Interleukin-6 (IL-6) is a unique cytokine that can play both pro- and anti-inflammatory roles depending on the anatomical site and conditions under which it has been induced. Specific neurons of the hypothalamus provide important signals to control food intake and energy expenditure. In individuals with obesity, a microglia-dependent inflammatory response damages the neural circuits responsible for maintaining whole-body energy homeostasis, resulting in a positive energy balance. However, little...
21h
Objective. To investigate the effects of different concentrations of Fe3+ on the acute toxicity and regeneration of planarian at different temperatures. Method. The planarians were treated with 40 mg/l, 50 mg/l, 60 mg/l, and 70 mg/l Fe3+ solution and placed in 15°C, 20°C, and 25°C, respectively, to observe the mortality and the poisoning pattern of the planarian. In addition, the planarians were cut into three parts of head, trunk, and tail, then placed in Fe3+ solution at concentrations of 10 mg/l,...
21h
Wound healing is a complex process regulated by multiple signals and consisting of several phases known as haemostasis, inflammation, proliferation, and remodelling. Keratinocytes, endothelial cells, macrophages, and fibroblasts are the major cell populations involved in wound healing process. Hypoxia plays a critical role in this process since cells sense and respond to hypoxic conditions by changing gene expression. This study assessed the in vitro expression of 77 genes involved in angiogenesis,...
21h
The immune system is involved in the development of diabetes complications and IgG Fc gamma receptors (FcgRs) are key immune receptors responsible for the effective control of both humoral and innate immunity. We investigated the effects of members of the FcgR superfamily into both the streptozotocin plus high fat-induced type 2 diabetes and high fat diet (HFD) models. FcgRIII-/- diabetic mice and FcgRIIb-/- diabetic mice had elevated levels of serum creatinine compared with wildtype (WT) diabetic...
21h
Watch the full Onlife interview with Professor Bax here: https://youtu.be/rUzgmvHBwYc.
20h
Commentary on ‘Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing’ by Nöthen et al., Nat Genet, 2019.1
20h
Severe aortic stenosis is a relatively common clinical condition, becoming more common with advancing age, and the traditional treatment has been surgical aortic valve replacement (SAVR). Almost a decade ago transcutaneous aortic valve replacement (TAVR), was introduced as an alternative treatment to medical therapy alone in patients who were considered too high risk for conventional SAVR. A randomized trial published in 20101 showed a dramatic reduction in mortality at 1 year in these patients receiving...
20h
In 2002, Cribier performed the first transcatheter aortic valve implantation (TAVI) in an inoperable patient using a transseptal antegrade approach and a balloon-expandable aortic valve prosthesis, demonstrating the feasibility of percutaneous valve implantation. From then on, the favourable effects of TAVI vs. optimal medical treatment and similar outcomes compared to surgical aortic valve replacement (SAVR) in intermediate- to high-risk patients with severe aortic stenosis have been shown by several...
20h
Journal of Interferon &Cytokine Research, Ahead of Print.
14h
Journal of Interferon &Cytokine Research, Ahead of Print.
12h
Abstract Background Health systems, globally, are attempting to strengthen primary care to promote a population-health management approach to care provision, incentivising prevention and self-management. This paper evaluates the "Enhanced Primary Care" model implemented in a geographical region in England. Enhanced Primary Care introduces a new non-medical role, health coaches, to the traditional primary care team to provide additional...
16h
Abstract Background Management for multi-drug-resistant tuberculosis (MDR-TB) is challenging and has poor patient outcomes. Peru has a high burden of MDR-TB. The Loreto region in the Peruvian Amazon is worst affected for reasons including high rates of poverty and poor healthcare access. Current evidence identifies factors that influence MDR-TB medication adherence, but there is limited understanding of the patient and healthcare...
16h
Abstract Background The key to the effective management of healthcare wastes is segregation of the waste at the point of generation; no matter what final strategy for treatment and disposal of wastes is selected, it is critical that waste streams are separated. In Ethiopia, healthcare waste segregation practice among healthcare workers is overlooked and scarcely addressed in the scientific literature. This hospital-based cross-sectional...
20h
Abstract Background The ‘Surviving Crying’ study was designed to develop and provisionally evaluate a support service for parents of excessively crying babies, including its suitability for use in the United Kingdom (UK) National Health Service (NHS). The resulting service includes three materials: a website, a printed booklet, and a Cognitive Behaviour Therapy (CBT) programme delivered to parents by a qualified professional. This...
20h
Abstract Objective Electronic data collection (EDC) has become a suitable alternative to paper based data collection (PBDC) in biomedical research even in resource poor settings. During a survey in Nepal, data were collected using both systems and data entry errors compared between both methods. Collected data were checked for completeness, values outside of realistic ranges, internal logic and date variables for reasonable time...
16h
Abstract Objective The purpose of this study was to assess the magnitude of premenstrual syndrome and its associated factors among secondary school students in Debremarkos, North west Ethiopia. Results Premenstrual syndrome was reported by 81.3% of the participants. Statistically significant association was observed between the occurrence of...
