Abstract Background Abacavir is associated with hypersensitivity reactions in individuals positive for the HLA‐B*57:01 allele. The drug binds within the peptide‐binding groove of HLA‐B*57:01 altering peptides displayed on the cell surface. Presentation of these HLA‐abacavir‐peptide complexes to T‐cells is hypothesised to trigger a CD8+ T‐cell response underpinning the hypersensitivity. Thus, the aim of this study was to explore the relationship between the structure of abacavir with HLA‐B*57:01...
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Publication date: Available online 23 September 2019Source: Atmospheric EnvironmentAuthor(s): Bing Gao, Wei Ouyang, Hongguang Cheng, Yi Xu, Chunye Lin, Jing ChenAbstractRainfall can directly remove atmospheric pollutants through the below-cloud scavenging process, and the atmospheric particles also affect the chemical composition of rainfall. Therefore, the interactions between rainfall properties and fine particulate matter (PM2.5) need deep investigation. Based on simultaneous in situ measurements...
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Publication date: Available online 23 September 2019Source: Experimental Cell ResearchAuthor(s): Floriane Pez, Patricia Gifu, Davide Degli Esposti, Nadim Fares, Anaïs Lopez, Lydie Lefrancois, Maud Michelet, Michel Rivoire, Brigitte Bancel, Bakary S. Sylla, Zdenko Herceg, Philippe Merle, Claude caron de FromentelAbstractHuman hepatocarcinogenesis is a complex process with many unresolved issues, including the cell of origin (differentiated and/or progenitor/stem cells) and the initial steps leading...
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Related ArticlesDoes Insurance Status Impact Delivery of Care with Upper Airway Stimulation for OSA? Ann Otol Rhinol Laryngol. 2019 Sep 22;:3489419878454 Authors: Patel J, Topf MC, Huntley C, Boon M Abstract OBJECTIVE: To understand differences in patient demographics, insurance-related treatment delays, and average waiting times for Medicare and private insurance patients undergoing upper airway stimulation (UAS) for treatment of obstructive sleep apnea...
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Abstract Purpose This study aimed to assess the impact of intensivist coverage on the incidence of acute kidney injury (AKI) and ventilator time among patients postoperatively admitted to the intensive care unit (ICU). Methods Adult patients postoperatively admitted to the ICU between January 2012 and December 2017 were retrospectively enrolled. The incidence...
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Abstract The 95th KoreAnesthesia Meeting was held successfully over 3 days from November 8 to 10, 2018 at Seoul Dragon-City Hotelplex, featuring 62 overseas speakers and 2960 attendees from 26 countries. KoreAnesthesia is the largest annual event hosted by the Korean Society of Anesthesiologists (KSA). The KSA hopes that many members of the Japanese Society of Anesthesiologists and readers of the Journal of Anesthesia will join us at the forthcoming KoreAnesthesia 2019 from October...
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Related ArticlesRisk factors of post-surgery complications in children with thyroid cancer. Int J Pediatr Otorhinolaryngol. 2019 Sep 10;127:109673 Authors: Babala J, Zahradníková P, Béder I, Fedorová L, Lindák M, Košťálová Ľ, Pribilincová Z, Staník J, Králik R Abstract INTRODUCTION: Thyroid cancer in children is a hot topic because of the large clinical heterogeneity and the risk of severe complications. We aimed to study 1. The frequency, 2. Etiology,...
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Related ArticlesSorafenib inhibits vascular endothelial cell proliferation stimulated by anaplastic thyroid cancer cells regardless of BRAF mutation status. Int J Oncol. 2019 Sep 19;: Authors: Ishihara S, Onoda N, Noda S, Asano Y, Tauchi Y, Morisaki T, Kashiwagi S, Takashima T, Ohira M Abstract Anaplastic thyroid cancer (ATC) is a rare refractory disease, frequently associated with BRAF mutations and aberrant vascular endothelial growth factor (VEGF)...
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Related ArticlesHePTP promotes migration and invasion in triple-negative breast cancer cells via activation of Wnt/β-catenin signaling. Biomed Pharmacother. 2019 Oct;118:109361 Authors: Yu L, Wang C, Pan F, Liu Y, Ren X, Zeng H, Shi Y Abstract AIM: Cancer metastasis remains a major challenge for the clinical management of breast cancer, especially triple-negative breast cancer (TNBC), and the underlying molecular mechanisms remain largely unknown. The...
