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Abstract Erosive pustular dermatosis of the leg (EPDL) is a rare inflammatory cutaneous disease characterized by non‐follicular sterile pustules, erosions and crusts on an erythematous background.1 EPDL prefers the middle third of the leg and typically affects elderly patients. Symptoms consist of pain, itch and/or sting. Lesions show a chronic progression and tend to relapses in the absence of a correct management. This article is protected by copyright. All rights reserved.
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Abstract Background A long‐term prospective observational safety study is essential to fully characterize the safety profile of systemic immunomodulating therapies for patients with atopic eczema. The TREatment of ATopic eczema (TREAT) Registry Taskforce offers a large platform to conduct such research using national registries that collect the same data using a predefined core dataset. Objectives We present a protocol for a safety study comparing dupilumab with other systemic immunomodulating...
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Abstract Brain metastases are frequent in metastatic melanoma patients and indicate poor prognosis. Approximately 20% of all melanomas harbor an NRAS mutation (1). Although direct targeting RAS GTPase is difficult, preclinical in‐vitro investigations suggest that melanomas harboring the NRAS mutation are sensitive to MEK inhibitors (2). Binimetinib, an orally bioavailable, selective and potent MEK1/2 inhibitor, has recently demonstrated improved progression‐free survival (PFS) in patients with NRAS‐mutant...
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Abstract Background Better understanding of the relationship between atopic dermatitis (AD) severity and health‐related quality of life (HRQoL) could help improve knowledge about the benefits of a more effective treatment of people with AD. Objectives To assess the relationship between AD severity and HRQoL as well as with perception of AD symptoms, among adults with moderate‐to‐severe AD in Europe (France, Germany, and the UK) and the US. Methods The survey panel participants for...
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Abstract In the article “Goblet cell scarcity and conjunctival inflammation during treatment with dupilumab in patients with atopic dermatitis,” Bakker et al. suggest that dupilumab‐associated conjunctivitis occurs because the “IL ‐13 blocking effect of dupilumab might lead to reduction of [conjunctival] G[oblet] C[ell]s and mucin production.1” We suggest that concomitant IL‐4 inhibition is important for conjunctivitis development as the lebrikizumab (IL‐13 Inhibitor) phase 2 trial data showed a...
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Serine proteases have important roles in the skin barrier function and desquamation. Kallikrein-related peptidases (KLKs) are 15 trypsin- or chymotrypsin-like serine proteases, and in the skin, KLK5 and KLK7 in particular have a prominent role in desquamation. [1] These two KLKs are produced mainly by keratinocytes of the stratum granulosum, and they degrade the corneodesmosome proteins such as desmoglein 1, desmocollin 1, and corneodesmosin. [2] The aberrant expression or the dysfunction of serine...
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Atopic dermatitis (AD) affects up to 15–20% of people in industrialized countries [1]. AD is one of the most common forms of inflammatory skin disease; it is characterized by chronic or recurrent eczema with pruritus, xerosis, and lichenification [2]. Recently, interleukin-33 (IL-33) has been shown to be involved in the pathophysiology of allergic disorders, including AD. There is no evidence that any one of the pathological conditions of AD is upstream. AD is a multifactorial, complex inflammatory...
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Systemic sclerosis (SSc) is a connective tissue disorder characterized by the development of fibrosis in the skin and internal organs, as well as microvascular dysfunction [1,2]. Vasculopathy occurs at an early step of SSc. Almost all patients present Raynaud's phenomenon as an initial symptom, and frequently show other manifestations of vascular diseases, including ischemic digital ulcers, pulmonary arterial hypertension, and renal arterial involvement associated with malignant hypertension and...
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Angiosarcoma (AS) develops in various soft tissues and organs, but the most frequently affected site is the skin, commonly occurring in the scalp of elderly people and typically presenting as an enlarging bruise-like purpura [1–5]. In the most of patients, AS is relatively large at the time of diagnosis because of a significant delay in diagnosis. There are some treatment options, however, an effective treatment has not been established yet, resulting in the poor prognosis.
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The anti-Ro52 antibody is found in a number of autoimmune diseases, including Sjögren’s syndrome (SS), systemic lupus erythematosus, systemic sclerosis and dermatomyositis (DM)/polymyositis (PM). It is most frequently found in SS (37.4–66.7%) and second-most frequently in DM/PM (26.3–31.2%) [1]. It is also one of the most common autoantibodies in inflammatory myopathies and is classified as a myositis-associated antibody (MAA), which is frequently found in PM/DM but not specific for this diagnosis...
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Abstract The microbiome is defined as the sum of microbes, their genomes, and interactions in a given ecological niche. Atopic dermatitis is a multifactorial chronic inflammatory skin disease leading to dryness and itchiness of the skin. It is often associated with comorbidities such as allergic rhinoconjunctivitis and asthma. Today, culture-free techniques have been established to define microbes and their genomes that may be both detrimental and beneficial for their host. There...
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Abstract Purpose of Review The aim of this work is to review the role of advanced non-invasive imaging, such as reflectance confocal microscopy (RCM) and optical coherence tomography (OCT), in malignant melanomas and non-melanoma skin cancers (NMSCs) using data coming from the most recent literature, with a particular highlight on the results of the European experience. Recent...
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Abstract The correlation between polymorphisms at the tumor necrosis factor (TNF) gene and generalized pustular psoriasis (GPP) has rarely been reported. The goal of this study is to investigate whether TNF polymorphisms (−238 A/G, −308 A/G, −857C/T) are associated with susceptibility to GPP in a Han population from Eastern China and to perform subgroup analysis to explore the influence of age onset. Polymorphisms were assessed by polymerase chain reaction amplification and resequencing in 91 GPP...
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Abstract Interstitial lung disease (ILD) is a rare complication of Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). In this study, we present the case of a 33‐year‐old woman who was diagnosed with ILD related to SJS/TEN overlap syndrome. Surprisingly, the patient did not respond to combination therapy with steroids and i.v. immunoglobulin, but rapidly improved after two doses of etanercept treatment. To our knowledge, this is the first case of SJS/TEN‐induced ILD that was successfully...
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Abstract Atopic dermatitis is a chronic, inflammatory skin disease characterized by intense pruritus and eczematous lesions. It is considered one of the most common chronic conditions, with an estimated global prevalence of nearly 230 million. As in the rest of the world, prevalence of atopic dermatitis has been increasing in Asian countries over the last few decades. This increased prevalence in Asian countries has been attributed to factors such as rapid urbanization, increasingly Westernized...
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Abstract The relation between tinea pedis and the internal environment of footwear has not been scientifically proven. This study aimed to determine whether the internal environment of footwear affects the incidence of tinea pedis and tinea unguium. This cross‐sectional, observatory study involved 420 outpatients who were categorized into non‐tinea, tinea pedis or tinea unguium groups based on mycological analysis. External climatic conditions, and temperature, humidity and dew points inside the...
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