategy in MCF‑7 breast cancer cells. Oncol Rep. 2019 Aug 02;: Authors: Gornowicz A, Szymanowski W, Bielawska A, Szymanowska A, Czarnomysy R, Kałuża Z, Bielawski K Abstract The aim of the present study was to examine the multi‑targeted potential of a monoclonal antibody against mucin‑1 (MUC1) and novel octahydropyrazin[2,1‑a:5,4‑a']diisoquinoline...
Tue Sep 17, 2019 16:12
Related ArticlesCell Cycle-specific Measurement of γH2AX and Apoptosis After Genotoxic Stress by Flow Cytometry. J Vis Exp. 2019 Sep 01;(151): Authors: Lopez Perez R, Münz F, Kroschke J, Brauer J, Nicolay NH, Huber PE Abstract The presented method or slightly modified versions have been devised to study specific treatment responses and side effects of various anti-cancer treatments as used in clinical oncology. It enables a quantitative and longitudinal...
Tue Sep 17, 2019 16:12
Related ArticlesNovel [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potent antitubulin agents: Design, multicomponent synthesis and antiproliferative activities. Bioorg Chem. 2019 Sep 10;92:103260 Authors: Yang F, Yu LZ, Diao PC, Jian XE, Zhou MF, Jiang CS, You WW, Ma WF, Zhao PL Abstract As restricted CA-4 analogues, a novel series of [1,2,4]triazolo[1,5-a]pyrimidines possessing 3,4,5-trimethoxylphenyl groups has been achieved successfully via an...
Tue Sep 17, 2019 16:12
Related ArticlesLower third molar displaced to lateral pharyngeal space after mandibular angle fracture: a case report. Oral Maxillofac Surg. 2018 Jun;22(2):231-233 Authors: Dos Santos Pereira R, da Silva JR, Bonardi JP, Hochuli-Vieira E Abstract The removal of displaced dental elements from deep anatomical spaces is a condition that requires the knowledge of the region and skills to perform the procedure. The lateral pharyngeal space contains important...
Tue Sep 17, 2019 13:13
Related ArticlesNonsurgical Treatment for Posttraumatic Complete Facial Nerve Paralysis. JAMA Otolaryngol Head Neck Surg. 2018 04 01;144(4):315-321 Authors: Thakar A, Gupta MP, Srivastava A, Agrawal D, Kumar A Abstract Importance: Current recommendations envisage early surgical exploration for complete facial nerve paralysis associated with temporal bone fracture and unfavorable electrophysiologic features (response to electroneuronography, <5%)....
Tue Sep 17, 2019 13:13
Related ArticlesMobilization of the outer cavernous membrane decreases bleeding and improves resection in spheno-clinoidal meningiomas without cavernous sinus extension: A randomized controlled trial. Neurol India. 2018 Mar-Apr;66(2):407-415 Authors: Hegazy A, Al-Shami H, Ali MFA, Fathallah M, Salah A, Mohamed H, Ahmed EI, Mohammed Osman HH, Biswas A Abstract Objective: The aim of this study was to determine whether adding mobilization of the outer...
Tue Sep 17, 2019 13:13
Related ArticlesTympanic Membrane Derived Stem Cell-Like Cultures for Tissue Regeneration. Stem Cells Dev. 2018 05 15;27(10):649-657 Authors: Liew LJ, Chen LQ, Wang AY, von Unge M, Atlas MD, Dilley RJ Abstract Epidermal cells with stem cell-like characteristics have been identified in the tympanic membrane (TM) and localized specifically to the umbo and annulus regions. While they have been proposed to play a role in the regeneration of both acute and...
Tue Sep 17, 2019 13:13
Related ArticlesGiant cell tumor at the clivus: Not an area 51. Neurol India. 2018 May-Jun;66(3):861-864 Authors: Satapathy A, Tripathi M, Chauhan RB, Gurnaani J, Mohindra S PMID: 29766962 [PubMed - indexed for MEDLINE]
Tue Sep 17, 2019 13:13
Related ArticlesLower doses to hippocampi and other brain structures for skull-base meningiomas with intensity modulated proton therapy compared to photon therapy. Radiother Oncol. 2019 Sep 12;: Authors: Florijn MA, Sharfo AWM, Wiggenraad RGJ, van Santvoort JPC, Petoukhova AL, Hoogeman MS, Mast ME, Dirkx MLP Abstract BACKGROUND AND PURPOSE: Radiotherapy of skull-base meningiomas is challenging due to the close proximity of multiple sensitive organs at...
Tue Sep 17, 2019 13:13
Related ArticlesRBE-weighted doses in target volumes of chordoma and chondrosarcoma patients treated with carbon ion radiotherapy: Comparison of local effect models I and IV. Radiother Oncol. 2019 Sep 12;: Authors: Gillmann C, Jäkel O, Karger CP Abstract BACKGROUND AND PURPOSE: To compare the relative biological effectiveness (RBE)-weighted dose distributions in the target volume of chordoma and chondrosarcoma patients when using two different versions...
Tue Sep 17, 2019 13:13
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