Abstract Neutrophil extracellular traps (NETs) are implicated in the pathogenesis of Systemic Lupus Erythematosus (SLE). However, little is known about the implication of NETs in cutaneous lupus. In this case series of 30 patients we compared the amounts of neutrophils producing NETs in cutaneous lesions of different subtypes of lupus (5 with Discoid Lupus or DLE, 5 with Subacute Cutaneous Lupus or SCLE, 11 with acute cutaneous SLE, 7 with lupus panniculitis and 2 with Chilblains). Immunofluorescence...
Mon Sep 16, 2019 20:08
Journal of Cutaneous Medicine and Surgery, Ahead of Print. Background:Punctate palmoplantar keratoderma type 1 (PPPK1) presents in late childhood to adulthood with multiple small discrete hyperkeratotic papules on palms and soles. PPPK1 is an autosomal dominant skin disease caused by AAGAB mutations. It has been suggested that PPPK1 may be associated with an increased predisposition to systemic malignancies.Objectives:To evaluate the presence of AAGAB mutations in Canadian families with PPPK1 and...
Tue Sep 17, 2019 09:31
This study is aimed at assessing the effects of a short-term high-salt (HS) diet on the peripheral blood leukocyte (PBL) activation status in healthy rats and young human individuals. Distribution of PBL subpopulations and surface expression of integrins were determined using flow cytometry in 36 men and women on a 7-day low-salt diet (
Tue Sep 17, 2019 11:05
Abstract Purpose Diffuse lower grade gliomas (LGG) with isocitrate dehydrogenase (IDH) gene mutations (IDHMUT) have a distinct survival advantage compared with IDH wild-type (IDHWT) cases but the mechanism underlying this disparity is not well understood. Diffusion Tensor Imaging (DTI) has identified infiltrated non-enhancing tumor regions that are characterized by low isotropic (p) and high anisotropic (q) diffusion tensor components...
Tue Sep 17, 2019 03:00
Abstract Objectives To investigate the mutations in Axenfeld‐Rieger syndrome (ARS) patients and the pattern of PITX2‐related tooth agenesis. Methods Whole‐exome sequencing (WES) and copy number variations (CNV) array were used to screen the mutations in four ARS probands. After Sanger sequencing and quantitative polymerase chain reaction (qPCR) validation, secondary structure prediction and dual‐luciferase assay were employed to investigate the functional impact. 18 PITX2‐mutated patients...
Mon Sep 16, 2019 20:24
Abstract Objective The aim of this study is to detect pyroptosis in macrophages stimulated with P. gingivalis and elucidate the mechanism by which P. gingivalis induces pyroptosis in macrophages. Methods The immortalized human monocyte cell line U937 was stimulated with P. gingivalis W83. Flow cytometry was carried out to detect pyroptosis in macrophages. The expression of miR‐155 was detected by real‐time PCR and inhibited using RNAi. Suppressor of cytokine signaling (SOCS)1, cleaved gasdermin...
Mon Sep 16, 2019 20:24
Abstract Objective To investigate the sex differences in clinical features, including salivary flow rate, psychological distress, and hypothalamic‐pituitary‐adrenal axis response and their inter‐relationships in patients with burning mouth syndrome. Subjects and Methods Eighteen men and 37 postmenopausal women with burning mouth syndrome underwent a comprehensive questionnaire evaluation, psychological evaluation, and salivary flow rate measurement. Laboratory tests were performed to investigate...
Mon Sep 16, 2019 20:25
Background Long noncoding RNAs (lncRNAs) play a role in the formation, development, and prognosis of various cancers. Our study aimed to identify prognostic-related lncRNAs in lung squamous cell carcinoma (LUSC), which may provide new perspectives for individualized treatment of patients. Materials and Methods The RNA sequencing (lncRNA, microRNA (miRNA), mRNA) data and clinical information related to LUSC were obtained from The Cancer Genome Atlas (TCGA) database. Differentially expressed...
Tue Sep 17, 2019 03:00
Background Alfalfa is the most widely cultivated forage legume and one of the most economically valuable crops in the world. Its survival and production are often hampered by environmental changes. However, there are few studies on stress-resistance genes in alfalfa because of its incomplete genomic information and rare expression profile data. The MYB proteins are characterized by a highly conserved DNA-binding domain, which is large, functionally diverse, and represented in all eukaryotes. The...
Tue Sep 17, 2019 03:00
Background Biomarkers are changes associated with the disease. Urine is not subject to homeostatic control and therefore accumulates very early changes, making it an ideal biomarker source. Usually, we have performed urinary biomarker studies involving at least thousands of tumor cells. However, no tumor starts from a thousand tumor cells. We therefore examined urine proteome changes in rats subcutaneously inoculated with approximately ten tumor cells. ...