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Related ArticlesPatient/Provider Discussions About Clinical Trial Participation and Reasons for Nonparticipation Among Adolescent and Young Adult Women with Cancer. J Adolesc Young Adult Oncol. 2019 Sep 23;: Authors: Anderson C, Smitherman AB, Meernik C, Edwards TP, Deal AM, Cannizzaro N, Baggett CD, Chao C, Nichols HB Abstract Purpose: Clinical trial enrollment is low among adolescents and young adults (AYAs) with cancer and may contribute to inferior...
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Related ArticlesUltrasound-Guided Core Needle Biopsy Techniques for Intermediate or Low Suspicion Thyroid Nodules: Which Method is Effective for Diagnosis? Korean J Radiol. 2019 Oct;20(10):1454-1461 Authors: Hahn SY, Shin JH, Oh YL, Park KW Abstract OBJECTIVE: To retrospectively compare the diagnostic performances of two different ultrasound (US)-guided core needle biopsy (CNB) techniques for intermediate or low suspicion thyroid nodules. MATERIALS...
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Related ArticlesEstimation of Absorbed Dose of the Thyroid Gland in Patients Undergoing 64-Slice Head Computed Tomography and Comparison the Results with ImPACT Software and Computed Tomography Scan Dose Index. J Med Signals Sens. 2019 Jul-Sep;9(3):190-195 Authors: Maziar A, Paydar R, Azadbakht G, Shahbazi-Gahrouei D Abstract Thyroid exposure to radiation in brain computed tomography (CT) scan is of great value since it is considered as a vital organ....
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Related ArticlesThe Role of Thyroid Hormones in Hepatocyte Proliferation and Liver Cancer. Front Endocrinol (Lausanne). 2019;10:532 Authors: Gionfra F, De Vito P, Pallottini V, Lin HY, Davis PJ, Pedersen JZ, Incerpi S Abstract Thyroid hormones T3 and T4 (thyroxine) control a wide variety of effects related to development, differentiation, growth and metabolism, through their interaction with nuclear receptors. But thyroid hormones also produce non-genomic...
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Related ArticlesSurgery alone for papillary thyroid microcarcinoma is less costly and more effective than long term active surveillance. Surgery. 2019 Sep 19;: Authors: Lin JF, Jonker PKC, Cunich M, Sidhu SB, Delbridge LW, Glover AR, Learoyd DL, Aniss A, Kruijff S, Sywak MS Abstract BACKGROUND: Papillary thyroid microcarcinoma is a subtype of thyroid cancer that may be managed with active surveillance rather than immediate surgery. Active surveillance...
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Related ArticlesComparison of the collection approaches of 2 large thyroid fine-needle aspiration practices reveals differing advantages for cytology and molecular testing adequacy rates. J Am Soc Cytopathol. 2019 Sep - Oct;8(5):243-249 Authors: Landau MS, Pearce TM, Carty SE, Wolfe J, Yip L, McCoy KL, LeBeau SO, Tublin ME, Ohori NP Abstract INTRODUCTION: At our institution, almost all thyroid fine-needle aspiration (FNA) procedures are performed by...
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Related ArticlesTreatment patterns and overall survival among patients with unresectable, stage III non-small-cell lung cancer. Future Oncol. 2019 Sep 23;: Authors: Bobbili P, Ryan K, Duh MS, Dua A, Fernandes AW, Pavilack M, Gomez JE Abstract Aim: To analyze treatment patterns and overall survival (OS) across time (2009-2014) among patients with unresected, stage III non-small-cell lung cancer (NSCLC). Patients & methods: Stage III NSCLC patients...
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Related ArticlesRedirecting the revolution: new developments in drug development for psychiatry. Expert Opin Drug Discov. 2019 Sep 23;:1-7 Authors: Brady LS, Potter WZ, Gordon JA PMID: 31545131 [PubMed - as supplied by publisher]
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Publication date: Available online 23 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Xiaomeng Wang, Xueping Zheng, Song Hu, Ang Xing, Zixuan Wang, Yan Song, Jingjiao Chen, Sijia Tian, Yongjun Mao, Xiaosa ChiAbstractThe efficacy of perioperative seizure prophylaxis in seizure-naïve glioma patients is still controversial. Thus we conducted this meta-analysis to assess the effectiveness of perioperative prophylactic antiepileptic drugs (AEDs) on postoperative seizures in seizure-naïve...
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Publication date: Available online 23 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Monica M. Diaz, Sarah F. WesleyAbstractBackgroundLyme disease is a common vector-borne illness in the U.S. caused by Borrelia species spirochetes. Neuroborreliosis has variable presentations, rarely manifesting as meningoradiculitis or "Bannwarth Syndrome", characterized by painful radiculopathy, neuropathy, varying degrees of motor weakness, peripheral facial nerve palsy andcerebrospinal fluid...