16h
Abstract Objective Dichelobacter nodosus is the primary aetiological agent of footrot in sheep. Ovine footrot causes considerable economic losses and substantial animal welfare issues in the Australian sheep industry. Current methods for detecting D. nodosus are difficult, laborious and time-consuming. Recently, we developed a robust LAMP assay (VDN LAMP) that was able to identify aprV2 positive D. nodosus in-field. A major advantage...
16h
Abstract Objective Although schoolboy rugby is growing in popularity and played at different competitive levels in Zimbabwe, the influence of playing standard on qualities or skills of older male adolescent rugby players is unknown. Utilising a cross-sectional design, this study determined anthropometric, physiological characteristics and rugby-specific game skills defining elite under 19 (U19) schoolboy rugby players. Following...
16h
Abstract Objective To assess the quality of life, physical and mental factors, determine association between age, education status, disease duration and MSQOL-54 physical and Mental Health Composite scores among Sudanese patients with multiple sclerosis. This cross-section study was conducted among 32 MS patients at the National center for Neurological Science, Khartoum from January 2017 to June 2018. Using Multiple sclerosis Quality...
20h
Abstract An extreme reduction in body size has been shown to negatively impact the memory retention level of the parasitic wasp Nasonia vitripennis. In addition, N. vitripennis and Nasonia giraulti, closely related parasitic wasps, differ markedly in the number of conditioning trials required to form long-term memory. These differences in memory dynamics may be associated with differences in the dopaminergic neurons in the Nasonia brains. Here, we used dopamine immunoreactivity...
22h
Abstract Caspase (CASP) 3 is known as a representative effector CASP of apoptosis and recently as a mediator in inflammatory cell death called pyroptosis. Interestingly, homozygotes of Casp3 knockout (KO) mice with 129-background show complete embryonic lethality; however, some of those with C57BL/6 (B6)-background (B6.129S1-Casp3tm1Flv/J) survived at a lower rate (KO, 11%; WT, 22%), developing immune abnormality-associated renal phenotypes. Homozygotes of Casp3 KO mice with B6-background...
22h
Abstract Galactomannan (GM), a natural polymer, is recognized to specifically target macrophage mannose receptors (CD206). Interestingly, some reports indicate that GM has an ability to induce pro-inflammatory (M1-like, tumericidal) polarization in macrophages, suggesting its potential use as an anti-cancer agent. Hydrazinocurcumin (HC), a pyrazole derivative of curcumin, is reported to possess increased anti-cancer efficacy over curcumin. Moreover, HC-encapsulated nanoparticles...
9h
Abstract This paper explains the institution of prison leave in Spain. Firstly, I will briefly describe the regulations governing prison leave and provide data on its use in Spain. I will point out that although half the prison population benefits from a prison leave, a main problem is that it is granted at a very late stage of the sentence, and that immigrants have a very low probability of obtaing it. Secondly, I will explain the criteria used in order to determine if a leave...
7h
Abstract Plasmonic Au nanoparticle (NP)–decorated g-C3N4 nanosheets were synthesized by a direct in situ decomposition-thermal polymerization method with dicyandiamide and gold chloride trihydrate (HAuCl4·3H2O) as the precursors. Au NPs were closely anchored on the surface of g-C3N4 with high dispersion, and Au/g-C3N4 composites showed strong surface plasmon resonance in the visible light region. The photocurrent density of Au/g-C3N4 composite with 1 wt% Au (0.32 μA/cm2) was...
8h
Abstract The monoclinic scheelite (ms) BiVO4 shows great potential applications in the photocatalyst due to its strong light absorption in the visible light region. To improve the separation of photoinduced charge carriers in BiVO4, such as election and hole, BiVO4/BiOBr photocatalyst with a high visible light activity was synthesized using an in situ chemical transformation method with BiVO4 as a matrix and hydrobromic acid (HBr) as a construction agent. The effect of the concentration...
12h
Abstract The recovery of nano-catalysts from organic wastewater is still one of the most significant problems in the catalytic industry. In this work, froth flotation was used to solve this problem. CuO nano-particles were considered as the desired materials. First, four surfactants were screened for determining a suitable collector through comparing their foam properties and capture capacity to CuO nano-particles. Subsequently, froth flotation was performed by using cocamidopropyl...
22h
Abstract Human pathogenic diseases are on the rage in the list of enfeebling diseases globally. The endless quest to salvage these drug-resistant pathogens ravaging our system through various therapies still posts serious challenge. This study engaged a biogenic synthesis that is benign, facile, biocompatible, cost-effective and eco-friendly to synthesized silver nanocapsule (AgNCs) via Moringa oleifera aqueous extract under incubation control. The flavonoid-kaempferol, phenolic-chlorogenic...
