Related ArticlesAuditory Late Latency Response in Individuals with Type 2 Diabetes Mellitus. J Int Adv Otol. 2018 Dec;14(3):408-411 Authors: Kumar K, Bhat J, Varghese A Abstract OBJECTIVES: The study was done to compare Auditory late latency response (ALLR) in normal-hearing individuals without diabetes mellitus and normal-hearing individuals with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: A total of 50 participants within the...
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Related ArticlesDifferential modulation of the auditory steady state response and inhibitory gating by chloral hydrate anesthesia. Sci Rep. 2018 02 27;8(1):3683 Authors: Wang Y, Ma L, Wang X, Qin L Abstract Auditory steady state response (ASSR) and inhibitory gating (IG) are electrophysiological examinations commonly used to evaluate the sensory and cognitive functions of the brain. In some clinic examinations and animal experiments, general anesthesia...
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Related Articles[Dysphagia in Tracheostomized Patients after Long-Term Mechanical Ventilation - Become Sensitive to Reduced Pharyngo-Laryngeal Sensitivity]. Pneumologie. 2019 Sep;73(9):533-537 Authors: Heidler MD Abstract Independent of the type of critical illness, tracheostomized patients have a high risk of developing a dysphagia. This is potentially life-threatening as it can lead to aspiration and pneumonia. It is therefore essential to perform...
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Related ArticlesThe Stability and Influence of Barriers to Medication Adherence on Seizure Outcomes and Adherence in Children With Epilepsy Over 2 Years. J Pediatr Psychol. 2018 03 01;43(2):122-132 Authors: Ramsey RR, Zhang N, Modi AC Abstract Objective: To determine the stability and influence of adherence barriers on medication adherence and seizure control in pediatric epilepsy. Methods: Caregivers of 118 children aged 2-12 years old with...
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Authors: Stéphane Simon, Benoit de Thoisy, Aurélien Mercier, Mathieu Nacher and Magalie Demar.<br />Parasite Vol. 26 , page 60<br />Published online: 24/09/2019<br /> Keywords: Toxoplasmosis ; Amazonian ; French Guiana ; Virulence ; Mice.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/PTRmZ3SxW9Q" height="1" width="1" alt=""/>
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Related ArticlesEURACAN/IASLC proposals for updating the histologic classification of pleural mesothelioma: towards a more multidisciplinary approach. J Thorac Oncol. 2019 Sep 20;: Authors: Nicholson AG, Sauter JL, Nowak AK, Kindler HL, Gill RR, Remy-Jardin M, Armato SG, Fernandez-Cuesta L, Bueno R, Alcala N, Foll M, Pass H, Attanoos R, Baas P, Beasley MB, Brcic L, Butnor KJ, Chirieac LR, Churg A, Courtiol P, Dacic S, De Perrot M, Frauenfelder T, Gibbs A, Hirsch FR, Hiroshima...
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Related ArticlesMicroRNA‑381 regulates the growth of gastric cancer cell by targeting TWIST1. Mol Med Rep. 2019 Sep 06;: Authors: Yin Y, Li X, Guo Z, Zhou F Abstract Gastric cancer (GC) has one of the highest mortality rates among all types of cancer in the world. At present, an efficient treatment for GC remains elusive. Studies have demonstrated that microRNAs (miRs) are abnormally expressed in cancer, and that these serve important roles in the development...
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Related ArticlesIn silico study of pseudoprogression in glioblastoma: collaboration of radiologists and radiation oncologists in the estimation of extent of high dose RT region. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019 Sep 13;: Authors: Belanova R, Sprlakova-Pukova A, Standara M, Janu E, Koukalova R, Kristek J, Burkon P, Kolouskova I, Prochazka T, Pospisil P, Chakravarti A, Slampa P, Slaby O, Kazda T Abstract BACKGROUND AND AIM: Oncologists...
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Related ArticlesInvestigational Monoclonal Antibodies in the Treatment of Multiple Myeloma: A Systematic Review of Agents under Clinical Development. Antibodies (Basel). 2019 May 24;8(2): Authors: Iftikhar A, Hassan H, Iftikhar N, Mushtaq A, Sohail A, Rosko N, Chakraborty R, Razzaq F, Sandeep S, Valent JN, Kanate AS, Anwer F Abstract BACKGROUND: Immunotherapy for multiple myeloma (MM) has been the focus in recent years due to its myeloma-specific immune...