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Publication date: Available online 23 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Elia Pancheri, Silvia Bozzetti, Paola Rimessi, Francesco Macchione, Marco Barillari, Anna Venturoli, Valeria Guglielmi, Fernanda Fortunato, Paola Tonin, Gaetano VattemiAbstractEmery Dreifuss muscular dystrophy (EDMD) is an inherited myopathy characterized by early contractures, slow progressive muscle weakness and cardiac involvement. To date at least seven genes have been associated to EDMD...
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Publication date: Available online 23 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Jesse J. Corry, Bridget Ho, Emily Marino, Aditi Gupta, Jaya Ravichandran, Michael A. Sperl, Megan E. TippsAbstractObjectiveInflammation and bacterial infection are common complicating factors in the treatment of patients with stroke. Inflammatory responses can manifest as systemic inflammatory response syndrome (SIRS), a condition with both infectious and non-infectious etiologies. Accurately...
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Publication date: Available online 23 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Masahito Katsuki, Yasunaga Yamamoto, Toshiya Uchiyama, Naomichi Wada, Yukinari KakizawaAbstractObjectivesAge of patients with subarachnoid hemorrhage (SAH) is increasing. It is challenging to decide whether to perform aneurysm treatment and to predict their prognosis. We assumed that elderly patients with SAH who do not suffer from sarcopenia tend to have good outcomes. Temporal muscle thickness...
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Publication date: Available online 23 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Diogo Cunha-Cabral, Susana M. Silva, Hélio Alves, Ricardo P. Vaz, Pedro A. Pereira, José P. AndradeAbstractOBJECTIVEThe purpose of this study was to clarify the morphology of the insular cortex focusing not only on the shape of the insula, but also on sulcal and gyral organization.PATIENTS AND METHODSSixty formalin-fixed adult brain hemispheres had their insula exposed and photographed. The dimensions...
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Related ArticlesFrom Receptor Selectivity to Functional Selectivity: The Rise of Biased Agonism in 5-HT1A Receptor Drug Discovery. Curr Top Med Chem. 2019 Sep 11;: Authors: Sniecikowska J, Newman-Tancredi A, Kolaczkowski M Abstract Despite extensive efforts to design serotonin 5-HT1A receptor compounds, there are currently no clinically available selective agonists to explore the therapeutic potential of activating this receptor. Commonly used drugs...
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Related ArticlesTechnical note: the use of frameless stereotactic guidance in the treatment of peripheral intracranial aneurysms. Br J Neurosurg. 2019 Sep 22;:1-5 Authors: Nussbaum LA, Kallmes KM, Nussbaum ES Abstract Frameless stereotactic guidance (FSG) has previously been reported to have advantages over intraoperative computed tomography (CT) and frame-based imaging guidance methods in the targeting of intracranial lesions. We report our experience...
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Related ArticlesSevere Daily Headache as an Uncommon Manifestation of Widespread Skull Base Osteomyelitis. Case Rep Neurol. 2019 May-Aug;11(2):178-182 Authors: van der Valk J, Treurniet F, Koopman JP, Koppen H Abstract Temporal bone osteomyelitis has been recognized for decades as a complication of otitis externa, specifically in elderly patients with diabetes. A much less prevalent form is skull base osteomyelitis. We report a 70-year-old man with diabetes...
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Related ArticlesSixth Cranial Nerve Palsy and Craniocervical Junction Instability due to Metastatic Urothelial Bladder Carcinoma. Case Rep Neurol. 2019 Jan-Apr;11(1):24-31 Authors: Nasi D, Dobran M, di Somma L, Santinelli A, Iacoangeli M Abstract Metastases involving the clivus and craniocervical junction (CCJ) are extremely rare. Skull base involvement can result in cranial nerve palsies, while an extensive CCJ involvement can lead to spinal instability....
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Related ArticlesImatinib and everolimus in patients with progressing advanced chordoma: A phase 2 clinical study. Cancer. 2018 10 15;124(20):4056-4063 Authors: Stacchiotti S, Morosi C, Lo Vullo S, Casale A, Palassini E, Frezza AM, Dinoi G, Messina A, Gronchi A, Cavalleri A, Venturelli E, Morelli D, Pilotti S, Collini P, Brich S, Tamborini E, Mariani L, Casali PG Abstract BACKGROUND: We present the results of an academic phase 2 study on imatinib plus...