8h
The adverse health effects of short-term exposure to ambient air pollution are well documented. Particulate matter (PM), especially, arouses public health concerns because of its toxicity and the widespread human exposure to this pollutant. PM, which includes inhalable particles with an aerodynamic…
3h
Ischemic heart disease is the most common and most lethal cause of heart failure. It is also the only cause of left ventricular dysfunction that is amenable to the benefit of surgical revascularization. The Surgical Treatment for Ischemic Heart Failure (STICH) trial and its extension study…
3h
Despite the availability of proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies for multiple myeloma, most patients will have a relapse and refractory disease will develop. An increasing number of patients have triple-class refractory myeloma, defined as disease refractory to…
3h
Acute heart failure remains a leading cause of hospitalization. Among hospitalized patients with acute heart failure, 10 to 15% have worsening heart failure during the hospitalization, and 10 to 15% die within 60 to 90 days after discharge; these numbers are dramatically higher than those among…
3h
Abstract Research is a particularly underexplored professional activity for physicians, leaving many medical students compelled to pursue a clinical career. However, the XXI century requires that physicians innovate and perform research that fuels their practice; students should have early exposure to research to explore it as a career path. It should be encouraged in the undergraduate program by having students take part in case reports, short communication presentations, and...
15h
Publication date: Available online 22 August 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Aneta Smidova, Katerina Stankova, Olivia Petrvalska, Josef Lazar, Hana Sychrova, Tomas Obsil, Olga Zimmermannova, Veronika ObsilovaAbstractNa+/H+ antiporters are involved in ensuring optimal intracellular concentrations of alkali-metal cations and protons in most organisms. In Saccharomyces cerevisiae, the plasma-membrane Na+, K+/H+ antiporter Nha1 mediates Na+ and K+ efflux,...
15h
Publication date: Available online 22 August 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Dimitrios Galaris, Alexandra Barbouti, Kostas PantopoulosAbstractIron is a transition metal and essential constituent of almost all living cells and organisms. As component of various metalloproteins it is involved in critical biochemical processes such as transport of oxygen in tissues, electron transfer reactions during respiration in mitochondria, synthesis and repair...
15h
Publication date: Available online 21 August 2019Source: Brain Research BulletinAuthor(s): Ilya D. Ionov, Irina I. Pushinskaya, Niсholas P. Gorev, David D. FrenkelAbstractNeural circuits involved in the development of depression are currently poorlyunderstood. To provide insight into this issue, we evaluated the influence of seven clinically effective antidepressants on neuronal activity in thirty rat brain areas. Drugs belonging to all major groups of antidepressants (imipramine, reboxetine, fluoxetine,...
19h
Publication date: Available online 21 August 2019Source: Brain Research BulletinAuthor(s): Cheng Chen, Jian-Hong Shen, Hui Xu, Peng Chen, Fei Chen, Yi-Xiang Guan, Bo Jiang, Zhong-Hua WuAbstractAlthough thought as a serotonin and norepinephrine reuptake inhibitor (SNRI), the antidepressant mechanisms of venlafaxine remain unknown. Previous reports have shown the role of peroxisome proliferator activated receptor α (PPARα) in depression. In this study, we investigated whether the antidepressant-like...
19h
Publication date: October 2019Source: Neuroscience Research, Volume 147Author(s):
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Publication date: Available online 22 August 2019Source: Neuroscience ResearchAuthor(s): John M. Andraka, Naveen Sharma, Yannick MarchalantAbstractMost neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, demonstrate preceding or on-going inflammatory processes. Therefore, discovering effective means of counteracting detrimental inflammatory mediators in the brain could help alter aging-related disease onset and progression. Fish oil and marine-derived omega-3, long-chain polyunsaturated...
19h
Publication date: Available online 21 August 2019Source: Neuroscience ResearchAuthor(s): Ryosuke Kuboki, Narihisa Matsumoto, Yasuko Sugase-Miyamoto, Tsuyoshi Setogawa, Barry. J. Richmond, Munetaka ShidaraAbstractVisual object recognition requires both visual sensory information and memory, and its mechanisms are often studied using old-world monkeys. Wittig et al. (2014, 2016) reported that Rhesus monkeys and humans seem to adopt different strategies in a short-term visual memory task. The Rhesus...
19h
Publication date: Available online 22 August 2019Source: Pathology - Research and PracticeAuthor(s): Christian Smolle, Lukas Holzer, Maria Anna Smolle, Kinga Szurian, Christian Viertler, Koppany Bodo, Bernadette Liegl-Atzwanger, Andreas LeithnerAbstractBackgroundIn Ewing sarcomas (ES), histological response to polychemotherapy is the main prognostic factor. We aimed at evaluating the histological response separately for the extraosseous and intraosseous tumor compartment as well as its prognostic...
17h
Publication date: October 2019Source: Research in Developmental Disabilities, Volume 93Author(s): Susanna Siu-sze Yeung, Shen QiaoAbstractBackgroundInvented spelling has been viewed as a window to young children’s spelling development.AimsThis longitudinal study investigated the developmental trends in invented spelling as a function of phoneme position in very young ESL children. It also investigated cognitive-linguistic precursors of L2 spelling difficulties.Methods and proceduresWe identified...
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Publication date: September 2019Source: Research in Developmental Disabilities, Volume 92Author(s):
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Publication date: September 2019Source: Research in Developmental Disabilities, Volume 92Author(s):
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