Tue Sep 17, 2019 03:00
Hepatic lipid metabolism is traditionally investigated in vitro using hepatocyte monocultures lacking the complex three-dimensional structure and interacting cell types essential liver function. Precision cut liver slice (PCLS) culture represents an alternative in vitro system, which benefits from retention of tissue architecture. Here, we present the first comprehensive evaluation of the PCLS method in fish (Atlantic salmon, Salmo salar L.) and validate it in the context of lipid metabolism using...
Tue Sep 17, 2019 03:00
Bacterial and fungal communities in biofilms are important components in driving biogeochemical processes in stream ecosystems. Previous studies have well documented the patterns of bacterial alpha diversity in stream biofilms in glacier-fed streams, where, however, beta diversity of the microbial communities has received much less attention especially considering both bacterial and fungal communities. A focus on beta diversity can provide insights into the mechanisms driving community changes associated...
Tue Sep 17, 2019 03:00
We previously reported that shokyo and kankyo, which are water-extracted fractions of ginger, reduced LPS-induced PGE2 production in human gingival fibroblasts. In this study, we examined the effects of these herbs on LPS-treated mouse macrophage RAW264.7 cells. Both shokyo and kankyo reduced LPS-induced PGE2 production in a concentration-dependent manner. Shokyo and kankyo did not inhibit cyclooxygenase (COX) activity, nor did they alter the expression of molecules in the arachidonic acid cascade....
Tue Sep 17, 2019 03:00
Descriptive studies of natural history have always been a source of knowledge on which experimental work and scientific progress rely. Poison frogs are a well-studied group of small Neotropical frogs with diverse parental behaviors, distinct calls, and bright colors that warn predators about their toxicity; and a showcase of advances in fundamental biology through natural history observations. The dyeing poison frog, Dendrobates tinctorius, is emblematic of the Guianas region, widespread in the pet...
Tue Sep 17, 2019 03:00
Background The pelvis is one of the primary sites of Ewing sarcoma (ES) and is associated with poorer prognoses than the extremities. Due to the rarity of this disease and limited data available, the prognostic factors of pelvic ES remain controversial. Thus, this study aimed to identify independent prognostic factors, and develop a nomogram for predicting survival rates in patients with pelvic ES. Methods Using data provided by the Surveillance, Epidemiology, and End Results (SEER) database,...
Tue Sep 17, 2019 03:00
Background Small size and large diversity of adaptations make invertebrates a group of animals which can be easily transported by different human activities. Many species can travel as “hitchhikers” with plant material (both on plant surfaces and in the soil), including plants used for decoration in vivaria. Vivaria are often tropical in nature environments, with high temperatures and humidity, suitable for invertebrates from tropical regions. Although many of such invertebrates...
Tue Sep 17, 2019 03:00
One of the goals of the neuromotor control system is to minimize the cost of locomotion by reducing mechanical energy losses. Collisional mechanics, which studies the redirection of the downwards motion of the center of mass (COM) by ground reaction forces (GRF) generated by the limbs, represents an important source of energy loss. The primary objective of this study was to compare collisional mechanics and the associated mechanical energy losses in horses performing diagonally-synchronized gaits...
Tue Sep 17, 2019 03:00
Above-ground biomass (AGB) is an important indicator for effectively assessing crop growth and yield and, in addition, is an important ecological indicator for assessing the efficiency with which crops use light and store carbon in ecosystems. However, most existing methods using optical remote sensing to estimate AGB cannot observe structures below the maize canopy, which may lead to poor estimation accuracy. This paper proposes to use the stem-leaf separation strategy integrated with unmanned aerial...
Tue Sep 17, 2019 03:00
A novel methodology for optimal land allocation for agricultural crops using Social Spider Algorithm
In the current agricultural scenario, availability of suitable land for cultivation is less and profitable allocation of the land for cultivating crops seems to be a cumbersome task. Crop planning optimization is a major research field in agriculture, in which land optimization is a significant challenge, which falls under the category of combinatorial optimization problems. The main objective of the present research is to maximize the net income from agriculture through optimal land allocation....
Tue Sep 17, 2019 03:00
There is currently enormous interest in how morphological and physiological responses of herbaceous plants may be affected by changing elevational gradient. Mountain regions provide an excellent opportunity to understand how closely related species may adapt to the conditions that rapidly change with elevation. We investigated the morphological and physiological responses of two Himalayan alpine gingers (Roscoea alpina and R. purpurea) along two different vertical transects of 400 m, R. purpurea...