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Related ArticlesPrevention of Gestational Diabetes Mellitus (GDM) and Probiotics: Mechanism of action: A Review. Curr Diabetes Rev. 2019 Jul 12;: Authors: Homayouni A, Bagheri N, Mohammad-Alizadeh-Charandabi S, Kashani N, Mobaraki-Asl N, Mirghafurvand M, Asgharian H, Ansari F, Pourjafar H Abstract BACKGROUND: Gestational Diabetes Mellitus (GDM) is a health problem that is increasing around the world. INTRODUCTION: Prevention of GDM, rather than...
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Related ArticlesAn Open-Source Tool for Anisotropic Radiation Therapy Planning in Neuro-oncology Using DW-MRI Tractography. Front Oncol. 2019;9:810 Authors: Jordan K, Morin O, Wahl M, Amirbekian B, Chapman C, Owen J, Mukherjee P, Braunstein S, Henry R Abstract There is evidence from histopathological studies that glioma tumor cells migrate preferentially along large white matter bundles. If the peritumoral white matter structures can be used to predict...
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Related ArticlesImplications of Cystectomy Travel Distance for Hospital Readmission and Survival. Clin Genitourin Cancer. 2019 Aug 20;: Authors: Hale NE, Macleod LC, Yabes JG, Turner RM, Fam MM, Gingrich JR, Skolarus TA, Borza T, Sabik LM, Davies BJ, Jacobs BL Abstract BACKGROUND: Regionalization of complex surgical care results in increasing need for patients to travel for complex oncologic procedures such as cystectomy in bladder cancer. We examined...
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Related Articles[E-health and "Cancer outside the hospital walls", Big Data and artificial intelligence]. Bull Cancer. 2019 Sep 19;: Authors: Bertucci F, Le Corroller-Soriano AG, Monneur A, Fluzin S, Viens P, Maraninchi D, Goncalves A Abstract To heal otherwise in oncology has become an imperative of Public Health and an economic imperative in France. Patients can therefore receive live most of their care outside of hospital with more ambulatory care....
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Related ArticlesCollecting ducts carcinoma: An orphan disease. Literature overview and future perspectives. Cancer Treat Rev. 2019 Sep;79:101891 Authors: Pagani F, Colecchia M, Sepe P, Apollonio G, Claps M, Verzoni E, de Braud F, Procopio G Abstract Collecting ducts carcinoma (CDC) is a rare and aggressive histological subtype of renal cancer accounting for only 1% of renal tumors. Usually patients present in bad clinical conditions due to a symptomatic...
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Functional lung imaging in radiation therapy for lung cancer: A systematic review and meta-analysis.
Related ArticlesFunctional lung imaging in radiation therapy for lung cancer: A systematic review and meta-analysis. Radiother Oncol. 2018 11;129(2):196-208 Authors: Bucknell NW, Hardcastle N, Bressel M, Hofman MS, Kron T, Ball D, Siva S Abstract RATIONALE: Advanced imaging techniques allow functional information to be derived and integrated into treatment planning. METHODS: A systematic review was conducted with the primary objective to evaluate...
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Related ArticlesUnravelling Pathophysiology of Crystalline Nephropathy in Ceftriaxone-Associated Acute Kidney Injury: A Cellular Proteomic Approach. Nephron. 2018;139(1):70-82 Authors: Chatchen S, Pongsakul N, Srisomsap C, Chiangjong W, Hongeng S, Svasti J, Chutipongtanate S Abstract BACKGROUND: Previous studies showed that ceftriaxone can cause acute kidney injury (AKI) in the pediatric population. This study proposed a cellular model of crystalline...
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Related ArticlesParadoxical side effects of bisphosphonates on the skeleton: What do we know and what can we do? J Cell Physiol. 2018 08;233(8):5696-5715 Authors: Vargas-Franco JW, Castaneda B, Rédiní F, Gómez DF, Heymann D, Lézot F Abstract Bisphosphonates are considered the most effective drugs for controlling adult and pediatric osteolytic diseases. Although they have been used successfully for many years, several side effects, such as osteonecrosis...
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Related ArticlesmiR-21-3p inhibits autophagy of bovine granulosa cells by targeting VEGFA via PI3K/AKT signaling. Reproduction. 2019 Sep 01;: Authors: Ma L, Zheng Y, Tang X, Gao H, Liu N, Gao Y, Hao L, Liu S, Jiang Z Abstract It is well documented that granulosa cell apoptosis is the main reason for follicular atresia and death, however, increasing evidence suggests that autophagy plays an important role in the fate of granulosa cells. MiR-21-3p regulated...