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Related ArticlesImpact of Body Mass Index on Operative Outcomes in Head and Neck Free Flap Surgery. Otolaryngol Head Neck Surg. 2018 11;159(5):817-823 Authors: Crippen MM, Brady JS, Mozeika AM, Eloy JA, Baredes S, Park RCW Abstract OBJECTIVE: Analyze the risk for perioperative complications associated with body mass index (BMI) class in patients undergoing head and neck free flap reconstruction. STUDY DESIGN AND SETTING: Retrospective cohort...
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Related ArticlesMulticenter US Clinical Trial With an Electric-Acoustic Stimulation (EAS) System in Adults: Final Outcomes. Otol Neurotol. 2018 03;39(3):299-305 Authors: Pillsbury HC, Dillon MT, Buchman CA, Staecker H, Prentiss SM, Ruckenstein MJ, Bigelow DC, Telischi FF, Martinez DM, Runge CL, Friedland DR, Blevins NH, Larky JB, Alexiades G, Kaylie DM, Roland PS, Miyamoto RT, Backous DD, Warren FM, El-Kashlan HK, Slager HK, Reyes C, Racey AI, Adunka OF Abstract...
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Related ArticlesUltra Long-Term Audiometric Outcomes in the Treatment of Vestibular Schwannoma With the Middle Cranial Fossa Approach. Otol Neurotol. 2018 02;39(2):e151-e157 Authors: Roche JP, Woodson EA, Hansen MR, Gantz BJ Abstract OBJECTIVE: Define the long-term audiometric outcomes of vestibular schwannomas treated using the middle cranial fossa (MCF) approach. STUDY DESIGN: Retrospective records review. SETTING: University-based...
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Pharmaceutics, Vol. 11, Pages 491: Quasi-Dynamic Dissolution of Electrospun Polymeric Nanofibers Loaded with Piroxicam Pharmaceutics doi: 10.3390/pharmaceutics11100491 Authors: Urve Paaver Jyrki Heinämäki Ivan Kassamakov Tuomo Ylitalo Edward Hæggström Ivo Laidmäe Karin Kogermann We investigated and monitored in situ the wetting and dissolution properties of polymeric nanofibers and determined the solid-state of a drug during dissolution. Piroxicam (PRX) was used as...
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Pharmaceutics, Vol. 11, Pages 490: Targeted Topical Delivery of Retinoids in the Management of Acne Vulgaris: Current Formulations and Novel Delivery Systems Pharmaceutics doi: 10.3390/pharmaceutics11100490 Authors: Gemma Latter Jeffrey E. Grice Yousuf Mohammed Michael S. Roberts Heather A. E. Benson Acne vulgaris is a common inflammatory pilosebaceous condition that affects 80–90% of adolescents. Since the introduction of tretinoin over 40 years ago, topical retinoid...
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Objective: We investigated the risk of sudden sensorineural hearing loss (SSNHL) in patients with autoimmune diseases compared with a control group in a population-based study using a National Health Insurance Service National Sample Cohort data from Korea. Methods:We enrolled autoimmune-disease patients who were ≥20 years of age in 2006 into the autoimmune-disease group, and selected a control group with similar demographic characteristics. We tracked the 2 groups from 2006 to 2015 and compared...
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Publication date: Available online 23 September 2019Source: Journal of Anxiety DisordersAuthor(s): David Rosenfield, Jasper A.J. Smits, Stefan G. Hofmann, David Mataix-Cols, Lorena Fernández de la Cruz, Erik Andersson, Christian Rück, Benedetta Monzani, Ana Pérez-Vigil, Paolo Frumento, Michael Davis, Rianne A. de Kleine, JoAnn Difede, Boadie W. Dunlop, Lara J. Farrell, Daniel Geller, Maryrose Gerardi, Adam J. Guastella, Gert-Jan Hendriks, Matt G. KushnerABSTRACTThe apparent efficacy of d-cycloserine...
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Publication date: October 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 4Author(s):
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Publication date: October 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 4Author(s): Zhi Ven Fong, David C. Chang, Henry A. Pitt
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Publication date: October 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 4Author(s): Jonathan P. Pearl, Raymond Price, Dimitrios Stefanidis
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Publication date: October 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 4Author(s): Thomas R. McLean
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Publication date: October 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 4Author(s): J. Emamaullee, Navpreet Kaur, Linda Sher, Yuri Genyk
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Publication date: October 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 4Author(s): Jason T. Wiseman, Jordan M. Cloyd
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Publication date: October 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 4Author(s): Chengcheng Zhang, Haisu Dai, Zhiyu Chen
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Publication date: October 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 4Author(s):
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Publication date: October 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 4Author(s):
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Publication date: October 2019Source: Journal of the American College of Surgeons, Volume 229, Issue 4Author(s): Babak Sarani
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