Tue Sep 17, 2019 03:00
Background RNA-binding proteins (RBPs) play important roles in cellular homeostasis by regulating the expression of thousands of transcripts, which have been reported to be involved in human tumorigenesis. Despite previous reports of the dysregulation of RBPs in cancers, the degree of dysregulation of RBPs in cancers and the intrinsic relevance between dysregulated RBPs and clinical TNM information remains unknown. Furthermore, the co-expressed networks of dysregulated RBPs with...
Tue Sep 17, 2019 03:00
Publication date: Available online 16 September 2019Source: Journal of VoiceAuthor(s): Craig Zalvan, Erick Yuen, Jan Geliebter, Raj TiwariAbstractObjectivesParadoxical vocal fold motion disorder (PVFMD), or induced laryngeal obstruction (ILO), is a clinical phenomenon characterized by inappropriate adduction of the true vocal folds during inspiration. The resultant episodes of acute respiratory distress marked by exercise-induced cough, inspiratory stridor, throat tightness, and shortness of breath...
Tue Sep 17, 2019 12:46
Related ArticlesRole of pyridoxine in the management of infantile spasms. Neurol India. 2018 Mar-Apr;66(2):330-331 Authors: Ravat S, Shah M PMID: 29547149 [PubMed - indexed for MEDLINE]
Tue Sep 17, 2019 13:03
Related ArticlesInfantile spasms: The quest for the most effective medical management. Neurol India. 2018 Mar-Apr;66(2):332-334 Authors: Kumar R PMID: 29547150 [PubMed - indexed for MEDLINE]
Tue Sep 17, 2019 13:03
Related ArticlesEpilepsy. Nat Rev Dis Primers. 2018 May 03;4:18025 Authors: PMID: 29722353 [PubMed - indexed for MEDLINE]
Tue Sep 17, 2019 13:03
Related ArticlesRetracing the natural history of Dravet syndrome: Report and review of literature. Neurol India. 2018 May-Jun;66(3):844-847 Authors: Sureshbabu S, Sebastian I, Peter S, Sobhana C, Mittal GK PMID: 29766956 [PubMed - indexed for MEDLINE]
Tue Sep 17, 2019 13:03
Related ArticlesStudies on drug switchability showed heterogeneity in methodological approaches: a scoping review. J Clin Epidemiol. 2018 09;101:5-16 Authors: Belleudi V, Trotta F, Vecchi S, Amato L, Addis A, Davoli M Abstract BACKGROUND AND OBJECTIVE: Several drugs share the same therapeutic indication, including those undergoing patent expiration. Concerns on the interchangeability are frequent in clinical practice, challenging the evaluation of...
Tue Sep 17, 2019 13:03
Related ArticlesIs Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery? SLAS Discov. 2018 12;23(10):991-1017 Authors: Swanton T, Cook J, Beswick JA, Freeman S, Lawrence CB, Brough D Abstract Neuroinflammation is becoming increasingly recognized as a critical factor in the pathology of both acute and chronic neurological conditions. Inflammasomes such as the one formed by NACHT, LRR, and PYD domains containing protein 3 (NLRP3) are...
Tue Sep 17, 2019 13:03
Related ArticlesEpilepsy surgery for focal cortical dysplasia: Seizure and quality of life (QOLIE-89) outcomes. Neurol India. 2018 Nov-Dec;66(6):1655-1666 Authors: Chaturvedi J, Rao MB, Arivazhagan A, Sinha S, Mahadevan A, Chowdary MR, Raghavendra K, Shreedhara AS, Pruthi N, Saini J, Bharath RD, Rajeswaran J, Satishchandra P Abstract Aim: Surgery for drug resistant epilepsy (DRE) with focal cortical dysplasia (FCD) often requires multiple non-invasive...
Tue Sep 17, 2019 13:03
Antiepileptic Drug Use Patterns in Suspect Epileptic Dogs Among Neurology and Emergency Specialists.
Related ArticlesAntiepileptic Drug Use Patterns in Suspect Epileptic Dogs Among Neurology and Emergency Specialists. J Am Anim Hosp Assoc. 2019 May/Jun;55(3):138-143 Authors: Meland T, Carrera-Justiz S, Buckley GJ Abstract This study used a cross-sectional survey designed to inquire about antiepileptic drug (AED) use in newly diagnosed idiopathic epileptic dogs among board-certified emergency and neurology specialists. Results were obtained from 300...