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Related ArticlesTargeting the miR-122/PKM2 autophagy axis relieves arsenic stress. J Hazard Mater. 2019 Sep 12;383:121217 Authors: Wang Y, Zhao H, Guo M, Fei D, Zhang L, Xing M Abstract Arsenic (As) is a natural hepatotoxicity inducer that is found ubiquitously in foods and environmental media. We found that arsenite exposure elicits autophagy in vivo and vitro, the specific role and regulatory mechanism of which are yet clear. MicroRNAs (miRNAs) are...
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Related ArticlesThe regulation of rapamycin in planarian Dugesia japonica Ichikawa & Kawakatsu, 1964 regeneration according to TOR signaling pathway. Ecotoxicol Environ Saf. 2019 Sep 20;185:109680 Authors: Kang J, Dong Z, Hao Q, Wang J, Chen G, Liu D Abstract The freshwater planarian mostly lives in the upper reaches of springs and rivers. Generally, it is realized as a suitable warning indicator of environmental toxicants. The freshwater planarian...
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Related ArticlesSIDT2 RNA Transporter Promotes Lung and Gastrointestinal Tumor Development. iScience. 2019 Sep 10;20:14-24 Authors: Nguyen TA, Bieging-Rolett KT, Putoczki TL, Wicks IP, Attardi LD, Pang KC Abstract RNautophagy is a newly described type of selective autophagy whereby cellular RNAs are transported into lysosomes for degradation. This process involves the transmembrane protein SIDT2, which transports double-stranded RNA (dsRNA) across the...
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Related ArticlesDexmedetomidine prevents septic myocardial dysfunction in rats via activation of α7nAChR and PI3K/Akt- mediated autophagy. Biomed Pharmacother. 2019 Sep 19;120:109231 Authors: Yu T, Liu D, Gao M, Yang P, Zhang M, Song F, Zhang X, Liu Y Abstract BACKGROUND AND PURPOSE: Dexmedetomidine (Dex) has been shown to elicit cardio-protective effects in sepsis. The aim of this study was to investigate the role of autophagy in the protective effects...
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Related ArticlesTrimetazidine ameliorates sunitinib-induced cardiotoxicity in mice via the AMPK/mTOR/autophagy pathway. Pharm Biol. 2019 Dec;57(1):625-631 Authors: Yang Y, Li N, Chen T, Zhang C, Liu L, Qi Y, Bu P Abstract Context: Sunitinib (SU) is a multi-targeted tyrosine kinase inhibitor anticancer agent whose clinical use is often limited by cardiovascular complications. Trimetazidine (TMZ) is an anti-angina agent that has been demonstrated cardioprotective...
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Related ArticlesActivation of G-protein-coupled receptor 30 protects neurons against excitotoxicity through inhibiting excessive autophagy induced by glutamate. ACS Chem Neurosci. 2019 Sep 23;: Authors: Yue J, Wang XS, Feng B, Hu LN, Yang LK, Lu L, Zhang K, Wang YT, Liu SB Abstract Autophagy is a protecting intracellular pathway to transmit unnecessary or dysfunctional components to the lysosome for degeneration. Autophagic imbalance is connected with...
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Related ArticlesRetraction: Autophagy in Muscle of Glucose-Infusion Hyperglycemia Rats and Streptozotocin-Induced Hyperglycemia Rats via Selective Activation of m-TOR or FoxO3. PLoS One. 2019;14(9):e0223144 Authors: PLOS ONE Editors PMID: 31545846 [PubMed - in process]
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Related ArticlesP38α MAPK coordinates the activities of several metabolic pathways that together induce atrophy of denervated muscles. FEBS J. 2019 Sep 23;: Authors: Odeh M, Tamir-Livne Y, Haas T, Bengal E Abstract Physiological or pathological muscle disuse/inactivity or loss of the neural-muscular junction cause muscle atrophy. Atrophy-inducing conditions cause metabolic oxidative stress in the muscle tissue, activation of the ubiquitin-proteasome...
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Related ArticlesIdentification of Eph receptor signaling as a regulator of autophagy and a therapeutic target in colorectal carcinoma. Mol Oncol. 2019 Sep 23;: Authors: DiPrima M, Wang D, TrÖster A, Maric D, Terrades-Garcia N, Ha T, Kwak H, Sanchez-Martin D, Kudlinzki D, Schwalbe H, Tosato G Abstract Advanced colorectal carcinoma is currently incurable, and new therapies are urgently needed. We report that phosphotyrosine-dependent Eph receptor signaling...