Tue Sep 17, 2019 13:03
Related ArticlesFebrile convulsions during recovery after anesthesia in an infant with history of MMR vaccination: A case report. Medicine (Baltimore). 2019 Aug;98(35):e17047 Authors: Lee HG, Bae HB, Choi JI, Pyeon T, Kim S, Kim J Abstract RATIONALE: Seizures are rare during the perioperative period; in most cases, there is a previous history of epilepsy or surgery-associated seizures. Febrile convulsions may occur when the body temperature rises above...
Tue Sep 17, 2019 13:03
Related ArticlesAntibody-Mediated Enzyme Therapeutics and Applications in Glycogen Storage Diseases. Trends Mol Med. 2019 Sep 12;: Authors: Zhou Z, Austin GL, Shaffer R, Armstrong DD, Gentry MS Abstract The use of antibodies as targeting molecules or cell-penetrating tools has emerged at the forefront of pharmaceutical research. Antibody-directed therapies in the form of antibody-drug conjugates, immune modulators, and antibody-directed enzyme prodrugs...
Tue Sep 17, 2019 13:03
Related ArticlesLevetiracetam and brivaracetam: a review of evidence from clinical trials and clinical experience. Ther Adv Neurol Disord. 2019;12:1756286419873518 Authors: Steinhoff BJ, Staack AM Abstract Until the early 1990s, a limited number of antiepileptic drugs (AEDs) were available. Since then, a large variety of new AEDs have been developed and introduced, several of them offering new modes of action. One of these new AED families is described...
Tue Sep 17, 2019 13:03
Related ArticlesMechanical thrombectomy for middle cerebral artery occlusion suspected of ovarian hyperstimulation syndrome. World Neurosurg. 2019 Sep 13;: Authors: Kuwano A, Kubota Y, Nonaka T, Miyao S, Nakamoto H, Kawamata T Abstract BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic disorder associated with infertility treatment. The main pathology of OHSS is intravascular dehydration and hyperestrogenemia. In mild cases, abdominal...
Tue Sep 17, 2019 16:50
Risk factors predisposing to psychotic symptoms during levetiracetam therapy: A retrospective study.
Related ArticlesRisk factors predisposing to psychotic symptoms during levetiracetam therapy: A retrospective study. Epilepsy Behav. 2019 Sep 13;100(Pt A):106344 Authors: Pinckaers FME, Boon ME, Majoie MHJM Abstract PURPOSE: While levetiracetam (LEV) usage is a known risk factor for psychosis in epilepsy, the modulating effect of certain patient and treatment characteristics on the risk of psychosis has yet to be fully elucidated. METHODS: In...
Tue Sep 17, 2019 16:50
Related ArticlesLow ambient temperature as the only meteorological risk factor of seizure occurrence: A multivariate study. Epilepsy Behav. 2019 Sep 13;100(Pt A):106283 Authors: Chang KC, Wu TH, Fann JC, Chen SL, Yen AM, Chiu SY, Liu FC, Chen HH, Liou HH Abstract BACKGROUND: The onset of epileptic seizures is influenced by weather, which is multifactorial. It is unknown which specific weather factors affect the occurrence of seizures. OBJECTIVES:...
Tue Sep 17, 2019 16:50
Related ArticlesPredictive value of high titer of GAD65 antibodies in a case of limbic encephalitis. J Neuroimmunol. 2019 Sep 10;337:577063 Authors: Di Giacomo R, Deleo F, Pastori C, Didato G, Andreetta F, Del Sole A, de Curtis M, Villani F Abstract We report the case of a 42-year-old woman who presented with vertigo and migraine and rapidly developed cognitive decline and seizures. Both serum and cerebro-spinal fluid samples showed high titer of anti-glutamic...
Tue Sep 17, 2019 16:50
Related ArticlesNew thin-film surface electrode array enables brain mapping with high spatial acuity in rodents. Sci Rep. 2018 02 28;8(1):3825 Authors: Konerding WS, Froriep UP, Kral A, Baumhoff P Abstract In neuroscience, single-shank penetrating multi-electrode arrays are standard for sequentially sampling several cortical sites with high spatial and temporal resolution, with the disadvantage of neuronal damage. Non-penetrating surface grids used...
Tue Sep 17, 2019 13:05
Related ArticlesTopography of sound level representation in the FM sweep selective region of the pallid bat auditory cortex. Hear Res. 2018 09;367:137-148 Authors: Measor K, Yarrow S, Razak KA Abstract Sound level processing is a fundamental function of the auditory system. To determine how the cortex represents sound level, it is important to quantify how changes in level alter the spatiotemporal structure of cortical ensemble activity. This is particularly...
Tue Sep 17, 2019 13:05
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