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Related ArticlesSimvastatin Increases Temozolomide-induced Cell Death by Targeting the Fusion of Autophagosomes and Lysosomes. FEBS J. 2019 Sep 23;: Authors: Shojaei S, Koleini N, Samiei E, Aghaei M, Cole LK, Alizadeh J, Islam MI, Vosoughi AR, Albokashy M, Butterfield Y, Marzban H, Xu F, Thliveris J, Kardami E, Hatch GM, Eftekharpour E, Akbari M, Hombach-Klonisch S, Klonisch T, Ghavami S Abstract Temozolomide (TMZ) is a chemotherapy agent used to treat...
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Related ArticlesAn integrative correlation of myopathology, phenotype, and genotype in late onset Pompe disease. Neuropathol Appl Neurobiol. 2019 Sep 23;: Authors: Kulessa M, Weyer-Menkhoff I, Viergutz L, Kornblum C, Claeys KG, Schneider I, Plöckinger U, Young P, Boentert M, Vielhaber S, Mawrin C, Bergmann M, Weis J, Ziagaki A, Stenzel W, Deschauer M, Nolte D, Hahn A, Schoser B, Schänzer A Abstract AIMS: Pompe disease is caused by pathogenic mutations...
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Related ArticlesApplication of capsaicin as a potential new therapeutic drug in human cancers. J Clin Pharm Ther. 2019 Sep 23;: Authors: Zhang S, Wang D, Huang J, Hu Y, Xu Y Abstract WHAT IS KNOWN AND OBJECTIVE: Capsaicin, the major active ingredient of chili pepper, may play a "dual role" in tumourigenesis, acting as a carcinogen or as a cancer preventive agent. The aim of this study was to investigate the anticancer mechanisms of capsaicin and the...
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Related ArticlesThe oncogenic role of NKAP in the growth and invasion of colon cancer cells. Oncol Rep. 2019 Sep 18;: Authors: Shu W, Liu G, Dai Y, Feng A, Chen Z, Han J, Li X Abstract It has been reported that NF‑κB activating protein (NKAP) is a transcriptional repressor of the Notch signaling pathway and is involved in the proliferation and survival of hematopoietic stem cells. In the present study, we aimed to investigate the effect of NKAP on the...
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Related ArticlesSpinosin and 6'''‑Feruloylspinosin protect the heart against acute myocardial ischemia and reperfusion in rats. Mol Med Rep. 2019 Sep 16;: Authors: Gu M, He P, Lyu C, Liu X, Xu Y, Cheng S, Gu Y, Jia Y Abstract Investigating active compounds from Chinese herbal medicine that can rescue myocardial cells is a good approach to preserve cardiac function. Several herbal formulae that containing Semen Ziziphi Spinosae (SZS), also called Suanzaoren...
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Related ArticlesIncremental load training improves renal fibrosis by regulating the TGF‑β1/TAK1/MKK3/p38MAPK signaling pathway and inducing the activation of autophagy in aged mice. Int J Mol Med. 2019 Sep 17;: Authors: Bao C, Yang Z, Cai Q, Li Q, Li H, Shu B Abstract Recent studies have confirmed that kidney tissue fibrosis is closely linked to the natural aging of organs. One of its major characteristics is the reduction of autophagic activity. However,...
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Related ArticlesHydroxychloroquine potentiates the anti-cancer effect of bevacizumab on glioblastoma via the inhibition of autophagy. Biomed Pharmacother. 2019 Oct;118:109339 Authors: Liu LQ, Wang SB, Shao YF, Shi JN, Wang W, Chen WY, Ye ZQ, Jiang JY, Fang QX, Zhang GB, Xuan ZX Abstract Bevacizumab (BEV) is widely used for the treatment of patients with recurrent glioblastoma (GBM), but recent evidence demonstrated that BEV induced cytoprotective autophagy,...
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Related ArticlesPCAF regulates H3 phosphorylation and promotes autophagy in osteosarcoma cells. Biomed Pharmacother. 2019 Oct;118:109395 Authors: Kong D, Ying B, Zhang J, Ying H Abstract BACKGROUND: Osteosarcoma is one of malignant cancer. Histone phosphorylation is common in tumors. We explored the effects of p300-CBP-associated factor (PCAF) and phosphorylation of H3S28 in osteosarcoma cancer cell autophagy. METHODS: Osteosarcoma cancer cell...
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Related ArticlesChicoric acid (CA) induces autophagy in gastric cancer through promoting endoplasmic reticulum (ER) stress regulated by AMPK. Biomed Pharmacother. 2019 Oct;118:109144 Authors: Sun X, Zhang X, Zhai H, Zhang D, Ma S Abstract Gastric cancer is one of the most common cancers leading to tumor-related deaths worldwide. Chicoric acid (CA) exhibits a variety of protective effects in different diseases. However, its role in regulating tumor progression...
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Related ArticlesLRP6 regulates Rab7-mediated autophagy through the Wnt/β-catenin pathway to modulate trophoblast cell migration and invasion. J Cell Biochem. 2019 Sep 23;: Authors: Li L, Peng W, Zhou Q, Wan JP, Wang XT, Qi HB Abstract Pre-eclampsia is a common complication during pregnancy; however, the underlying mechanisms of the crosstalk between low-density lipoprotein receptor-related protein 6 (LRP6) and autophagy in trophoblast cells are still...
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Related ArticlesDeacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer. J Cell Physiol. 2019 Sep 23;: Authors: Panda PK, Patra S, Naik PP, Praharaj PP, Mukhopadhyay S, Meher BR, Gupta PK, Verma RS, Maiti TK, Bhutia SK Abstract Therapy-induced senescence in cancer cells is an irreversible antiproliferative state, which inhibits tumor growth and is therefore a potent...
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Related ArticlesAutophagy promotes longevity-except in the presence of 'leaky' mitochondria. Cardiovasc Res. 2019 Oct 01;115(12):e118-e120 Authors: Abdellatif M PMID: 31544942 [PubMed - in process]
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Related ArticlesSTK38 kinase acts as XPO1 gatekeeper regulating the nuclear export of autophagy proteins and other cargoes. EMBO Rep. 2019 Sep 23;:e48150 Authors: Martin AP, Jacquemyn M, Lipecka J, Chhuon C, Aushev VN, Meunier B, Singh MK, Carpi N, Piel M, Codogno P, Hergovich A, Parrini MC, Zalcman G, Guerrera IC, Daelemans D, Camonis JH Abstract STK38 (also known as NDR1) is a Hippo pathway serine/threonine protein kinase with multifarious functions...
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Related ArticlesKRAS-Driven Metabolic Rewiring Reveals Novel Actionable Targets in Cancer. Front Oncol. 2019;9:848 Authors: Pupo E, Avanzato D, Middonti E, Bussolino F, Lanzetti L Abstract Tumors driven by mutant KRAS are among the most aggressive and refractory to treatment. Unfortunately, despite the efforts, targeting alterations of this GTPase, either directly or by acting on the downstream signaling cascades, has been, so far, largely unsuccessful....
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Related ArticlesActivation of autophagy in the retina after optic nerve crush injury in rats. Int J Ophthalmol. 2019;12(9):1395-1401 Authors: Kang LH, Zhang S, Jiang S, Hu N Abstract AIM: To investigate the activation of autophagy in rat retina after optic nerve crush (ONC) and evaluate its relationship with apoptosis of retinal ganglion cells (RGCs). METHODS: The ONC model was established. Western blots were performed to investigate expression...
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Related ArticlesSustaining Life: Maintaining Chloroplasts and Mitochondria and their Genomes in Plants. Yale J Biol Med. 2019 Sep;92(3):499-510 Authors: Rose RJ Abstract Chloroplasts (members of the plastid family) and mitochondria are central to the energy cycles of ecosystems and the biosphere. They both contain DNA, organized into nucleoids, coding for critical genes for photosynthetic and respiratory energy production. This review updates the cellular...
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Related ArticlesLipid Droplets and the Management of Cellular Stress. Yale J Biol Med. 2019 Sep;92(3):435-452 Authors: Jarc E, Petan T Abstract Lipid droplets are cytosolic fat storage organelles present in most eukaryotic cells. Long regarded merely as inert fat reservoirs, they are now emerging as major regulators of cellular metabolism. They act as hubs that coordinate the pathways of lipid uptake, distribution, storage, and use in the cell. Recent...
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Related ArticlesCell Competition Is Driven by Autophagy. Dev Cell. 2019 Sep 13;: Authors: Nagata R, Nakamura M, Sanaki Y, Igaki T Abstract Cell competition is a quality control process that selectively eliminates unfit cells from the growing tissue via cell-cell interaction. Despite extensive mechanistic studies, the mechanism by which cell elimination is triggered has been elusive. Here, through a genetic screen in Drosophila, we discover that V-ATPase,...
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Related ArticlesRoundup® induced AMPK/mTOR mediated autophagy in human A549 cells. J Agric Food Chem. 2019 Sep 21;: Authors: Hao Y, Xu W, Gao J, Zhang Y, Yang Y, Tao L Abstract The extensive use of pesticide caused amount of pressure on the environment and increase the potential human health risk. Glyphosate-based herbicide (GBH) is one of the most widely used pesticides based on 5-enolpyruvylshikimate-3-phosphate synthase target which does not exist...
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